Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin, whose only member is Transient receptor potential cation channel subfamily A member 1, TrpA1), TRPP (polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogeneous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The TRPV (vanilloid) subfamily can be divided into two distinct groups. The first, which comprises TrpV1, TrpV2, TrpV3, and TrpV4, with nonselective cation conducting pores, has members which can be activated by temperature as well as chemical stimuli. They are involved in a range of functions including nociception, thermosensing and osmolarity sensing. The second group, which consists of TrpV5 and TrpV6, (also known as epithelial calcium channels 1 and 2), highly calcium selective, are involved in renal Ca2+ absorption/reabsorption [, ].TrpV4 is a non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. It is expressed at high levels in the kidney, liver, heart and central nervous system, and activated by extracellular hypo-osmoticity, leading to increased transcellular ion flux and paracellular permeability, which may allow the cells to adjust to changes in extracellular osmolarity [, , ]. TRPV4 is can also be activated chemically by metabolites of arachidonic acid and alpha-isomers of phorbol esters [], by heat []and other factors []. This protein has been related to infectious diseases []and other pathologies [, ]. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
104
 |
Fragment?: |
true |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6202567 |
Assay Type: |
RT-PCR |
Annotation Date: |
2018-10-17 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3602628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6202586 |
Age: |
postnatal adult |
|
|
Specimen Label: |
TRPV4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liedtke W |
Year: |
2000 |
Journal: |
Cell |
Title: |
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. |
Volume: |
103 |
Issue: |
3 |
Pages: |
525-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Köttgen M |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
TRPP2 and TRPV4 form a polymodal sensory channel complex. |
Volume: |
182 |
Issue: |
3 |
Pages: |
437-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe H |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. |
Volume: |
277 |
Issue: |
16 |
Pages: |
13569-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berciano J |
Year: |
2011 |
Journal: |
J Neurol |
Title: |
Reduced penetrance in hereditary motor neuropathy caused by TRPV4 Arg269Cys mutation. |
Volume: |
258 |
Issue: |
8 |
Pages: |
1413-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doñate-Macián P |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garcia-Elias A |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. |
Volume: |
283 |
Issue: |
46 |
Pages: |
31284-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
871
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Li D |
Year: |
2020 |
Journal: |
J Mech Behav Biomed Mater |
Title: |
The structural changes of the mutated ankyrin repeat domain of the human TRPV4 channel alter its ATP binding ability. |
Volume: |
101 |
|
Pages: |
103407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Long Y |
Year: |
2024 |
Journal: |
Front Cell Neurosci |
Title: |
TRPV4 affects visual signals in photoreceptors and rod bipolar cells. |
Volume: |
18 |
|
Pages: |
1404929 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tabuchi K |
Year: |
2005 |
Journal: |
Neurosci Lett |
Title: |
Hearing impairment in TRPV4 knockout mice. |
Volume: |
382 |
Issue: |
3 |
Pages: |
304-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith PL |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Bisandrographolide from Andrographis paniculata activates TRPV4 channels. |
Volume: |
281 |
Issue: |
40 |
Pages: |
29897-904 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dupont C |
Year: |
2020 |
Journal: |
Ann Neurol |
Title: |
TRPV4 Antagonism Prevents Mechanically Induced Myotonia. |
Volume: |
88 |
Issue: |
2 |
Pages: |
297-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Akiyama T |
Year: |
2016 |
Journal: |
J Invest Dermatol |
Title: |
Involvement of TRPV4 in Serotonin-Evoked Scratching. |
Volume: |
136 |
Issue: |
1 |
Pages: |
154-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goswami R |
Year: |
2017 |
Journal: |
J Invest Dermatol |
Title: |
TRPV4 ION Channel Is Associated with Scleroderma. |
Volume: |
137 |
Issue: |
4 |
Pages: |
962-965 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao A |
Year: |
2023 |
Journal: |
Br J Pharmacol |
Title: |
Functional role of coupling the endothelial TRPV4 and K(Ca) 3.1 channels in regulating coronary vascular tone. |
Volume: |
180 |
Issue: |
17 |
Pages: |
2266-2279 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scheraga RG |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis. |
Volume: |
196 |
Issue: |
1 |
Pages: |
428-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nilius B |
Year: |
