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Search results 1 to 100 out of 200 for Ptx3

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Hits by Strain

Type Details Score
Gene
5806 | PTX3
Type: gene
Organism: human
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Gene
100494643 | ptx3
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR042837 | PTX3
Type: Family
Description: Pentraxin-related protein PTX3 is a long pentraxin that provides defence against infectious agents and plays several functions in tissue repair and regulation of cancer-related inflammation [].Pentraxins are a family of evolutionarily conserved molecules with regulatory role in inflammation. They share the "pentraxin signature"(His-x-Cys-x-Ser/Thr-Trp-x-Ser, where x is any amino acid) and can be divided into a short and a long arm based on their structural organization. Short pentraxins, feature a peculiar quaternary structure with five or ten identical protomer subunits arranged into symmetric pentamers, such as CRP and SAP, are secreted proteins produced by hepatocytes in response to IL-6. Long pentraxins, on the other end, display an unrelated amino-terminal region coupled to a C-terminal pentraxin domain. PTX3 is the prototype of the long pentraxin subfamily produced by myeloid and stromal cells, but not by hepatocytes, in response to primary pro-inflammatory cytokines or microbial moieties [].
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Gene
689388 | Ptx3
Type: gene
Organism: rat
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Gene
460807 | PTX3
Type: gene
Organism: chimpanzee
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Gene
541148 | PTX3
Type: gene
Organism: cattle
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Gene
100685178 | PTX3
Type: gene
Organism: dog, domestic
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Gene
548626 | PTX3
Type: gene
Organism: chicken
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Gene
704985 | PTX3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:104641 | Ptx3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P48759
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: false
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Publication
26921689 | -
First Author: Bottazzi B
Year: 2016
Journal: J Hepatol
Title: The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.
Volume: 64
Issue: 6
Pages: 1416-27
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Publication
31019517 | -
 
First Author: Doni A
Year: 2019
Journal: Front Immunol
Title: The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer.
Volume: 10
Pages: 712
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Publication
8634434 | J:31648
First Author: Introna M
Year: 1996
Journal: Blood
Title: Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites.
Volume: 87
Issue: 5
Pages: 1862-72
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Publication
7592730 | J:29540
First Author: Altmeyer A
Year: 1995
Journal: J Biol Chem
Title: Promoter structure and transcriptional activation of the murine TSG-14 gene encoding a tumor necrosis factor/interleukin-1-inducible pentraxin protein.
Volume: 270
Issue: 43
Pages: 25584-90
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Publication
25679762 | J:219871
First Author: Bonavita E
Year: 2015
Journal: Cell
Title: PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Volume: 160
Issue: 4
Pages: 700-14
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Publication
26763449 | J:229904
First Author: Cappuzzello C
Year: 2016
Journal: J Invest Dermatol
Title: Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling.
Volume: 136
Issue: 1
Pages: 293-300
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Publication
34093560 | J:312765
 
First Author: Asgari F
Year: 2021
Journal: Front Immunol
Title: The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection.
Volume: 12
Pages: 666198
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Publication
28864415 | J:311699
First Author: Koh SH
Year: 2017
Journal: Biochem Biophys Res Commun
Title: Long pentraxin PTX3 mediates acute inflammatory responses against pneumococcal infection.
Volume: 493
Issue: 1
Pages: 671-676
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Publication
23372656 | J:295325
First Author: Suzuki S
Year: 2013
Journal: PLoS One
Title: Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction.
Volume: 8
Issue: 1
Pages: e53133
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Publication
18292565 | J:131523
First Author: Reading PC
Year: 2008
Journal: J Immunol
Title: Antiviral activity of the long chain pentraxin PTX3 against influenza viruses.
Volume: 180
Issue: 5
Pages: 3391-8
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Publication
25342475 | J:320631
First Author: Ishino M
Year: 2015
Journal: J Atheroscler Thromb
Title: Deficiency of Long Pentraxin PTX3 Promoted Neointimal Hyperplasia after Vascular Injury.
Volume: 22
Issue: 4
Pages: 372-8
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Publication
17389238 | J:125610
First Author: Jaillon S
Year: 2007
Journal: J Exp Med
Title: The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.
Volume: 204
Issue: 4
Pages: 793-804
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Publication
25786110 | J:295326
First Author: Bottazzi B
Year: 2015
Journal: PLoS One
Title: Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant.
Volume: 10
Issue: 3
Pages: e0120807
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Publication
12432394 | J:85080
First Author: Garlanda C
Year: 2002
Journal: Nature
Title: Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.
Volume: 420
Issue: 6912
Pages: 182-6
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Publication
39640269 | J:360752
 
