| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes VDAC3 from animals. Recombinant VDAC3 shows a channel activity with a very small conductance []. VDAC3 is involved in the transport of ADP across the mitochondrial outer membrane in the cardiac muscle (oxidative muscle) but not in the gastrocnemius muscle (mixed muscle) []. VDAC3 is also a centrosomal protein that interacts with the centrosomal protein kinase Mps1 []. VDAC3 and Mps1 negatively regulate ciliogenesis; they promote ciliary disassembly during cell cycle entry and suppress cilia assembly in proliferating cells []. Mice lacking VDAC3 suffered from immotile sperm and infertility [].Voltage dependent anion channels (VDACs) or porins by analogy with bacterial porins, are pore-forming proteins associated with mitochondria, although they are also present in the endoplasmic reticulum (ER) []and plasma membrane []. In mammals, three VDAC isoforms have been identified: VDAC1 to 3. They have a very similar predicted structure, consisting of a 19 amphipathic β-strands barrel with an N-terminal α-helix in the central pore [, ]. The channel opening faces both the cytosol and mitochondrial intermembrane space [, ]. They play a major role in cellular energetic metabolism due to its ability to allow the exchange of molecules between the cytosol and the mitochondrial intermembrane space. They may also play a role in cell death. However, several mouse gene knock out studies show that VDACs are dispensable for both MPT (mitochondrial permeability transition) and Bcl-2 family member-driven cell death [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anflous-Pharayra K |
| Year: |
2011 |
| Journal: |
Biochim Biophys Acta |
| Title: |
VDAC3 has differing mitochondrial functions in two types of striated muscles. |
| Volume: |
1807 |
| Issue: |
1 |
| Pages: |
150-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sampson MJ |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Immotile sperm and infertility in mice lacking mitochondrial voltage-dependent anion channel type 3. |
| Volume: |
276 |
| Issue: |
42 |
| Pages: |
39206-12 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baines CP |
| Year: |
2007 |
| Journal: |
Nat Cell Biol |
| Title: |
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. |
| Volume: |
9 |
| Issue: |
5 |
| Pages: |
550-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Majumder S |
| Year: |
2013 |
| Journal: |
Cell Cycle |
| Title: |
VDAC3 and Mps1 negatively regulate ciliogenesis. |
| Volume: |
12 |
| Issue: |
5 |
| Pages: |
849-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Majumder S |
| Year: |
2012 |
| Journal: |
Cell Cycle |
| Title: |
VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes. |
| Volume: |
11 |
| Issue: |
19 |
| Pages: |
3666-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sampson MJ |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
A novel isoform of the mitochondrial outer membrane protein VDAC3 via alternative splicing of a 3-base exon. Functional characteristics and subcellular localization. |
| Volume: |
273 |
| Issue: |
46 |
| Pages: |
30482-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Checchetto V |
| Year: |
2014 |
| Journal: |
Cell Physiol Biochem |
| Title: |
Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance. |
| Volume: |
34 |
| Issue: |
3 |
| Pages: |
842-53 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
283
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
284
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
283
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
75
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
284
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
283
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hiller S |
| Year: |
2008 |
| Journal: |
Science |
| Title: |
Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. |
| Volume: |
321 |
| Issue: |
5893 |
| Pages: |
1206-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Pinto V |
| Year: |
2010 |
| Journal: |
FEBS Lett |
| Title: |
Voltage-dependent anion-selective channel (VDAC) in the plasma membrane. |
| Volume: |
584 |
| Issue: |
9 |
| Pages: |
1793-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shoshan-Barmatz V |
| Year: |
2004 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Subcellular localization of VDAC in mitochondria and ER in the cerebellum. |
| Volume: |
1657 |
| Issue: |
2-3 |
| Pages: |
105-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Choudhary OP |
| Year: |
2014 |
| Journal: |
Nat Struct Mol Biol |
| Title: |
Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. |
| Volume: |
21 |
| Issue: |
7 |
| Pages: |
626-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Pinto V |
| Year: |
2010 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Characterization of human VDAC isoforms: a peculiar function for VDAC3? |
| Volume: |
1797 |
| Issue: |
6-7 |
| Pages: |
1268-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maurya SR |
| Year: |
2014 |
| Journal: |
PLoS One |
| Title: |
Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2. |
| Volume: |
9 |
| Issue: |
3 |
| Pages: |
e92183 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martel C |
| Year: |
2014 |
| Journal: |
Mitochondrion |
| Title: |
VDAC phosphorylation, a lipid sensor influencing the cell fate. |
| Volume: |
19 Pt A |
|
| Pages: |
69-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mise S |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
1071 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zou L |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Knockout of mitochondrial voltage-dependent anion channel type 3 increases reactive oxygen species (ROS) levels and alters renal sodium transport. |
| Volume: |
293 |
| Issue: |
5 |
| Pages: |
