Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
UBE3A (also known as E6-AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. It regulates cell proliferation by promoting proteasomal degradation of p27 []. It can also serve as a molecular circadian clock through regulating the BMAL1 transcription factor []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Gossan NC |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor. |
Volume: |
42 |
Issue: |
9 |
Pages: |
5765-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mishra A |
Year: |
2009 |
Journal: |
Neurobiol Dis |
Title: |
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27. |
Volume: |
36 |
Issue: |
1 |
Pages: |
26-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burette AC |
Year: |
2017 |
Journal: |
J Comp Neurol |
Title: |
Subcellular organization of UBE3A in neurons. |
Volume: |
525 |
Issue: |
2 |
Pages: |
233-251 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
906
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Jordan C |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Ube3a expression is not altered in Mecp2 mutant mice. |
Volume: |
15 |
Issue: |
14 |
Pages: |
2210-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi SQ |
Year: |
2015 |
Journal: |
Curr Biol |
Title: |
Ube3a imprinting impairs circadian robustness in Angelman syndrome models. |
Volume: |
25 |
Issue: |
5 |
Pages: |
537-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miura K |
Year: |
2002 |
Journal: |
Neurobiol Dis |
Title: |
Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice. |
Volume: |
9 |
Issue: |
2 |
Pages: |
149-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vihma H |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Ube3a unsilencer for the potential treatment of Angelman syndrome. |
Volume: |
15 |
Issue: |
1 |
Pages: |
5558 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yashiro K |
Year: |
2009 |
Journal: |
Nat Neurosci |
Title: |
Ube3a is required for experience-dependent maturation of the neocortex. |
Volume: |
12 |
Issue: |
6 |
Pages: |
777-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Elgersma Y |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles of Ube3a |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Colas D |
Year: |
2005 |
Journal: |
Neurobiol Dis |
Title: |
Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome. |
Volume: |
20 |
Issue: |
2 |
Pages: |
471-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Punt AM |
Year: |
2022 |
Journal: |
JCI Insight |
Title: |
Molecular and behavioral consequences of Ube3a gene overdosage in mice. |
Volume: |
7 |
Issue: |
18 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Furumai R |
Year: |
2019 |
Journal: |
Hum Mol Genet |
Title: |
UBE3A regulates the transcription of IRF, an antiviral immunity. |
Volume: |
28 |
Issue: |
12 |
Pages: |
1947-1958 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sen D |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Evaluation of UBE3A antibodies in mice and human cerebral organoids. |
Volume: |
11 |
Issue: |
1 |
Pages: |
6323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang HS |
Year: |
2011 |
Journal: |
Nature |
Title: |
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. |
Volume: |
481 |
Issue: |
7380 |
Pages: |
185-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith SE |
Year: |
2011 |
Journal: |
Sci Transl Med |
Title: |
Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. |
Volume: |
3 |
Issue: |
103 |
Pages: |
103ra97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu B |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice. |
Volume: |
129 |
Issue: |
1 |
Pages: |
163-168 |
|
•
•
•
•
•
|
Publication |
First Author: |
Avagliano Trezza R |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Mono-ubiquitination of Rabphilin 3A by UBE3A serves a non-degradative function. |
Volume: |
11 |
Issue: |
1 |
Pages: |
3007 |
|
•
•
•
•
•
|
Publication |
First Author: |
Avagliano Trezza R |
Year: |
2019 |
Journal: |
Nat Neurosci |
Title: |
Loss of nuclear UBE3A causes electrophysiological and behavioral deficits in mice and is associated with Angelman syndrome. |
Volume: |
22 |
Issue: |
8 |
Pages: |
1235-1247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Copping NA |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome. |
Volume: |
26 |
Issue: |
20 |
Pages: |
3995-4010 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wallace ML |
Year: |
2012 |
Journal: |
Neuron |
Title: |
Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects. |
Volume: |
74 |
Issue: |
5 |
Pages: |
793-800 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng L |
Year: |
2013 |
Journal: |
PLoS Genet |
Title: |
Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model. |
Volume: |
9 |
Issue: |
12 |
Pages: |
e1004039 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krishnan V |
Year: |
2017 |
Journal: |
Nature |
Title: |
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. |
Volume: |
543 |
Issue: |
7646 |
Pages: |
507-512 |
|
•
•
•
•
•
|
Publication |
First Author: |
Born HA |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
8451 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonzogni M |
Year: |
2019 |
Journal: |
Mol Autism |
Title: |
Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes. |
Volume: |
10 |
|
Pages: |
23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hillman PR |
Year: |
2017 |
Journal: |
Epigenetics Chromatin |
Title: |
Genomic imprinting does not reduce the dosage of UBE3A in neurons. |
Volume: |
10 |
|
Pages: |
27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hao X |
Year: |
2023 |
Journal: |
Exp Neurol |
Title: |
UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways. |
Volume: |
363 |
|
Pages: |
114358 |
|
•
•
•
•
•
|
Publication |
First Author: |
Greer PL |
Year: |
2010 |
Journal: |
Cell |
Title: |
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. |
Volume: |
140 |
Issue: |
5 |
Pages: |
