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Search results 1 to 100 out of 727 for Timp3

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7078 | TIMP3
Type: gene
Organism: human
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Gene
100489929 | timp3
Type: gene
Organism: frog, western clawed
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Gene
282094 | TIMP3
Type: gene
Organism: cattle
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Gene
25358 | Timp3
Type: gene
Organism: rat
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Gene
481289 | TIMP3
Type: gene
Organism: dog, domestic
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Gene
458784 | TIMP3
Type: gene
Organism: chimpanzee
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Gene
396483 | TIMP3
Type: gene
Organism: chicken
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Gene
574381 | TIMP3
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR015612 | TIMP3
Type: Family
Description: TIMP-3 (MEROPS identifier I35.003) is known to inhibit matrix metalloproteinases, aggrecanases, and tumour necrosis factor (TNF)-alpha-converting enzyme (TACE, ADAM17), and mutations in the Human TIMP-3 gene cause a dominantly inherited, adult-onset blindness (Sorsby's fundus dystrophy or SFD) []. Deletion of the Mouse Timp3 gene results in an increase in TNF-alpha converting enzyme activity, constitutive release of TNF and activation of TNF signalling in the liver []. The knockout animals also develop spontaneous air space enlargement in the lung that is evident at 2 weeks after birth and progresses with age of the animal, and succumb to death as early as 13 months of age []. TIMP-3 has been shown to regulate agonist-induced vascular remodelling and hypertension [].Tissue inhibitors of metalloproteinases (TIMPs) are natural inhibitors of matrix metalloproteinases (MMPs) found in most tissues and body fluids. By inhibiting MMPs activities, they participate in tissue remodeling of the extracellular matrix (ECM). The balance between MMPs and TIMPs activities is involved in both normal and pathological events such as wound healing, tissue remodeling, angiogenesis, invasion, tumourigenesis and metastasis []. TIMPs also exhibit functions that appear to be independent of their metalloproteinase inhibitory capacity []. There are four mammalian TIMPs (TIMP-1 to -4), and each TIMP has its own profile of metalloproteinase inhibition.
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Protein Coding Gene
MGI:98754 | Timp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23524300 | J:211441
First Author: Basu R
Year: 2013
Journal: Cardiovasc Res
Title: TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension.
Volume: 98
Issue: 3
Pages: 360-71
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GXD Expression
GXD Expression
 
Probe: MGI:994332
Assay Type: RNA in situ
Annotation Date: 2009-01-15
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2622022
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:3825829
Age: embryonic day 14.5
Image: Additional file 4 Timp3
Specimen Label: Additional file 4 Timp3
Detected: true
Specimen Num: 1
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Publication
15322543 | J:92948
First Author: Mohammed FF
Year: 2004
Journal: Nat Genet
Title: Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
Volume: 36
Issue: 9
Pages: 969-77
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Publication
11560951 | J:71609
First Author: Leco KJ
Year: 2001
Journal: J Clin Invest
Title: Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3).
Volume: 108
Issue: 6
Pages: 817-29
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GXD Expression
GXD Expression
 
Probe: MGI:994332
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684623
Pattern: Single cells
Stage: TS23
Assay Id: MGI:4828723
Age: embryonic day 14.5
Note: Expression is present in single cells in which the intercellular distance between stained cells is much larger than the cell diameter of an individual cell and in circles of cells. A thumbnail photo of the staining is contained in the table.
Specimen Label: Table S9 - Timp3
Detected: true
Specimen Num: 1
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Publication
22896043 | J:189948
First Author: Basu R
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Loss of TIMP3 selectively exacerbates diabetic nephropathy.
Volume: 303
Issue: 9
Pages: F1341-52
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Publication
24943223 | J:271160
First Author: Stöhr R
Year: 2014
Journal: Atherosclerosis
Title: Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice.
