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Search results 1 to 100 out of 641 for Tfeb

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
7942 | TFEB
Type: gene
Organism: human
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Gene
780105 | tfeb
Type: gene
Organism: frog, western clawed
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Gene
107975137 | TFEB
Type: gene
Organism: chimpanzee
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Gene
316214 | Tfeb
Type: gene
Organism: rat
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Gene
609046 | TFEB
Type: gene
Organism: dog, domestic
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Gene
510032 | TFEB
Type: gene
Organism: cattle
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Gene
419922 | TFEB
Type: gene
Organism: chicken
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Gene
562289 | tfeb
Type: gene
Organism: zebrafish
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Gene
694214 | TFEB
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR024098 | TFEB
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').In association with TFE3, TFEB activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity []. It also plays a role in the signal transduction processes required for normal vascularisation of the placenta [].
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Protein Coding Gene
MGI:103270 | Tfeb
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9806910 | J:50513
First Author: Steingrímsson E
Year: 1998
Journal: Development
Title: The bHLH-Zip transcription factor Tfeb is essential for placental vascularization.
Volume: 125
Issue: 23
Pages: 4607-16
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Publication
16936731 | J:112628
First Author: Huan C
Year: 2006
Journal: Nat Immunol
Title: Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity.
Volume: 7
Issue: 10
Pages: 1082-91
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Protein
Q60982
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Publication
21617040 | J:172732
First Author: Settembre C
Year: 2011
Journal: Science
Title: TFEB links autophagy to lysosomal biogenesis.
Volume: 332
Issue: 6036
Pages: 1429-33
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Publication
21804531 | J:175613
First Author: Peña-Llopis S
Year: 2011
Journal: EMBO J
Title: Regulation of TFEB and V-ATPases by mTORC1.
Volume: 30
Issue: 16
Pages: 3242-58
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Publication
36987696 | J:335554
First Author: Di Malta C
Year: 2023
Journal: EMBO Mol Med
Title: TFEB and TFE3 drive kidney cystogenesis and tumorigenesis.
Volume: 15
Issue: 5
Pages: e16877
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Publication
28143903 | J:259533
 
First Author: Lu H
Year: 2017
Journal: Sci Signal
Title: TFEB inhibits endothelial cell inflammation and reduces atherosclerosis.
Volume: 10
Issue: 464
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Publication
31694921 | J:282176
First Author: Curnock R
Year: 2019
Journal: J Cell Biol
Title: TFEB controls retromer expression in response to nutrient availability.
Volume: 218
Issue: 12
Pages: 3954-3966
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Publication
29467198 | J:273486
First Author: Fan Y
Year: 2018
Journal: Circ Res
Title: Endothelial TFEB (Transcription Factor EB) Positively Regulates Postischemic Angiogenesis.
Volume: 122
Issue: 7
Pages: 945-957
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Publication
23604321 | J:198501
First Author: Settembre C
Year: 2013
Journal: Nat Cell Biol
Title: TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.
Volume: 15
Issue: 6
Pages: 647-58
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Publication
32424153 | J:292019
First Author: Pastore N
Year: 2020
Journal: Nat Commun
Title: TFEB regulates murine liver cell fate during development and regeneration.
Volume: 11
Issue: 1
Pages: 2461
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Protein
E9PWJ9
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true
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Protein
D3Z782
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein
D3YZM7
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: true
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Protein
D3Z1X9
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: true
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Protein
E9PXZ1
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Publication
15507434 | -
First Author: Miller AJ
Year: 2005
Journal: J Biol Chem
Title: Sumoylation of MITF and its related family members TFE3 and TFEB.
Volume: 280
Issue: 1
Pages: 146-55
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Publication
7958932 | J:19536
First Author: Hemesath TJ
Year: 1994
Journal: Genes Dev
Title: microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.
Volume: 8
Issue: 22
Pages: 2770-80
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Publication
1748288 | J:22960
First Author: Fisher DE
Year: 1991
Journal: Genes Dev
Title: TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.
Volume: 5
Issue: 12A
Pages: 2342-52
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Publication
38195686 | J:351179
First Author: Alesi N
Year: 2024
Journal: Nat Commun
Title: TFEB drives mTORC1 hyperactivation and kidney disease in Tuberous Sclerosis Complex.
Volume: 15
Issue: 1
Pages: 406
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Publication
25108912 | J:215742
First Author: Cortes CJ
Year: 2014
Journal: Nat Neurosci
Title: Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
Volume: 17
Issue: 9
Pages: 1180-9
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Publication
26813791 | J:230443
First Author: Martina JA
Year: 2016
Journal: EMBO J
Title: TFEB and TFE3 are novel components of the integrated stress response.
Volume: 35
Issue: 5
Pages: 479-95
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Publication
33516944 | J:305765
 
