| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000874 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2775623 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5448145 |
| Age: |
embryonic day 15.5 |
| Image: |
3A Pax8 |
|
| Specimen Label: |
3A Pax8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000874 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2767823 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5448145 |
| Age: |
embryonic day 15.5 |
| Image: |
6 Pax8 |
|
| Specimen Label: |
6 Pax8 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7571530 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3675817 |
| Pattern: |
Regionally restricted |
| Stage: |
TS17 |
| Assay Id: |
MGI:7571564 |
| Age: |
embryonic day 10.5 |
| Image: |
9E Pax8 |
| Note: |
Virtually all expressing cells senescent placode cells in epibranchial placode 2 are predominantly weakly Pax8-expressing progenitors. |
| Specimen Label: |
9E Pax8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000874 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2775623 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5448145 |
| Age: |
embryonic day 15.5 |
| Image: |
6 Pax8 |
|
| Specimen Label: |
6 Pax8 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5000874 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2013-01-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2767823 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:5448145 |
| Age: |
embryonic day 15.5 |
| Image: |
3A Pax8 |
|
| Specimen Label: |
3A Pax8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouchard M |
| Year: |
2004 |
| Journal: |
Genesis |
| Title: |
Tissue-specific expression of cre recombinase from the Pax8 locus. |
| Volume: |
38 |
| Issue: |
3 |
| Pages: |
105-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouchard M |
| Year: |
2002 |
| Journal: |
Genes Dev |
| Title: |
Nephric lineage specification by Pax2 and Pax8. |
| Volume: |
16 |
| Issue: |
22 |
| Pages: |
2958-70 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7578917 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-01-30 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1796221 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:7578921 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
S7e Pax8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Damante G |
| Year: |
1998 |
| Journal: |
Eur J Endocrinol |
| Title: |
Thyroid defects due to Pax8 gene mutations. |
| Volume: |
139 |
| Issue: |
6 |
| Pages: |
563-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mansouri A |
| Year: |
1998 |
| Journal: |
Nat Genet |
| Title: |
Follicular cells of the thyroid gland require Pax8 gene function. |
| Volume: |
19 |
| Issue: |
1 |
| Pages: |
87-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marotta P |
| Year: |
2014 |
| Journal: |
Mol Cell Endocrinol |
| Title: |
The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. |
| Volume: |
396 |
| Issue: |
1-2 |
| Pages: |
26-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Di Palma T |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. |
| Volume: |
278 |
| Issue: |
5 |
| Pages: |
3395-402 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bouchard M |
| Year: |
2010 |
| Journal: |
BMC Dev Biol |
| Title: |
Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. |
| Volume: |
10 |
|
| Pages: |
89 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Cristofaro T |
| Year: |
2012 |
| Journal: |
Mol Endocrinol |
| Title: |
An essential role for Pax8 in the transcriptional regulation of cadherin-16 in thyroid cells. |
| Volume: |
26 |
| Issue: |
1 |
| Pages: |
67-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Christ S |
| Year: |
2004 |
| Journal: |
Audiol Neurootol |
| Title: |
Hearing loss in athyroid pax8 knockout mice and effects of thyroxine substitution. |
| Volume: |
9 |
| Issue: |
2 |
| Pages: |
88-106 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Di Palma T |
| Year: |
2009 |
| Journal: |
Exp Cell Res |
| Title: |
TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. |
| Volume: |
315 |
| Issue: |
2 |
| Pages: |
162-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Y |
| Year: |
2016 |
| Journal: |
J Cell Mol Med |
| Title: |
Pax8 plays a pivotal role in regulation of cardiomyocyte growth and senescence. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
644-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Narlis M |
| Year: |
2007 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. |
| Volume: |
18 |
| Issue: |
4 |
| Pages: |
1121-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Glaschke A |
| Year: |
2010 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Developmental changes of cone opsin expression but not retinal morphology in the hypothyroid Pax8 knockout mouse. |
| Volume: |
51 |
| Issue: |
3 |
| Pages: |
1719-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pfeffer PL |
| Year: |
1998 |
| Journal: |
Development |
| Title: |
Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function. |
| Volume: |
125 |
| Issue: |
16 |
| Pages: |
3063-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu DJ |
| Year: |
2020 |
| Journal: |
Dis Model Mech |
| Title: |
Cells expressing PAX8 are the main source of homeostatic regeneration of adult mouse endometrial epithelium and give rise to serous endometrial carcinoma. |
| Volume: |
13 |
| Issue: |
10 |
|
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6191026 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Pax8 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191026 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Pax8 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6191026 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Pax8 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6191026 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Pax8 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6191026 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Pax8 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191026 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Pax8 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6180112 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6191026 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Pax8 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martin-Montalvo A |
