| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Cytokine signaling mediated by the JAK-STAT pathway plays essential roles in differentiation, maturation, proliferation and apoptosis of a various types of cells. Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the JAK-STAT signaling pathway. SOCS1 and SOCS3 are potent inhibitors of JAKs and can play pivotal roles in inflammation, as well as in the development and progression of cancers []. All SOCS share a central SH2 domain and a C-terminal SOCS box, but only SOCS1 and SOCS3 possess a kinase inhibitory region immediately upstream of the central SH2 [].SOCS3 interacts with gp130, a common cytokine receptor for interleukin (IL)-6, leukemia inhibitory factor (LIF) and other members of the IL-6 family of cytokines. SOCS3 has been reported also to interact with the leptin receptor, erythropoietin receptor, insulin receptor, IL-12beta receptor and granulocyte-colony stimulating factor receptor []. |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boyle K |
| Year: |
2008 |
| Journal: |
J Reprod Immunol |
| Title: |
The role of SOCS3 in modulating leukaemia inhibitory factor signalling during murine placental development. |
| Volume: |
77 |
| Issue: |
1 |
| Pages: |
1-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hill GR |
| Year: |
2010 |
| Journal: |
Blood |
| Title: |
SOCS3 regulates graft-versus-host disease. |
| Volume: |
116 |
| Issue: |
2 |
| Pages: |
287-96 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng ZP |
| Year: |
2012 |
| Journal: |
Proteins |
| Title: |
The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5. |
| Volume: |
80 |
| Issue: |
3 |
| Pages: |
946-57 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inagaki-Ohara K |
| Year: |
2013 |
| Journal: |
JAKSTAT |
| Title: |
SOCS, inflammation, and cancer. |
| Volume: |
2 |
| Issue: |
3 |
| Pages: |
e24053 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
225
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
225
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Croker BA |
| Year: |
2003 |
| Journal: |
Nat Immunol |
| Title: |
SOCS3 negatively regulates IL-6 signaling in vivo. |
| Volume: |
4 |
| Issue: |
6 |
| Pages: |
540-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stahl A |
| Year: |
2012 |
| Journal: |
Blood |
| Title: |
SOCS3 is an endogenous inhibitor of pathologic angiogenesis. |
| Volume: |
120 |
| Issue: |
14 |
| Pages: |
2925-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le Provost F |
| Year: |
2005 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
SOCS3 promotes apoptosis of mammary differentiated cells. |
| Volume: |
338 |
| Issue: |
4 |
| Pages: |
1696-701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Smith PD |
| Year: |
2009 |
| Journal: |
Neuron |
| Title: |
SOCS3 deletion promotes optic nerve regeneration in vivo. |
| Volume: |
64 |
| Issue: |
5 |
| Pages: |
617-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qin H |
| Year: |
2012 |
| Journal: |
J Immunol |
| Title: |
SOCS3 deficiency promotes M1 macrophage polarization and inflammation. |
| Volume: |
189 |
| Issue: |
7 |
| Pages: |
3439-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Emery B |
| Year: |
2006 |
| Journal: |
Mol Cell Neurosci |
| Title: |
SOCS3 negatively regulates LIF signaling in neural precursor cells. |
| Volume: |
31 |
| Issue: |
4 |
| Pages: |
739-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Berger H |
| Year: |
2013 |
| Journal: |
Cancer Res |
| Title: |
SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. |
| Volume: |
73 |
| Issue: |
12 |
| Pages: |
3578-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jorgensen SB |
| Year: |
2013 |
| Journal: |
Diabetes |
| Title: |
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. |
| Volume: |
62 |
| Issue: |
1 |
| Pages: |
56-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martino N |
| Year: |
2021 |
| Journal: |
JCI Insight |
| Title: |
Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice. |
| Volume: |
6 |
| Issue: |
14 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Narayana Y |
| Year: |
2009 |
| Journal: |
Mol Immunol |
| Title: |
SOCS3 expression induced by PIM2 requires PKC and PI3K signaling. |
| Volume: |
46 |
| Issue: |
15 |
| Pages: |
2947-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
San Martin S |
| Year: |
2013 |
| Journal: |
Eur J Histochem |
| Title: |
Stat3 and Socs3 expression patterns during murine placenta development. |
| Volume: |
57 |
| Issue: |
2 |
| Pages: |
e19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ohno-Urabe S |
| Year: |
