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Search results 1 to 100 out of 138 for Sh2b3

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
10019 | SH2B3
Type: gene
Organism: human
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Gene
100101733 | sh2b3
Type: gene
Organism: frog, western clawed
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Gene
58838 | Sh2b3
Type: gene
Organism: rat
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Gene
452245 | SH2B3
Type: gene
Organism: chimpanzee
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Gene
614726 | SH2B3
Type: gene
Organism: cattle
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Gene
100683018 | SH2B3
Type: gene
Organism: dog, domestic
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Gene
416876 | SH2B3
Type: gene
Organism: chicken
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Gene
710839 | SH2B3
Type: gene
Organism: macaque, rhesus
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Gene
101884640 | sh2b3
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:893598 | Sh2b3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR030522 | SH2B3
Type: Family
Description: SH2B adapter protein 3 (SH2B3) belongs to the SH2B family of adapter proteins []. It is involved in the homeostasis of hematopoietic stem cells and lymphoid progenitors, and plays a tumour suppressor role in the acute lymphoblastic leukemia [, , ]. SH2B3 (Lnk) may also influence inflammatory immune responses in peripheral lymphoid tissues []. A link has been established between polymorphism in this adaptor protein and autoimmune diseases, including type 1 diabetes and celiac disease [, , ].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor [].
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Publication
25024389 | J:244053
First Author: Mori T
Year: 2014
Journal: J Immunol
Title: Lnk/Sh2b3 controls the production and function of dendritic cells and regulates the induction of IFN-γ-producing T cells.
Volume: 193
Issue: 4
Pages: 1728-36
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Publication
11805142 | J:76219
First Author: Takaki S
Year: 2002
Journal: J Exp Med
Title: Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.
Volume: 195
Issue: 2
Pages: 151-60
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Publication
23908464 | -
First Author: Perez-Garcia A
Year: 2013
Journal: Blood
Title: Genetic loss of SH2B3 in acute lymphoblastic leukemia.
Volume: 122
Issue: 14
Pages: 2425-32
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Publication
38417019 | J:358257
 
First Author: Zhang Y
Year: 2024
Journal: J Exp Med
Title: Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity.
Volume: 221
Issue: 4
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Publication
34341450 | J:359912
First Author: Bagheri M
Year: 2021
Journal: Sci Rep
Title: The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.
Volume: 11
Issue: 1
Pages: 15652
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Publication
19073967 | -
First Author: Smyth DJ
Year: 2008
Journal: N Engl J Med
Title: Shared and distinct genetic variants in type 1 diabetes and celiac disease.
Volume: 359
Issue: 26
Pages: 2767-77
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Publication
18311140 | -
First Author: Hunt KA
Year: 2008
Journal: Nat Genet
Title: Newly identified genetic risk variants for celiac disease related to the immune response.
Volume: 40
Issue: 4
Pages: 395-402
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Publication
19648290 | -
First Author: Coenen MJ
Year: 2009
Journal: Hum Mol Genet
Title: Common and different genetic background for rheumatoid arthritis and coeliac disease.
Volume: 18
Issue: 21
Pages: 4195-203
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Publication
24092923 | -
First Author: Willman CL
Year: 2013
Journal: Blood
Title: SH2B3: a new leukemia predisposition gene.
Volume: 122
Issue: 14
Pages: 2293-5
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Protein
D3Z0T9
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
A0A0G2JE79
Organism: Mus musculus/domesticus
Length: 250  
Fragment?: true
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Publication
11498022 | -
First Author: Ahmed Z
Year: 2001
Journal: Biochem Soc Trans
Title: Functional effects of APS and SH2-B on insulin receptor signalling.
Volume: 29
Issue: Pt 4
Pages: 529-34
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Publication
17140804 | -
First Author: Maures TJ
Year: 2007
Journal: Trends Endocrinol Metab
Title: SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other.
Volume: 18
Issue: 1
Pages: 38-45
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Protein
O09039
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
D3Z3Y5
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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Protein
D6RCY9
Organism: Mus musculus/domesticus
Length: 370  
Fragment?: false
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Publication
26101343 | J:259635
First Author: Zhu X
Year: 2015
Journal: Hypertension
Title: Exacerbating Pressure Overload-Induced Cardiac Hypertrophy: Novel Role of Adaptor Molecule Src Homology 2-B3.
Volume: 66
Issue: 3
Pages: 571-81
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Publication
25882670 | J:355959
First Author: Huan T
Year: 2015
Journal: Mol Syst Biol
Title: Integrative network analysis reveals molecular mechanisms of blood pressure regulation.
Volume: 11
Issue: 1
Pages: 799
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Publication
30333305 | J:287207
 
