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Search results 1 to 100 out of 355 for Pf4

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Type Details Score
Gene
Type: gene
Organism: Not Specified
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: macaque, rhesus
Protein Domain
Type: Family
Description: Platelet factor 4, also known as CXC chemokine 4, is released during platelet aggregation []. It neutralises the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule []. It is chemotactic (CXCR3 as its receptor) for neutrophils and monocytes []. It inhibits endothelial cell proliferation [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Rauova L
Year: 2010
Journal: Blood
Title: Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia.
Volume: 116
Issue: 23
Pages: 5021-31
Publication
First Author: Watanabe O
Year: 1999
Journal: J Hum Genet
Title: Significantly elevated expression of PF4 (platelet factor 4) and eotaxin in the NOA mouse, a model for atopic dermatitis.
Volume: 44
Issue: 3
Pages: 173-6
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: false
Publication
First Author: Lecomte-Raclet L
Year: 1998
Journal: Blood
Title: New insights into the negative regulation of hematopoiesis by chemokine platelet factor 4 and related peptides.
Volume: 91
Issue: 8
Pages: 2772-80
Publication
First Author: Gupta SK
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4.
Volume: 92
Issue: 17
Pages: 7799-803
Publication
First Author: Deuel TF
Year: 1981
Journal: Proc Natl Acad Sci U S A
Title: Platelet factor 4 is chemotactic for neutrophils and monocytes.
Volume: 78
Issue: 7
Pages: 4584-7
Publication
First Author: Gerotziafas GT
Year: 2001
Journal: Blood Coagul Fibrinolysis
Title: The role of platelet factor 4 in platelet aggregation induced by the antibodies implicated in heparin-induced thrombocytopenia.
Volume: 12
Issue: 7
Pages: 511-20
Publication
First Author: Wang D
Year: 2019
Journal: J Biol Chem
Title: ELF4 facilitates innate host defenses against Plasmodium by activating transcription of Pf4 and Ppbp.
Volume: 294
Issue: 19
Pages: 7787-7796
GXD Expression      
Probe: MGI:7563867
Assay Type: Western blot
Annotation Date: 2023-12-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604217
Stage: TS17
Assay Id: MGI:7563964
Age: embryonic day 10.0
Specimen Label: PF4 +/+
Detected: true
Specimen Num: 4
Publication
First Author: Shi G
Year: 2013
Journal: Blood
Title: Platelet factor 4 mediates vascular smooth muscle cell injury responses.
Volume: 121
Issue: 21
Pages: 4417-27
Publication
First Author: Love MS
Year: 2012
Journal: Cell Host Microbe
Title: Platelet factor 4 activity against P. falciparum and its translation to nonpeptidic mimics as antimalarials.
Volume: 12
Issue: 6
Pages: 815-23
Publication
First Author: Field DJ
Year: 2017
Journal: Immunol Res
Title: Platelet factor 4 increases bone marrow B cell development and differentiation.
Volume: 65
Issue: 5
Pages: 1089-1094
Publication
First Author: Eslin DE
Year: 2004
Journal: Blood
Title: Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin.
Volume: 104
Issue: 10
Pages: 3173-80
Publication
First Author: Johnston I
Year: 2020
Journal: Blood
Title: Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.
Volume: 135
Issue: 15
Pages: 1270-1280
Publication
First Author: Kizlik-Masson C
Year: 2019
Journal: Blood
Title: Cleavage of anti-PF4/heparin IgG by a bacterial protease and potential benefit in heparin-induced thrombocytopenia.
Volume: 133
Issue: 22
Pages: 2427-2435
Publication
First Author: Gollomp K
Year: 2020
Journal: Blood
Title: Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.
Volume: 135
Issue: 10
Pages: 743-754
Publication
First Author: Jian J
Year: 2017
Journal: Oncotarget
Title: Platelet factor 4 is produced by subsets of myeloid cells in premetastatic lung and inhibits tumor metastasis.
