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Search results 1 to 100 out of 102 for Sash1

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Categories

Hits by Category

Hits by Strain

Type Details Score
Gene
23328 | SASH1
Type: gene
Organism: human
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Gene
100379806 | sash1
Type: gene
Organism: frog, western clawed
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Gene
608649 | SASH1
Type: gene
Organism: dog, domestic
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Gene
463055 | SASH1
Type: gene
Organism: chimpanzee
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Gene
365037 | Sash1
Type: gene
Organism: rat
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Gene
539603 | SASH1
Type: gene
Organism: cattle
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Gene
421621 | SASH1
Type: gene
Organism: chicken
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Gene
574384 | SASH1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1917347 | Sash1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23776175 | J:205449
First Author: Dauphinee SM
Year: 2013
Journal: J Immunol
Title: SASH1 is a scaffold molecule in endothelial TLR4 signaling.
Volume: 191
Issue: 2
Pages: 892-901
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Publication
31067462 | J:276950
First Author: Coulombe P
Year: 2019
Journal: Cell Rep
Title: Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.
Volume: 27
Issue: 6
Pages: 1769-1780.e4
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Protein Coding Gene
MGP_CAROLIEiJ_G0015107 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200009242 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195008646 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220007326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180020420 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175011840 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1917347 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215005064 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005017060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210012329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185009900 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205008189 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230015968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000019258 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190021574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225015845 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010019741 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005013407 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023726 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010006356 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
22859403 | J:188618
First Author: Thaisz J
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.
Volume: 303
Issue: 7
Pages: F972-81
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Publication
19004805 | J:142511
First Author: Nautiyal KM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Brain mast cells link the immune system to anxiety-like behavior.
Volume: 105
Issue: 46
Pages: 18053-7
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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HT Experiment
GSE123889 | Endothelial Sash1 is required for alveolar surfactant production through nitric oxide signaling
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
28138250 | -
 
First Author: Gong X
Year: 2017
Journal: Onco Targets Ther
Title: Correlation of SASH1 expression and ultrasonographic features in breast cancer.
Volume: 10
Pages: 271-276
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Interaction Experiment
Dauphinee SM (2013)
Description: SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling.
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Publication
17088907 | -
First Author: Rimkus C
Year: 2006
Journal: Br J Cancer
Title: Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer.
Volume: 95
Issue: 10
Pages: 1419-23
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Publication
21820526 | -
First Author: Martini M
Year: 2011
Journal: Int J Biochem Cell Biol
Title: The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.
Volume: 43
Issue: 11
Pages: 1630-40
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Publication
37155029 | -
First Author: Clements CM
Year: 2023
Journal: Biomol NMR Assign
Title: Solution NMR backbone assignment of the SASH1 SLy proteins associated disordered region (SPIDER).
Volume: 17
Issue: 1
Pages: 151-157
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Publication
23333244 | -
First Author: Zhou D
Year: 2013
Journal: Cell Signal
Title: SASH1 regulates melanocyte transepithelial migration through a novel G?s-SASH1-IQGAP1-E-Cadherin dependent pathway.
Volume: 25
Issue: 6
Pages: 1526-38
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Publication
25315659 | -
First Author: Courcet JB
Year: 2015
Journal: Eur J Hum Genet
Title: Autosomal-recessive SASH1 variants associated with a new genodermatosis with pigmentation defects, palmoplantar keratoderma and skin carcinoma.
Volume: 23
Issue: 7
Pages: 957-62
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Protein Domain
IPR037627 | SASH1_SAM_repeat1
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) domain repeat 1 of SASH1, which is a predicted protein-protein interaction domain. SASH1 contains an SH3 domain and two SAM domains, and is a member of the SH3/SAM adapter molecules family. SASH1 has been identified as a tumour suppressor and critical protein in signal transduction [, ].
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Publication
12771949 | -
First Author: Zeller C
Year: 2003
Journal: Oncogene
Title: SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer.
Volume: 22
Issue: 19
Pages: 2972-83
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Protein Domain
IPR035720 | SASH1_SH3
Type: Domain
Description: SASH1 is a potential tumour suppressor in breast and colon cancer. Its decreased expression is associated with aggressive tumour growth, metastasis, and poor prognosis [, ]. It is widely expressed in normal tissues (except lymphocytes and dendritic cells) and is localized in the nucleus and the cytoplasm []. SASH1 interacts with the oncoprotein cortactin and is important in cell migration and adhesion. It is a member of the SLY family of proteins, which are adaptor proteins containing a central conserved region with a bipartite nuclear localization signal (NLS) as well as SAM (sterile alpha motif) and SH3 domains [].This entry represents the SH3 domain of SASH1.
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Protein Domain
IPR037630 | SASH1_SAM_repeat2
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) repeat 2 of SASH1, which is a predicted protein-protein interaction domain. SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a tumour suppressor and critical protein in signal transduction [, ].
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Publication
11594764 | -
First Author: Uchida T
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Identification of Nash1, a novel protein containing a nuclear localization signal, a sterile alpha motif, and an SH3 domain preferentially expressed in mast cells.
Volume: 288
Issue: 1
Pages: 137-41
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Publication
16227612 | J:102171
First Author: Beer S
Year: 2005
Journal: Mol Cell Biol
Title: Impaired immune responses and prolonged allograft survival in Sly1 mutant mice.
Volume: 25
Issue: 21
Pages: 9646-60
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Publication
32147820 | -
First Author: Franke FC
Year: 2020
Journal: Int J Cancer
Title: Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness.
Volume: 147
Issue: 6
Pages: 1715-1731
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Protein Domain
IPR021090 | SPIDER
Type: Domain
Description: This entry represents the SLy proteins associated disordered region (SPIDER), which is conserved in the SLy protein family. It has a disordered nature and ranges from 143 to 154 residues long. The region includes a conserved LGKK motif of unknown function as well as a nuclear localisation sequence [, , , ]. In most members of this group of proteins from vertebrates, this region is followed by SH3 () and SAM () domains, suggesting a role in the signalling function of these proteins []. SPIDER is a part of the SASH1 protein that plays essential roles in tumour cell adhesion and migration []. Multiple disease variants in the SPIDER of SASH1 suggest that it may be involved in the regulation of skin pigmentation [].
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Protein
Q8C9Q7
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: false
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Publication
33569544 | J:304430
 
