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Search results 1 to 100 out of 270 for Socs2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
8835 | SOCS2
Type: gene
Organism: human
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Gene
100151723 | socs2
Type: gene
Organism: frog, western clawed
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Gene
84607 | Socs2
Type: gene
Organism: rat
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Gene
452127 | SOCS2
Type: gene
Organism: chimpanzee
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Gene
338437 | SOCS2
Type: gene
Organism: cattle
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Gene
100855737 | SOCS2
Type: gene
Organism: dog, domestic
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Gene
395219 | SOCS2
Type: gene
Organism: chicken
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Gene
562062 | socs2
Type: gene
Organism: zebrafish
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Gene
715772 | SOCS2
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028410 | SOCS2
Type: Family
Description: Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS2 is necessary for normal growth regulation []. It appears to be a negative regulator in the growth hormone/IGF1 signaling pathway [, ].
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Protein Coding Gene
MGI:1201787 | Socs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
144481 | SOCS2-AS1
Type: gene
Organism: human
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Publication
11401434 | J:68342
First Author: Horvat S
Year: 2001
Journal: Genomics
Title: Lack of Socs2 expression causes the high-growth phenotype in mice.
Volume: 72
Issue: 2
Pages: 209-12
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Publication
31578312 | J:280563
 
First Author: Lear TB
Year: 2019
Journal: JCI Insight
Title: KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Volume: 4
Issue: 19
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Publication
16469767 | J:108377
First Author: Harris J
Year: 2006
Journal: Mol Endocrinol
Title: Socs2 and elf5 mediate prolactin-induced mammary gland development.
Volume: 20
Issue: 5
Pages: 1177-87
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Publication
31816561 | J:302381
 
First Author: Val CH
Year: 2020
Journal: J Nutr Biochem
Title: SOCS2 modulates adipose tissue inflammation and expansion in mice.
Volume: 76
Pages: 108304
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Publication
16360125 | J:105348
First Author: Scott HJ
Year: 2006
Journal: Brain Res
Title: Differential effects of SOCS2 on neuronal differentiation and morphology.
Volume: 1067
Issue: 1
Pages: 138-45
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Publication
26703468 | J:231036
First Author: Masuzaki R
Year: 2016
Journal: J Biol Chem
Title: SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration.
Volume: 291
Issue: 7
Pages: 3346-58
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Publication
36398696 | J:334345
 
First Author: Li K
Year: 2022
Journal: Biosci Rep
Title: SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.
Volume: 42
Issue: 12
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Publication
38391249 | J:360859
 
First Author: Ivanova E
Year: 2024
Journal: Development
Title: Mutation of SOCS2 induces structural and functional changes in mammary development.
Volume: 151
Issue: 6
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Publication
22824785 | J:193154
First Author: Hansen N
Year: 2013
Journal: Leukemia
Title: SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.
Volume: 27
Issue: 1
Pages: 130-5
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Publication
15690087 | J:95918
First Author: Greenhalgh CJ
Year: 2005
Journal: J Clin Invest
Title: SOCS2 negatively regulates growth hormone action in vitro and in vivo.
Volume: 115
Issue: 2
Pages: 397-406
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Publication
24031028 | J:205064
First Author: Iglesias-Gato D
Year: 2014
Journal: Carcinogenesis
Title: SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.
Volume: 35
Issue: 1
Pages: 24-33
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Publication
36455458 | J:332258
 