704-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ehlen JC |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact. |
Volume: |
35 |
Issue: |
40 |
Pages: |
13587-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. |
Volume: |
10 |
Issue: |
1 |
Pages: |
9824 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gustin RM |
Year: |
2010 |
Journal: |
Neurobiol Dis |
Title: |
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome. |
Volume: |
39 |
Issue: |
3 |
Pages: |
283-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maheshwari M |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Deficiency of Ube3a in Huntington's disease mice brain increases aggregate load and accelerates disease pathology. |
Volume: |
23 |
Issue: |
23 |
Pages: |
6235-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Su H |
Year: |
2011 |
Journal: |
Neurosci Lett |
Title: |
Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. |
Volume: |
487 |
Issue: |
2 |
Pages: |
129-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmid RS |
Year: |
2021 |
Journal: |
J Clin Invest |
Title: |
CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice. |
Volume: |
131 |
Issue: |
5 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lawson-Yuen A |
Year: |
2007 |
Journal: |
Brain Res |
Title: |
Ube3a mRNA and protein expression are not decreased in Mecp2R168X mutant mice. |
Volume: |
1180 |
|
Pages: |
1-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Landers M |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
Maternal disruption of Ube3a leads to increased expression of Ube3a-ATS in trans. |
Volume: |
33 |
Issue: |
13 |
Pages: |
3976-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Judson MC |
Year: |
2014 |
Journal: |
J Comp Neurol |
Title: |
Allelic specificity of Ube3a expression in the mouse brain during postnatal development. |
Volume: |
522 |
Issue: |
8 |
Pages: |
1874-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zampeta FI |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms. |
Volume: |
29 |
Issue: |
18 |
Pages: |
3032-3043 |
|
•
•
•
•
•
|
Publication |
First Author: |
Silva-Santos S |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. |
Volume: |
125 |
Issue: |
5 |
Pages: |
2069-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh BK |
Year: |
2017 |
Journal: |
Hum Mol Genet |
Title: |
Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer's disease. |
Volume: |
26 |
Issue: |
20 |
Pages: |
4042-4054 |
|
•
•
•
•
•
|
Publication |
First Author: |
Milazzo C |
Year: |
2021 |
Journal: |
JCI Insight |
Title: |
Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model. |
Volume: |
6 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Reiter LT |
Year: |
2006 |
Journal: |
Hum Mol Genet |
Title: |
Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase. |
Volume: |
15 |
Issue: |
18 |
Pages: |
2825-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rotaru DC |
Year: |
2023 |
Journal: |
JCI Insight |
Title: |
UBE3A expression during early postnatal brain development is required for proper dorsomedial striatal maturation. |
Volume: |
8 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Miao S |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
The Angelman syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons. |
Volume: |
33 |
Issue: |
1 |
Pages: |
327-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis. |
Volume: |
12 |
Issue: |
3 |
Pages: |
449-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mardirossian S |
Year: |
2009 |
Journal: |
Exp Neurol |
Title: |
Impaired hippocampal plasticity and altered neurogenesis in adult Ube3a maternal deficient mouse model for Angelman syndrome. |
Volume: |
220 |
Issue: |
2 |
Pages: |
341-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Judson MC |
Year: |
2016 |
Journal: |
Neuron |
Title: |
GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility. |
Volume: |
90 |
Issue: |
1 |
Pages: |
56-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
Maternal Loss of Ube3a Impairs Experience-Driven Dendritic Spine Maintenance in the Developing Visual Cortex. |
Volume: |
36 |
Issue: |
17 |
Pages: |
4888-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xing L |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice. |
Volume: |
42 |
Issue: |
7 |
Pages: |
112706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maheshwari M |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington disease. |
Volume: |
287 |
Issue: |
35 |
Pages: |
29949-57 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191529 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Ube3a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191529 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Ube3a |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191529 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Ube3a |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191529 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Ube3a |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191529 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Ube3a |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191529 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Ube3a |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6186230 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191529 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Ube3a |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang YH |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. |
Volume: |
5 |
Issue: |
8 |
Pages: |
e12278 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsai TF |
Year: |
1999 |
Journal: |
Hum Mol Genet |
Title: |
Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome. |
Volume: |
8 |
Issue: |
8 |
Pages: |
1357-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sonzogni M |
Year: |
2020 |
Journal: |
Mol Autism |
Title: |
Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome. |
Volume: |
11 |
Issue: |
1 |
Pages: |