Volume: 8
Issue: 17
Pages: 27725-27739
Publication
First Author: Lapchak PH
Year: 2012
Journal: PLoS One
Title: The role of platelet factor 4 in local and remote tissue damage in a mouse model of mesenteric ischemia/reperfusion injury.
Volume: 7
Issue: 7
Pages: e39934
Publication
First Author: Shi G
Year: 2014
Journal: J Clin Invest
Title: Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection.
Volume: 124
Issue: 2
Pages: 543-52
Publication
First Author: Dai J
Year: 2018
Journal: Blood
Title: Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.
Volume: 132
Issue: 7
Pages: 727-734
Publication  
First Author: Drescher HK
Year: 2019
Journal: Front Physiol
Title: Platelet Factor 4 Attenuates Experimental Acute Liver Injury in Mice.
Volume: 10
Pages: 326
Publication
First Author: Lambert MP
Year: 2007
Journal: Blood
Title: Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications.
Volume: 110
Issue: 4
Pages: 1153-60
Publication
First Author: Le HT
Year: 2022
Journal: Sci Rep
Title: Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts.
Volume: 12
Issue: 1
Pages: 18636
Publication
First Author: Kowalska MA
Year: 2007
Journal: Blood
Title: Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge.
Volume: 110
Issue: 6
Pages: 1903-5
Publication
First Author: Reilly MP
Year: 2006
Journal: J Thromb Haemost
Title: Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model.
Volume: 4
Issue: 12
Pages: 2687-94
Publication
First Author: Srivastava K
Year: 2010
Journal: PLoS One
Title: Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria.
Volume: 5
Issue: 5
Pages: e10413
Publication
First Author: Kowalska MA
Year: 2011
Journal: Blood
Title: Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT.
Volume: 118
Issue: 10
Pages: 2882-8
Publication
First Author: Lambert MP
Year: 2009
Journal: Blood
Title: Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes.
Volume: 114
Issue: 11
Pages: 2290-8
Publication
First Author: Zhang C
Year: 2001
Journal: Blood
Title: Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.
Volume: 98
Issue: 3
Pages: 610-7
Publication
First Author: Wang H
Year: 2009
Journal: Arterioscler Thromb Vasc Biol
Title: Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice.
Volume: 29
Issue: 7
Pages: 1053-9
Publication
First Author: Pucci F
Year: 2016
Journal: Cell Rep
Title: PF4 Promotes Platelet Production and Lung Cancer Growth.
Volume: 17
Issue: 7
Pages: 1764-1772
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Cines DB
Year: 2020
Journal: Blood
Title: FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
Volume: 135
Issue: 23
Pages: 2085-2093
Publication
First Author: Reilly MP
Year: 2001
Journal: Blood
Title: Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA.
Volume: 98
Issue: 8
Pages: 2442-7
Publication
First Author: Tutwiler V
Year: 2016
Journal: Blood
Title: Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia.
Volume: 127
Issue: 4
Pages: 464-72
Publication
First Author: Guo L
Year: 2017
Journal: Mucosal Immunol
Title: Critical role of CXCL4 in the lung pathogenesis of influenza (H1N1) respiratory infection.
Volume: 10
Issue: 6
Pages: 1529-1541
Publication
First Author: Affandi AJ
Year: 2022
Journal: Cell Rep
Title: CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Volume: 38
Issue: 1
Pages: 110189
Publication
First Author: Yue L
Year: 2018
Journal: PLoS One
Title: CXCL4 contributes to host defense against acute Pseudomonas aeruginosa lung infection.
Volume: 13
Issue: 10
Pages: e0205521
Publication
First Author: Chapman LM
Year: 2012
Journal: J Immunol
Title: Platelets present antigen in the context of MHC class I.