2004 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
TRPV4 calcium entry channel: a paradigm for gating diversity. |
Volume: |
286 |
Issue: |
2 |
Pages: |
C195-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alpizar YA |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides. |
Volume: |
11 |
|
Pages: |
799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Derouiche S |
Year: |
2018 |
Journal: |
FASEB J |
Title: |
TRPV4 heats up ANO1-dependent exocrine gland fluid secretion. |
Volume: |
32 |
Issue: |
4 |
Pages: |
1841-1854 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonkusare SK |
Year: |
2012 |
Journal: |
Science |
Title: |
Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. |
Volume: |
336 |
Issue: |
6081 |
Pages: |
597-601 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du K |
Year: |
2023 |
Journal: |
Exp Neurol |
Title: |
Activation of TRPV4 induces intraneuronal tau hyperphosphorylation via cholesterol accumulation. |
Volume: |
364 |
|
Pages: |
114392 |
|
•
•
•
•
•
|
Publication |
First Author: |
Güler AD |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
Heat-evoked activation of the ion channel, TRPV4. |
Volume: |
22 |
Issue: |
15 |
Pages: |
6408-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harteneck C |
Year: |
2007 |
Journal: |
Biochem Soc Trans |
Title: |
TRP channels activated by extracellular hypo-osmoticity in epithelia. |
Volume: |
35 |
Issue: |
Pt 1 |
Pages: |
91-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brierley SM |
Year: |
2008 |
Journal: |
Gastroenterology |
Title: |
Selective role for TRPV4 ion channels in visceral sensory pathways. |
Volume: |
134 |
Issue: |
7 |
Pages: |
2059-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
D'hoedt D |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. |
Volume: |
283 |
Issue: |
10 |
Pages: |
6272-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahaman SO |
Year: |
2014 |
Journal: |
J Clin Invest |
Title: |
TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. |
Volume: |
124 |
Issue: |
12 |
Pages: |
5225-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karasawa T |
Year: |
2008 |
Journal: |
J Cell Sci |
Title: |
TRPV4 enhances the cellular uptake of aminoglycoside antibiotics. |
Volume: |
121 |
Issue: |
Pt 17 |
Pages: |
2871-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yarishkin O |
Year: |
2018 |
Journal: |
Adv Exp Med Biol |
Title: |
TRPV4 Does Not Regulate the Distal Retinal Light Response. |
Volume: |
1074 |
|
Pages: |
553-560 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zaccor NW |
Year: |
2020 |
Journal: |
J Biol Chem |
Title: |
The nonselective cation channel TRPV4 inhibits angiotensin II receptors. |
Volume: |
295 |
Issue: |
29 |
Pages: |
9986-9997 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuyama R |
Year: |
2012 |
Journal: |
J Bone Miner Res |
Title: |
Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. |
Volume: |
27 |
Issue: |
8 |
Pages: |
1708-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sokabe T |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
The TRPV4 channel contributes to intercellular junction formation in keratinocytes. |
Volume: |
285 |
Issue: |
24 |
Pages: |
18749-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weber J |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema. |
Volume: |
5 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chung MK |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. |
Volume: |
279 |
Issue: |
20 |
Pages: |
21569-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aisenberg WH |
Year: |
2022 |
Journal: |
J Biol Chem |
Title: |
Multiubiquitination of TRPV4 reduces channel activity independent of surface localization. |
Volume: |
298 |
Issue: |
4 |
Pages: |
101826 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chung MK |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Warm temperatures activate TRPV4 in mouse 308 keratinocytes. |
Volume: |
278 |
Issue: |
34 |
Pages: |
32037-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomilin V |
Year: |
2019 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
TRPV4 deletion protects against hypokalemia during systemic K+ deficiency. |
Volume: |
316 |
Issue: |
5 |
Pages: |
F948-F956 |
|
•
•
•
•
•
|
Publication |
First Author: |
Janas S |
Year: |
2016 |
Journal: |
Pflugers Arch |
Title: |
TRPV4 is associated with central rather than nephrogenic osmoregulation. |
Volume: |
468 |
Issue: |
9 |
Pages: |
1595-607 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ji C |
Year: |
2023 |
Journal: |
FASEB J |
Title: |
TRPV4 regulates β1 integrin-mediated cell-matrix adhesions and collagen remodeling. |
Volume: |
37 |
Issue: |
6 |
Pages: |
e22946 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
558
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
764
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Swain SM |
Year: |
2020 |
Journal: |
J Clin Invest |
Title: |
TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. |
Volume: |
130 |
Issue: |
5 |