First Author: Doni A
Year: 2024
Journal: Front Immunol
Title: PTX3 is expressed in terminal lymphatics and shapes their organization and function.
Volume: 15
Pages: 1426869
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Publication
19286566 | J:147054
First Author: Souza DG
Year: 2009
Journal: Am J Pathol
Title: The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice.
Volume: 174
Issue: 4
Pages: 1309-18
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Publication
30319631 | J:337308
 
First Author: Marschner JA
Year: 2018
Journal: Front Immunol
Title: The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.
Volume: 9
Pages: 2173
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Publication
19667236 | J:167113
First Author: Norata GD
Year: 2009
Journal: Circulation
Title: Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis.
Volume: 120
Issue: 8
Pages: 699-708
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Publication
18268142 | J:148653
First Author: Salio M
Year: 2008
Journal: Circulation
Title: Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction.
Volume: 117
Issue: 8
Pages: 1055-64
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Publication
17675295 | J:126717
First Author: Scarchilli L
Year: 2007
Journal: J Biol Chem
Title: PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion.
Volume: 282
Issue: 41
Pages: 30161-70
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Publication
34305885 | J:312793
 
First Author: Balhara J
Year: 2021
Journal: Front Immunol
Title: PTX3 Deficiency Promotes Enhanced Accumulation and Function of CD11c+CD11b+ DCs in a Murine Model of Allergic Inflammation.
Volume: 12
Pages: 641311
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Publication
14726497 | J:89006
First Author: Diniz SN
Year: 2004
Journal: J Leukoc Biol
Title: PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages.
Volume: 75
Issue: 4
Pages: 649-56
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Publication
22732935 | J:188421
First Author: Han B
Year: 2012
Journal: Lab Invest
Title: Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.
Volume: 92
Issue: 9
Pages: 1285-96
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Publication
14998931 | J:91829
First Author: Salustri A
Year: 2004
Journal: Development
Title: PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.
Volume: 131
Issue: 7
Pages: 1577-86
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Publication
25964372 | J:224615
First Author: Doni A
Year: 2015
Journal: J Exp Med
Title: An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.
Volume: 212
Issue: 6
Pages: 905-25
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Publication
33953334 | J:312110
First Author: Oggioni M
Year: 2021
Journal: Sci Rep
Title: Long pentraxin PTX3 is upregulated systemically and centrally after experimental neurotrauma, but its depletion leaves unaltered sensorimotor deficits or histopathology.
Volume: 11
Issue: 1
Pages: 9616
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Publication
21619930 | J:175258
First Author: Ievoli E
Year: 2011
Journal: Matrix Biol
Title: Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly.
Volume: 30
Issue: 5-6
Pages: 330-7
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Publication
35194044 | J:322043
First Author: Liu M
Year: 2022
Journal: Nat Commun
Title: Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling.
Volume: 13
Issue: 1
Pages: 1006
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Publication
24745336 | J:209948
First Author: Jaillon S
Year: 2014
Journal: Immunity
Title: The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Volume: 40
Issue: 4
Pages: 621-32
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Publication
21637713 | J:172567
First Author: Lech M
Year: 2011
Journal: PLoS One
Title: Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus.
Volume: 6
Issue: 5
Pages: e20118
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Publication
21441447 | J:172858
First Author: Moalli F
Year: 2011
Journal: J Immunol
Title: The therapeutic potential of the humoral pattern recognition molecule PTX3 in chronic lung infection caused by Pseudomonas aeruginosa.
Volume: 186
Issue: 9
Pages: 5425-34
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Publication
27621420 | J:237271
First Author: Chorny A
Year: 2016
Journal: J Exp Med
Title: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
Volume: 213
Issue: 10
Pages: 2167-85
