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Search results 1 to 100 out of 913 for Tlr7

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
51284 | TLR7
Type: gene
Organism: human
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Gene
100151703 | tlr7
Type: gene
Organism: frog, western clawed
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Gene
317468 | Tlr7
Type: gene
Organism: rat
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Gene
491743 | TLR7
Type: gene
Organism: dog, domestic
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Gene
473521 | TLR7
Type: gene
Organism: chimpanzee
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Gene
493686 | TLR7
Type: gene
Organism: cattle
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Gene
418638 | TLR7
Type: gene
Organism: chicken
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Gene
100534776 | tlr7
Type: gene
Organism: zebrafish
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Gene
574291 | TLR7
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR026880 | TLR7
Type: Family
Description: Toll-like receptor 7 (TLR7) is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR, which is activated by single-stranded RNA, acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [, ].
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Protein Coding Gene
MGI:2176882 | Tlr7
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18250417 | J:131922
First Author: Gantier MP
Year: 2008
Journal: J Immunol
Title: TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages.
Volume: 180
Issue: 4
Pages: 2117-24
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Publication
14976261 | J:90024
First Author: Diebold SS
Year: 2004
Journal: Science
Title: Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.
Volume: 303
Issue: 5663
Pages: 1529-31
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GXD Expression
GXD Expression
   
Probe: MGI:5609311
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Present
Sex: Female
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:5609326
Age: embryonic day 17.5
Image: 2
Specimen Label: TLR7 KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5609311
Assay Type: RT-PCR
Annotation Date: 2015-01-09
Strength: Not Specified
Sex: Female
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:5609329
Age: embryonic day 17.5
Image: 2
Specimen Label: TLR7 KO
Specimen Num: 2
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Publication
31546246 | J:287430
First Author: Majer O
Year: 2019
Journal: Nature
Title: UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.
Volume: 575
Issue: 7782
Pages: 366-370
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Publication
23382559 | J:193610
First Author: Sun X
Year: 2013
Journal: J Immunol
Title: Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice.
Volume: 190
Issue: 6
Pages: 2536-43
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Publication
31642126 | J:298049
First Author: Javmen A
Year: 2020
Journal: J Leukoc Biol
Title: Frontline Science: Targeting the TLR7 signalosome assembly.
Volume: 108
Issue: 6
Pages: 1697-1706
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Protein
Q599W9
Organism: Mus musculus/domesticus
Length: 10  
Fragment?: true
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Publication
35477763 | J:324448
First Author: Brown GJ
Year: 2022
Journal: Nature
Title: TLR7 gain-of-function genetic variation causes human lupus.
Volume: 605
Issue: 7909
Pages: 349-356
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Protein
Q3T997
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Protein
P58681
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Protein
U5LLB3
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
U5LLA9
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
U5LI18
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
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Protein
Q548J0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
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Publication
37795093 | J:347835
 
First Author: Miles MA
Year: 2023
Journal: Front Immunol
Title: TLR7 promotes chronic airway disease in RSV-infected mice.
Volume: 14
Pages: 1240552
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Publication
24145511 | J:207730
First Author: Giltiay NV
Year: 2013
Journal: J Exp Med
Title: Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.
Volume: 210
Issue: 12
Pages: 2773-89
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Publication
25794167 | J:229194
First Author: Boneparth A
Year: 2015
Journal: PLoS One
Title: TLR7 influences germinal center selection in murine SLE.
Volume: 10
Issue: 3
Pages: e0119925
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Publication
34108972 | J:312592
 
First Author: Wang Y
Year: 2021
Journal: Front Immunol
Title: TLR7 Signaling Drives the Development of Sjögren's Syndrome.
Volume: 12
Pages: 676010
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Publication
25648980 | J:221365
 
First Author: Kanno A
Year: 2015
Journal: Nat Commun
Title: Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Volume: 6
Pages: 6119
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Publication
21801870 | J:174600
First Author: Butchi NB
Year: 2011
Journal: Am J Pathol
Title: TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS.
Volume: 179
Issue: 2
Pages: 783-94
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Publication
22916010 | J:195368
First Author: Maschalidi S
Year: 2012
Journal: PLoS Pathog
Title: Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation.
Volume: 8
Issue: 8
Pages: e1002841
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Publication
22615569 | J:195383
First Author: Karnam G
Year: 2012
Journal: PLoS Pathog
Title: CD200 receptor controls sex-specific TLR7 responses to viral infection.
Volume: 8
Issue: 5
Pages: e1002710
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Publication
37606042 | J:342540
 