70 |
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First Author: |
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Year: |
2022 |
Journal: |
Cells |
Title: |
Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Ube3a Gene. |
Volume: |
11 |
Issue: |
18 |
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2001 |
Journal: |
Genomics |
Title: |
The Prader-Willi syndrome imprinting center activates the paternally expressed murine Ube3a antisense transcript but represses paternal Ube3a. |
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73 |
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3 |
Pages: |
316-22 |
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2004 |
Journal: |
Nucleic Acids Res |
Title: |
Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn. |
Volume: |
32 |
Issue: |
11 |
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First Author: |
Berrios J |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation. |
Volume: |
7 |
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Pages: |
10702 |
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First Author: |
Musi CA |
Year: |
2020 |
Journal: |
Neurobiol Dis |
Title: |
JNK signaling activation in the Ube3a maternal deficient mouse model: its specific inhibition prevents post-synaptic protein-enriched fraction alterations and cognitive deficits in Angelman Syndrome model. |
Volume: |
140 |
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Pages: |
104812 |
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First Author: |
Grier MD |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Toward a Broader View of Ube3a in a Mouse Model of Angelman Syndrome: Expression in Brain, Spinal Cord, Sciatic Nerve and Glial Cells. |
Volume: |
10 |
Issue: |
4 |
Pages: |
e0124649 |
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First Author: |
Pignatelli M |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Changes in mGlu5 receptor-dependent synaptic plasticity and coupling to homer proteins in the hippocampus of Ube3A hemizygous mice modeling angelman syndrome. |
Volume: |
34 |
Issue: |
13 |
Pages: |
4558-66 |
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First Author: |
Wallace ML |
Year: |
2017 |
Journal: |
J Neurophysiol |
Title: |
Ube3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice. |
Volume: |
118 |
Issue: |
1 |
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634-646 |
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First Author: |
Rotaru DC |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Adult Ube3a Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome. |
Volume: |
38 |
Issue: |
37 |
Pages: |
8011-8030 |
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First Author: |
Judson MC |
Year: |
2021 |
Journal: |
JCI Insight |
Title: |
Dual-isoform hUBE3A gene transfer improves behavioral and seizure outcomes in Angelman syndrome model mice. |
Volume: |
6 |
Issue: |
20 |
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First Author: |
Khatri N |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
The Autism Protein Ube3A/E6AP Remodels Neuronal Dendritic Arborization via Caspase-Dependent Microtubule Destabilization. |
Volume: |
38 |
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2 |
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363-378 |
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Shi SQ |
Year: |
2022 |
Journal: |
Front Behav Neurosci |
Title: |
Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a. |
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16 |
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Neuron |
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Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. |
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Neuroscience |
Title: |
Fast cerebellar oscillation associated with ataxia in a mouse model of Angelman syndrome. |
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130 |
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Sci Transl Med |
Title: |
Decreased tonic inhibition in cerebellar granule cells causes motor dysfunction in a mouse model of Angelman syndrome. |
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Title: |
Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome. |
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Commun Biol |
Title: |
Dysfunction of the ubiquitin ligase E3A Ube3A/E6-AP contributes to synaptic pathology in Alzheimer's disease. |
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Title: |
The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. |
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Title: |
Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome. |
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Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model. |
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J Neurosci |
Title: |
The Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation. |
Volume: |
33 |
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Behav Brain Res |
Title: |
Of mothers and myelin: Aberrant myelination phenotypes in mouse model of Angelman syndrome are dependent on maternal and dietary influences. |
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Sci Rep |
Title: |
Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses. |
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Altered serotonin, dopamine and norepinepherine levels in 15q duplication and Angelman syndrome mouse models. |
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Rescue of altered HDAC activity recovers behavioural abnormalities in a mouse model of Angelman syndrome. |
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Title: |
The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. |
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Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome. |
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