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Publication
20829368 | J:167412
First Author: Moalli F
Year: 2010
Journal: Blood
Title: Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus.
Volume: 116
Issue: 24
Pages: 5170-80
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Publication
23863905 | J:205828
First Author: Jaillon S
Year: 2013
Journal: J Immunol
Title: Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.
Volume: 191
Issue: 4
Pages: 1873-82
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Publication
24307735 | J:207165
First Author: Job ER
Year: 2014
Journal: J Immunol
Title: A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Volume: 192
Issue: 1
Pages: 271-81
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Publication
11483299 | J:126907
First Author: Ravizza T
Year: 2001
Journal: Neuroscience
Title: Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Volume: 105
Issue: 1
Pages: 43-53
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Publication
26267536 | J:224913
First Author: Ronca R
Year: 2015
Journal: Cancer Cell
Title: Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy.
Volume: 28
Issue: 2
Pages: 225-39
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Publication
25695775 | J:229639
First Author: Foo SS
Year: 2015
Journal: PLoS Pathog
Title: Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.
Volume: 11
Issue: 2
Pages: e1004649
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Publication
33326783 | J:298860
First Author: Gupta G
Year: 2020
Journal: Cell Rep
Title: The Long Pentraxin 3 (PTX3) Suppresses Immunity to Cutaneous Leishmaniasis by Regulating CD4+ T Helper Cell Response.
Volume: 33
Issue: 11
Pages: 108513
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Publication
29492210 | J:295327
First Author: Yoshida M
Year: 2018
Journal: Oncotarget
Title: Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.
Volume: 9
Issue: 9
Pages: 8489-8501
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Publication
22425349 | J:322968
First Author: Real JM
Year: 2012
Journal: Mol Immunol
Title: Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice.
Volume: 51
Issue: 1
Pages: 82-90
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Publication
17538075 | J:128320
First Author: Tranguch S
Year: 2007
Journal: Biol Reprod
Title: Maternal pentraxin 3 deficiency compromises implantation in mice.
Volume: 77
Issue: 3
Pages: 425-32
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Publication
26578407 | J:234519
First Author: Paeschke A
Year: 2016
Journal: Eur J Immunol
Title: The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3.
Volume: 46
Issue: 3
Pages: 619-33
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Publication
39348530 | J:359657
First Author: Pathak V
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Modulation of diabetes-related retinal pathophysiology by PTX3.
Volume: 121
Issue: 41
Pages: e2320034121
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Publication
30315331 | J:295247
First Author: Rajkovic I
Year: 2018
Journal: J Mol Med (Berl)
Title: Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke.
Volume: 96
Issue: 12
Pages: 1319-1332
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Publication
23325083 | J:341930
First Author: Lech M
Year: 2013
Journal: Kidney Int
Title: Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury.
Volume: 83
Issue: 4
Pages: 647-61
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Publication
30859179 | J:294976
First Author: Bonacina F
Year: 2019
Journal: Cardiovasc Res
Title: Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity.
Volume: 115
Issue: 13
Pages: 1861-1872
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Publication
26576501 | J:247256
First Author: Ummenthum K
Year: 2016
Journal: Eur J Immunol
Title: Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease.
Volume: 46
Issue: 3
Pages: 701-11
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Publication
30718300 | J:272943
First Author: Batista NV
Year: 2019
Journal: J Immunol
Title: The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals.
Volume: 202
Issue: 6
Pages: 1807-1814
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Publication
24145127 | J:211516
First Author: Yao G
Year: 2014
Journal: Mol Cell Endocrinol
Title: MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3.
Volume: 382
Issue: 1
Pages: 244-53
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Publication
37542771 | J:340047
 
