| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
Tob (transducer of ErbB2) is a member of the BTG/Tob family. Tob2 consists of 344 amino acids with high similarity to the Tob1 protein. Like the Tob1 protein, Tob2 can inhibit cell cycle progression from the G0/G1 to S phases. This cell cycle regulatory function may occur in part, through their interaction with CAF1 [].The BTG/Tob family members contain an conserved N-terminal domain, known as APRO domain (AntiPROliferative) or BTG domain. In mammals, six family members have been identified: BTG1, BTG2/PC3/Tis21, BTG3/ANA, BTG4/PC3B, Tob1/Tob and Tob2. They interact with CAF1, a subunit of the CCR4-NOT complex. They display antiproliferative properties as their ectopic expression in a variety of cell lines reduced cell proliferation []. |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
44
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ajima R |
| Year: |
2000 |
| Journal: |
Gene |
| Title: |
Cloning and characterization of the mouse tob2 gene. |
| Volume: |
253 |
| Issue: |
2 |
| Pages: |
215-20 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
345
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ikematsu N |
| Year: |
1999 |
| Journal: |
Oncogene |
| Title: |
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. |
| Volume: |
18 |
| Issue: |
52 |
| Pages: |
7432-41 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
345
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Winkler GS |
| Year: |
2010 |
| Journal: |
J Cell Physiol |
| Title: |
The mammalian anti-proliferative BTG/Tob protein family. |
| Volume: |
222 |
| Issue: |
1 |
| Pages: |
66-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jiang G |
| Year: |
2020 |
| Journal: |
J Immunol |
| Title: |
Tob2 Inhibits TLR-Induced Inflammatory Responses by Association with TRAF6 and MyD88. |
| Volume: |
205 |
| Issue: |
4 |
| Pages: |
981-986 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gámez B |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
MicroRNA-322 (miR-322) and its target protein Tob2 modulate Osterix (Osx) mRNA stability. |
| Volume: |
288 |
| Issue: |
20 |
| Pages: |
14264-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ajima R |
| Year: |
2008 |
| Journal: |
FEBS Lett |
| Title: |
Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. |
| Volume: |
582 |
| Issue: |
9 |
| Pages: |
1313-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Takahashi A |
| Year: |
2012 |
| Journal: |
Mol Cell Biol |
| Title: |
Tob2 inhibits peroxisome proliferator-activated receptor γ2 expression by sequestering Smads and C/EBPα during adipocyte differentiation. |
| Volume: |
32 |
| Issue: |
24 |
| Pages: |
5067-77 |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Perez RC |
| Year: |
2024 |
| Journal: |
J Mol Histol |
| Title: |
TOB1 and TOB2 mark distinct RNA processing granules in differentiating lens fiber cells. |
| Volume: |
55 |
| Issue: |
1 |
| Pages: |
121-138 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen Y |
| Year: |
2015 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
BTG/Tob family members Tob1 and Tob2 inhibit proliferation of mouse embryonic stem cells via Id3 mRNA degradation. |
| Volume: |
462 |
| Issue: |
3 |
| Pages: |
208-14 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Protein Tob2 |
| Type: |
chain |
| End: |
345 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
testis |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
kidney |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3598828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
skeletal muscle |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
liver |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
lung |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
spleen |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
brain |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3586333 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
heart |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662572 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783823 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:7662580 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
E15.5 + |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662572 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783825 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7662580 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
E17.5 + |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662572 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287127 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7662580 |
| Age: |
postnatal day 3 |
|
|
| Specimen Label: |
P3-Epi + |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662572 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784127 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:7662580 |
| Age: |
postnatal day 3 |
|
|
| Specimen Label: |
P3-Fib + |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-03-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3270422 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7614580 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_02 |
|
| Specimen Label: |
euxassay_002023_02 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_03 |
|
| Specimen Label: |
euxassay_002023_03 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_04 |
|
| Specimen Label: |
euxassay_002023_04 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_05 |
|
| Specimen Label: |
euxassay_002023_05 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_06 |
|
| Specimen Label: |
euxassay_002023_06 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_07 |
|
| Specimen Label: |
euxassay_002023_07 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_16 |
|
| Specimen Label: |
euxassay_002023_16 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_17 |
|
| Specimen Label: |
euxassay_002023_17 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_18 |
|
| Specimen Label: |
euxassay_002023_18 |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_19 |
|
| Specimen Label: |
euxassay_002023_19 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_20 |
|
| Specimen Label: |
euxassay_002023_20 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1763523 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_21 |
|
| Specimen Label: |
euxassay_002023_21 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662574 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783923 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:7662597 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
1b |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783921 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Little or no staining was observed in the anterior epithelium. |