Pages: |
2527-2541 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma S |
Year: |
2019 |
Journal: |
J Cell Mol Med |
Title: |
TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition. |
Volume: |
23 |
Issue: |
2 |
Pages: |
761-774 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
811
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
824
 |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
|
Stage: |
TS19 |
Assay Id: |
MGI:6191515 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Trpv4 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191515 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Trpv4 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191515 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Trpv4 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191515 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Trpv4 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191515 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Trpv4 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191515 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Trpv4 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6185911 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191515 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Trpv4 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vriens J |
Year: |
2009 |
Journal: |
Mol Pharmacol |
Title: |
Pharmacology of vanilloid transient receptor potential cation channels. |
Volume: |
75 |
Issue: |
6 |
Pages: |
1262-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Samanta A |
Year: |
2018 |
Journal: |
Subcell Biochem |
Title: |
Transient Receptor Potential (TRP) Channels. |
Volume: |
87 |
|
Pages: |
141-165 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boudaka A |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Deletion of TRPV4 enhances in vitro wound healing of murine esophageal keratinocytes. |
Volume: |
10 |
Issue: |
1 |
Pages: |
11349 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gaudet R |
Year: |
2008 |
Journal: |
J Physiol |
Title: |
TRP channels entering the structural era. |
Volume: |
586 |
Issue: |
15 |
Pages: |
3565-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latorre R |
Year: |
2009 |
Journal: |
Q Rev Biophys |
Title: |
Structure-functional intimacies of transient receptor potential channels. |
Volume: |
42 |
Issue: |
3 |
Pages: |
201-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gees M |
Year: |
2010 |
Journal: |
Cold Spring Harb Perspect Biol |
Title: |
The role of transient receptor potential cation channels in Ca2+ signaling. |
Volume: |
2 |
Issue: |
10 |
Pages: |
a003962 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo J |
Year: |
2018 |
Journal: |
Immunity |
Title: |
TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. |
Volume: |
49 |
Issue: |
1 |
Pages: |
107-119.e4 |
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Publication |
First Author: |
Hamanaka K |
Year: |
2010 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
TRPV4 channels augment macrophage activation and ventilator-induced lung injury. |
Volume: |
299 |
Issue: |
3 |
Pages: |
L353-62 |
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Publication |
First Author: |
Ye L |
Year: |
2012 |
Journal: |
Cell |
Title: |
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. |
Volume: |
151 |
Issue: |
1 |
Pages: |
96-110 |
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Publication |
First Author: |
Ciura S |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. |
Volume: |
23 |
Issue: |
8 |
Pages: |
2245-2253 |
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Publication |
First Author: |
Palaniyandi S |
Year: |
2020 |
Journal: |
Lab Invest |
Title: |
TRPV4 is dispensable for the development of airway allergic asthma. |
Volume: |
100 |
Issue: |
2 |
Pages: |
265-273 |
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Publication |
First Author: |
Takayama Y |
Year: |
2014 |
Journal: |
FASEB J |
Title: |
Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. |
Volume: |
28 |
Issue: |
5 |
Pages: |
2238-48 |
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Publication |
First Author: |
Adapala RK |
Year: |
2016 |
Journal: |
Oncogene |
Title: |
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy. |
Volume: |
35 |
Issue: |
3 |
Pages: |
314-22 |
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Publication |
First Author: |
Thoppil RJ |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway. |
Volume: |
7 |
Issue: |
18 |
Pages: |
25849-61 |
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Publication |
First Author: |
Schaller L |
Year: |
2024 |
Journal: |
Cells |
Title: |
TRPV4 Mediates Alveolar Epithelial Barrier Integrity and Induces ADAM10-Driven E-Cadherin Shedding. |
Volume: |
13 |
Issue: |
20 |
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Publication |
First Author: |
Shibasaki K |
Year: |
2020 |
Journal: |
Lab Invest |
Title: |
Temperature elevation in epileptogenic foci exacerbates epileptic discharge through TRPV4 activation. |