2018 |
| Journal: |
J Am Heart Assoc |
| Title: |
Role of Macrophage Socs3 in the Pathogenesis of Aortic Dissection. |
| Volume: |
7 |
| Issue: |
2 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marine JC |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
SOCS3 is essential in the regulation of fetal liver erythropoiesis. |
| Volume: |
98 |
| Issue: |
5 |
| Pages: |
617-27 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nadrah K |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. |
| Volume: |
10 |
| Issue: |
8 |
| Pages: |
e0136061 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ozawa Y |
| Year: |
2007 |
| Journal: |
Dev Biol |
| Title: |
SOCS3 is required to temporally fine-tune photoreceptor cell differentiation. |
| Volume: |
303 |
| Issue: |
2 |
| Pages: |
591-600 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Le Y |
| Year: |
2007 |
| Journal: |
Immunity |
| Title: |
SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. |
| Volume: |
27 |
| Issue: |
5 |
| Pages: |
811-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Korovina I |
| Year: |
2020 |
| Journal: |
J Innate Immun |
| Title: |
Myeloid SOCS3 Deficiency Regulates Angiogenesis via Enhanced Apoptotic Endothelial Cell Engulfment. |
| Volume: |
12 |
| Issue: |
3 |
| Pages: |
248-256 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bajpai A |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Insights into gene expression profiles induced by Socs3 depletion in keratinocytes. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
15830 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogata H |
| Year: |
2006 |
| Journal: |
Gastroenterology |
| Title: |
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. |
| Volume: |
131 |
| Issue: |
1 |
| Pages: |
179-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Torisu T |
| Year: |
2007 |
| Journal: |
Genes Cells |
| Title: |
The dual function of hepatic SOCS3 in insulin resistance in vivo. |
| Volume: |
12 |
| Issue: |
2 |
| Pages: |
143-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ramos-Lobo AM |
| Year: |
2017 |
| Journal: |
Neuroscience |
| Title: |
SOCS3 ablation in SF1 cells causes modest metabolic effects during pregnancy and lactation. |
| Volume: |
365 |
|
| Pages: |
114-124 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pedroso JAB |
| Year: |
2017 |
| Journal: |
J Endocrinol |
| Title: |
SOCS3 expression in SF1 cells regulates adrenal differentiation and exercise performance. |
| Volume: |
235 |
| Issue: |
3 |
| Pages: |
207-222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Palanivel R |
| Year: |
2012 |
| Journal: |
Diabetologia |
| Title: |
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. |
| Volume: |
55 |
| Issue: |
11 |
| Pages: |
3083-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kiu H |
| Year: |
2009 |
| Journal: |
Growth Factors |
| Title: |
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2. |
| Volume: |
27 |
| Issue: |
6 |
| Pages: |
384-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu S |
| Year: |
2019 |
| Journal: |
Front Immunol |
| Title: |
Influenza Virus-Induced Robust Expression of SOCS3 Contributes to Excessive Production of IL-6. |
| Volume: |
10 |
|
| Pages: |
1843 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Croker BA |
| Year: |
2004 |
| Journal: |
Immunity |
| Title: |
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. |
| Volume: |
20 |
| Issue: |
2 |
| Pages: |
153-65 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ushiki T |
| Year: |
2016 |
| Journal: |
PLoS One |
| Title: |
Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells. |
| Volume: |
11 |
| Issue: |
9 |
| Pages: |
e0162111 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yasukawa H |
| Year: |
2003 |
| Journal: |
Nat Immunol |
| Title: |
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. |
| Volume: |
4 |
| Issue: |
6 |
| Pages: |
551-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Geoffroy CG |
| Year: |
2022 |
| Journal: |
iScience |
| Title: |
Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting. |
| Volume: |
25 |
| Issue: |
11 |
| Pages: |
105383 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li L |
| Year: |
2020 |
| Journal: |
Mol Immunol |
| Title: |
SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection. |
| Volume: |
125 |
|
| Pages: |
51-62 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jones SA |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
SOCS3 deletion in B cells alters cytokine responses and germinal center output. |
| Volume: |
187 |
| Issue: |
12 |
