Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye B |
Year: |
2020 |
Journal: |
EMBO J |
Title: |
The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. |
Volume: |
39 |
Issue: |
13 |
Pages: |
e103786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CW |
Year: |
2023 |
Journal: |
Cell Stem Cell |
Title: |
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation. |
Volume: |
30 |
Issue: |
11 |
Pages: |
1503-1519.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding C |
Year: |
2024 |
Journal: |
Cell Rep |
Title: |
Srcap haploinsufficiency induced autistic-like behaviors in mice through disruption of Satb2 expression. |
Volume: |
43 |
Issue: |
5 |
Pages: |
114231 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ruhl DD |
Year: |
2006 |
Journal: |
Biochemistry |
Title: |
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. |
Volume: |
45 |
Issue: |
17 |
Pages: |
5671-7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
109
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3816488 |
Age: |
postnatal |
|
|
Specimen Label: |
Metaphase II |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 1.5 |
|
|
Specimen Label: |
2-cell embryo |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360433 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 2.0 |
|
|
Specimen Label: |
4-cell embryo |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-cell embryo |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
E3.5 blastocyst |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360465 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 blastocyst |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815684 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160415 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816488 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 inner cell mass |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3102528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3816489 |
Age: |
postnatal |
|
|
Specimen Label: |
Metaphase II |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360422 |
|
Stage: |
TS02 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 1.5 |
|
|
Specimen Label: |
2-cell embryo |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360433 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 2.0 |
|
|
Specimen Label: |
4-cell embryo |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360443 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 2.5 |
|
|
Specimen Label: |
8-cell embryo |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360453 |
|
Stage: |
TS03 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 3.0 |
|
|
Specimen Label: |
Morula |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360464 |
|
Stage: |
TS04 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 3.5 |
|
|
Specimen Label: |
E3.5 blastocyst |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:360465 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 blastocyst |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3815685 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-11-20 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160415 |
|
Stage: |
TS05 |
Assay Id: |
MGI:3816489 |
Age: |
embryonic day 4.5 |
|
|
Specimen Label: |
E4.5 inner cell mass |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525240 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-08-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7711566 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary Table 3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525240 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4426712 |
Assay Type: |
RNA in situ |
Annotation Date: |
2024-08-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7711566 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary Table 3 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elsen GE |
Year: |
2018 |
Journal: |
Front Neurosci |
Title: |
The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1. |
Volume: |
12 |
|
Pages: |
571 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Guo G |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |
Volume: |
18 |
Issue: |
4 |
Pages: |
675-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gray PA |
Year: |
2004 |
Journal: |
Science |
Title: |
Mouse brain organization revealed through direct genome-scale TF expression analysis. |
Volume: |
306 |
Issue: |
5705 |
Pages: |
2255-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Xu M |
Year: |
2021 |
Journal: |
Development |
Title: |
The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. |
Volume: |
148 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ye B |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1518 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang X |
Year: |
2016 |
Journal: |
Nat Struct Mol Biol |
Title: |
Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. |
Volume: |
23 |
Issue: |
4 |
Pages: |
317-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eissenberg JC |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. |
Volume: |
25 |
Issue: |
15 |
Pages: |
6559-69 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuadrado A |
Year: |
2010 |
Journal: |
EMBO J |
Title: |
Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2014-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao B |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. |
Volume: |
10 |
Issue: |
1 |
Pages: |
1071 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi Y |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy. |
Volume: |
7 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sun S |
Year: |
2022 |
Journal: |
Dev Cell |
Title: |
Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. |
Volume: |
57 |
Issue: |
7 |
Pages: |
901-913.e4 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry include a group of proteins involved in chromatin remodelling, including Vps72 (vacuolar protein sorting-associated protein 72) from budding yeasts. Vps72 is a Htz1-binding component of the SWR1 complex, which is required for the incorporation of the histone variant H2AZ into chromatin []. It is also required for vacuolar protein sorting in budding yeasts [].The Vps72 homologue from animals, YL-1, is a deposition-and-exchangehistone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is component of the SRCAP and Tip60 complexes, and mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling [, ].This is the N-terminal region from Vps72/YL1, which covers the aspartate- and glutamate-rich N-terminal domain and the central DNA-binding domain [, ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
368
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe S |
Year: |
2013 |
Journal: |
Science |
Title: |
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme. |
Volume: |
340 |
Issue: |
6129 |
Pages: |
195-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kusch T |
Year: |
2004 |
Journal: |
Science |
Title: |
Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. |
Volume: |
306 |
Issue: |
5704 |
Pages: |
2084-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latrick CM |
Year: |
2016 |
Journal: |
Nat Struct Mol Biol |
Title: |
Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1. |
Volume: |
23 |
Issue: |
4 |
Pages: |
309-16 |
|
•
•
•
•
•
|