First Author: Qiu C
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation.
Volume: 677
Pages: 20-25
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Publication
31209269 | J:303598
First Author: Guo H
Year: 2020
Journal: Int J Obes (Lond)
Title: Pentraxin 3 deficiency exacerbates lipopolysaccharide-induced inflammation in adipose tissue.
Volume: 44
Issue: 2
Pages: 525-538
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Publication
29556234 | J:311866
 
First Author: Grčević D
Year: 2018
Journal: Front Immunol
Title: The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair.
Volume: 9
Pages: 417
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Publication
26470821 | J:251451
First Author: Shimizu T
Year: 2015
Journal: J Mol Cell Cardiol
Title: Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury.
Volume: 89
Issue: Pt B
Pages: 306-13
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Publication
27659908 | J:241740
First Author: Wang L
Year: 2016
Journal: J Pathol
Title: Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation.
Volume: 240
Issue: 4
Pages: 495-506
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Publication
38068970 | J:343694
 
First Author: Granata V
Year: 2023
Journal: Int J Mol Sci
Title: Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions.
Volume: 24
Issue: 23
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Publication
20208538 | J:158981
First Author: Deban L
Year: 2010
Journal: Nat Immunol
Title: Regulation of leukocyte recruitment by the long pentraxin PTX3.
Volume: 11
Issue: 4
Pages: 328-34
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Publication
16840729 | J:140456
First Author: Bozza S
Year: 2006
Journal: Blood
Title: Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation.
Volume: 108
Issue: 10
Pages: 3387-96
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Publication
18218986 | J:159816
First Author: Norata GD
Year: 2008
Journal: Arterioscler Thromb Vasc Biol
Title: Long pentraxin 3, a key component of innate immunity, is modulated by high-density lipoproteins in endothelial cells.
Volume: 28
Issue: 5
Pages: 925-31
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Publication
26976330 | J:256818
First Author: Bonacina F
Year: 2016
Journal: Biochim Biophys Acta
Title: Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.
Volume: 1862
Issue: 6
Pages: 1182-90
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Publication
30396995 | J:295098
 
First Author: Fossati G
Year: 2019
Journal: EMBO J
Title: Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Volume: 38
Issue: 1
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Publication
19734205 | J:152794
First Author: D'Angelo C
Year: 2009
Journal: J Immunol
Title: Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease.
Volume: 183
Issue: 7
Pages: 4609-18
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Publication
25747934 | J:234322
First Author: Carrizzo A
Year: 2015
Journal: Circulation
Title: Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway.
Volume: 131
Issue: 17
Pages: 1495-505; discussion 1505
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Publication
36012705 | J:327934
 
First Author: Coltrini D
Year: 2022
Journal: Int J Mol Sci
Title: β-Galactosylceramidase Deficiency Causes Upregulation of Long Pentraxin-3 in the Central Nervous System of Krabbe Patients and Twitcher Mice.
Volume: 23
Issue: 16
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Publication
12040004 | J:76877
First Author: Varani S
Year: 2002
Journal: Mol Endocrinol
Title: Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility.
Volume: 16
Issue: 6
Pages: 1154-67
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Publication
30105036 | J:311857
 
First Author: Shin MK
Year: 2018
Journal: Front Immunol
Title: Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling.
Volume: 9
Pages: 1790
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Publication
22895517 | J:198404
First Author: Chen J
Year: 2012
Journal: Kidney Int
Title: Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury.
Volume: 82
Issue: 11
Pages: 1195-207
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Publication
24470395 | J:210680
First Author: Rudnicki A
Year: 2014
Journal: Hum Mol Genet
Title: microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation.
Volume: 23
Issue: 12
Pages: 3138-46
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Publication
34411594 | J:317152
 
First Author: Dehghan Z
Year: 2021
Journal: Dev Biol
Title: MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development.
Volume: 480
Pages: 69-77
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Protein Coding Gene
MGP_CAROLIEiJ_G0025048 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0027276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0027237 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0027206 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0027249 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026993 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104641 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026440 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027212 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027090 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026174 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026518 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026491 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025990 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11404378 | J:69952
First Author: Dias AA
Year: 2001
Journal: J Leukoc Biol
Title: TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis.
Volume: 69
Issue: 6
Pages: 928-36
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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