First Author: Cabrera-Galván JJ
Year: 2023
Journal: Biomed Pharmacother
Title: SOCS2 protects against chemical-induced hepatocellular carcinoma progression by modulating inflammation and cell proliferation in the liver.
Volume: 157
Pages: 114060
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Publication
22562833 | J:186227
First Author: Zadjali F
Year: 2012
Journal: FASEB J
Title: SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.
Volume: 26
Issue: 8
Pages: 3282-91
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Publication
22228213 | J:233281
First Author: Pass C
Year: 2012
Journal: J Bone Miner Res
Title: SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.
Volume: 27
Issue: 5
Pages: 1055-66
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Publication
21646394 | J:176819
First Author: Knosp CA
Year: 2011
Journal: J Exp Med
Title: SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
Volume: 208
Issue: 7
Pages: 1523-31
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Publication
25833299 | J:324536
First Author: Dobie R
Year: 2015
Journal: J Cell Physiol
Title: Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.
Volume: 230
Issue: 11
Pages: 2796-806
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Publication
25858143 | J:221953
First Author: Vitali C
Year: 2015
Journal: Cancer Res
Title: SOCS2 Controls Proliferation and Stemness of Hematopoietic Cells under Stress Conditions and Its Deregulation Marks Unfavorable Acute Leukemias.
Volume: 75
Issue: 11
Pages: 2387-99
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Publication
16684815 | J:110357
First Author: Lavens D
Year: 2006
Journal: J Cell Sci
Title: A complex interaction pattern of CIS and SOCS2 with the leptin receptor.
Volume: 119
Issue: Pt 11
Pages: 2214-24
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Publication
18803233 | J:225936
First Author: Macrae VE
Year: 2009
Journal: J Cell Physiol
Title: Increased bone mass, altered trabecular architecture and modified growth plate organization in the growing skeleton of SOCS2 deficient mice.
Volume: 218
Issue: 2
Pages: 276-84
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Publication
22658486 | J:185514
First Author: Esper L
Year: 2012
Journal: Am J Pathol
Title: Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease.
Volume: 181
Issue: 1
Pages: 130-40
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Publication
17666591 | J:200410
First Author: Uyttendaele I
Year: 2007
Journal: Mol Endocrinol
Title: Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.
Volume: 21
Issue: 11
Pages: 2821-31
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Protein
O35717
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
Q8CCG3
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Protein
F6RVG2
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
D3YZ26
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
D3Z355
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein
D3Z441
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Protein
Q548Q7
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Publication
22423360 | -
First Author: Feng ZP
Year: 2012
Journal: Proteins
Title: The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.
Volume: 80
Issue: 3
Pages: 946-57
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Publication
9727029 | -
First Author: Dey BR
Year: 1998
Journal: J Biol Chem
Title: Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.
Volume: 273
Issue: 37
Pages: 24095-101
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Publication
24069550 | -
First Author: Inagaki-Ohara K
Year: 2013
Journal: JAKSTAT
Title: SOCS, inflammation, and cancer.
Volume: 2
Issue: 3
Pages: e24053
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Publication
12552091 | -
First Author: Leung KC
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Volume: 100
Issue: 3
Pages: 1016-21
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Publication
12645661 | -
First Author: Larsen L
Year: 2002
Journal: APMIS
Title: Suppressors of cytokine signalling: SOCS.
Volume: 110
Issue: 12
Pages: 833-44
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Publication
11015596 | J:65388
First Author: Corva PM
Year: 2000
Journal: Physiol Genomics
Title: Diet effects on weight gain and body composition in high growth (hg/hg) mice.
Volume: 3
Issue: 1
Pages: 17-23