Volume: 189
Issue: 2
Pages: 916-23
GXD Expression    
Probe: MGI:3801173
Assay Type: RT-PCR
Annotation Date: 2008-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:3801189
Age: embryonic day 9.5
Image: 5
Specimen Label: LCM-EPI
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3801173
Assay Type: RT-PCR
Annotation Date: 2008-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:3801189
Age: embryonic day 9.5
Image: 5
Specimen Label: LCM-ERY
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:3803180
Age: embryonic day 9.5
Specimen Label: E9.5 +/+
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608515
Stage: TS15
Assay Id: MGI:3803180
Age: embryonic day 9.5
Specimen Label: E9.5 -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Stage: TS17
Assay Id: MGI:3803180
Age: embryonic day 10.5
Specimen Label: E10.5 +/+
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608517
Stage: TS17
Assay Id: MGI:3803180
Age: embryonic day 10.5
Specimen Label: E10.5 -/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608519
Stage: TS19
Assay Id: MGI:3803180
Age: embryonic day 11.5
Specimen Label: E11.5 +/+
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608519
Stage: TS19
Assay Id: MGI:3803180
Age: embryonic day 11.5
Specimen Label: E11.5 -/-
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:3803000
Assay Type: RT-PCR
Annotation Date: 2008-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3803180
Age: postnatal adult
Specimen Label: Bone Marrow
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6161638
Age: embryonic day 11.0
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6161638
Age: embryonic day 11.0
Specimen Label: Fli-1-/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6161642
Age: embryonic day 11.0
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603918
Stage: TS18
Assay Id: MGI:6161642
Age: embryonic day 11.0
Specimen Label: GABPalphatp/tp
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:6161647
Age: embryonic day 12.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:6161623
Assay Type: RT-PCR
Annotation Date: 2018-06-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:6161647
Age: embryonic day 12.5
Specimen Label: GABPalphatp/tp
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:7547064
Assay Type: RT-PCR
Annotation Date: 2023-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:7547082
Age: embryonic day 16.5
Image: 3
Specimen Label: H2A.Z.2 fl/fl
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:7547064
Assay Type: RT-PCR
Annotation Date: 2023-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:7547082
Age: embryonic day 16.5
Image: 3
Specimen Label: H2A.Z.2 cKO(Nes)
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:7703581
Assay Type: RT-PCR
Annotation Date: 2024-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7703605
Age: embryonic day 13.5
Specimen Label: WT
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:7703581
Assay Type: RT-PCR
Annotation Date: 2024-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:7703605
Age: embryonic day 13.5
Specimen Label: S-II KO
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945736
Age: embryonic day 11.5
Image: g01380 E11.5
Specimen Label: g01380 E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691623
Stage: TS23
Assay Id: MGI:4945736
Age: embryonic day 15.5
Image: g01380 E15.5
Specimen Label: g01380 E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284223
Stage: TS23
Assay Id: MGI:4945736
Age: embryonic day 15.5
Image: g01380 E15.5
Specimen Label: g01380 E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 7
Image: g01380 P7
Specimen Label: g01380 P7
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 42
Image: g01380 Adult
Specimen Label: g01380 Adult
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697419
Pattern: Scattered
Stage: TS19
Assay Id: MGI:4945736
Age: embryonic day 11.5
Image: g01380 E11.5
Specimen Label: g01380 E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697423
Stage: TS23
Assay Id: MGI:4945736
Age: embryonic day 15.5
Image: g01380 E15.5
Specimen Label: g01380 E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 7
Image: g01380 P7
Specimen Label: g01380 P7
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 42
Image: g01380 Adult
Specimen Label: g01380 Adult
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716823
Stage: TS23
Assay Id: MGI:4945736
Age: embryonic day 15.5
Image: g01380 E15.5
Specimen Label: g01380 E15.5
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 7
Image: g01380 P7
Specimen Label: g01380 P7
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:4885198
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716828
Stage: TS28
Assay Id: MGI:4945736
Age: postnatal day 42
Image: g01380 Adult
Specimen Label: g01380 Adult
Detected: false
Specimen Num: 4
GXD Expression  
Probe: MGI:4417214
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1755023
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4827161
Age: embryonic day 14.5
Image: euxassay_012683_17
Specimen Label: euxassay_012683_17
Detected: true
Specimen Num: 17