First Author: Parsa S
Year: 2020
Journal: Nat Cancer
Title: The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing.
Volume: 1
Pages: 653-664
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Publication
11470164 | -
First Author: Beer S
Year: 2001
Journal: Biochim Biophys Acta
Title: Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells.
Volume: 1520
Issue: 1
Pages: 89-93
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Publication
15381729 | J:93919
First Author: Zhu YX
Year: 2004
Journal: J Exp Med
Title: The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.
Volume: 200
Issue: 6
Pages: 737-47
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Publication
29749928 | -
   
First Author: Wang Y
Year: 2018
Journal: Elife
Title: Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.
Volume: 7
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Publication
33188360 | -
First Author: Kwan JJ
Year: 2020
Journal: Commun Biol
Title: HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain.
Volume: 3
Issue: 1
Pages: 672
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Publication
37619706 | -
First Author: Ding Y
Year: 2023
Journal: J Mol Biol
Title: SASH1: A Novel Eph Receptor Partner and Insights into SAM-SAM Interactions.
Volume: 435
Issue: 19
Pages: 168243
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Protein Domain
IPR051725 | SASH_SAMSN1
Type: Family
Description: This family comprises SAM and SH3 domain-containing proteins, including SASH1, SASH3, SAMSN1 (also known as HACS1 or SLy2), and SAMD5. These proteins primarily function as signalling adaptors or scaffold molecules in various cellular processes. SASH1 acts as a scaffold that positively regulates NF-kappa-B signalling downstream of TLR4 activation, and is involved in cellmigration and skin pigmentation [, ]. It also interacts with Eph receptors []. SAMSN1 is a negative regulator of B-cell activation and promotes RAC1-dependent membrane ruffle formation and actin cytoskeleton reorganization [, , ]. SASH3 functions as a signalling adapter protein in lymphocytes []. SAMD5 interacts with Eph receptors via its SAM domain []. Members of this family typically contain a Src homology 3 (SH3) domain and one or more sterile alpha motif (SAM) domains, which mediate protein-protein interactions.
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Protein
P59808
Organism: Mus musculus/domesticus
Length: 1230  
Fragment?: false
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Protein
F8VQK5
Organism: Mus musculus/domesticus
Length: 1230  
Fragment?: false
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Protein
Q6ZQ46
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: true
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Publication
21296879 | -
First Author: von Holleben M
Year: 2011
Journal: J Biol Chem
Title: Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
Volume: 286
Issue: 15
Pages: 13489-501
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Protein
Q8BRY6
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
P57725
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: false
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Protein
Q8K352
Organism: Mus musculus/domesticus
Length: 380  
Fragment?: false
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Protein
Q9D4W6
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: false
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Protein
Q3V1H9
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
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