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Search results 1 to 100 out of 435 for Trpm5

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
101730333 | trpm5
Type: gene
Organism: frog, western clawed
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Gene
29850 | TRPM5
Type: gene
Organism: human
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Gene
365391 | Trpm5
Type: gene
Organism: rat
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Gene
483668 | TRPM5
Type: gene
Organism: dog, domestic
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Gene
466320 | TRPM5
Type: gene
Organism: chimpanzee
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Gene
100299596 | TRPM5
Type: gene
Organism: cattle
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Gene
423091 | TRPM5
Type: gene
Organism: chicken
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Gene
557722 | trpm5
Type: gene
Organism: zebrafish
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Gene
705070 | TRPM5
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR029577 | TRPM5
Type: Family
Description: The TRPM subfamily of mammalian TRP channels includes TRPM5, which is essential for the detection of bitter, sweet, and amino acid tastes []. TRPM5 forms a nonselective cation channel that is activated by intracellular Ca(2+) [, ]. In addition to the taste system, TRPM5 is expressed in chemosensory cells in the digestive tract, respiratory and olfactory systems. It is also found in pancreatic islets, where it contributes to insulin secretion [].
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Protein Coding Gene
MGI:1861718 | Trpm5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
14657398 | J:86984
First Author: Liu D
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.
Volume: 100
Issue: 25
Pages: 15160-5
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Publication
15731110 | -
First Author: Liu D
Year: 2005
Journal: J Biol Chem
Title: Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains.
Volume: 280
Issue: 21
Pages: 20691-9
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Publication
28188885 | J:261444
 
First Author: Pyrski M
Year: 2017
Journal: Mol Cell Neurosci
Title: Trpm5 expression in the olfactory epithelium.
Volume: 80
Pages: 75-88
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Publication
25940069 | J:263255
First Author: Kusumakshi S
Year: 2015
Journal: Chem Senses
Title: A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.
Volume: 40
Issue: 6
Pages: 413-25
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Protein
F6RUN7
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: true
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Protein
F7CCW2
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: true
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Publication
24756718 | -
 
First Author: Liman ER
Year: 2014
Journal: Handb Exp Pharmacol
Title: TRPM5.
Volume: 222
Pages: 489-502
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Publication
12842017 | J:354157
First Author: Hofmann T
Year: 2003
Journal: Curr Biol
Title: TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel.
Volume: 13
Issue: 13
Pages: 1153-8
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Publication
16355226 | J:103852
First Author: Talavera K
Year: 2005
Journal: Nature
Title: Heat activation of TRPM5 underlies thermal sensitivity of sweet taste.
Volume: 438
Issue: 7070
Pages: 1022-5
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Publication
16436689 | J:122002
First Author: Damak S
Year: 2006
Journal: Chem Senses
Title: Trpm5 null mice respond to bitter, sweet, and umami compounds.
Volume: 31
Issue: 3
Pages: 253-64
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Publication
26571400 | J:229827
First Author: Shigeto M
Year: 2015
Journal: J Clin Invest
Title: GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Volume: 125
Issue: 12
Pages: 4714-28
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Protein
Q9JJH7
Organism: Mus musculus/domesticus
Length: 1158  
Fragment?: false
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Protein
Q8BS44
Organism: Mus musculus/domesticus
Length: 1030  
Fragment?: true
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Publication
17522321 | J:121857
First Author: Zhang Z
Year: 2007
Journal: J Neurosci
Title: The transduction channel TRPM5 is gated by intracellular calcium in taste cells.
Volume: 27
Issue: 21
Pages: 5777-86
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Publication
32521253 | J:300847
First Author: Sakaguchi T
Year: 2020
Journal: Cell Rep
Title: TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes.
Volume: 31
Issue: 10
Pages: 107755
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Publication
34819493 | J:315176
First Author: Bos R
Year: 2021
Journal: Nat Commun
Title: Trpm5 channels encode bistability of spinal motoneurons and ensure motor control of hindlimbs in mice.
Volume: 12
Issue: 1
Pages: 6815
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Publication
28361903 | J:244737
 