Volume: 235
Issue: 2
Pages: 438-43
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Publication
25347747 | J:224257
First Author: Defamie V
Year: 2015
Journal: Oncogene
Title: TIMP3 controls cell fate to confer hepatocellular carcinoma resistance.
Volume: 34
Issue: 31
Pages: 4098-108
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Publication
23797704 | J:271335
First Author: Fiorentino L
Year: 2013
Journal: Acta Diabetol
Title: Regulation of TIMP3 in diabetic nephropathy: a role for microRNAs.
Volume: 50
Issue: 6
Pages: 965-9
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Publication
22383695 | J:315804
First Author: Schrimpf C
Year: 2012
Journal: J Am Soc Nephrol
Title: Pericyte TIMP3 and ADAMTS1 modulate vascular stability after kidney injury.
Volume: 23
Issue: 5
Pages: 868-83
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Publication
9164653 | -
First Author: Anand-Apte B
Year: 1996
Journal: Biochem Cell Biol
Title: A review of tissue inhibitor of metalloproteinases-3 (TIMP-3) and experimental analysis of its effect on primary tumor growth.
Volume: 74
Issue: 6
Pages: 853-62
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Publication
26648042 | J:325199
First Author: Capone C
Year: 2016
Journal: Ann Neurol
Title: Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.
Volume: 79
Issue: 3
Pages: 387-403
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Publication
19406980 | J:164969
First Author: Kassiri Z
Year: 2009
Journal: J Am Soc Nephrol
Title: Loss of TIMP3 enhances interstitial nephritis and fibrosis.
Volume: 20
Issue: 6
Pages: 1223-35
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Publication
23401241 | J:232308
First Author: Fiorentino L
Year: 2013
Journal: EMBO Mol Med
Title: Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Volume: 5
Issue: 3
Pages: 441-55
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Publication
25807548 | J:229619
First Author: Jackson HW
Year: 2015
Journal: PLoS One
Title: Timp3 deficient mice show resistance to developing breast cancer.
Volume: 10
Issue: 3
Pages: e0120107
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Publication
29373036 | J:261490
First Author: Zhabyeyev P
Year: 2018
Journal: Am J Physiol Heart Circ Physiol
Title: TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.
Volume: 314
Issue: 5
Pages: H978-H990
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Protein
E9QAB2
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Publication
27373162 | J:238581
First Author: Mavilio M
Year: 2016
Journal: Cell Rep
Title: A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction.
Volume: 16
Issue: 3
Pages: 731-43
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Protein
P39876
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q54AE5
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
Q6GXA7
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
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Publication
15036259 | -
First Author: Lambert E
Year: 2004
Journal: Crit Rev Oncol Hematol
Title: TIMPs as multifacial proteins.
Volume: 49
Issue: 3
Pages: 187-98
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Publication
17454105 | J:147695
First Author: Martin EL
Year: 2007
Journal: Exp Lung Res
Title: Lung mechanics in the TIMP3 null mouse and its response to mechanical ventilation.
Volume: 33
Issue: 2
Pages: 99-113
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Publication
18295466 | J:140813
First Author: Fogarasi M
Year: 2008
Journal: Matrix Biol
Title: Molecular dissection of TIMP3 mutation S156C associated with Sorsby fundus dystrophy.
Volume: 27
Issue: 5
Pages: 381-92
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Publication
23760282 | J:319451
First Author: Wang Z
Year: 2014
Journal: Kidney Int
Title: TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury.
Volume: 85
Issue: 1
Pages: 82-93
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Publication
26500845 | J:271161
First Author: Stöhr R
Year: 2015
Journal: Mol Metab
Title: TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.
