| Type |
Details |
Score |
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Selen ES |
| Year: |
2022 |
| Journal: |
J Biol Chem |
| Title: |
Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet. |
| Volume: |
298 |
| Issue: |
12 |
| Pages: |
102648 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1178
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagliarini DJ |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
| Volume: |
134 |
| Issue: |
1 |
| Pages: |
112-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
She P |
| Year: |
2000 |
| Journal: |
Mol Cell Biol |
| Title: |
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. |
| Volume: |
20 |
| Issue: |
17 |
| Pages: |
6508-17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Visel A |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
| Volume: |
32 |
| Issue: |
Database issue |
| Pages: |
D552-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Da Cruz S |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Proteomic analysis of the mouse liver mitochondrial inner membrane. |
| Volume: |
278 |
| Issue: |
42 |
| Pages: |
41566-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang J |
| Year: |
1993 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Adipose pyruvate carboxylase: amino acid sequence and domain structure deduced from cDNA sequencing. |
| Volume: |
90 |
| Issue: |
5 |
| Pages: |
1766-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Trigg M |
| Year: |
1972 |
| Journal: |
Mouse News Lett |
| Title: |
New Mutations - provisional gene symbol act (adult cataract) and provisional gene symbol fp (flopsy) |
| Volume: |
47 |
|
| Pages: |
19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li X |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells. |
| Volume: |
7 |
|
| Pages: |
11740 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bowman CE |
| Year: |
2016 |
| Journal: |
Mol Cell Biol |
| Title: |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
| Volume: |
36 |
| Issue: |
15 |
| Pages: |
2089-104 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schatton D |
| Year: |
2017 |
| Journal: |
J Cell Biol |
| Title: |
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. |
| Volume: |
216 |
| Issue: |
3 |
| Pages: |
675-693 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cappel DA |
| Year: |
2019 |
| Journal: |
Cell Metab |
| Title: |
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
1291-1305.e8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu Y |
| Year: |
2016 |
| Journal: |
PLoS Genet |
| Title: |
Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. |
| Volume: |
12 |
| Issue: |
9 |
| Pages: |
e1006355 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Deja S |
| Year: |
2024 |
| Journal: |
Cell Metab |
| Title: |
Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bose SK |
| Year: |
2016 |
| Journal: |
Endocrinology |
| Title: |
Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation. |
| Volume: |
157 |
| Issue: |
12 |
| Pages: |
4943-4960 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao K |
| Year: |
2022 |
| Journal: |
Development |
| Title: |
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. |
| Volume: |
149 |
| Issue: |
6 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mayeuf-Louchart A |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation. |
| Volume: |
29 |
| Issue: |
6 |
| Pages: |
1410-1418.e6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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|
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|
•
•
•
•
•
|
| Publication |
| First Author: |
Bulusu V |
| Year: |
2017 |
| Journal: |
Dev Cell |
| Title: |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
| Volume: |
40 |
| Issue: |
4 |
| Pages: |
331-341.e4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jitrapakdee S |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro. |
| Volume: |
280 |
| Issue: |
29 |
| Pages: |
27466-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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|
•
•
•
•
•
|
| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
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| Publication |
| First Author: |
Dickinson ME |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
High-throughput discovery of novel developmental phenotypes. |
| Volume: |
537 |
| Issue: |
7621 |
| Pages: |
508-514 |
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•
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•
•
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| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
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| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
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10 |
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| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Cyagen Biosciences Inc. |
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Am J Physiol Gastrointest Liver Physiol |
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Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. |
| Volume: |
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Mouse Genome Informatics Scientific Curators |
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Gene Ontology Annotation by the MGI Curatorial Staff |
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The Gene Ontology Consortium |
| Year: |
2010 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Diabetes |
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Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. |
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The Gene Ontology Consortium |
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J Biol Chem |
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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
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UniProt-GOA |
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365-373 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7547454 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-11-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1920922 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7547503 |
| Age: |
embryonic day 14.5 |
| Image: |
S4 |
|
| Specimen Label: |
E14.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7547454 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-11-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1920923 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:7547503 |
| Age: |
embryonic day 15.5 |
| Image: |
S4 |
|
| Specimen Label: |
E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7547454 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-11-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1920924 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7547503 |
| Age: |
embryonic day 16.5 |
| Image: |
S4 |
|
| Specimen Label: |
E16.5 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7547454 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-11-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1920925 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7547503 |
| Age: |
embryonic day 17.5 |
| Image: |
S4 |
|
| Specimen Label: |
E17.5 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7547454 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-11-13 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1920926 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7547503 |
| Age: |
embryonic day 18.5 |
| Image: |
S4 |
|
| Specimen Label: |
E18.5 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7576599 |
| Age: |
embryonic day 18.5 |
| Image: |
S2 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7576627 |
| Age: |
postnatal week 8 |
| Image: |
6 |
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576184 |
| Assay Type: |
Western blot |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
|
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7576627 |
| Age: |
postnatal week 8 |
| Image: |
6 |
|
| Specimen Label: |
KO |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576201 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7576637 |
| Age: |
postnatal week 8 |
| Image: |
6 |
|
| Specimen Label: |
Li-CluhWT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7576201 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-01-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:7576637 |
| Age: |
postnatal week 8 |
| Image: |
6 |
|
| Specimen Label: |
Li-CluhKO |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7628103 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-05-10 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754425 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7628438 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
WT |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7628103 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-05-10 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754425 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7628438 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
KI/KI |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|