First Author: Laroumanie F
Year: 2018
Journal: JCI Insight
Title: LNK deficiency promotes acute aortic dissection and rupture.
Volume: 3
Issue: 20
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Publication
32629392 | J:291143
 
First Author: Wolfien M
Year: 2020
Journal: EBioMedicine
Title: Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3.
Volume: 57
Pages: 102862
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Protein Coding Gene
MGP_CAROLIEiJ_G0027693 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030038 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030003 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030014 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_893598 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029851 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029940 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029838 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028854 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0024273 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028691 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
11114373 | J:66032
First Author: Takaki S
Year: 2000
Journal: Immunity
Title: Control of B cell production by the adaptor protein lnk. Definition Of a conserved family of signal-modulating proteins.
Volume: 13
Issue: 5
Pages: 599-609
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Publication
27793180 | J:312647
First Author: Lee JH
Year: 2016
Journal: Stem Cell Res Ther
Title: Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment.
Volume: 7
Issue: 1
Pages: 158
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Publication
20855498 | J:165802
First Author: Matsumoto T
Year: 2010
Journal: J Exp Med
Title: Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.
Volume: 207
Issue: 10
Pages: 2207-23
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Publication
16332975 | J:131265
First Author: Takizawa H
Year: 2006
Journal: Blood
Title: Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.
Volume: 107
Issue: 7
Pages: 2968-75
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Publication
31301301 | J:283765
 
