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Search results 1 to 100 out of 155 for Snx1

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
6642 | SNX1
Type: gene
Organism: human
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Gene
100145678 | snx1
Type: gene
Organism: frog, western clawed
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Gene
84471 | Snx1
Type: gene
Organism: rat
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Gene
478336 | SNX1
Type: gene
Organism: dog, domestic
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Gene
453503 | SNX1
Type: gene
Organism: chimpanzee
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Gene
512029 | SNX1
Type: gene
Organism: cattle
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Gene
427480 | SNX1
Type: gene
Organism: chicken
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Gene
706544 | SNX1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1928395 | Snx1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR028660 | SNX1
Type: Family
Description: Sorting nexin-1 (SNX1) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that is responsible for binding to specific phosphoinositides []. SNX1 and SNX2 are orthologues of yeast Vps5, which is a component of retromer complex that is essential in endosome-to-Golgi retrograde transport []. The mammalian retromer complex is composed of the SNX1/SNX2 alternative heterodimer or homodimer and the Vps26-Vps29-Vps35 obligate heterotrimer []. Like SNX2, SNX1 also has an additional C-terminal BAR domain. SNX1 and SNX2 play interchangeable but essential roles in retromer structure and function [].SNX1 may have a role in sensing membrane curvature and inducing the formation of tubules [, ].
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GXD Expression
GXD Expression
   
Probe: MGI:3613083
Assay Type: RT-PCR
Annotation Date: 2006-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:3613297
Age: embryonic day 8.5
Image: 1
Specimen Label: Snx1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:3613083
Assay Type: RT-PCR
Annotation Date: 2006-02-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:3613297
Age: embryonic day 8.5
Image: 1
Specimen Label: Snx1
Detected: true
Specimen Num: 7
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Publication
17101778 | -
First Author: Rojas R
Year: 2007
Journal: Mol Cell Biol
Title: Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.
Volume: 27
Issue: 3
Pages: 1112-24
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Publication
15695093 | -
First Author: Seaman MN
Year: 2005
Journal: Trends Cell Biol
Title: Recycle your receptors with retromer.
Volume: 15
Issue: 2
Pages: 68-75
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Publication
16179610 | -
First Author: Carlton JG
Year: 2005
Journal: J Cell Sci
Title: Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport.
Volume: 118
Issue: Pt 19
Pages: 4527-39
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Publication
15498486 | -
First Author: Carlton J
Year: 2004
Journal: Curr Biol
Title: Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.
Volume: 14
Issue: 20
Pages: 1791-800
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Protein
Q9WV80
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q6NZD2
Organism: Mus musculus/domesticus
Length: 521  
Fragment?: false
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Protein
Q3TI63
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3U4S1
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q3UDY9
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: true
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Protein
D3YWH1
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Publication
16243015 | -
First Author: Carlton JG
Year: 2005
Journal: Curr Biol
Title: Sorting nexins.
Volume: 15
Issue: 20
Pages: R819-20
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Publication
32293069 | J:329420
First Author: Yang J
Year: 2020
Journal: FASEB J
Title: Sorting nexin 1 loss results in increased oxidative stress and hypertension.
Volume: 34
Issue: 6
Pages: 7941-7957
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Publication
23213485 | J:187359
First Author: Lim JP
Year: 2012
Journal: Biol Open
Title: SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages.
Volume: 1
Issue: 9
Pages: 904-14
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Publication
23152498 | J:193740
First Author: Villar VA
Year: 2013
Journal: J Biol Chem
Title: Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice.
Volume: 288
Issue: 1
Pages: 152-63
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Publication
16214895 | J:102476
First Author: Griffin CT
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.
Volume: 102
Issue: 42
Pages: 15173-7
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Publication
12388759 | J:103556
First Author: Schwarz DG
Year: 2002
Journal: Mol Biol Cell
Title: Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice.
Volume: 13
Issue: 10
Pages: 3588-600
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Publication
9819414 | J:212820
First Author: Haft CR
Year: 1998
Journal: Mol Cell Biol
Title: Identification of a family of sorting nexin molecules and characterization of their association with receptors.
Volume: 18
Issue: 12
Pages: 7278-87
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Publication
24261326 | J:208189
First Author: Fukaya M
Year: 2014
Journal: J Neurochem
Title: EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth.
Volume: 129
Issue: 1
Pages: 21-36
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Protein Coding Gene
MGP_CAROLIEiJ_G0032375 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034972 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034952 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034945 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1928395 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035464 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033976 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034626 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034727 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034769 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035486 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033680 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0034089 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015240 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033514 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:7484735
Assay Type: RT-PCR
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7484767
Age: embryonic day 18.5
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7484735
Assay Type: RT-PCR
Annotation Date: 2023-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283426
Stage: TS26
Assay Id: MGI:7484767
Age: embryonic day 18.5
Specimen Label: KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:6711816
Assay Type: Immunohistochemistry
Annotation Date: 2021-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160508
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:6711978
Age: embryonic day 6.0
Image: 5A WT
Note: Intracellular expressed in early endosomes, coexpressed with Dkk1.
Specimen Label: 5A WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6711816
Assay Type: Immunohistochemistry
Annotation Date: 2021-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160518
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:6711978
Age: embryonic day 6.0
Image: 5A WT
Note: Intracellular expressed in early endosomes, coexpressed with Dkk1.
Specimen Label: 5A WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:6711816
Assay Type: Immunohistochemistry
Annotation Date: 2021-05-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160518
Pattern: Not Specified
Stage: TS08
Assay Id: MGI:6711978
Age: embryonic day 6.0
Image: 5A -/-
Note: Expressed broadly, reflecting trafficking defects in the endocytic pathway. Not coexpressed with Dkk1.
Specimen Label: 5A -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7464564
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:7464746
Age: embryonic day 6.5
Note: Expression in visceral endoderm distributed evenly in cytoplasm, excluding the nucleus.
Specimen Label: 1D WT sagittal
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7464564
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:7464746
Age: embryonic day 6.5
Note: Expression in visceral endoderm distributed evenly in cytoplasm, excluding the nucleus.
Specimen Label: 1D WT parasagittal
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7464564
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:7464746
Age: embryonic day 6.5
Note: Expression pattern indistinguishable from wild-type embryos.
Specimen Label: 1D mVam2-/- sagittal
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7464564
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Pattern: Regionally restricted
Stage: TS09
Assay Id: MGI:7464746
Age: embryonic day 6.5
Note: Expression pattern indistinguishable from wild-type embryos.
Specimen Label: 1D mVam2-/- parasagittal
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:7541046
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:381337
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:7541125
Age: embryonic day 5.5
Image: 3e/g
Note: Expressed in the early endocytic compartments in the subapical cytoplasm.
Specimen Label: 3e/g
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7541046
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:381337
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:7541125
Age: embryonic day 5.5
Image: 3h/j
Note: Reduced expression compared with the wild-type.
Specimen Label: 3h/j
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7541046
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:381337
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:7541128
Age: embryonic day 5.5
Image: 5a
Note: Expressed in both apical and basolateral regions but was enriched in the apical region.
Specimen Label: 5a
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7541046
Assay Type: Immunohistochemistry
Annotation Date: 2023-10-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:381337
Pattern: Not Specified
Stage: TS07
Assay Id: MGI:7541128
Age: embryonic day 5.5
Image: 5b
Note: Expression decreased in mutant cells.
Specimen Label: 5b
Detected: true
Specimen Num: 2
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Publication
- | J:66360
   
