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Search results 1 to 100 out of 105 for Ten1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
100379818 | ten1
Type: gene
Organism: frog, western clawed
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Gene
100134934 | TEN1
Type: gene
Organism: human
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Gene
100529060 | TEN1
Type: gene
Organism: chicken
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Gene
609475 | TEN1
Type: gene
Organism: dog, domestic
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Gene
360664 | Ten1
Type: gene
Organism: rat
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Gene
510634 | TEN1
Type: gene
Organism: cattle
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Gene
100611802 | TEN1
Type: gene
Organism: chimpanzee
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Gene
336811 | ten1
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:1916785 | Ten1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19854130 | J:159049
First Author: Miyake Y
Year: 2009
Journal: Mol Cell
Title: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.
Volume: 36
Issue: 2
Pages: 193-206
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Protein Coding Gene
MGP_CAROLIEiJ_G0017435 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0019419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019388 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019358 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019362 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019168 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916785 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0019812 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0018723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019251 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019243 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019321 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0019850 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0018487 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0018775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0018564 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018280 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein
Q9D7K2
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Publication
23604909 | J:198500
First Author: Nakahara M
Year: 2013
Journal: Mamm Genome
Title: Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Volume: 24
Issue: 5-6
Pages: 228-39
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Publication
10512203 | J:93290
First Author: Araki K
Year: 1999
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Exchangeable gene trap using the Cre/mutated lox system.
Volume: 45
Issue: 5
Pages: 737-50
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Publication
15840001 | J:110088
First Author: Taniwaki T
Year: 2005
Journal: Dev Growth Differ
Title: Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.
Volume: 47
Issue: 3
Pages: 163-72
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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UniProt Feature
UniProt Feature
Begin: 1
Description: CST complex subunit TEN1
Type: chain
End: 161
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Gene
100653507 | ten1.L
Type: gene
Organism: frog, African clawed
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Allele
Ten1<+> | MGI:5428698
 
Name: TEN1 telomerase capping complex subunit; wild type
Allele Type: Not Specified
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Allele
Ten1<Gt(OST15469)Lex> | MGI:4140558
 
Name: TEN1 telomerase capping complex subunit; gene trap OST15469, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST154985)Lex> | MGI:4207885
 
Name: TEN1 telomerase capping complex subunit; gene trap OST154985, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST279504)Lex> | MGI:4261809
 
Name: TEN1 telomerase capping complex subunit; gene trap OST279504, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST290036)Lex> | MGI:4266826
 
Name: TEN1 telomerase capping complex subunit; gene trap OST290036, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST339221)Lex> | MGI:4285886
 
Name: TEN1 telomerase capping complex subunit; gene trap OST339221, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST339213)Lex> | MGI:4285881
 
Name: TEN1 telomerase capping complex subunit; gene trap OST339213, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST393725)Lex> | MGI:4304412
 
Name: TEN1 telomerase capping complex subunit; gene trap OST393725, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(OST409612)Lex> | MGI:4308394
 
Name: TEN1 telomerase capping complex subunit; gene trap OST409612, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(Ayu21-T277)Imeg> | MGI:3923510
 
Name: TEN1 telomerase capping complex subunit; gene trap Ayu21-T277, Institute of Molecular Embryology and Genetics
Allele Type: Gene trapped
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Allele
Ten1<Gt(EUCE0031d11)Hmgu> | MGI:4372998
 
Name: TEN1 telomerase capping complex subunit; gene trap EUCE0031d11, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Ten1<tm1e(EUCOMM)Hmgu> | MGI:4434655
Name: TEN1 telomerase capping complex subunit; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ten1<tm1a(EUCOMM)Hmgu> | MGI:4435028
Name: TEN1 telomerase capping complex subunit; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Ten1<Gt(IST13755E11)Tigm> | MGI:5190926
 