First Author: Cosgrove HA
Year: 2023
Journal: JCI Insight
Title: B cell-intrinsic TLR7 expression drives severe lupus in TLR9-deficient mice.
Volume: 8
Issue: 16
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Publication
26567289 | J:249473
First Author: Celhar T
Year: 2016
Journal: Int Immunol
Title: TLR7 and TLR9 ligands regulate antigen presentation by macrophages.
Volume: 28
Issue: 5
Pages: 223-32
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Publication
23843519 | J:199815
First Author: Liu HY
Year: 2013
Journal: J Neurosci
Title: TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway.
Volume: 33
Issue: 28
Pages: 11479-93
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Publication
18490763 | J:136380
First Author: Butchi NB
Year: 2008
Journal: J Immunol
Title: Analysis of the neuroinflammatory response to TLR7 stimulation in the brain: comparison of multiple TLR7 and/or TLR8 agonists.
Volume: 180
Issue: 11
Pages: 7604-12
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Publication
24018482 | J:208210
First Author: Lalive PH
Year: 2014
Journal: Eur J Immunol
Title: TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3+ Treg cells.
Volume: 44
Issue: 1
Pages: 46-57
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Publication
35126381 | J:337165
 
First Author: Chang X
Year: 2021
Journal: Front Immunol
Title: TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization.
Volume: 12
Pages: 827256
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Publication
17371961 | J:145062
First Author: Berghöfer B
Year: 2007
Journal: J Immunol
Title: Natural and synthetic TLR7 ligands inhibit CpG-A- and CpG-C-oligodeoxynucleotide-induced IFN-alpha production.
Volume: 178
Issue: 7
Pages: 4072-9
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Publication
16709748 | J:109758
First Author: Pisitkun P
Year: 2006
Journal: Science
Title: Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication.
Volume: 312
Issue: 5780
Pages: 1669-72
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Publication
32521271 | J:301712
First Author: Regli IB
Year: 2020
Journal: Cell Rep
Title: TLR7 Sensing by Neutrophils Is Critical for the Control of Cutaneous Leishmaniasis.
Volume: 31
Issue: 10
Pages: 107746
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Publication
30630901 | J:295155
 
First Author: Akilesh HM
Year: 2019
Journal: Science
Title: Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes.
Volume: 363
Issue: 6423
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Publication
34530852 | J:314199
First Author: Proskocil BJ
Year: 2021
Journal: J Neuroinflammation
Title: TLR7 is expressed by support cells, but not sensory neurons, in ganglia.
Volume: 18
Issue: 1
Pages: 209
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Publication
27622045 | J:264952
First Author: Wiedemann GM
Year: 2016
Journal: Oncoimmunology
Title: A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice.
Volume: 5
Issue: 7
Pages: e1189051
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Publication
32849556 | J:308206
 
First Author: Chodisetti SB
Year: 2020
Journal: Front Immunol
Title: TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner.
Volume: 11
Pages: 1632
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Publication
25074614 | J:215986
First Author: Chatterjee S
Year: 2014
Journal: Cancer Res
Title: TLR7 promotes tumor progression, chemotherapy resistance, and poor clinical outcomes in non-small cell lung cancer.
Volume: 74
Issue: 18
Pages: 5008-18
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Publication
34473195 | J:317308
 
First Author: Rappe JCF
Year: 2021
Journal: J Exp Med
Title: A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.
Volume: 218
Issue: 11
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Publication
23303674 | J:193249
First Author: Buechler MB
Year: 2013
Journal: J Immunol
Title: Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling.
Volume: 190
Issue: 3
Pages: 886-91
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Publication
24698267 | J:213160
First Author: Park CK
Year: 2014
Journal: Neuron
Title: Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.
Volume: 82
Issue: 1
Pages: 47-54
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Publication
27600904 | J:246481
First Author: Desnues B
Year: 2016
Journal: Eur J Immunol
Title: The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.
Volume: 46
Issue: 12
Pages: 2801-2811
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Publication
20624950 | J:162380
First Author: Lukacs NW
Year: 2010
Journal: J Immunol
Title: Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation.
Volume: 185
Issue: 4
Pages: 2231-9
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Publication
34381063 | J:359915
First Author: Lee J
Year: 2021
Journal: Sci Rep
Title: Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice.
Volume: 11
Issue: 1
Pages: 16348
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Publication
37566453 | J:354783
   