Volume: |
100 |
Issue: |
2 |
Pages: |
274-284 |
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Publication |
First Author: |
Okada Y |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas. |
Volume: |
11 |
Issue: |
12 |
Pages: |
e0167200 |
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Publication |
First Author: |
Pivonkova H |
Year: |
2018 |
Journal: |
Neuroscience |
Title: |
The Contribution of TRPV4 Channels to Astrocyte Volume Regulation and Brain Edema Formation. |
Volume: |
394 |
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Pages: |
127-143 |
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Publication |
First Author: |
Mamenko MV |
Year: |
2017 |
Journal: |
Kidney Int |
Title: |
The renal TRPV4 channel is essential for adaptation to increased dietary potassium. |
Volume: |
91 |
Issue: |
6 |
Pages: |
1398-1409 |
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Publication |
First Author: |
Chen Y |
Year: |
2013 |
Journal: |
Pain |
Title: |
Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. |
Volume: |
154 |
Issue: |
8 |
Pages: |
1295-304 |
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Publication |
First Author: |
O'Conor CJ |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. |
Volume: |
6 |
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Pages: |
29053 |
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Publication |
First Author: |
Scheraga RG |
Year: |
2020 |
Journal: |
J Immunol |
Title: |
TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching. |
Volume: |
204 |
Issue: |
5 |
Pages: |
1310-1321 |
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Publication |
First Author: |
Alpizar YA |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells. |
Volume: |
8 |
Issue: |
1 |
Pages: |
1059 |
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Publication |
First Author: |
Zhang Y |
Year: |
2022 |
Journal: |
Elife |
Title: |
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. |
Volume: |
11 |
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Publication |
First Author: |
Harraz OF |
Year: |
2018 |
Journal: |
Elife |
Title: |
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. |
Volume: |
7 |
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Publication |
First Author: |
Gualdani R |
Year: |
2020 |
Journal: |
Sci Signal |
Title: |
Mechanical activation of TRPV4 channels controls albumin reabsorption by proximal tubule cells. |
Volume: |
13 |
Issue: |
653 |
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Publication |
First Author: |
Hoshi Y |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation. |
Volume: |
38 |
Issue: |
25 |
Pages: |
5700-5709 |
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Publication |
First Author: |
Hartmannsgruber V |
Year: |
2007 |
Journal: |
PLoS One |
Title: |
Arterial response to shear stress critically depends on endothelial TRPV4 expression. |
Volume: |
2 |
Issue: |
9 |
Pages: |
e827 |
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Publication |
First Author: |
Tomilin VN |
Year: |
2021 |
Journal: |
Cells |
Title: |
With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron. |
Volume: |
10 |
Issue: |
6 |
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Publication |
First Author: |
Ota H |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. |
Volume: |
8 |
Issue: |
6 |
Pages: |
e65751 |
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Publication |
First Author: |
Ueda T |
Year: |
2015 |
Journal: |
Biochem Biophys Rep |
Title: |
Basal cells express functional TRPV4 channels in the mouse nasal epithelium. |
Volume: |
4 |
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Pages: |
169-174 |
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Publication |
First Author: |
Seghers F |
Year: |
2016 |
Journal: |
J Physiol |
Title: |
TRPV4 participates in pressure-induced inhibition of renin secretion by juxtaglomerular cells. |
Volume: |
594 |
Issue: |
24 |
Pages: |
7327-7340 |
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Publication |
First Author: |
Feng X |
Year: |
2020 |
Journal: |
Commun Biol |
Title: |
Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury. |
Volume: |
3 |
Issue: |
1 |
Pages: |
716 |
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Publication |
First Author: |
Mueller-Tribbensee SM |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e0128242 |
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Publication |
First Author: |
Servin-Vences MR |
Year: |
2017 |
Journal: |
Elife |
Title: |
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes. |
Volume: |
6 |
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Publication |
First Author: |
Sanjel B |
Year: |
2022 |
Journal: |
Br J Pharmacol |
Title: |
Glucosylsphingosine evokes pruritus via activation of 5-HT(2A) receptor and TRPV4 in sensory neurons. |
Volume: |
179 |
Issue: |
10 |
Pages: |
2193-2207 |
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