First Author: Takahara K
Year: 1999
Journal: GenBank Submission
Title: Mus musculus sorting nexin 1 (Snx1), mRNA, complete cds
Pages: AF154120
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Publication
15882442 | J:121601
First Author: Simpson F
Year: 2005
Journal: Traffic
Title: A novel hook-related protein family and the characterization of hook-related protein 1.
Volume: 6
Issue: 6
Pages: 442-58
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Publication
18656452 | J:138999
First Author: Kim E
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Identification of novel retromer complexes in the mouse testis.
Volume: 375
Issue: 1
Pages: 16-21
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Publication
19549681 | J:150327
First Author: Sun-Wada GH
Year: 2009
Journal: J Cell Sci
Title: Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification.
Volume: 122
Issue: Pt 14
Pages: 2504-13
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Publication
15078902 | J:89488
First Author: Seaman MN
Year: 2004
Journal: J Cell Biol
Title: Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer.
Volume: 165
Issue: 1
Pages: 111-22
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Publication
22990867 | J:187732
 
First Author: Kawamura N
Year: 2012
Journal: Nat Commun
Title: Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos.
Volume: 3
Pages: 1071
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Publication
38687251 | J:351573
First Author: Sasner M
Year: 2024
Journal: Alzheimers Dement
Title: In vivo validation of late-onset Alzheimer's disease genetic risk factors.
Volume: 20
Issue: 7
Pages: 4970-4984
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Publication
15239668 | J:93750
First Author: Piek E
Year: 2004
Journal: Biochem J
Title: RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta.
Volume: 383
Issue: Pt 1
Pages: 187-99
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Publication
34588579 | J:312380
First Author: Sun-Wada GH
Year: 2021
Journal: Sci Rep
Title: Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm.
Volume: 11
Issue: 1
Pages: 19355
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Publication
17983586 | J:130260
First Author: Van Dyck F
Year: 2007
Journal: Cell Metab
Title: Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.
Volume: 6
Issue: 5
Pages: 406-13
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Publication
33966596 | J:317416
First Author: Liu J
Year: 2021
Journal: Autophagy
Title: CREG1 promotes lysosomal biogenesis and function.
Volume: 17
Issue: 12
Pages: 4249-4265
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Publication
32521258 | J:295945
First Author: Kawamura N
Year: 2020
Journal: Cell Rep
Title: Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism.
Volume: 31
Issue: 10
Pages: 107733
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Publication
22698281 | J:184591
First Author: Aoyama M
Year: 2012
Journal: Dev Cell
Title: Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway.
Volume: 22
Issue: 6
Pages: 1163-75
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Publication
15102471 | J:114108
First Author: Papin J
Year: 2004
Journal: Curr Opin Biotechnol
Title: Bioinformatics and cellular signaling.
Volume: 15
Issue: 1
Pages: 78-81
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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