First Author: Jackson WD
Year: 2023
Journal: Elife
Title: TLR7 activation at epithelial barriers promotes emergency myelopoiesis and lung antiviral immunity.
Volume: 12
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Publication
26154133 | J:245564
First Author: Yelamanchili SV
Year: 2015
Journal: PLoS Pathog
Title: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease.
Volume: 11
Issue: 7
Pages: e1005032
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Publication
25763771 | J:229712
First Author: Khan AR
Year: 2015
Journal: Eur J Immunol
Title: Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
Volume: 45
Issue: 6
Pages: 1842-54
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Publication
23029281 | J:191976
First Author: Hayashi T
Year: 2012
Journal: PLoS One
Title: Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.
Volume: 7
Issue: 9
Pages: e45860
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Publication
21131420 | J:168697
First Author: Grela F
Year: 2011
Journal: J Immunol
Title: The TLR7 agonist R848 alleviates allergic inflammation by targeting invariant NKT cells to produce IFN-gamma.
Volume: 186
Issue: 1
Pages: 284-90
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Publication
34313894 | J:341307
First Author: Wu N
Year: 2021
Journal: Mol Cell Biochem
Title: Sequence-specific extracellular microRNAs activate TLR7 and induce cytokine secretion and leukocyte migration.
Volume: 476
Issue: 11
Pages: 4139-4151
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Publication
31930147 | J:292422
 
First Author: Qu J
Year: 2019
Journal: J Immunol Res
Title: TLR7 Modulated T Cell Response in the Mesenteric Lymph Node of Schistosoma japonicum-Infected C57BL/6 Mice.
Volume: 2019
Pages: 2691808
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Publication
28843858 | J:251169
First Author: Liao YR
Year: 2017
Journal: Biochem Biophys Res Commun
Title: TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response.
Volume: 493
Issue: 2
Pages: 1136-1142
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Publication
21383246 | J:170458
First Author: Iavarone C
Year: 2011
Journal: J Immunol
Title: A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.
Volume: 186
Issue: 7
Pages: 4213-22
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Publication
24909816 | J:215509
 
First Author: Nazmi A
Year: 2014
Journal: Neurobiol Dis
Title: TLR7 is a key regulator of innate immunity against Japanese encephalitis virus infection.
Volume: 69
Pages: 235-47
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Publication
27003259 | J:234870
First Author: Nyberg WA
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Imiquimod induces ER stress and Ca(2+) influx independently of TLR7 and TLR8.
Volume: 473
Issue: 4
Pages: 789-794
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Publication
31998321 | J:297922
 
First Author: Wirth JR
Year: 2019
Journal: Front Immunol
Title: TLR7 Agonism Accelerates Disease and Causes a Fatal Myeloproliferative Disorder in NZM 2410 Lupus Mice.
Volume: 10
Pages: 3054
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Publication
30930901 | J:284385
 
First Author: Solmaz G
Year: 2019
Journal: Front Immunol
Title: TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion.
Volume: 10
Pages: 466
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Publication
28652396 | J:251506
First Author: Ye J
Year: 2017
Journal: J Immunol
Title: TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy.
Volume: 199
Issue: 3
Pages: 941-954
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Publication
18581336 | J:137453
First Author: Anders HJ
Year: 2008
Journal: Eur J Immunol
Title: Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus.
Volume: 38
Issue: 7
Pages: 1795-9
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Publication
23918369 | J:200675
First Author: Pang IK
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Efficient influenza A virus replication in the respiratory tract requires signals from TLR7 and RIG-I.
Volume: 110
Issue: 34
Pages: 13910-5
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Publication
31552019 | J:283144
 
First Author: Hanna Kazazian N
Year: 2019
Journal: Front Immunol
Title: Lupus Autoimmunity and Metabolic Parameters Are Exacerbated Upon High Fat Diet-Induced Obesity Due to TLR7 Signaling.
Volume: 10
Pages: 2015
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Publication
33443222 | J:300027
 