First Author: Sass F
Year: 2021
Journal: Mol Metab
Title: TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.
Volume: 47
Pages: 101173
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Publication
38968109 | J:360773
First Author: Zheng W
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: TFEB safeguards trophoblast syncytialization in humans and mice.
Volume: 121
Issue: 28
Pages: e2404062121
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Publication
31690633 | J:284441
 
First Author: Evans TD
Year: 2019
Journal: Sci Signal
Title: TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction.
Volume: 12
Issue: 606
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Publication
35288580 | J:327283
First Author: Park K
Year: 2022
Journal: Nat Commun
Title: Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress.
Volume: 13
Issue: 1
Pages: 1300
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Publication
29066772 | J:256367
First Author: Murano T
Year: 2017
Journal: Sci Rep
Title: Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo.
Volume: 7
Issue: 1
Pages: 13938
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Publication
37712288 | J:342172
First Author: Pasquier A
Year: 2023
Journal: EMBO J
Title: TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression.
Volume: 42
Issue: 21
Pages: e113928
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Publication
32487570 | J:294653
 
First Author: Li Y
Year: 2020
Journal: J Immunother Cancer
Title: TFEB is a master regulator of tumor-associated macrophages in breast cancer.
Volume: 8
Issue: 1
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Publication
27875531 | J:237194
First Author: Ugolino J
Year: 2016
Journal: PLoS Genet
Title: Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling.
Volume: 12
Issue: 11
Pages: e1006443
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Publication
35864246 | J:339479
First Author: Schuster EM
Year: 2022
Journal: Nat Metab
Title: TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages.
Volume: 4
Issue: 7
Pages: 856-866
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Publication
30591554 | J:328468
 
First Author: Doronzo G
Year: 2019
Journal: EMBO J
Title: TFEB controls vascular development by regulating the proliferation of endothelial cells.
Volume: 38
Issue: 3
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Publication
29146937 | J:274781
First Author: Willett R
Year: 2017
Journal: Nat Commun
Title: TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.
Volume: 8
Issue: 1
Pages: 1580
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Publication
28275133 | J:247799
First Author: Kim YS
Year: 2017
Journal: J Immunol
Title: PPAR-α Activation Mediates Innate Host Defense through Induction of TFEB and Lipid Catabolism.
Volume: 198
Issue: 8
Pages: 3283-3295
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Publication
22786682 | J:186693
First Author: Tsunemi T
Year: 2012
Journal: Sci Transl Med
Title: PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
Volume: 4
Issue: 142
Pages: 142ra97
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Publication
32989250 | J:307304
First Author: Nakamura S
Year: 2020
Journal: Nat Cell Biol
Title: LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
Volume: 22
Issue: 10
Pages: 1252-1263
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Publication
31474573 | J:283754
First Author: Zhang H
Year: 2019
Journal: Mol Cell
Title: Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence.
Volume: 76
Issue: 1
Pages: 110-125.e9
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Protein
Q9R210
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Protein
Q3UKG7
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q6P203
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q3U327
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Publication
29046293 | J:257558
First Author: Erlich AT
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner.
Volume: 314
Issue: 1
Pages: C62-C72
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Publication
31126958 | J:277239
 
First Author: Pastore N
Year: 2019
Journal: EMBO J
Title: Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.
Volume: 38
Issue: 12
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Publication
30108137 | J:265995
First Author: Martini-Stoica H
Year: 2018
Journal: J Exp Med
Title: TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.
Volume: 215
Issue: 9
Pages: 2355-2377
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Protein
Q8C5F1
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
F6W7D6
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: true
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Protein
D3Z6Q7
Organism: Mus musculus/domesticus
Length: 267  
Fragment?: false
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Publication
15994295 | J:101038
First Author: Huan C
Year: 2005
Journal: J Biol Chem
Title: Renal carcinoma-associated transcription factors TFE3 and TFEB are leukemia inhibitory factor-responsive transcription activators of E-cadherin.
Volume: 280
Issue: 34
Pages: 30225-35
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Publication
33297755 | J:318576
First Author: Sun J
Year: 2021
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2.
Volume: 41
Issue: 2
Pages: 783-795
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Publication
31515484 | J:295877
First Author: Wang YT
Year: 2019
Journal: Cell Death Dis
Title: Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet.
Volume: 10
Issue: 9
Pages: 676
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Publication
34229273 | J:313596
 
