| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents TRADD (or tumour necrosis factor receptor type 1-associated DEATH domain protein). TRADD interacts with the cytoplasmic domain of activated TNFRSF1A/TNFR1, which in turn enables it to interact with FADD. Overexpression of TRADD results in apoptosis and activation of NF-kappa-B []. TRADD shuttles from the cytoplasm into the nucleus. The nuclear form of TRADD is a tumour suppressor, which by interacting with TRIP12 disrupts its complex with isoform p19ARF/ARF of CDKN2A, preventing ubiquitination and degradation []. |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chio II |
| Year: |
2012 |
| Journal: |
Nat Cell Biol |
| Title: |
TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. |
| Volume: |
14 |
| Issue: |
6 |
| Pages: |
625-33 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsu H |
| Year: |
1995 |
| Journal: |
Cell |
| Title: |
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. |
| Volume: |
81 |
| Issue: |
4 |
| Pages: |
495-504 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
58
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
64
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
310
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
310
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu D |
| Year: |
2020 |
| Journal: |
Nature |
| Title: |
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. |
| Volume: |
587 |
| Issue: |
7832 |
| Pages: |
133-138 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wesemann DR |
| Year: |
2004 |
| Journal: |
Nat Immunol |
| Title: |
TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. |
| Volume: |
5 |
| Issue: |
2 |
| Pages: |
199-207 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao X |
| Year: |
2011 |
| Journal: |
FASEB J |
| Title: |
The role of TRADD in TRAIL-induced apoptosis and signaling. |
| Volume: |
25 |
| Issue: |
4 |
| Pages: |
1353-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen NJ |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. |
| Volume: |
105 |
| Issue: |
34 |
| Pages: |
12429-34 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kim JY |
| Year: |
2011 |
| Journal: |
FEBS Lett |
| Title: |
TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation. |
| Volume: |
585 |
| Issue: |
14 |
| Pages: |
2144-50 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Michallet MC |
| Year: |
2008 |
| Journal: |
Immunity |
| Title: |
TRADD protein is an essential component of the RIG-like helicase antiviral pathway. |
| Volume: |
28 |
| Issue: |
5 |
| Pages: |
651-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pan MG |
|
| Journal: |
J Inflamm |
| Title: |
Sequence, genomic organization, and chromosome localization of the mouse TRADD gene. |
| Volume: |
46 |
| Issue: |
3 |
| Pages: |
168-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pobezinskaya YL |
| Year: |
2011 |
| Journal: |
J Immunol |
| Title: |
The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling. |
| Volume: |
186 |
| Issue: |
9 |
| Pages: |
5212-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pobezinskaya YL |
| Year: |
2008 |
| Journal: |
Nat Immunol |
| Title: |
The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. |
| Volume: |
9 |
| Issue: |
9 |
| Pages: |
1047-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ermolaeva MA |
| Year: |
2008 |
| Journal: |
Nat Immunol |
| Title: |
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses. |
| Volume: |
9 |
| Issue: |
9 |
| Pages: |
1037-46 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Dowling JP |
| Year: |
2019 |
| Journal: |
Nat Commun |
| Title: |
TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3. |
| Volume: |
10 |
| Issue: |
1 |
| Pages: |
705 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu L |
| Year: |
2017 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Loss of TRADD attenuates pressure overload-induced cardiac hypertrophy through regulating TAK1/P38 MAPK signalling in mice. |
| Volume: |
483 |
| Issue: |
2 |
| Pages: |
810-815 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hsu H |
| Year: |
1996 |
| Journal: |
Cell |
| Title: |
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. |
| Volume: |
84 |
| Issue: |
2 |
| Pages: |
299-308 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kumari S |
| Year: |
2014 |
| Journal: |
Elife |
| Title: |
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. |
| Volume: |
3 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaklamanos A |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
2397 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adam-Klages S |
| Year: |
1998 |
| Journal: |
J Leukoc Biol |
| Title: |
Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. |
| Volume: |
63 |
| Issue: |
6 |
| Pages: |
678-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anderton H |
| Year: |
2019 |
| Journal: |
Cell Death Differ |
| Title: |
RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
877-889 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Feng Q |
| Year: |
2020 |
| Journal: |
Am J Pathol |
| Title: |
miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression. |
| Volume: |
190 |
| Issue: |
2 |
| Pages: |
469-483 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
liver |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
spleen |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
lung |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
kidney |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1738328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
gonad |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
brain |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3557728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal |
|
|
| Specimen Label: |
muscle |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1842628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal week 3 |
|
|
| Specimen Label: |
3wk adr |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1842628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
adult adr |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3528461 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2005-03-07 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1842627 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:3528462 |
| Age: |
postnatal newborn |
|
|
| Specimen Label: |
P1 adr |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684620 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