Name: TEN1 telomerase capping complex subunit; gene trap IST13755E11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Ten1<em1(IMPC)Hmgu> | MGI:6449028
Name: TEN1 telomerase capping complex subunit; endonuclease-mediated mutation 1, Helmholtz Zentrum Muenchen GmbH
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GO Term
GO:1990879 | CST complex
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Strain
MGI:7570415 | C57BL/6NCrl-Ten1<em1(IMPC)Hmgu>/Ieg
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
25329641 | -
First Author: Renfrew KB
Year: 2014
Journal: PLoS Genet
Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
Volume: 10
Issue: 10
Pages: e1004738
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Protein Domain
IPR029146 | Ten1_animal_plant
Type: Family
Description: This entry represents the CST complex subunit Ten1 homologue from plants and animals []. Even though the protein sequence similarity is very low between budding yeast Ten1 () and animal/plant Ten1, they are evolutionarily related. Ten1 is essential for telomere integrity and it negatively regulates telomerase activity [].Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex [].Similar to budding yeast Ten1, mammalian Ten1 forms the CST complex with Stn1 homologue and binds to single strand DNA (ssDNA). However, unlike budding yeast CST, the binding of mammalian CST to ssDNA is not sequence specific. The mammalian CST complex may have both telomeric and non-telomeric functions [].In plants, the CST complex is structurally analogous to mammalian CST and it plays a role in chromosome end protection [].
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Publication
19854124 | -
First Author: Wellinger RJ
Year: 2009
Journal: Mol Cell
Title: The CST complex and telomere maintenance: the exception becomes the rule.
Volume: 36
Issue: 2
Pages: 168-9
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Protein Domain
IPR024222 | Ten1_fungal
Type: Family
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length []. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast, and a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. S.pombe has Stn1- and Ten1-like proteins that are essential for chromosome end protection. Stn1 orthologues exist in all species that have Pot1, whereas Ten1-like proteins can be found in all fungi. Fission yeast Stn1 and Ten1 localise at telomeres in a manner that correlates with the length of the ssDNA overhang, suggesting that they specifically associate with the telomeric ssDNA. Two separate protein complexes are required for chromosome end protection in fission yeast. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution []. Ten1 is one of the three components of the CST complex, which, in conjunction with the Shelterin complex helps protect telomeres from attack by DNA-repair mechanisms [].This entry represent Ten1 from fungi.
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Publication
20697207 | -
First Author: Price CM
Year: 2010
Journal: Cell Cycle
Title: Evolution of CST function in telomere maintenance.
Volume: 9
Issue: 16
Pages: 3157-65
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Publication
17293872 | -
First Author: Gao H
Year: 2007
Journal: Nat Struct Mol Biol
Title: RPA-like proteins mediate yeast telomere function.
Volume: 14
Issue: 3
Pages: 208-14
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Publication
17715303 | -
First Author: Martín V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Protection of telomeres by a conserved Stn1-Ten1 complex.
Volume: 104
Issue: 35
Pages: 14038-43
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Publication
19884503 | -
First Author: Gelinas AD
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain.
Volume: 106
Issue: 46
Pages: 19298-303
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Protein Domain
IPR042617 | CTC1-like
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
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Protein Domain
IPR038240 | Stn1_C_sf
Type: Homologous_superfamily
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Protein Domain
IPR024263 | Stn1_C_fungi
Type: Domain
Description: Stn1 and Ten1 are DNA-binding proteins with specificity for telomeric DNA substrates and both protect chromosome termini from unregulated resection and regulate telomere length. Stn1 complexes with Ten1 and Cdc13 to function as a telomere-specific replication protein A (RPA)-like complex []. These three interacting proteins associate with the telomeric overhang in budding yeast, whereas a single protein known as Pot1 (protection of telomeres-1) performs this function in fission yeast. Two separate protein complexes are required for chromosome end protection in fission yeast while a two-subunit complex consisting of POT1 and TPP1 associates with telomeric ssDNA in humans. Protection of telomeres by multiple proteins with OB-fold domains is conserved in eukaryotic evolution [].This entry represents the C-terminal domain of Stn1 and consists of tandem winged helix-turn-helix motifs [, ].
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Protein Domain
IPR029156 | CTC1
Type: Family
Description: In animals and plants, CTC1 is a component of the CST complex (consists of Ten1, Stn1 and CTC1), a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation []. Two distinct telomere capping complexes have evolved: CST complex in budding yeast and shelterin complex in vertebrates. Budding yeast CST is composed of Cdc13, Ten1 and Stn1 []. The homologues of Ten1 and Stn1 have been identified in vertebrates and plants. The vertebrate CST complex does not appear to play a primary role in telomere protection, but may complement the function of shelterin complex []. The mammalian CST complex may have both telomeric and non-telomeric function [].In plants, the contribution of the CST components to chromosome end protection, telomeric DNA replication or both processes remains to be determined [].
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Protein
Q5SUQ9
Organism: Mus musculus/domesticus
Length: 1212  
Fragment?: false
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Protein
E0CXE7
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: false
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Publication
25963976 | J:237751
First Author: Hirawatari K
Year: 2015
Journal: Mamm Genome
Title: A Cascade of epistatic interactions regulating teratozoospermia in mice.
Volume: 26
Issue: 5-6
Pages: 248-56
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Publication
20008938 | -
First Author: Sun J
Year: 2009
Journal: Genes Dev
Title: Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.
Volume: 23
Issue: 24
Pages: 2900-14
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Protein Domain
IPR040650 | Cdc13_OB2
Type: Domain
Description: Cdc13 is an essential yeast protein required for telomere length regulation and genome stability. Cdc13, like a number of single-stranded telomere binding proteins, consists of several oligonucleotide-oligosaccharide binding (OB) folds. These folds potentially arise from evolutionary gene duplication and are involved in multiple functions, including nucleic acid and protein binding and Cdc13 dimerization. This entry represents the OB2 domain, second OB-fold counting from the N terminus of Cdc13. Biochemical assays indicate OB2 is not involved in telomeric DNA or Stn1 binding. However, disruption of the OB2 dimer in full-length Cdc13 affects Cdc13-Stn1 association, leading to telomere length deregulation, increased temperature sensitivity, and Stn1 binding defects. Hence it is suggested that the dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping [].
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Protein Coding Gene
MGI:1915581 | Stn1
Type: protein_coding_gene
Organism: mouse, laboratory
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