First Author: Philippaert K
Year: 2017
Journal: Nat Commun
Title: Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.
Volume: 8
Pages: 14733
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Publication
29311301 | J:258599
First Author: Dutta Banik D
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.
Volume: 115
Issue: 4
Pages: E772-E781
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Publication
17652359 | J:125704
First Author: Sclafani A
Year: 2007
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins.
Volume: 293
Issue: 4
Pages: R1504-13
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Publication
34998826 | J:332955
 
First Author: Sclafani A
Year: 2022
Journal: Physiol Behav
Title: Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.
Volume: 246
Pages: 113695
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Publication
19244541 | J:145940
First Author: Riera CE
Year: 2009
Journal: J Neurosci
Title: Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels.
Volume: 29
Issue: 8
Pages: 2654-62
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Publication
29293602 | J:257029
First Author: Qian J
Year: 2018
Journal: PLoS One
Title: Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).
Volume: 13
Issue: 1
Pages: e0190465
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Publication
16935556 | J:116742
First Author: Oike H
Year: 2006
Journal: Biochim Biophys Acta
Title: Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells.
Volume: 1761
Issue: 9
Pages: 1078-84
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Publication
26397098 | J:269033
First Author: Larsson MH
Year: 2015
Journal: PLoS One
Title: Ablation of TRPM5 in Mice Results in Reduced Body Weight Gain and Improved Glucose Tolerance and Protects from Excessive Consumption of Sweet Palatable Food when Fed High Caloric Diets.
Volume: 10
Issue: 9
Pages: e0138373
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Publication
35954259 | J:352988
 
First Author: Hollenhorst MI
Year: 2022
Journal: Cells
Title: Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca(2+), cAMP and ACh.
Volume: 11
Issue: 15
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Publication
20194741 | J:158750
First Author: Colsoul B
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice.
Volume: 107
Issue: 11
Pages: 5208-13
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Publication
24573286 | J:209134
First Author: López F
Year: 2014
Journal: J Neurosci
Title: Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5.
Volume: 34
Issue: 9
Pages: 3268-78
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Publication
23884414 | J:203543
First Author: Uchida K
Year: 2013
Journal: J Biol Chem
Title: Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain.
Volume: 288
Issue: 36
Pages: 25950-5
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Publication
20498227 | J:176764
First Author: Huang YA
Year: 2010
Journal: J Physiol
Title: Intracellular Ca(2+) and TRPM5-mediated membrane depolarization produce ATP secretion from taste receptor cells.
Volume: 588
Issue: Pt 13
Pages: 2343-50
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Publication
21653867 | J:173455
First Author: Liu P
Year: 2011
Journal: J Neurosci
Title: Transient receptor potential channel type M5 is essential for fat taste.
Volume: 31
Issue: 23
Pages: 8634-42
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Publication
19025635 | J:256601
 
First Author: Lin W
Year: 2008
Journal: BMC Neurosci
Title: TRPM5-expressing microvillous cells in the main olfactory epithelium.
Volume: 9
Pages: 114
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Publication
23613997 | J:200107
First Author: Oshimoto A
Year: 2013
Journal: PLoS One
Title: Potential role of transient receptor potential channel M5 in sensing putative pheromones in mouse olfactory sensory neurons.
Volume: 8
Issue: 4
Pages: e61990
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Publication
29216297 | J:253654
First Author: Yamashita J
Year: 2017
Journal: PLoS One
Title: Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice.
Volume: 12
Issue: 12
Pages: e0189340
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Publication
17925404 | J:129007
First Author: Hisatsune C
Year: 2007
Journal: J Biol Chem
Title: Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.
Volume: 282
Issue: 51
Pages: 37225-31
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Publication
17376151 | J:145607
First Author: Blednov YA
Year: 2008
Journal: Genes Brain Behav
Title: Perception of sweet taste is important for voluntary alcohol consumption in mice.
Volume: 7
Issue: 1
Pages: 1-13
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Publication
30819885 | J:273080
First Author: Luo XC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells.
Volume: 116
Issue: 12
Pages: 5564-5569
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Publication
20689832 | J:163066
First Author: Ogura T
Year: 2010
Journal: PLoS One
Title: Chemoreception regulates chemical access to mouse vomeronasal organ: role of solitary chemosensory cells.
Volume: 5
Issue: 7
Pages: e11924
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Publication
34341568 | J:348113
First Author: Duquenne M
Year: 2021
Journal: Nat Metab
Title: Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.
Volume: 3
Issue: 8
Pages: 1071-1090
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Publication
36129169 | J:344004
   