| Pages: |
6318-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu S |
| Year: |
2021 |
| Journal: |
Front Cell Dev Biol |
| Title: |
SOCS3 Negatively Regulates Cardiac Hypertrophy via Targeting GRP78-Mediated ER Stress During Pressure Overload. |
| Volume: |
9 |
|
| Pages: |
629932 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gu X |
| Year: |
2024 |
| Journal: |
FASEB J |
| Title: |
MiR-9 promotes G-MDSC recruitment and tumor proliferation by targeting SOCS3 in breast cancer. |
| Volume: |
38 |
| Issue: |
1 |
| Pages: |
e23388 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pillemer BB |
| Year: |
2007 |
| Journal: |
Eur J Immunol |
| Title: |
Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. |
| Volume: |
37 |
| Issue: |
8 |
| Pages: |
2082-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miao T |
| Year: |
2008 |
| Journal: |
Mol Cell Neurosci |
| Title: |
SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. |
| Volume: |
37 |
| Issue: |
2 |
| Pages: |
367-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Walker EC |
| Year: |
2020 |
| Journal: |
Elife |
| Title: |
Cortical bone maturation in mice requires SOCS3 suppression of gp130/STAT3 signalling in osteocytes. |
| Volume: |
9 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu X |
| Year: |
2008 |
| Journal: |
Mol Immunol |
| Title: |
SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling. |
| Volume: |
45 |
| Issue: |
5 |
| Pages: |
1405-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Z |
| Year: |
2006 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. |
| Volume: |
103 |
| Issue: |
21 |
| Pages: |
8137-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wiejak J |
| Year: |
2014 |
| Journal: |
FEBS Lett |
| Title: |
The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs. |
| Volume: |
588 |
| Issue: |
9 |
| Pages: |
1556-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Croker BA |
| Year: |
2008 |
| Journal: |
Exp Hematol |
| Title: |
Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation. |
| Volume: |
36 |
| Issue: |
7 |
| Pages: |
786-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yan Z |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
Deficiency of Socs3 leads to brain-targeted EAE via enhanced neutrophil activation and ROS production. |
| Volume: |
5 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu S |
| Year: |
2018 |
| Journal: |
Cell Physiol Biochem |
| Title: |
Cardiac Ablation of SOCS3 Aggravates DOCA-Salt-Induced Hypertrophic Remodeling by Activation of Gp130-Dependent Signaling in Mice. |
| Volume: |
47 |
| Issue: |
1 |
| Pages: |
140-150 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakaya M |
| Year: |
2009 |
| Journal: |
J Immunol |
| Title: |
SOCS3 in T and NKT cells negatively regulates cytokine production and ameliorates ConA-induced hepatitis. |
| Volume: |
183 |
| Issue: |
11 |
| Pages: |
7047-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nohara S |
| Year: |
2021 |
| Journal: |
PLoS One |
| Title: |
SOCS3 deficiency in cardiomyocytes elevates sensitivity of ischemic preconditioning that synergistically ameliorates myocardial ischemia reperfusion injury. |
| Volume: |
16 |
| Issue: |
7 |
| Pages: |
e0254712 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu BM |
| Year: |
2008 |
| Journal: |
J Invest Dermatol |
| Title: |
SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing. |
| Volume: |
128 |
| Issue: |
7 |
| Pages: |
1821-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim E |
| Year: |
2017 |
| Journal: |
J Exp Med |
| Title: |
Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression. |
| Volume: |
214 |
| Issue: |
7 |
| Pages: |
1901-1912 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cho K |
| Year: |
2021 |
| Journal: |
iScience |
| Title: |
Altered microbiota by a high-fat diet accelerates lethal myeloid hematopoiesis associated with systemic SOCS3 deficiency. |
| Volume: |
24 |
| Issue: |
10 |
| Pages: |
103117 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mori H |
| Year: |
2007 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. |
| Volume: |
359 |
| Issue: |
4 |
| Pages: |
952-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mise-Omata S |
| Year: |
2023 |
| Journal: |
Cell Rep |
| Title: |
SOCS3 deletion in effector TÂ cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. |
| Volume: |
42 |
| Issue: |
8 |
| Pages: |
112940 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li S |
| Year: |
2015 |
| Journal: |
Neurobiol Dis |
| Title: |
Injured adult retinal axons with Pten and Socs3 co-deletion reform active synapses with suprachiasmatic neurons. |