1666-1675 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wu S |
| Year: |
1999 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration. |
| Volume: |
1452 |
| Issue: |
1 |
| Pages: |
68-78 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Anflous-Pharayra K |
| Year: |
2007 |
| Journal: |
Biochim Biophys Acta |
| Title: |
VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles. |
| Volume: |
1767 |
| Issue: |
2 |
| Pages: |
136-42 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huang H |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. |
| Volume: |
288 |
| Issue: |
27 |
| Pages: |
19870-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sampson MJ |
| Year: |
1997 |
| Journal: |
J Biol Chem |
| Title: |
The murine voltage-dependent anion channel gene family. Conserved structure and function. |
| Volume: |
272 |
| Issue: |
30 |
| Pages: |
18966-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shimada K |
| Year: |
2021 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility. |
| Volume: |
118 |
| Issue: |
6 |
|
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Weeber EJ |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. |
| Volume: |
277 |
| Issue: |
21 |
| Pages: |
18891-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sampson MJ |
| Year: |
1996 |
| Journal: |
Genomics |
| Title: |
A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. |
| Volume: |
36 |
| Issue: |
1 |
| Pages: |
192-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sabirov RZ |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. |
| Volume: |
281 |
| Issue: |
4 |
| Pages: |
1897-904 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
De Marchi U |
| Year: |
2008 |
| Journal: |
Biochim Biophys Acta |
| Title: |
A maxi-chloride channel in the inner membrane of mammalian mitochondria. |
| Volume: |
1777 |
| Issue: |
11 |
| Pages: |
1438-48 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jones SP |
| Year: |
2008 |
| Journal: |
Circulation |
| Title: |
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. |
| Volume: |
117 |
| Issue: |
9 |
| Pages: |
1172-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ha SD |
| Year: |
2012 |
| Journal: |
Mol Cell Biol |
| Title: |
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. |
| Volume: |
32 |
| Issue: |
23 |
| Pages: |
4846-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Da Cruz S |
| Year: |
2003 |
| Journal: |
J Biol Chem |
| Title: |
Proteomic analysis of the mouse liver mitochondrial inner membrane. |
| Volume: |
278 |
| Issue: |
42 |
| Pages: |
41566-71 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory DNA Panel Mapping Resource |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
JAX Interspecific Backcross BSS and BSB Public Mapping Data |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mootha VK |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
| Volume: |
115 |
| Issue: |
5 |
| Pages: |
629-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pagliarini DJ |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
A mitochondrial protein compendium elucidates complex I disease biology. |
| Volume: |
134 |
| Issue: |
1 |
| Pages: |
112-23 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen J |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
| Volume: |
100 |
| Issue: |
17 |
| Pages: |
9918-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Friedel RH |
| Year: |
2007 |
| Journal: |
Brief Funct Genomic Proteomic |
| Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
| Volume: |
6 |
| Issue: |
3 |
| Pages: |
180-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2016 |
|
| Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hansen GM |
| Year: |
2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
|
| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kawai J |
| Year: |
2001 |
| Journal: |
Nature |
| Title: |
Functional annotation of a full-length mouse cDNA collection. |
| Volume: |
409 |
| Issue: |
6821 |
| Pages: |
685-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
| Issue: |
8002 |
| Pages: |
130-136 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zambrowicz BP |
| Year: |
2003 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
| Volume: |
100 |
| Issue: |
24 |
| Pages: |
14109-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
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| Publication |
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2002 |
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Nature |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
| Issue: |
6915 |
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563-73 |
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The Gene Ontology Consortium |
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2010 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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2010 |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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MGI Genome Annotation Group and UniGene Staff |
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MGI-UniGene Interconnection Effort |
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2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
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2000 |
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Database Release |
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Allen Institute for Brain Science |
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2004 |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
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Automatic Encodes (AutoE) Reference |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
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