First Author: Huang H
Year: 2022
Journal: Elife
Title: Contribution of Trp63(CreERT2)-labeled cells to alveolar regeneration is independent of tuft cells.
Volume: 11
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Publication
23639808 | J:202786
First Author: Ren Z
Year: 2013
Journal: Am J Physiol Gastrointest Liver Physiol
Title: TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.
Volume: 305
Issue: 1
Pages: G106-17
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Publication
19211717 | J:146842
First Author: Ohkuri T
Year: 2009
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity.
Volume: 296
Issue: 4
Pages: R960-71
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Publication
22183726 | J:195604
First Author: Yasumatsu K
Year: 2012
Journal: J Physiol
Title: Umami taste in mice uses multiple receptors and transduction pathways.
Volume: 590
Issue: 5
Pages: 1155-70
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Publication
37954611 | J:348004
 
First Author: Lei H
Year: 2023
Journal: Front Immunol
Title: Tuft cells utilize taste signaling molecules to respond to the pathobiont microbe Ruminococcus gnavus in the proximal colon.
Volume: 14
Pages: 1259521
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Publication
30022164 | J:265297
First Author: Miller CN
Year: 2018
Journal: Nature
Title: Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Volume: 559
Issue: 7715
Pages: 627-631
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Publication
24972051 | J:225628
 
First Author: Uhl S
Year: 2014
Journal: J Mol Cell Cardiol
Title: Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice.
Volume: 74
Pages: 307-17
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Publication
24428937 | J:226215
 
First Author: Yamaguchi T
Year: 2014
Journal: BMC Neurosci
Title: Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium.
Volume: 15
Pages: 13
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Protein Coding Gene
MGP_CAROLIEiJ_G0030735 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033269 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033183 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032968 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1861718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033093 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033041 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033185 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033075 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033782 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032402 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013931 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031845 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17267604 | J:119745
First Author: Lin W
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals.
Volume: 104
Issue: 7
Pages: 2471-6
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Publication
24712876 | J:213138
First Author: Kyriazis GA
Year: 2014
Journal: Endocrinology
Title: Sweet taste receptors regulate basal insulin secretion and contribute to compensatory insulin hypersecretion during the development of diabetes in male mice.
Volume: 155
Issue: 6
Pages: 2112-21
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Publication
18367093 | J:136043
First Author: de Araujo IE
Year: 2008
Journal: Neuron
Title: Food reward in the absence of taste receptor signaling.
Volume: 57
Issue: 6
Pages: 930-41
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Publication
24381247 | J:206211
 
First Author: Domingos AI
Year: 2013
Journal: Elife
Title: Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar.
Volume: 2
Pages: e01462
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Publication
19164511 | J:144486
First Author: Oliveira-Maia AJ
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Nicotine activates TRPM5-dependent and independent taste pathways.
Volume: 106
Issue: 5
Pages: 1596-601
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Publication
20534849 | J:160888
First Author: Ren X
Year: 2010
Journal: J Neurosci
Title: Nutrient selection in the absence of taste receptor signaling.
Volume: 30
Issue: 23
Pages: 8012-23
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2451074
Age: embryonic day 12.5
Specimen Label: SD7xBL6 B
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2451074
Age: embryonic day 12.5
Specimen Label: SD7xBL6 D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2451082
Age: embryonic day 12.5
Specimen Label: BL6xSD7 B
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:2451082
Age: embryonic day 12.5
Specimen Label: BL6xSD7 D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Brain B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Brain D
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718527
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Tongue B
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1718527
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Tongue D
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Lung B
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672827
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Lung D
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Heart B
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Heart D
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Liver B
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Liver D
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Kidney B
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737327
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Kidney D
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876727
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Spleen B
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:2451008
Assay Type: RT-PCR
Annotation Date: 2003-03-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876727
Stage: TS27
Assay Id: MGI:2451084
Age: postnatal newborn
Specimen Label: Spleen D
Detected: true
Specimen Num: 14
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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