First Author: Wang H
Year: 2021
Journal: Neurobiol Aging
Title: TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.
Volume: 106
Pages: 26-36
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Publication
36794754 | J:350273
First Author: Shillingford JM
Year: 2023
Journal: Am J Physiol Renal Physiol
Title: Functional TFEB activation characterizes multiple models of renal cystic disease and loss of polycystin-1.
Volume: 324
Issue: 4
Pages: F404-F422
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Publication
30816805 | J:291376
First Author: Song W
Year: 2019
Journal: Arterioscler Thromb Vasc Biol
Title: Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.
Volume: 39
Issue: 4
Pages: 719-730
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Publication
28483914 | J:244363
 
First Author: Salma N
Year: 2017
Journal: Mol Cell Biol
Title: Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.
Volume: 37
Issue: 15
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Publication
10036191 | J:53287
First Author: Rehli M
Year: 1999
Journal: Genomics
Title: Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members.
Volume: 56
Issue: 1
Pages: 111-20
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Publication
11930005 | J:89821
First Author: Steingrimsson E
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development.
Volume: 99
Issue: 7
Pages: 4477-82
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Publication
33420039 | J:301059
First Author: Kim J
Year: 2021
Journal: Nat Commun
Title: An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer.
Volume: 12
Issue: 1
Pages: 183
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Publication
36868222 | J:355533
First Author: Ozcan M
Year: 2023
Journal: Cell Metab
Title: Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity.
Volume: 35
Issue: 6
Pages: 928-942.e4
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Publication
35662396 | J:342735
First Author: Zhang Z
Year: 2022
Journal: Mol Cell
Title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.
Volume: 82
Issue: 15
Pages: 2844-2857.e10
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Publication
35149590 | J:322602
First Author: Fernandez MR
Year: 2022
Journal: Cancer Res
Title: Disrupting the MYC-TFEB Circuit Impairs Amino Acid Homeostasis and Provokes Metabolic Anergy.
Volume: 82
Issue: 7
Pages: 1234-1250
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Publication
34717896 | J:317215
First Author: Chao X
Year: 2022
Journal: Am J Pathol
Title: Loss of Hepatic Transcription Factor EB Attenuates Alcohol-Associated Liver Carcinogenesis.
Volume: 192
Issue: 1
Pages: 87-103
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Publication
27184844 | J:233673
First Author: Najibi M
Year: 2016
Journal: Cell Rep
Title: An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.
Volume: 15
Issue: 8
Pages: 1728-42
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Publication
25069841 | J:232466
First Author: Polito VA
Year: 2014
Journal: EMBO Mol Med
Title: Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Volume: 6
Issue: 9
Pages: 1142-60
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Publication
35895684 | J:336031
First Author: Xia M
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor EB coordinates environmental cues to regulate T regulatory cells' mitochondrial fitness and function.
Volume: 119
Issue: 31
Pages: e2205469119
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Publication
27668431 | J:238095
   
First Author: Calcagnì A
Year: 2016
Journal: Elife
Title: Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling.
Volume: 5
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Publication
32681035 | J:292083
First Author: Wang Y
Year: 2020
Journal: Nat Commun
Title: An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis.
Volume: 11
Issue: 1
Pages: 3612
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Publication
32437957 | J:297734
First Author: Trivedi PC
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.
Volume: 1866
Issue: 10
Pages: 165832
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Publication
32354235 | J:302270
First Author: Lu H
Year: 2020
Journal: Circulation
Title: Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell Transcription Factor EB.
Volume: 142
Issue: 5
Pages: 483-498
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Publication
37864249 | J:342061
First Author: Wang X
Year: 2023
Journal: J Neuroinflammation
Title: Intermittent hypoxia therapy ameliorates beta-amyloid pathology via TFEB-mediated autophagy in murine Alzheimer's disease.
Volume: 20
Issue: 1
Pages: 240
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Publication
34253722 | J:307919
First Author: Alesi N
Year: 2021
Journal: Nat Commun
Title: TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Volume: 12
Issue: 1
Pages: 4245
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Publication
28011087 | J:251928
First Author: Mansueto G
Year: 2017
Journal: Cell Metab
Title: Transcription Factor EB Controls Metabolic Flexibility during Exercise.
Volume: 25
Issue: 1
Pages: 182-196
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Publication
29686050 | J:263174
First Author: Hayama Y
Year: 2018
Journal: J Immunol
Title: Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Volume: 200
Issue: 11
Pages: 3790-3800
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Publication
38259303 | J:346051
 