| Specimen Label: |
3a |
|
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783922 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Little or no staining was observed in the anterior epithelium. |
| Specimen Label: |
3c |
|
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Ambiguous |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1783924 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Little or no staining was observed in the anterior epithelium. |
| Specimen Label: |
3e |
|
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Very strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3598826 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:3586334 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3586331 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2005-08-30 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603926 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:3586334 |
| Age: |
embryonic day 18.5 |
|
| Note: |
Ubiquitous expression. |
| Specimen Label: |
3B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_01 |
|
| Specimen Label: |
euxassay_002023_01 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_02 |
|
| Specimen Label: |
euxassay_002023_02 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_03 |
|
| Specimen Label: |
euxassay_002023_03 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_19 |
|
| Specimen Label: |
euxassay_002023_19 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_20 |
|
| Specimen Label: |
euxassay_002023_20 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_21 |
|
| Specimen Label: |
euxassay_002023_21 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1871923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828866 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_002023_22 |
|
| Specimen Label: |
euxassay_002023_22 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784121 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 13.5 |
|
| Note: |
In E13.5 lenses, distinct reactivity was detected in the differentiating primary and secondary fibers. |
| Specimen Label: |
3a |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784122 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression increased as the fiber cells underwent elongation. Immunoreactivity was predominantly present as cytoplasmic puncta, with larger and more intensely labelled granules evident in the cortical fibers. |
| Specimen Label: |
3c |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784124 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Expression increased as the fiber cells underwent elongation. Immunoreactivity was predominantly present as cytoplasmic puncta, with larger and more intensely labelled granules evident in the cortical fibers. |
| Specimen Label: |
3e |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1784121 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Expression was most strongly localized to the anterior regions of the lens fibers cells. There was partial overlap with Eif3b in some of the cytoplasmic granules. |
| Specimen Label: |
4b |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:213725 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-03-20 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7614580 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662574 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-07-03 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827723 |
| Pattern: |
Not Specified |
| Stage: |
TS23 |
| Assay Id: |
MGI:7662597 |
| Age: |
embryonic day 15.5 |
|
| Note: |
Weak expression was observed in cells just above the lens equator, which will become the germinative zone. |
| Specimen Label: |
1b |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827821 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Weak staining was detected in the germinative zone epithelium. |
| Specimen Label: |
3a |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827822 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Weak staining was detected in the germinative zone epithelium. |
| Specimen Label: |
3c |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827824 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Weak staining was detected in the germinative zone epithelium. |
| Specimen Label: |
3e |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662574 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2024-07-03 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:7662597 |
| Age: |
embryonic day 15.5 |
|
| Note: |
Expression was detected in fiber cells of the transitional zone. No signal was detected in differentiated fibers. |
| Specimen Label: |
1b |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827921 |
| Pattern: |
Regionally restricted |
| Stage: |
TS21 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 13.5 |
|
| Note: |
Expression was detected in granular or vesicular staining in the transitional zone. |
| Specimen Label: |
3a |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827922 |
| Pattern: |
Regionally restricted |
| Stage: |
TS22 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 14.5 |
|
| Note: |
Expression was detected in granular or vesicular staining in the transitional zone. |
| Specimen Label: |
3c |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7662590 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2024-07-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3827924 |
| Pattern: |
Regionally restricted |
| Stage: |
TS24 |
| Assay Id: |
MGI:7662979 |
| Age: |
embryonic day 16.5 |
|
| Note: |
Expression was detected in granular or vesicular staining in the transitional zone. |
| Specimen Label: |
3e |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Matsuda S |
| Year: |
2001 |
| Journal: |
FEBS Lett |
| Title: |
In search of a function for the TIS21/PC3/BTG1/TOB family. |
| Volume: |
497 |
| Issue: |
2-3 |
| Pages: |
67-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lorda-Diez CI |
| Year: |
2015 |
| Journal: |
Aging (Albany NY) |
| Title: |
Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. |
| Volume: |
7 |
| Issue: |
11 |
| Pages: |
974-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Islam M |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Temporal recording of mammalian development and precancer. |
| Volume: |
634 |
| Issue: |
8036 |
| Pages: |
1187-1195 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lee YJ |
| Year: |
2000 |
| Journal: |
FEBS Lett |
| Title: |
Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). |
| Volume: |
472 |
| Issue: |
2-3 |
| Pages: |
230-4 |
|
•
•
•
•
•
|