| Volume: |
73 |
|
| Pages: |
366-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
McFarland BC |
| Year: |
2016 |
| Journal: |
Oncotarget |
| Title: |
Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma. |
| Volume: |
7 |
| Issue: |
15 |
| Pages: |
20621-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun W |
| Year: |
2018 |
| Journal: |
Exp Cell Res |
| Title: |
MBD2-mediated Th17 differentiation in severe asthma is associated with impaired SOCS3 expression. |
| Volume: |
371 |
| Issue: |
1 |
| Pages: |
196-204 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hao Y |
| Year: |
2023 |
| Journal: |
Brain Res |
| Title: |
Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice. |
| Volume: |
1822 |
|
| Pages: |
148608 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kershaw NJ |
| Year: |
2013 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. |
| Volume: |
20 |
| Issue: |
4 |
| Pages: |
469-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Speth JM |
| Year: |
2019 |
| Journal: |
JCI Insight |
| Title: |
Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics. |
| Volume: |
4 |
| Issue: |
20 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zampieri TT |
| Year: |
2015 |
| Journal: |
Mol Metab |
| Title: |
SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes. |
| Volume: |
4 |
| Issue: |
3 |
| Pages: |
237-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Inagaki-Ohara K |
| Year: |
2014 |
| Journal: |
Oncogene |
| Title: |
Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. |
| Volume: |
33 |
| Issue: |
1 |
| Pages: |
74-84 |
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•
•
•
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| Publication |
| First Author: |
Cho DC |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
Bone corticalization requires local SOCS3 activity and is promoted by androgen action via interleukin-6. |
| Volume: |
8 |
| Issue: |
1 |
| Pages: |
806 |
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•
•
•
•
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| Publication |
| First Author: |
Mori H |
| Year: |
2004 |
| Journal: |
Nat Med |
| Title: |
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. |
| Volume: |
10 |
| Issue: |
7 |
| Pages: |
739-43 |
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•
•
•
•
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| Publication |
| First Author: |
Hiwatashi K |
| Year: |
2011 |
| Journal: |
Cancer Lett |
| Title: |
Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. |
| Volume: |
308 |
| Issue: |
2 |
| Pages: |
172-80 |
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•
•
•
•
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| Publication |
| First Author: |
Sun Y |
| Year: |
2015 |
| Journal: |
Sci Signal |
| Title: |
SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. |
| Volume: |
8 |
| Issue: |
395 |
| Pages: |
ra94 |
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•
•
•
•
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| Publication |
| First Author: |
Hackett AR |
| Year: |
2016 |
| Journal: |
Neurobiol Dis |
| Title: |
STAT3 and SOCS3 regulate NG2 cell proliferation and differentiation after contusive spinal cord injury. |
| Volume: |
89 |
|
| Pages: |
10-22 |
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•
•
•
•
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| Publication |
| First Author: |
Pedroso JA |
| Year: |
2016 |
| Journal: |
Endocrinology |
| Title: |
Changes in Leptin Signaling by SOCS3 Modulate Fasting-Induced Hyperphagia and Weight Regain in Mice. |
| Volume: |
157 |
| Issue: |
10 |
| Pages: |
3901-3914 |
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•
•
•
•
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| Publication |
| First Author: |
Zhang R |
| Year: |
2008 |
| Journal: |
Endocrinology |
| Title: |
Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. |
| Volume: |
149 |
| Issue: |
11 |
| Pages: |
5654-61 |
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•
•
•
•
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| Publication |
| First Author: |
Lu Y |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. |
| Volume: |
281 |
| Issue: |
48 |
| Pages: |
36683-90 |
|
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•
•
•
•
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| Publication |
| First Author: |
Wang Z |
| Year: |
2019 |
| Journal: |
Am J Physiol Regul Integr Comp Physiol |
| Title: |
Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation. |