First Author: Wang Q
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.
Volume: 118
Issue: 1
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Publication
29150602 | J:256313
First Author: Saitoh SI
Year: 2017
Journal: Nat Commun
Title: TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.
Volume: 8
Issue: 1
Pages: 1592
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Publication
27405980 | J:260301
First Author: Liu B
Year: 2016
Journal: Sci Signal
Title: Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.
Volume: 9
Issue: 436
Pages: ra70
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Publication
25239130 | J:337115
First Author: Li X
Year: 2015
Journal: Int Immunol
Title: Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.
Volume: 27
Issue: 2
Pages: 83-94
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Publication
21765012 | J:179158
First Author: Fishelevich R
Year: 2011
Journal: J Immunol
Title: Imiquimod-induced TLR7 signaling enhances repair of DNA damage induced by ultraviolet light in bone marrow-derived cells.
Volume: 187
Issue: 4
Pages: 1664-73
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Publication
16105838 | J:102910
First Author: Nishiya T
Year: 2005
Journal: J Biol Chem
Title: TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements.
Volume: 280
Issue: 44
Pages: 37107-17
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Publication
21966467 | J:177864
First Author: Jeisy-Scott V
Year: 2011
Journal: PLoS One
Title: Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice.
Volume: 6
Issue: 9
Pages: e25242
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Publication
21813451 | J:177064
First Author: Oh JZ
Year: 2011
Journal: Blood
Title: TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathway.
Volume: 118
Issue: 11
Pages: 3028-38
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Publication
19587008 | J:151708
First Author: Green NM
Year: 2009
Journal: J Immunol
Title: Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop.
Volume: 183
Issue: 3
Pages: 1569-76
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Publication
23761632 | J:204821
First Author: Clingan JM
Year: 2013
Journal: J Immunol
Title: B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection.
Volume: 191
Issue: 2
Pages: 810-8
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Publication
18424698 | J:134322
First Author: Zucchini N
Year: 2008
Journal: J Immunol
Title: Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.
Volume: 180
Issue: 9
Pages: 5799-803
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Publication
18824599 | J:144246
First Author: Baenziger S
Year: 2009
Journal: Blood
Title: Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.
Volume: 113
Issue: 2
Pages: 377-88
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Publication
12032557 | J:114769
First Author: Jurk M
Year: 2002
Journal: Nat Immunol
Title: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.
Volume: 3
Issue: 6
Pages: 499
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Publication
18606711 | J:137656
First Author: Santiago-Raber ML
Year: 2008
Journal: J Immunol
Title: Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.
Volume: 181
Issue: 2
Pages: 1556-62
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Publication
37180169 | J:346115
 
First Author: Li J
Year: 2023
Journal: Front Immunol
Title: TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-γ.
Volume: 14
Pages: 1123074
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Publication
26474053 | J:243980
First Author: Zacca ER
Year: 2015
Journal: PLoS One
Title: Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand.
Volume: 10
Issue: 10
Pages: e0140672
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Publication
24376264 | J:207307
First Author: Lebel MÈ
Year: 2014
Journal: J Immunol
Title: Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection.
Volume: 192
Issue: 3
Pages: 1071-8
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Publication
25252960 | J:329665
First Author: Soni C
Year: 2014
Journal: J Immunol
Title: B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.
Volume: 193
Issue: 9
Pages: 4400-14
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Publication
34211367 | J:312766
 
First Author: Dieu RS
Year: 2021
Journal: Front Neurosci
Title: Central Nervous System-Endogenous TLR7 and TLR9 Induce Different Immune Responses and Effects on Experimental Autoimmune Encephalomyelitis.
Volume: 15
Pages: 685645
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Publication
31354711 | J:281852
 
First Author: Celhar T
Year: 2019
Journal: Front Immunol
Title: TLR7 Protein Expression in Mild and Severe Lupus-Prone Models Is Regulated in a Leukocyte, Genetic, and IRAK4 Dependent Manner.
Volume: 10
Pages: 1546
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Publication
22777843 | J:188005
First Author: Biondo C
Year: 2012
Journal: Eur J Immunol
Title: Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis.
Volume: 42
Issue: 10
Pages: 2632-43
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Publication
11812998 | J:90979
First Author: Hemmi H
Year: 2002
Journal: Nat Immunol
Title: Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Volume: 3
Issue: 2
Pages: 196-200
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Publication
19430477 | J:149541
First Author: Mancuso G
Year: 2009
Journal: Nat Immunol
Title: Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells.
Volume: 10
Issue: 6
Pages: 587-94
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Publication
39289468 | J:354283
First Author: Wang C
Year: 2024
Journal: Commun Biol
Title: Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production.
Volume: 7
Issue: 1
Pages: 1162
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First Author: Beutler B
Year: 2007
Journal: MGI Direct Data Submission
Title: An ENU-induced point mutation of Tlr7 specifically ablates immune response to resiquimod
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Publication
30867286 | J:273874
First Author: Wang Y
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway.
Volume: 116
Issue: 13
Pages: 6162-6171
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18340381 | J:135976
First Author: Thibault DL
Year: 2008
Journal: J Clin Invest
Title: IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice.
Volume: 118
Issue: 4
Pages: 1417-26
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22636319 | J:189565
First Author: Sinha S
Year: 2012
Journal: J Leukoc Biol
Title: IFN type I and type II independent enhancement of B cell TLR7 expression by natural killer cells.
Volume: 92
Issue: 4
Pages: 713-22
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21115693 | J:176864
First Author: Guiducci C
Year: 2010
Journal: J Exp Med
Title: Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
Volume: 207
Issue: 13
Pages: 2931-42
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