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Publication
5168371 | J:220666
First Author: Bradford GE
Year: 1971
Journal: Genetics
Title: Growth and reproduction in mice selected for rapid body weight gain.
Volume: 69
Issue: 4
Pages: 499-512
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Publication
7868304 | J:21392
First Author: Summers PJ
Year: 1994
Journal: Growth Dev Aging
Title: Morphometric analysis of skeletal muscle growth in the high growth mouse.
Volume: 58
Issue: 3
Pages: 135-48
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Publication
10377060 | J:56149
First Author: Cargill SL
Year: 1999
Journal: Biol Reprod
Title: Infertility in a line of mice with the high growth mutation is due to luteal insufficiency resulting from disruption at the hypothalamic-pituitary axis.
Volume: 61
Issue: 1
Pages: 283-7
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Publication
10969883 | J:63855
First Author: Cargill SL
Year: 2000
Journal: Growth Dev Aging
Title: Effects of the high growth (hg) mutation on reproduction in high growth (HG) female mice.
Volume: 64
Issue: 1-2
Pages: 21-31
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Publication
6530139 | J:7780
First Author: Bradford GE
Year: 1984
Journal: Genet Res
Title: Evidence for a major gene for rapid postweaning growth in mice.
Volume: 44
Issue: 3
Pages: 293-308
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Publication
3957811 | J:8237
First Author: Calvert CC
Year: 1986
Journal: J Anim Sci
Title: Efficiency of growth in mice with a major gene for rapid postweaning gain.
Volume: 62
Issue: 1
Pages: 77-85
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Publication
5664389 | J:220665
First Author: Bradford GE
Year: 1968
Journal: Genetics
Title: Selection for litter size in mice in the presence and absence of gonadotropin treatment.
Volume: 58
Issue: 2
Pages: 283-95
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Publication
1938644 | J:601
First Author: Dilts RB
Year: 1991
Journal: J Anim Sci
Title: Ovulation rate and pre- and postimplantation survival in mice with a major gene for rapid postweaning gain.
Volume: 69
Issue: 9
Pages: 3590-6
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Publication
9111530 | J:39871
First Author: Summers PJ
Year: 1997
Journal: Proc Soc Exp Biol Med
Title: Delayed myogenesis associated with muscle fiber hyperplasia in high-growth mice.
Volume: 214
Issue: 4
Pages: 380-5
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Publication
1936984 | J:76315
First Author: Medrano JF
Year: 1991
Journal: Genet Res
Title: Growth hormone and insulin-like growth factor-I measurements in high growth (hg) mice.
Volume: 58
Issue: 1
Pages: 67-74
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Publication
20032064 | J:265388
First Author: Casellas J
Year: 2010
Journal: J Hered
Title: Segregation analysis of a sex ratio distortion locus in congenic mice.
Volume: 101
Issue: 3
Pages: 351-9
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Publication
19336533 | J:148540
First Author: Farber CR
Year: 2009
Journal: Physiol Genomics
Title: Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling.
Volume: 37
Issue: 3
Pages: 294-302
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Publication
15965258 | J:102238
First Author: Wu R
Year: 2005
Journal: Genetics
Title: Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice.
Volume: 171
Issue: 1
Pages: 239-49
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Publication
9806843 | J:51044
First Author: Horvat S
Year: 1998
Journal: Genomics
Title: A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region.
Volume: 54
Issue: 1
Pages: 159-64
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Publication
12459263 | J:80771
First Author: Wong ML
Year: 2002
Journal: Gene
Title: Structural characterization of the mouse high growth deletion and discovery of a novel fusion transcript between suppressor of cytokine signaling-2 (Socs-2) and viral encoded semaphorin receptor (Plexin C1).
Volume: 299
Issue: 1-2
Pages: 153-63
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Publication
8853393 | J:35613
First Author: Reiser K
Year: 1996
Journal: Am J Physiol
Title: Effects of elevated circulating IGF-1 on the extracellular matrix in "high-growth" C57BL/6J mice.
Volume: 271
Issue: 3 Pt 2
Pages: R696-703
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Publication
33933990 | J:305525
 