First Author: Dörmann N
Year: 2023
Journal: Front Cardiovasc Med
Title: Metabolic remodeling in cardiac hypertrophy and heart failure with reduced ejection fraction occurs independent of transcription factor EB in mice.
Volume: 10
Pages: 1323760
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Publication
28424277 | J:321056
First Author: Alghamdi TA
Year: 2017
Journal: J Am Soc Nephrol
Title: Janus Kinase 2 Regulates Transcription Factor EB Expression and Autophagy Completion in Glomerular Podocytes.
Volume: 28
Issue: 9
Pages: 2641-2653
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Publication
23606558 | J:274005
First Author: Spampanato C
Year: 2013
Journal: EMBO Mol Med
Title: Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease.
Volume: 5
Issue: 5
Pages: 691-706
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Publication
39054068 | J:355468
 
First Author: Patel AA
Year: 2024
Journal: J Neurosci
Title: TFEB/3 Govern Repair Schwann Cell Generation and Function Following Peripheral Nerve Injury.
Volume: 44
Issue: 35
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Publication
30870143 | J:295397
   
First Author: Lynch MR
Year: 2019
Journal: JCI Insight
Title: TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance.
Volume: 5
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Publication
32950676 | J:301012
First Author: Li B
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Volume: 1866
Issue: 12
Pages: 165971
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Publication
28283651 | J:262473
First Author: Pastore N
Year: 2017
Journal: EMBO Mol Med
Title: TFE3 regulates whole-body energy metabolism in cooperation with TFEB.
Volume: 9
Issue: 5
Pages: 605-621
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Publication
28754656 | J:248774
First Author: Sha Y
Year: 2017
Journal: EMBO J
Title: STUB1 regulates TFEB-induced autophagy-lysosome pathway.
Volume: 36
Issue: 17
Pages: 2544-2552
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Publication
37543947 | J:341709
First Author: Zhang T
Year: 2023
Journal: Cell Rep
Title: Autophagy collaborates with apoptosis pathways to control oligodendrocyte number.
Volume: 42
Issue: 8
Pages: 112943
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HT Experiment
GSE252252 | TFEB safeguards trophoblast syncytialization in humans and mice (mouse RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
24356961 | J:213033
First Author: Scott I
Year: 2014
Journal: J Biol Chem
Title: GCN5-like protein 1 (GCN5L1) controls mitochondrial content through coordinated regulation of mitochondrial biogenesis and mitophagy.
Volume: 289
Issue: 5
Pages: 2864-72
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Publication
23599343 | J:198454
First Author: Ferron M
Year: 2013
Journal: Genes Dev
Title: A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Volume: 27
Issue: 8
Pages: 955-69
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Publication
32612235 | J:296987
First Author: Napolitano G
Year: 2020
Journal: Nature
Title: A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Volume: 585
Issue: 7826
Pages: 597-602
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Publication
36649084 | J:336316
 
First Author: Nakamura J
Year: 2023
Journal: JCI Insight
Title: TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidney.
Volume: 8
Issue: 4
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Publication
31987928 | J:341768
First Author: Wang S
Year: 2020
Journal: Cell Mol Gastroenterol Hepatol
Title: Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans.
Volume: 10
Issue: 1
Pages: 59-81
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Publication
30503207 | J:267929
First Author: Sun LO
Year: 2018
Journal: Cell
Title: Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.
Volume: 175
Issue: 7
Pages: 1811-1826.e21
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Publication
30773991 | J:294389
First Author: Ma X
Year: 2019
Journal: J Am Heart Assoc
Title: Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization.
Volume: 8
Issue: 4
Pages: e010866
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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