| Volume: |
316 |
| Issue: |
4 |
| Pages: |
R338-R351 |
|
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•
•
•
•
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| Publication |
| First Author: |
Wang T |
| Year: |
2024 |
| Journal: |
Mol Ther |
| Title: |
SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages. |
| Volume: |
32 |
| Issue: |
5 |
| Pages: |
1425-1444 |
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•
•
•
•
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| Publication |
| First Author: |
Meguro K |
| Year: |
2016 |
| Journal: |
J Invest Dermatol |
| Title: |
SOCS3 Expressed in M2 Macrophages Attenuates Contact Hypersensitivity by Suppressing MMP-12 Production. |
| Volume: |
136 |
| Issue: |
3 |
| Pages: |
649-57 |
|
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•
•
•
•
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| Publication |
| First Author: |
Kimura A |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. |
| Volume: |
279 |
| Issue: |
8 |
| Pages: |
6905-10 |
|
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•
•
•
•
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| Publication |
| First Author: |
Matarazzo V |
| Year: |
2012 |
| Journal: |
J Neurosci |
| Title: |
Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling. |
| Volume: |
32 |
| Issue: |
48 |
| Pages: |
17097-107 |
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•
•
•
•
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| Publication |
| First Author: |
Nagata T |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. |
| Volume: |
10 |
| Issue: |
5 |
| Pages: |
e0127942 |
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•
•
•
•
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| Publication |
| First Author: |
Fischer P |
| Year: |
2004 |
| Journal: |
Biochem J |
| Title: |
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. |
| Volume: |
378 |
| Issue: |
Pt 2 |
| Pages: |
449-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Luckey MA |
| Year: |
2020 |
| Journal: |
Eur J Immunol |
| Title: |
SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells. |
| Volume: |
50 |
| Issue: |
7 |
| Pages: |
986-999 |
|
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•
•
•
•
|
| Publication |
| First Author: |
Yan C |
| Year: |
2013 |
| Journal: |
FASEB J |
| Title: |
Myeloid depletion of SOCS3 enhances LPS-induced acute lung injury through CCAAT/enhancer binding protein δ pathway. |
| Volume: |
27 |
| Issue: |
8 |
| Pages: |
2967-76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Du X |
| Year: |
2021 |
| Journal: |
Mol Neurodegener |
| Title: |
Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pedroso JA |
| Year: |
2014 |
| Journal: |
Mol Metab |
| Title: |
Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity. |
| Volume: |
3 |
| Issue: |
6 |
| Pages: |
608-18 |
|
•
•
•
•
•
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| Publication |
| First Author: |
Taleb S |
| Year: |
2009 |
| Journal: |
J Exp Med |
| Title: |
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. |
| Volume: |
206 |
| Issue: |
10 |
| Pages: |
2067-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang M |
| Year: |
2007 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1beta. |
| Volume: |
292 |
| Issue: |
4 |
| Pages: |
H1694-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yajima T |
| Year: |
2011 |
| Journal: |
Circulation |
| Title: |
Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. |
| Volume: |
124 |
| Issue: |
24 |
| Pages: |
2690-701 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Bucher F |
| Year: |
2016 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
CNTF Attenuates Vasoproliferative Changes Through Upregulation of SOCS3 in a Mouse-Model of Oxygen-Induced Retinopathy. |
| Volume: |
57 |
| Issue: |
10 |
| Pages: |
4017-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Satoh T |
| Year: |
2012 |
| Journal: |
Eur J Immunol |
| Title: |
The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter. |
| Volume: |
42 |
| Issue: |
9 |
| Pages: |
2329-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2016 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells. |
| Volume: |
311 |
| Issue: |
1 |
| Pages: |
H146-56 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Son HJ |
| Year: |
2017 |
| Journal: |
J Immunol |
| Title: |
Oncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells. |
| Volume: |
198 |
| Issue: |
4 |
| Pages: |
1484-1491 |
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•
•
•
•
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