Volume: 4
Issue: 10
Pages: 741-52
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Publication
23299479 | J:214565
First Author: Hewing NJ
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Volume: 54
Issue: 1
Pages: 864-70
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Publication
31292722 | J:291370
First Author: Casagrande V
Year: 2019
Journal: Acta Diabetol
Title: Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Volume: 56
Issue: 12
Pages: 1265-1274
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Publication
24692173 | J:229787
First Author: Fan D
Year: 2014
Journal: Cardiovasc Res
Title: Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Volume: 103
Issue: 2
Pages: 268-80
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Publication
28751722 | J:252350
First Author: Casagrande V
Year: 2017
Journal: Sci Rep
Title: Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Volume: 7
Issue: 1
Pages: 6747
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Publication
22053204 | J:178068
First Author: Hojilla CV
Year: 2011
Journal: PLoS One
Title: TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.
Volume: 6
Issue: 10
Pages: e26718
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Publication
23144462 | J:193744
First Author: Basu R
Year: 2012
Journal: J Biol Chem
Title: Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Volume: 287
Issue: 53
Pages: 44083-96
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Publication
22323541 | J:181856
First Author: Murthy A
Year: 2012
Journal: J Immunol
Title: Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis.
Volume: 188
Issue: 6
Pages: 2876-83
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Publication
16294222 | J:104707
First Author: Federici M
Year: 2005
Journal: J Clin Invest
Title: Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Volume: 115
Issue: 12
Pages: 3494-505
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Publication
37456993 | J:338186
 
First Author: Fang L
Year: 2023
Journal: Front Neurosci
Title: TIMP3 promotes the maintenance of neural stem-progenitor cells in the mouse subventricular zone.
Volume: 17
Pages: 1149603
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Publication
22228717 | J:196779
First Author: Menghini R
Year: 2012
Journal: Diabetes
Title: TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Volume: 61
Issue: 2
Pages: 454-62
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Publication
20675565 | J:162765
First Author: Kandalam V
Year: 2010
Journal: Am J Physiol Heart Circ Physiol
Title: Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction.
Volume: 299
Issue: 4
Pages: H1012-23
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Publication
12652295 | J:82659
First Author: Qi JH
Year: 2003
Journal: Nat Med
Title: A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
Volume: 9
Issue: 4
Pages: 407-15
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Publication
20682640 | J:164237
First Author: Liu H
Year: 2010
Journal: J Cell Sci
Title: TIMP3: a physiological regulator of adult myogenesis.
Volume: 123
Issue: Pt 17
Pages: 2914-21
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Publication
7782289 | J:26093
First Author: Apte SS
Year: 1995
Journal: J Biol Chem
Title: The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.
Volume: 270
Issue: 24
Pages: 14313-8
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Publication
32828705 | J:312625
 
First Author: Wolk A
Year: 2020
Journal: Redox Biol
Title: The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration.
Volume: 37
Pages: 101681
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Publication
20008147 | J:156478
First Author: Gill SE
Year: 2010
Journal: Am J Pathol
Title: Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
Volume: 176
Issue: 1
Pages: 64-73
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Publication
26993226 | J:234715
First Author: Arpino V
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Tissue inhibitor of metalloproteinases 3-dependent microvascular endothelial cell barrier function is disrupted under septic conditions.
Volume: 310
Issue: 11
Pages: H1455-67
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Publication
19128402 | J:161579
First Author: Gill SE
Year: 2009
Journal: Dev Growth Differ
Title: Absence of tissue inhibitor of metalloproteinases 3 disrupts alveologenesis in the mouse.
Volume: 51
Issue: 1
Pages: 17-24
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Publication
29134286 | J:268558
First Author: Rossi C
Year: 2018
Journal: Acta Diabetol
Title: Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
Volume: 55
Issue: 2
Pages: 121-129
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Publication
18408187 | J:136890
First Author: Janssen A
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3.
Volume: 49
Issue: 7
Pages: 2812-22
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Publication
32518385 | J:294861
First Author: Nakamura H
Year: 2020
Journal: Sci Rep
Title: Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis.