| Year: |
2019 |
| Journal: |
Diabetes |
| Title: |
Transient PAX8 Expression in Islets During Pregnancy Correlates With β-Cell Survival, Revealing a Novel Candidate Gene in Gestational Diabetes Mellitus. |
| Volume: |
68 |
| Issue: |
1 |
| Pages: |
109-118 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Albano F |
| Year: |
2021 |
| Journal: |
Int J Mol Sci |
| Title: |
ZFP36L2 Role in Thyroid Functionality. |
| Volume: |
22 |
| Issue: |
17 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iervolino A |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Selective dicer suppression in the kidney alters GSK3β/β-catenin pathways promoting a glomerulocystic disease. |
| Volume: |
10 |
| Issue: |
3 |
| Pages: |
e0119142 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bartram MP |
| Year: |
2016 |
| Journal: |
BMC Mol Biol |
| Title: |
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure. |
| Volume: |
17 |
|
| Pages: |
11 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koumarianou P |
| Year: |
2017 |
| Journal: |
J Cell Sci |
| Title: |
Pax8 controls thyroid follicular polarity through cadherin-16. |
| Volume: |
130 |
| Issue: |
1 |
| Pages: |
219-231 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Verissimo T |
| Year: |
2023 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
PCK1 is a key regulator of metabolic and mitochondrial functions in renal tubular cells. |
| Volume: |
324 |
| Issue: |
6 |
| Pages: |
F532-F543 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cullen PF |
| Year: |
2024 |
| Journal: |
Glia |
| Title: |
Transcriptional profiling of retinal astrocytes identifies a specific marker and points to functional specialization. |
| Volume: |
72 |
| Issue: |
9 |
| Pages: |
1604-1628 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iervolino A |
| Year: |
2018 |
| Journal: |
Front Physiol |
| Title: |
Integrin Beta 1 Is Crucial for Urinary Concentrating Ability and Renal Medulla Architecture in Adult Mice. |
| Volume: |
9 |
|
| Pages: |
1273 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao XP |
| Year: |
2023 |
| Journal: |
Diabetologia |
| Title: |
Hedgehog interacting protein activates sodium-glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes. |
| Volume: |
66 |
| Issue: |
1 |
| Pages: |
223-240 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lo CS |
| Year: |
2019 |
| Journal: |
Sci Rep |
| Title: |
Tubular Deficiency of Heterogeneous Nuclear Ribonucleoprotein F Elevates Systolic Blood Pressure and Induces Glycosuria in Mice. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
15765 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fenton RA |
| Year: |
2015 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3. |
| Volume: |
308 |
| Issue: |
12 |
| Pages: |
F1409-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fenton RA |
| Year: |
2017 |
| Journal: |
Kidney Int |
| Title: |
Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. |
| Volume: |
92 |
| Issue: |
2 |
| Pages: |
397-414 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reale C |
| Year: |
2016 |
| Journal: |
J Biol Chem |
| Title: |
NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function. |
| Volume: |
291 |
| Issue: |
11 |
| Pages: |
5765-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Harris AN |
| Year: |
2021 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Role of the renal androgen receptor in sex differences in ammonia metabolism. |
| Volume: |
321 |
| Issue: |
5 |
| Pages: |
F629-F644 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee HW |
| Year: |
2022 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B. |
| Volume: |
322 |
| Issue: |
2 |
| Pages: |
F208-F224 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marsching C |
| Year: |
2014 |
| Journal: |
J Lipid Res |
| Title: |
Quantitative imaging mass spectrometry of renal sulfatides: validation by classical mass spectrometric methods. |
| Volume: |
55 |
| Issue: |
11 |
| Pages: |
2343-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hayashi S |
| Year: |
2011 |
| Journal: |
Mol Biol Evol |
| Title: |
Lack of in vivo functional compensation between Pax family groups II and III in rodents. |
| Volume: |
28 |
| Issue: |
10 |
| Pages: |
2787-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stransky LA |
| Year: |
2024 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Toward a CRISPR-based mouse model of Vhl-deficient clear cell kidney cancer: Initial experience and lessons learned. |
| Volume: |
121 |
| Issue: |
41 |
| Pages: |
e2408549121 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mittag J |
| Year: |
2007 |
| Journal: |
Endocrinology |
| Title: |
Congenital hypothyroid female pax8-deficient mice are infertile despite thyroid hormone replacement therapy. |
| Volume: |
148 |
| Issue: |
2 |
| Pages: |
719-25 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
251
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Antonica F |
| Year: |
2012 |
| Journal: |
Nature |
| Title: |
Generation of functional thyroid from embryonic stem cells. |
| Volume: |
491 |
| Issue: |
7422 |
| Pages: |
66-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grieco G |
| Year: |
2018 |
| Journal: |
Sci Rep |
| Title: |
Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
14133 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Possik E |
| Year: |
2015 |
| Journal: |
PLoS Genet |
| Title: |
FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. |
| Volume: |
11 |
| Issue: |
10 |
| Pages: |
e1005520 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Poleev A |
| Year: |
1992 |
| Journal: |
Development |
| Title: |
PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors. |
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