First Author: Huang J
Year: 2019
Journal: J Mol Cell Cardiol
Title: The lymphocyte adapter protein: A negative regulator of myocardial ischemia/reperfusion injury.
Volume: 134
Pages: 107-118
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Publication
15935779 | J:99403
First Author: Ema H
Year: 2005
Journal: Dev Cell
Title: Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.
Volume: 8
Issue: 6
Pages: 907-14
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Publication
19859984 | J:161092
First Author: Kamei N
Year: 2010
Journal: Stem Cells
Title: Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury.
Volume: 28
Issue: 2
Pages: 365-75
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Publication
12070287 | J:77248
First Author: Velazquez L
Year: 2002
Journal: J Exp Med
Title: Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.
Volume: 195
Issue: 12
Pages: 1599-611
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Publication
20458146 | J:161643
First Author: Bersenev A
Year: 2010
Journal: J Clin Invest
Title: Lnk constrains myeloproliferative diseases in mice.
Volume: 120
Issue: 6
Pages: 2058-69
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Publication
22942183 | J:192918
First Author: Lin DC
Year: 2012
Journal: Blood
Title: Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
Volume: 120
Issue: 16
Pages: 3310-7
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Publication
22812478 | J:214933
First Author: Bersenev A
Year: 2012
Journal: Aging Cell
Title: Lnk deficiency partially mitigates hematopoietic stem cell aging.
Volume: 11
Issue: 6
Pages: 949-59
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Publication
24297922 | J:205505
First Author: Louria-Hayon I
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.
Volume: 110
Issue: 51
Pages: 20599-604
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Publication
20870899 | J:167392
First Author: Baran-Marszak F
Year: 2010
Journal: Blood
Title: Expression level and differential JAK2-V617F-binding of the adaptor protein Lnk regulates JAK2-mediated signals in myeloproliferative neoplasms.
Volume: 116
Issue: 26
Pages: 5961-71
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Publication
12517931 | J:81168
First Author: Takaki S
Year: 2003
Journal: J Immunol
Title: Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein.
Volume: 170
Issue: 2
Pages: 703-10
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Publication
23897412 | J:200074
First Author: Kawakami Y
Year: 2013
Journal: Lab Invest
Title: A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.
Volume: 93
Issue: 9
Pages: 1036-53
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620415
Stage: TS15
Assay Id: MGI:3043065
Age: embryonic day 9.5
Specimen Label: E9.5 Aorta
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620422
Stage: TS22
Assay Id: MGI:3043065
Age: embryonic day 14.5
Specimen Label: E14.5 Aorta
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:3043065
Age: embryonic day 14.5
Specimen Label: E14.5 Fetal Liver
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3043065
Age: postnatal adult
Specimen Label: muscle
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Stage: TS19
Assay Id: MGI:3043069
Age: embryonic day 11.5
Specimen Label: Lnk
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3043058
Assay Type: RT-PCR
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820119
Stage: TS19
Assay Id: MGI:3043065
Age: embryonic day 11.5
Specimen Label: E11.5 AGM
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_07
Specimen Label: euxassay_003586_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_08
Specimen Label: euxassay_003586_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1792123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_16
Specimen Label: euxassay_003586_16
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_07
Specimen Label: euxassay_003586_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_08
Specimen Label: euxassay_003586_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:1448741
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1794223
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828032
Age: embryonic day 14.5
Image: euxassay_003586_16
Specimen Label: euxassay_003586_16
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3043057
Assay Type: Immunohistochemistry
Annotation Date: 2004-06-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1620419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:3043066
Age: embryonic day 11.5
Note: Expression is present in the endothelial cells lining the dorsal aorta.
Specimen Label: 1B
Detected: true
Specimen Num: 1
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Publication
25664851 | J:220548
First Author: Saleh MA
Year: 2015
Journal: J Clin Invest
Title: Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.
Volume: 125
Issue: 3
Pages: 1189-202
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Publication
30110639 | J:271115
First Author: Mori T
Year: 2018
Journal: Cell Rep
Title: Lnk/Sh2b3 Regulates Adipose Inflammation and Glucose Tolerance through Group 1 ILCs.
Volume: 24
Issue: 7
Pages: 1830-1841
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Publication
18456388 | J:136990
First Author: Takizawa H
Year: 2008
Journal: Exp Hematol
Title: Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.
Volume: 36
Issue: 7
Pages: 897-906
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Publication
16882979 | J:111140
First Author: Buza-Vidas N
Year: 2006
Journal: Genes Dev
Title: Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK.
Volume: 20
Issue: 15
Pages: 2018-23
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Publication
22101255 | J:191381
First Author: Suzuki N
Year: 2012
Journal: Exp Hematol
Title: Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL.
Volume: 40
Issue: 2
Pages: 166-74.e3
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Publication
20571037 | J:165616
First Author: Gueller S
Year: 2010
Journal: J Leukoc Biol
Title: Adaptor protein Lnk inhibits c-Fms-mediated macrophage function.
Volume: 88
Issue: 4
Pages: 699-706
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Publication
30254368 | J:268393
First Author: Balcerek J
Year: 2018
Journal: Nat Commun
Title: Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia.
Volume: 9
Issue: 1
Pages: 3915
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Publication
28067429 | J:273993
First Author: Olivos DJ 3rd
Year: 2017
Journal: J Cell Biochem
Title: Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
Volume: 118
Issue: 8
Pages: 2231-2240
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Publication
21310211 | J:177967
First Author: Gueller S
Year: 2011
Journal: Exp Hematol
Title: Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling.
Volume: 39
Issue: 5
Pages: 591-600
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Publication
34846914 | J:340936
First Author: Dou H
Year: 2021
Journal: Circulation
Title: Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Volume: 144
Issue: 24
Pages: 1940-1954
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Publication
20038804 | J:156695
First Author: Takizawa H
Year: 2010
Journal: J Clin Invest
Title: Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.
Volume: 120
Issue: 1
Pages: 179-90
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Publication
22496561 | J:184453
First Author: Ahlenius H
Year: 2012
Journal: J Neurosci
Title: Adaptor protein LNK is a negative regulator of brain neural stem cell proliferation after stroke.
Volume: 32
Issue: 15
Pages: 5151-64
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Publication
14766215 | J:88311
First Author: Kubo-Akashi C
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly.
Volume: 315
Issue: 2
Pages: 356-62
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Publication
15337790 | J:93918
First Author: Tong W
Year: 2004
Journal: J Exp Med
Title: Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis.
Volume: 200
Issue: 5
Pages: 569-80
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Publication
18618018 | J:140879
First Author: Bersenev A
Year: 2008
Journal: J Clin Invest
Title: Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.
Volume: 118
Issue: 8
Pages: 2832-44
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Publication
19293402 | J:149617
First Author: Gery S
Year: 2009
Journal: J Leukoc Biol
Title: Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F.
Volume: 85
Issue: 6
Pages: 957-65
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Publication
26974155 | J:234661
First Author: Cheng Y
Year: 2016
Journal: J Clin Invest
Title: LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
Volume: 126
Issue: 4
Pages: 1267-81
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Publication
27430239 | J:242558
First Author: Wang W
Year: 2016
Journal: Circ Res
Title: LNK/SH2B3 Loss of Function Promotes Atherosclerosis and Thrombosis.
Volume: 119
Issue: 6
Pages: e91-e103
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Publication
14612394 | J:89937
First Author: Nobuhisa I
Year: 2003
Journal: Mol Cell Biol
Title: Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein.
Volume: 23
Issue: 23
Pages: 8486-94
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Publication
18753636 | J:142462
First Author: Simon C
Year: 2008
Journal: Blood
Title: Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells.
Volume: 112
Issue: 10
Pages: 4039-47
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Publication
15705783 | J:107464
First Author: Tong W
Year: 2005
Journal: Blood
Title: Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways.
Volume: 105
Issue: 12
Pages: 4604-12
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Publication
28611190 | J:243931
First Author: Lv K
Year: 2017
Journal: Genes Dev
Title: CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies.
Volume: 31
Issue: 10
Pages: 1007-1023
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