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Search results 1 to 100 out of 117 for Ufl1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
23376 | UFL1
Type: gene
Organism: human
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Gene
100486377 | ufl1
Type: gene
Organism: frog, western clawed
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Gene
313115 | Ufl1
Type: gene
Organism: rat
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Gene
474999 | UFL1
Type: gene
Organism: dog, domestic
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Gene
462889 | UFL1
Type: gene
Organism: chimpanzee
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Gene
515894 | UFL1
Type: gene
Organism: cattle
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Gene
421804 | UFL1
Type: gene
Organism: chicken
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Gene
393578 | ufl1
Type: gene
Organism: zebrafish
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Gene
704454 | UFL1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR018611 | Ufl1
Type: Family
Description: The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzyme (Uba5), an E2-conjugating enzyme (Ufc1), and a E3-ligating enzyme []. This entry represents E3 UFM1-protein ligase 1 (Ufl1) which mediates the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins and plays a key role in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress [, , , , ].
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Protein Coding Gene
MGI:1914740 | Ufl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
20228063 | J:163051
First Author: Wu J
Year: 2010
Journal: J Biol Chem
Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
Volume: 285
Issue: 20
Pages: 15126-36
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Gene
100861530 | UFL1-AS1
Type: gene
Organism: human
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Publication
36120581 | J:333491
 
First Author: Wang K
Year: 2022
Journal: Front Cell Dev Biol
Title: Ufl1 deficiency causes skin pigmentation by up-regulation of Endothelin-1.
Volume: 10
Pages: 961675
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Publication
38377992 | J:347152
First Author: He C
Year: 2024
Journal: Mol Cell
Title: UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.
Volume: 84
Issue: 6
Pages: 1120-1138.e8
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Publication
35871231 | J:344597
First Author: Tao Y
Year: 2023
Journal: Cell Death Differ
Title: UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation.
Volume: 30
Issue: 1
Pages: 16-26
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Publication
30354401 | J:319822
First Author: Li J
Year: 2018
Journal: Circ Heart Fail
Title: Ufm1-Specific Ligase Ufl1 Regulates Endoplasmic Reticulum Homeostasis and Protects Against Heart Failure.
Volume: 11
Issue: 10
Pages: e004917
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Publication
34148841 | J:333688
First Author: Zhou Y
Year: 2021
Journal: J Genet Genomics
Title: Ufl1 deficiency causes kidney atrophy associated with disruption of endoplasmic reticulum homeostasis.
Volume: 48
Issue: 5
Pages: 403-410
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Publication
30635284 | J:272566
 
First Author: Yang R
Year: 2019
Journal: Development
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Volume: 146
Issue: 2
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Publication
20018847 | J:158995
First Author: Tatsumi K
Year: 2010
Journal: J Biol Chem
Title: A novel type of E3 ligase for the Ufm1 conjugation system.
Volume: 285
Issue: 8
Pages: 5417-27
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Protein
Q8CCJ3
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Publication
25219498 | J:215542
First Author: Yoo HM
Year: 2014
Journal: Mol Cell
Title: Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.
Volume: 56
Issue: 2
Pages: 261-74
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Publication
32160526 | -
First Author: Liang JR
Year: 2020
Journal: Cell
Title: A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
Volume: 180
Issue: 6
Pages: 1160-1177.e20
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Publication
20164180 | -
First Author: Kwon J
Year: 2010
Journal: J Biol Chem
Title: A novel LZAP-binding protein, NLBP, inhibits cell invasion.
Volume: 285
Issue: 16
Pages: 12232-40
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Publication
36893266 | J:340279
First Author: Zhou J
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Dysregulation of PD-L1 by UFMylation imparts tumor immune evasion and identified as a potential therapeutic target.
Volume: 120
Issue: 11
Pages: e2215732120
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Publication
30701081 | J:298771
 
