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Search results 1 to 100 out of 110 for Orc4

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
5000 | ORC4
Type: gene
Organism: human
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Gene
448135 | orc4
Type: gene
Organism: frog, western clawed
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Gene
295596 | Orc4
Type: gene
Organism: rat
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Gene
476141 | ORC4
Type: gene
Organism: dog, domestic
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Gene
459647 | ORC4
Type: gene
Organism: chimpanzee
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Gene
529245 | ORC4
Type: gene
Organism: cattle
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Gene
424307 | ORC4
Type: gene
Organism: chicken
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Gene
406462 | orc4
Type: gene
Organism: zebrafish
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Gene
721876 | ORC4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1347043 | Orc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR016527 | ORC4
Type: Family
Description: The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded in yeast by ORC1-6 []. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle []. ORC directs DNA replication throughout the genome and is required for its initiation [, , ]. ORC bound at replication origins serves as the foundation for assembly of the pre-replicative complex (pre-RC), which includes Cdc6, Tah11 (aka Cdt1), and the Mcm2-7 complex [, , ]. Pre-RC assembly during G1 is required for replication licensing of chromosomes prior to DNA synthesis during S phase [, , ]. Cell cycle-regulated phosphorylation of ORC2, ORC6, Cdc6, and MCM by the cyclin-dependent protein kinase Cdc28 regulates initiation of DNA replication, including blocking reinitiation in G2/M phase [, , , ]. In yeast, ORC also plays a role in the establishment of silencing at the mating-type loci Hidden MAT Left (HML) and Hidden MAT Right (HMR) [, , ]. ORC participates in the assembly of transcriptionally silent chromatin at HML and HMR by recruiting the Sir1 silencing protein to the HML and HMR silencers [, , ]. Both ORC1 and ORC5 bind ATP, although only ORC1 has ATPase activity []. The binding of ATP by ORC1 is required for ORC binding to DNA and is essential for cell viability []. The ATPase activity of ORC1 is involved in formation of the pre-RC [, , ]. ATP binding by ORC5 is crucial for the stability of ORC as a whole. Only the ORC1-5 subunits are required for origin binding; ORC6 is essential for maintenance of pre-RCs once formed []. Interactions within ORC suggest that ORC2-3-6 may form a core complex []. ORC homologues have been found in various eukaryotes, including fission yeast, insects, amphibians, and humans []. This group represents an origin recognition complex, subunit 4.
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Publication
34977916 | J:326522
First Author: Nguyen H
Year: 2022
Journal: Biol Reprod
Title: Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication†.
Volume: 106
Issue: 4
Pages: 730-740
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Publication
28230328 | J:326604
First Author: Nguyen H
Year: 2017
Journal: J Cell Biochem
Title: Higher Order Oligomerization of the Licensing ORC4 Protein Is Required for Polar Body Extrusion in Murine Meiosis.
Volume: 118
Issue: 9
Pages: 2941-2949
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Publication
9829972 | J:43876
First Author: Tugal T
Year: 1998
Journal: J Biol Chem
Title: The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.
Volume: 273
Issue: 49
Pages: 32421-9
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Publication
10460412 | J:57660
First Author: Springer J
Year: 1999
Journal: Chromosoma
Title: Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex.
Volume: 108
Issue: 4
Pages: 243-9
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Protein
O88708
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
A2AI40
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Protein
Q8BN98
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q9CZF7
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: false
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Protein
Q8BTB0
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: false
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Protein
Q8C693
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Publication
17241905 | -
 
First Author: Chesnokov IN
Year: 2007
Journal: Int Rev Cytol
Title: Multiple functions of the origin recognition complex.
Volume: 256
Pages: 69-109
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Publication
17825065 | -
First Author: Matsuda K
Year: 2007
Journal: FEMS Yeast Res
Title: Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.
Volume: 7
Issue: 8
Pages: 1263-9
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Publication
1579162 | -
First Author: Bell SP
Year: 1992
Journal: Nature
Title: ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex.
Volume: 357
Issue: 6374
Pages: 128-34
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Publication
7585959 | -
First Author: Bell SP
Year: 1995
Journal: Cell
Title: The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing.
Volume: 83
Issue: 4
Pages: 563-8
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Publication
16716188 | -
First Author: Gibson DG
Year: 2006
Journal: Genes Cells
Title: Cell cycle execution point analysis of ORC function and characterization of the checkpoint response to ORC inactivation in Saccharomyces cerevisiae.
Volume: 11
Issue: 6
Pages: 557-73
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Publication
7892251 | -
First Author: Rao H
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.
Volume: 92
Issue: 6
Pages: 2224-8
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Publication
7781615 | -
First Author: Rowley A
Year: 1995
Journal: EMBO J
Title: Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.
Volume: 14
Issue: 11
Pages: 2631-41
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Publication
10966477 | -
 
