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Search results 1 to 100 out of 111 for Rgs6

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
9628 | RGS6
Type: gene
Organism: human
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Gene
100486845 | rgs6
Type: gene
Organism: frog, western clawed
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Gene
54295 | Rgs6
Type: gene
Organism: rat
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Gene
480380 | RGS6
Type: gene
Organism: dog, domestic
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Gene
453009 | RGS6
Type: gene
Organism: chimpanzee
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Gene
517545 | RGS6
Type: gene
Organism: cattle
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Gene
395618 | RGS6
Type: gene
Organism: chicken
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Gene
562667 | rgs6
Type: gene
Organism: zebrafish
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Gene
694620 | RGS6
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1354730 | Rgs6
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32755589 | J:316073
First Author: Gao Y
Year: 2020
Journal: Cell Rep
Title: RGS6 Mediates Effects of Voluntary Running on Adult Hippocampal Neurogenesis.
Volume: 32
Issue: 5
Pages: 107997
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Publication
23338613 | J:196894
First Author: Yang J
Year: 2013
Journal: Cancer Res
Title: G-protein inactivator RGS6 mediates myocardial cell apoptosis and cardiomyopathy caused by doxorubicin.
Volume: 73
Issue: 6
Pages: 1662-7
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Publication
25501001 | J:222655
First Author: Bifsha P
Year: 2014
Journal: PLoS Genet
Title: Rgs6 is required for adult maintenance of dopaminergic neurons in the ventral substantia nigra.
Volume: 10
Issue: 12
Pages: e1004863
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Publication
32513692 | J:294115
First Author: Anderson A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.
Volume: 117
Issue: 25
Pages: 14522-14531
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Publication
27713144 | J:314298
First Author: Yang J
Year: 2016
Journal: Oncotarget
Title: RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
Volume: 7
Issue: 43
Pages: 69159-69172
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Publication
20864673 | J:178185
First Author: Yang J
Year: 2010
Journal: Circ Res
Title: RGS6, a modulator of parasympathetic activation in heart.
Volume: 107
Issue: 11
Pages: 1345-9
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Publication
25646431 | J:220008
First Author: Stewart A
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol.
Volume: 112
Issue: 7
Pages: E786-95
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Publication
22179605 | J:182452
First Author: Maity B
Year: 2012
Journal: J Biol Chem
Title: Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.
Volume: 287
Issue: 7
Pages: 4972-81
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Publication
31120439 | J:290016
   
First Author: Luo Z
Year: 2019
Journal: JCI Insight
Title: Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.
Volume: 5
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Publication
34880111 | J:327747
 
First Author: Ahlers-Dannen KE
Year: 2022
Journal: eNeuro
Title: Protein Profiling of RGS6, a Pleiotropic Gene Implicated in Numerous Neuropsychiatric Disorders, Reveals Multi-Isoformic Expression and a Novel Brain-Specific Isoform.
Volume: 9
Issue: 1
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Publication
23598467 | J:199490
First Author: Maity B
Year: 2013
Journal: Carcinogenesis
Title: Regulator of G protein signaling 6 is a novel suppressor of breast tumor initiation and progression.
Volume: 34
Issue: 8
Pages: 1747-55
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Publication
20884879 | J:178182
First Author: Posokhova E
Year: 2010
Journal: Circ Res
Title: RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate.
Volume: 107
Issue: 11
Pages: 1350-4
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Publication
29668674 | J:261949
First Author: Kulkarni K
Year: 2018
Journal: PLoS One
Title: The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart.
Volume: 13
Issue: 4
Pages: e0193798
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Publication
24318880 | J:209527
First Author: Wydeven N
Year: 2014
Journal: J Biol Chem
Title: RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.
Volume: 289
Issue: 4
Pages: 2440-9
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Publication
22371490 | J:184922
First Author: Shim H
Year: 2012
Journal: J Biol Chem
Title: Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
Volume: 287
Issue: 18
Pages: 14873-9
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Publication
24204714 | J:209181
First Author: Posokhova E
Year: 2013
Journal: PLoS One
Title: Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.
Volume: 8
Issue: 10
Pages: e76973
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Publication
24421401 | J:211611
First Author: Stewart A
Year: 2014
Journal: FASEB J
Title: Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
Volume: 28
Issue: 4
Pages: 1735-44
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Publication
29079565 | J:320799
 