First Author: Cai Y
Year: 2019
Journal: Cell Discov
Title: Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Volume: 5
Pages: 7
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Publication
21494687 | J:217277
First Author: Lemaire K
Year: 2011
Journal: PLoS One
Title: Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.
Volume: 6
Issue: 4
Pages: e18517
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Protein Coding Gene
MGP_CAROLIEiJ_G0025857 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028103 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028061 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028026 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028072 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0027802 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1914740 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028515 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027257 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0027775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0027918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0027884 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028574 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026977 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027334 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023980 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0026805 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
28104585 | J:241953
First Author: Miller C
Year: 2017
Journal: Am J Physiol Gastrointest Liver Physiol
Title: RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas.
Volume: 312
Issue: 3
Pages: G314-G326
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: Atx-KI
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: Atx-KI
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Western blot
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:5638162
Age: postnatal week 16
Specimen Label: Atx-KI
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423428
Age: embryonic day 16.5
Image: 6
Specimen Label: Input
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423434
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423434
Age: embryonic day 16.5
Image: 6
Specimen Label: WT
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423434
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6423434
Age: embryonic day 16.5
Image: 6
Specimen Label: KO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423442
Age: postnatal month 1
Image: S6
Specimen Label: Con
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423442
Age: postnatal month 1
Image: S6
Specimen Label: Con
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423442
Age: postnatal month 1
Image: S6
Specimen Label: CKO
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6423132
Assay Type: Western blot
Annotation Date: 2020-05-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6423442
Age: postnatal month 1
Image: S6
Specimen Label: CKO
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:7524613
Assay Type: Western blot
Annotation Date: 2023-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:7524621
Age: embryonic day 11.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7524613
Assay Type: Western blot
Annotation Date: 2023-09-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:7524621
Age: embryonic day 11.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:7524613
Assay Type: Western blot
Annotation Date: 2023-09-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603919
Stage: TS19
Assay Id: MGI:7524621
Age: embryonic day 11.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 1
Note: Expression was high in Glast-positive Bergmann glia.
Specimen Label: 2C WT
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 1
Note: Expression was reduced in Bergmann glia in the mutant.
Specimen Label: 2C Atx-KI
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 16
Note: Expression was high in Gfap-positive Bergmann glia.
Specimen Label: 2D WT
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 16
Note: Expression was reduced in Bergmann glia in the mutant.
Specimen Label: 2D Atx1-KI
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 1
Note: Expression was detected in PCNA-positive cells.
Specimen Label: 2F
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 16
Note: Expression was in Bergmann glia, but not in Purkinje cells.
Specimen Label: S1A
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 16
Note: Expression was in Sox2-positive Bergmann glia.
Specimen Label: S1B
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5638165
Age: embryonic day 17.0
Note: There was expression in Glast-positive radial glia.
Specimen Label: 2B upper,middle
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754425
Pattern: Regionally restricted
Stage: TS25
Assay Id: MGI:5638165
Age: embryonic day 17.0
Note: Expression was detected in Sox2-positive neural stem cells.
Specimen Label: 2B lower
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5638059
Assay Type: Immunohistochemistry
Annotation Date: 2015-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3522328
Stage: TS28
Assay Id: MGI:5638165
Age: postnatal week 16
Specimen Label: S1A
Detected: false
Specimen Num: 8
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Publication
23152784 | J:195351
First Author: Zhang Y
Year: 2012
Journal: PLoS One
Title: Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.
Volume: 7
Issue: 11
Pages: e48587
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Publication
25952549 | J:238253
First Author: Zhang M
Year: 2015
Journal: Cell Death Differ
Title: RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis.
Volume: 22
Issue: 12
Pages: 1922-34
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Publication
20531390 | J:162095
First Author: Shiwaku H
Year: 2010
Journal: EMBO J
Title: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
Volume: 29
Issue: 14
Pages: 2446-60
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
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First Author: Mouse Genome Informatics Scientific Curators
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