12 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684621 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
13 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
14 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684623 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
15 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684624 |
|
| Stage: |
TS24 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 16.5 |
|
|
| Specimen Label: |
16 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684625 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
17 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
18 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684626 |
|
| Stage: |
TS26 |
| Assay Id: |
MGI:7523908 |
| Age: |
embryonic day 19.5 |
|
|
| Specimen Label: |
19 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684620 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
Wildtype 12 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684621 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Wildtype 13 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Wildtype 14 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684620 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
RelA-/- 12 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684621 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
RelA-/- 13 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
RelA-/- 14 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684620 |
|
| Stage: |
TS20 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
TNFR-1-/- 12 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684621 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
TNFR-1-/- 13 |
| Detected: |
true |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7523910 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-09-05 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684622 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7523916 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
TNFR-1-/- 14 |
| Detected: |
true |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562235 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603914 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:7562279 |
| Age: |
embryonic day 8.75 |
|
|
| Specimen Label: |
E8.75 EM NC |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562235 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616416 |
|
| Stage: |
TS16 |
| Assay Id: |
MGI:7562279 |
| Age: |
embryonic day 10.0 |
|
|
| Specimen Label: |
E10 NT NC |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562235 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616418 |
|
| Stage: |
TS18 |
| Assay Id: |
MGI:7562279 |
| Age: |
embryonic day 11.0 |
|
|
| Specimen Label: |
E11 NT NC |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562230 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1616417 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:7562318 |
| Age: |
embryonic day 10.0-11.0 |
|
|
| Specimen Label: |
NC |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562230 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603914 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:7562322 |
| Age: |
embryonic day 8.75 |
|
|
| Specimen Label: |
Nondiabetic |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562235 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603914 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:7562324 |
| Age: |
embryonic day 8.75 |
|
|
| Specimen Label: |
Nondiabetic |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562230 |
| Assay Type: |
Western blot |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603914 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:7562352 |
| Age: |
embryonic day 8.75 |
|
|
| Specimen Label: |
Nondiabetic |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7562235 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2023-12-01 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603914 |
|
| Stage: |
TS14 |
| Assay Id: |
MGI:7562353 |
| Age: |
embryonic day 8.75 |
|
|
| Specimen Label: |
Nondiabetic |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417420 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3271122 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7530798 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417420 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-26 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7530798 |
| Age: |
embryonic day 14.5 |
|
|
| Specimen Label: |
Supplementary table 2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yazdanpanah B |
| Year: |
2009 |
| Journal: |
Nature |
| Title: |
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. |
| Volume: |
460 |
| Issue: |
7259 |
| Pages: |
1159-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tong X |
| Year: |
2006 |
| Journal: |
Genes Dev |
| Title: |
Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. |
| Volume: |
20 |
| Issue: |
10 |
| Pages: |
1353-64 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu W |
| Year: |
2019 |
| Journal: |
EMBO J |
| Title: |
TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity. |
| Volume: |
38 |
| Issue: |
18 |
| Pages: |
e102075 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haas TL |
| Year: |
2009 |
| Journal: |
Mol Cell |
| Title: |
Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. |
| Volume: |
36 |
| Issue: |
5 |
| Pages: |
831-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kalkavan H |
| Year: |
2018 |
| Journal: |
Cell Death Differ |
| Title: |
MOMP, cell suicide as a BCL-2 family business. |
| Volume: |
25 |
| Issue: |
1 |
| Pages: |
46-55 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baker SJ |
| Year: |
1998 |
| Journal: |
Oncogene |
| Title: |
Modulation of life and death by the TNF receptor superfamily. |
| Volume: |
17 |
| Issue: |
25 |
| Pages: |
3261-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rosenfeld ME |
| Year: |
2000 |
| Journal: |
Am J Pathol |
| Title: |
Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice. |
| Volume: |
156 |
| Issue: |
3 |
| Pages: |
997-1007 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wertz IE |
| Year: |
2015 |
| Journal: |
Nature |
| Title: |
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. |
| Volume: |
528 |
| Issue: |
7582 |
| Pages: |
370-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Vanlangenakker N |
| Year: |
2011 |
| Journal: |
Cell Death Dis |
| Title: |
TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. |
| Volume: |
2 |
|
| Pages: |
e230 |
|
•
•
•
•
•
|