First Author: Chakravarti B
Year: 2017
Journal: J Am Heart Assoc
Title: Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.
Volume: 6
Issue: 11
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Protein Coding Gene
MGP_CAROLIEiJ_G0017917 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019911 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019844 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019848 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019654 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1354730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019203 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019765 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018967 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019255 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029673 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018762 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3515224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Specimen Label: S8B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3542824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Expressed in transitional sinoatrial conduction pathways (Hcn4-/Rgs6+, or Hcn4+/Rgs6+).
Specimen Label: 8C-0
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3542824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Expressed in transitional sinoatrial conduction pathways (Hcn4-/Rgs6+, or Hcn4+/Rgs6+).
Specimen Label: 8C-90
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3542824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Expressed in transitional sinoatrial conduction pathways (Hcn4-/Rgs6+, or Hcn4+/Rgs6+).
Specimen Label: 8C-225
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Coexpressed with Hcn4.
Specimen Label: 8C-0
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Coexpressed with Hcn4.
Specimen Label: 8C-90
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6730345
Age: embryonic day 16.5
Note: Coexpressed with Hcn4.
Specimen Label: 8C-225
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6730172
Assay Type: Immunohistochemistry
Annotation Date: 2021-08-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3577224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6730370
Age: embryonic day 16.5
Note: Expressed in the compact sinoatrial node and transitional cells.
Specimen Label: S5D
Detected: true
Specimen Num: 1
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Publication
- | J:61056
   
First Author: He W
Year: 1998
Journal: GenBank Submission
Title: Mus musculus regulator of G-protein signaling 6 mRNA, partial cds
Pages: AF061933
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Publication
24755289 | J:213237
 
First Author: Ostrovskaya O
Year: 2014
Journal: Elife
Title: RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.
Volume: 3
Pages: e02053
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Publication
29352184 | J:260122
First Author: Anderson A
Year: 2018
Journal: Sci Rep
Title: Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.
Volume: 8
Issue: 1
Pages: 1192
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Publication
22689652 | J:185272
First Author: Orlandi C
Year: 2012
Journal: J Cell Biol
Title: GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.
Volume: 197
Issue: 6
Pages: 711-9
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Publication
20616094 | J:163324
First Author: Villasenor A
Year: 2010
Journal: Dis Model Mech
Title: Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of diabetes.
Volume: 3
Issue: 9-10
Pages: 567-80
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Publication
15897264 | J:100172
First Author: Drenan RM
Year: 2005
Journal: J Cell Biol
Title: Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.
Volume: 169
Issue: 4
Pages: 623-33
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Publication
31284824 | J:306155
First Author: Goodyer WR
Year: 2019
Journal: Circ Res
Title: Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution.
Volume: 125
Issue: 4
Pages: 379-397
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Publication
11342430 | J:69278
First Author: Nagata Y
Year: 2001
Journal: Blood
Title: A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.
Volume: 97
Issue: 10
Pages: 3051-60
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Publication
27568557 | J:239022
First Author: Klein AD
Year: 2016
Journal: Cell Rep
Title: Identification of Modifier Genes in a Mouse Model of Gaucher Disease.
Volume: 16
Issue: 10
Pages: 2546-2553
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Publication
11829488 | J:74612
First Author: Sierra DA
Year: 2002
Journal: Genomics
Title: Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Volume: 79
Issue: 2
Pages: 177-85
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Publication
- | J:29505
     
First Author: Copeland NG
Year: 1999
Journal: Database Release
Title: Copeland-Jenkins (Frederick) Interspecific Backcross Mapping Data
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Publication
19906978 | J:154739
First Author: Quina LA
Year: 2009
Journal: J Neurosci
Title: Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Volume: 29
Issue: 45
Pages: 14309-22
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q9Z2H2
Organism: Mus musculus/domesticus
Length: 472  
Fragment?: false
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Publication
14734556 | -
First Author: Liu Z
Year: 2004
Journal: J Biol Chem
Title: RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.
Volume: 279
Issue: 14
Pages: 14120-8
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Publication
12140291 | -
First Author: Liu Z
Year: 2002
Journal: J Biol Chem
Title: RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.
Volume: 277
Issue: 40
Pages: 37832-9
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Publication
12761221 | -
First Author: Chatterjee TK
Year: 2003
Journal: J Biol Chem
Title: Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants.
Volume: 278
Issue: 32
Pages: 30261-71
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GO Term
GO:0070313 | RGS6-DNMT1-DMAP1 complex
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Publication
19521673 | -
First Author: Anderson GR
Year: 2009
Journal: Cell Biochem Biophys
Title: The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling.
Volume: 54
Issue: 1-3
Pages: 33-46
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Protein Domain
IPR037956 | RGS6_RGS
Type: Domain
Description: This entry represents the RGS domain of RGS6 (regulator of G-protein signaling 6). RGS6 is a member of the R7 RGS protein subfamily. Other members of the R7 subfamily (Neuronal RGS) include: RGS7, RGS9, and RGS11, all of which are expressed predominantly in the nervous system, form an obligatory complex with G-beta-5, and play important roles in the regulation of crucial neuronal processes such as vision and motor control []. RGS6 exists in multiple splice isoforms with identical RGS domains, but possess complete or incomplete GGL domains and distinct N- and C-terminal domains []. RGS6 interacts with SCG10, a neuronal growth-associated protein and therefore regulates neuronal differentiation []. Another RGS6-binding protein is DMAP1, a component of the Dnmt1 complex involved in repression of newly replicated genes [].
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