| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Tubulin polyglutamylation plays an important role for several MT-related processes, such as motility of cilia and flagella, stability of centrosomes, and neurite outgrowth. Glutamylation is catalyzed by polyglutamylases, also called as tubulin tyrosine ligase-like (TTLL) enzymes[].This entry represents the TTLL3 monoglycylase. It is involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. However, it is not involved in elongation step of the polyglycylation reaction []. TTLL3 is a monoglycylase, which modifies alpha and beta tubulin, generating side chains of glycine on the γ-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha and beta tubulin []. |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogowski K |
| Year: |
2009 |
| Journal: |
Cell |
| Title: |
Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. |
| Volume: |
137 |
| Issue: |
6 |
| Pages: |
1076-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
van Dijk J |
| Year: |
2007 |
| Journal: |
Mol Cell |
| Title: |
A targeted multienzyme mechanism for selective microtubule polyglutamylation. |
| Volume: |
26 |
| Issue: |
3 |
| Pages: |
437-48 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
68
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
266
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wloga D |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia. |
| Volume: |
16 |
| Issue: |
6 |
| Pages: |
867-76 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
927
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
721
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
928
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rocha C |
| Year: |
2014 |
| Journal: |
EMBO J |
| Title: |
Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon. |
| Volume: |
33 |
| Issue: |
19 |
| Pages: |
2247-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bosch Grau M |
| Year: |
2013 |
| Journal: |
J Cell Biol |
| Title: |
Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. |
| Volume: |
202 |
| Issue: |
3 |
| Pages: |
441-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gadadhar S |
| Year: |
2021 |
| Journal: |
Science |
| Title: |
Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. |
| Volume: |
371 |
| Issue: |
6525 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Janečková E |
| Year: |
2023 |
| Journal: |
Development |
| Title: |
Canonical Wnt signaling regulates soft palate development by mediating ciliary homeostasis. |
| Volume: |
150 |
| Issue: |
5 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7488400 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Not Specified |
| Stage: |
TS12 |
| Assay Id: |
MGI:7531164 |
| Age: |
embryonic day 8.0 |
| Image: |
6a |
| Note: |
Expression is seen in the left-right organizer. |
| Specimen Label: |
6a |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7488400 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1607512 |
| Pattern: |
Not Specified |
| Stage: |
TS12 |
| Assay Id: |
MGI:7531164 |
| Age: |
embryonic day 8.0 |
| Image: |
6b |
| Note: |
Expression is seen in the left-right organizer. |
| Specimen Label: |
6b |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417710 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1756623 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828999 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_010602_10 |
|
| Specimen Label: |
euxassay_010602_10 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4417710 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697923 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4828999 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_010602_10 |
|
| Specimen Label: |
euxassay_010602_10 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7488400 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:7488418 |
| Age: |
embryonic day 13.5 |
| Image: |
4O,Q |
|
| Specimen Label: |
4O,Q |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7488400 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2023-06-08 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1736421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:7488418 |
| Age: |
embryonic day 13.5 |
| Image: |
4P,R |
| Note: |
Expression increased compared to control. |
| Specimen Label: |
4P,R |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bosch Grau M |
| Year: |
2017 |
| Journal: |
J Cell Sci |
| Title: |
Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration. |
| Volume: |
130 |
| Issue: |
5 |
| Pages: |
938-949 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bellchambers HM |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
Single cell RNA analysis of the left-right organizer transcriptome reveals potential novel heterotaxy genes. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
10688 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhu X |
| Year: |
2022 |
| Journal: |
Cancer Res |
| Title: |
Asialoglycoprotein Receptor 1 Functions as a Tumor Suppressor in Liver Cancer via Inhibition of STAT3. |
| Volume: |
82 |
| Issue: |
21 |
| Pages: |
3987-4000 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adissu HA |
| Year: |
2014 |
| Journal: |
Dis Model Mech |
| Title: |
Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. |
| Volume: |
7 |
| Issue: |
5 |
| Pages: |
515-24 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the Europhenome Mouse Phenotyping Resource |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from Europhenome |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Collin GB |
| Year: |
2020 |
| Journal: |
Cells |
| Title: |
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss. |
| Volume: |
9 |
| Issue: |
4 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ingham NJ |
| Year: |
2019 |
| Journal: |
PLoS Biol |
| Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
| Volume: |
17 |
| Issue: |
4 |
| Pages: |
e3000194 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wellcome Trust Sanger Institute |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Velocigene |
| Year: |
2008 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Skarnes WC |
| Year: |
2011 |
| Journal: |
Nature |
| Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
| Volume: |
474 |
| Issue: |
7351 |
| Pages: |
337-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Okazaki Y |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
| Pages: |
563-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|