First Author: Kelly TJ
Year: 2000
Journal: Annu Rev Biochem
Title: Regulation of chromosome replication.
Volume: 69
Pages: 829-80
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Publication
12045100 | -
 
First Author: Bell SP
Year: 2002
Journal: Annu Rev Biochem
Title: DNA replication in eukaryotic cells.
Volume: 71
Pages: 333-74
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Publication
15680967 | -
First Author: Stillman B
Year: 2005
Journal: FEBS Lett
Title: Origin recognition and the chromosome cycle.
Volume: 579
Issue: 4
Pages: 877-84
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Publication
11572976 | -
First Author: Weinreich M
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle.
Volume: 98
Issue: 20
Pages: 11211-7
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Publication
11429609 | -
First Author: Nguyen VQ
Year: 2001
Journal: Nature
Title: Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms.
Volume: 411
Issue: 6841
Pages: 1068-73
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Publication
16024805 | -
First Author: Archambault V
Year: 2005
Journal: Mol Cell Biol
Title: Disruption of mechanisms that prevent rereplication triggers a DNA damage response.
Volume: 25
Issue: 15
Pages: 6707-21
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Publication
8622770 | -
First Author: Triolo T
Year: 1996
Journal: Nature
Title: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.
Volume: 381
Issue: 6579
Pages: 251-3
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Publication
9171055 | -
First Author: Fox CA
Year: 1997
Journal: Science
Title: The origin recognition complex, SIR1, and the S phase requirement for silencing.
Volume: 276
Issue: 5318
Pages: 1547-51
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Publication
9038340 | -
First Author: Klemm RD
Year: 1997
Journal: Cell
Title: Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex.
Volume: 88
Issue: 4
Pages: 493-502
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Publication
11459976 | -
First Author: Klemm RD
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: ATP bound to the origin recognition complex is important for preRC formation.
Volume: 98
Issue: 15
Pages: 8361-7
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Publication
15610739 | -
First Author: Bowers JL
Year: 2004
Journal: Mol Cell
Title: ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
Volume: 16
Issue: 6
Pages: 967-78
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
17053779 | -
First Author: Semple JW
Year: 2006
Journal: EMBO J
Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
Volume: 25
Issue: 21
Pages: 5150-8
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Publication
9442876 | -
 
First Author: Dutta A
Year: 1997
Journal: Annu Rev Cell Dev Biol
Title: Initiation of DNA replication in eukaryotic cells.
Volume: 13
Pages: 293-332
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Protein Coding Gene
MGP_CAROLIEiJ_G0023543 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0025696 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0025666 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0025691 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0025452 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1347043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0026137 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0024917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0025432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0025563 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0025525 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0025651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0025556 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0026195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0024658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024984 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024994 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0024463 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:5615152
Assay Type: RT-PCR
Annotation Date: 2015-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:5615161
Age: embryonic day 21.0
Image: 2
Specimen Label: Mdb5+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5615152
Assay Type: RT-PCR
Annotation Date: 2015-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:5615161
Age: embryonic day 21.0
Image: 2
Specimen Label: Mdb5+/GT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5615152
Assay Type: RT-PCR
Annotation Date: 2015-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:5615161
Age: embryonic day 21.0
Image: 2
Specimen Label: Mdb5GT/GT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:347243
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3564522
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825888
Age: embryonic day 14.5
Image: Additional file 4 Orc4l
Specimen Label: Additional file 4 Orc4l
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:347243
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Scattered
Stage: TS23
Assay Id: MGI:4826982
Age: embryonic day 14.5
Image: euxassay_000026_11
Note: Staining was noted in dispersed cells in all tissues and organs.
Specimen Label: euxassay_000026_11
Detected: true
Specimen Num: 1
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Publication
12614612 | J:82383
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
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Publication
25001218 | J:212073
First Author: Camarena V
Year: 2014
Journal: EMBO Mol Med
Title: Disruption of Mbd5 in mice causes neuronal functional deficits and neurobehavioral abnormalities consistent with 2q23.1 microdeletion syndrome.
Volume: 6
Issue: 8
Pages: 1003-15
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Publication
32808929 | J:339148
   
First Author: Jaremko MJ
Year: 2020
Journal: Elife
Title: The dynamic nature of the human origin recognition complex revealed through five cryoEM structures.
Volume: 9
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Publication
- | J:165965
     
First Author: Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource
Year: 2010
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Europhenome
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Publication
- | J:104881
     
First Author: The RIKEN BioResource Center
Year: 2006
Journal: Unpublished
Title: Information obtained from The RIKEN BioResource Center
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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