First Author: Cho K
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy.
Volume: 559
Pages: 21-27
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Publication
18439298 | J:135426
 
First Author: Farber CR
Year: 2008
Journal: BMC Genet
Title: Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.
Volume: 9
Pages: 34
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Publication
16410303 | J:108364
First Author: Michaylira CZ
Year: 2006
Journal: Endocrinology
Title: Haplotype insufficiency for suppressor of cytokine signaling-2 enhances intestinal growth and promotes polyp formation in growth hormone-transgenic mice.
Volume: 147
Issue: 4
Pages: 1632-41
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Publication
20499047 | J:162155
First Author: Lebrun P
Year: 2010
Journal: Diabetologia
Title: The suppressor of cytokine signalling 2 (SOCS2) is a key repressor of insulin secretion.
Volume: 53
Issue: 9
Pages: 1935-46
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Publication
15563548 | J:259902
First Author: Rico-Bautista E
Year: 2005
Journal: Mol Endocrinol
Title: Suppressor of cytokine signaling-2 deficiency induces molecular and metabolic changes that partially overlap with growth hormone-dependent effects.
Volume: 19
Issue: 3
Pages: 781-93
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Publication
28009300 | J:241966
First Author: Zeng X
Year: 2016
Journal: Cell Rep
Title: Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.
Volume: 17
Issue: 12
Pages: 3333-3346
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Publication
19919527 | J:191784
First Author: Kiu H
Year: 2009
Journal: Growth Factors
Title: Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.
Volume: 27
Issue: 6
Pages: 384-93
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Publication
17110492 | J:117545
First Author: Farber CR
Year: 2007
Journal: Genetics
Title: Fine mapping reveals sex bias in quantitative trait loci affecting growth, skeletal size and obesity-related traits on mouse chromosomes 2 and 11.
Volume: 175
Issue: 1
Pages: 349-60
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Publication
27655030 | J:259177
First Author: Basrai HS
Year: 2017
Journal: Cell Mol Neurobiol
Title: Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation.
Volume: 37
Issue: 5
Pages: 899-909
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Publication
29343614 | J:257033
 
First Author: Dobie R
Year: 2018
Journal: Dis Model Mech
Title: Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.
Volume: 11
Issue: 1
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Publication
28383049 | J:274603
 
First Author: Kim WS
Year: 2017
Journal: Sci Rep
Title: Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.
Volume: 7
Pages: 46153
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Publication
15525267 | J:95077
First Author: Goldshmit Y
Year: 2004
Journal: Eur J Neurosci
Title: Suppressor of cytokine signalling-2 and epidermal growth factor regulate neurite outgrowth of cortical neurons.
Volume: 20
Issue: 9
Pages: 2260-6
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Publication
11309659 | J:68441
First Author: Corva PM
Year: 2001
Journal: Mamm Genome
Title: Quantitative trait loci affecting growth in high growth (hg) mice.
Volume: 12
Issue: 4
Pages: 284-90
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Publication
23949579 | J:203844
First Author: Jiao Y
Year: 2013
Journal: Diabetologia
Title: CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice.
Volume: 56
Issue: 11
Pages: 2435-45
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Publication
28122728 | J:240956
First Author: Rocha-Resende C
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels.
Volume: 312
Issue: 4
Pages: C478-C486
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Publication
23455506 | J:194824
First Author: Knosp CA
Year: 2013
Journal: J Immunol
Title: Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
Volume: 190
Issue: 7
Pages: 3235-45
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Publication
28666115 | J:243565
First Author: Nirschl CJ
Year: 2017
Journal: Cell
Title: IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.
Volume: 170
Issue: 1
Pages: 127-141.e15
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Publication
12368809 | J:79885
First Author: Turnley AM
Year: 2002
Journal: Nat Neurosci
Title: Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling.
Volume: 5
Issue: 11
Pages: 1155-62
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Publication
15090034 | J:89635
First Author: Ransome MI
Year: 2004
Journal: Eur J Neurosci
Title: Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness.
Volume: 19
Issue: 8
Pages: 2069-79
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Publication
20348236 | J:160765
First Author: Newton VA
Year: 2010
Journal: Am J Pathol
Title: Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation.
Volume: 176
Issue: 5
Pages: 2320-32
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Publication
24484474 | J:208778
First Author: Uren RT
Year: 2014
Journal: J Neurochem
Title: A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.
Volume: 129
Issue: 4
Pages: 614-27
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Publication
16574995 | J:112996
First Author: Michaylira CZ
Year: 2006
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo.
Volume: 291
Issue: 3
Pages: G472-81
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Publication
16670015 | J:111441
 
First Author: Farber CR
Year: 2006
Journal: BMC Genomics
Title: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.
Volume: 7
Pages: 102
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Publication
15837129 | J:97505
First Author: Ransome MI
Year: 2005
Journal: Neuroscience
Title: Analysis of neuronal subpopulations in mice over-expressing suppressor of cytokine signaling-2.
Volume: 132
Issue: 3
Pages: 673-87
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Protein Coding Gene
MGP_CAROLIEiJ_G0015748 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017668 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017647 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017605 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1201787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016998 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017508 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017582 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017531 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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