Volume: 10
Issue: 1
Pages: 9288
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Publication
16393953 | J:126607
First Author: Smookler DS
Year: 2006
Journal: J Immunol
Title: Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Volume: 176
Issue: 2
Pages: 721-5
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Publication
27476853 | J:235433
   
First Author: Capone C
Year: 2016
Journal: Elife
Title: Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Volume: 5
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Publication
12147610 | J:78059
First Author: Weber BH
Year: 2002
Journal: Invest Ophthalmol Vis Sci
Title: A mouse model for Sorsby fundus dystrophy.
Volume: 43
Issue: 8
Pages: 2732-40
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Publication
22015660 | J:195978
First Author: Casagrande V
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice.
Volume: 32
Issue: 1
Pages: 74-81
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Publication
24812324 | J:223602
First Author: Kim CW
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.
Volume: 34
Issue: 7
Pages: 1412-21
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Publication
19027012 | J:145876
First Author: Menghini R
Year: 2009
Journal: Gastroenterology
Title: Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Volume: 136
Issue: 2
Pages: 663-72.e4
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Publication
17327279 | J:120719
First Author: Hojilla CV
Year: 2007
Journal: J Cell Sci
Title: Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.
Volume: 120
Issue: Pt 6
Pages: 1050-60
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Publication
29456135 | J:263837
First Author: Dave JM
Year: 2018
Journal: Dev Cell
Title: Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.
Volume: 44
Issue: 6
Pages: 665-678.e6
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Publication
16890932 | J:119278
First Author: Gill SE
Year: 2006
Journal: Dev Biol
Title: Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix--cell signaling during bronchiole branching morphogenesis.
Volume: 298
Issue: 2
Pages: 540-54
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Publication
19625257 | J:156980
First Author: Kassiri Z
Year: 2009
Journal: J Biol Chem
Title: Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart.
Volume: 284
Issue: 43
Pages: 29893-904
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Publication
28002442 | J:254498
First Author: Poulet B
Year: 2016
Journal: PLoS One
Title: Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.
Volume: 11
Issue: 12
Pages: e0167971
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Publication
27821617 | J:283127
First Author: Baron-Menguy C
Year: 2017
Journal: Hypertension
Title: Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries.
Volume: 69
Issue: 1
Pages: 60-70
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Publication
20628198 | J:163773
First Author: Murthy A
Year: 2010
Journal: J Clin Invest
Title: Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice.
Volume: 120
Issue: 8
Pages: 2731-44
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Protein Coding Gene
MGP_CAROLIEiJ_G0015693 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017589 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017549 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0017375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_98754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0018009 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016941 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017344 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017451 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017523 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0018046 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016722 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031393 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016511 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
8132674 | J:17354
First Author: Leco KJ
Year: 1994
Journal: J Biol Chem
Title: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.
Volume: 269
Issue: 12
Pages: 9352-60
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Publication
7642607 | J:28204
First Author: Sun Y
Year: 1995
Journal: J Biol Chem
Title: Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation.
Volume: 270
Issue: 33
Pages: 19312-9
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Publication
19478078 | J:152625
First Author: Qi JH
Year: 2009
Journal: J Biol Chem
Title: S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis.
Volume: 284
Issue: 30
Pages: 19927-36
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Publication
20798233 | J:166628
First Author: Nakajima H
Year: 2010
Journal: Blood
Title: TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
Volume: 116
Issue: 22
Pages: 4474-82
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Publication
21282576 | J:181444
First Author: Ebrahem Q
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3.
Volume: 52
Issue: 9
Pages: 6117-23
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Publication
15949468 | J:263599
First Author: Singh RJ
Year: 2005
Journal: Cardiovasc Res
Title: Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3.
Volume: 67
Issue: 1
Pages: 39-49
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Publication
12909586 | J:108353
First Author: Martin EL
Year: 2003
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis.
Volume: 285
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Title: Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia.
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Year: 2013
Journal: Am J Respir Cell Mol Biol
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