| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697923 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_13 |
|
| Specimen Label: |
euxassay_006203_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697923 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_14 |
|
| Specimen Label: |
euxassay_006203_14 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697923 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_15 |
|
| Specimen Label: |
euxassay_006203_15 |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1697923 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_16 |
|
| Specimen Label: |
euxassay_006203_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_07 |
| Note: |
facial motor nucleus |
| Specimen Label: |
euxassay_006203_07 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_13 |
| Note: |
facial motor nucleus |
| Specimen Label: |
euxassay_006203_13 |
| Detected: |
true |
| Specimen Num: |
13 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1755823 |
| Pattern: |
Regionally restricted |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_14 |
| Note: |
facial motor nucleus |
| Specimen Label: |
euxassay_006203_14 |
| Detected: |
true |
| Specimen Num: |
14 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_11 |
|
| Specimen Label: |
euxassay_006203_11 |
| Detected: |
true |
| Specimen Num: |
11 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_12 |
|
| Specimen Label: |
euxassay_006203_12 |
| Detected: |
true |
| Specimen Num: |
12 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_16 |
|
| Specimen Label: |
euxassay_006203_16 |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:970415 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2010-09-14 |
| Strength: |
Moderate |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1778223 |
| Pattern: |
Uniform |
| Stage: |
TS23 |
| Assay Id: |
MGI:4822868 |
| Age: |
embryonic day 14.5 |
| Image: |
euxassay_006203_17 |
|
| Specimen Label: |
euxassay_006203_17 |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
de Coignac AB |
| Year: |
1998 |
| Journal: |
MGI Direct Data Submission |
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•
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Reprod Fertil Dev |
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Transcription profile during maternal to zygotic transition in the mouse embryo. |
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Overbeek PA |
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2011 |
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MGI Direct Data Submission |
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Direct Data Submission for Overbeek Lentiviral Transgenic Lines |
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•
•
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Shanghai Model Organisms Center |
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2017 |
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MGI Direct Data Submission |
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Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
•
•
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NIH Mouse Knockout Inventory |
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2004 |
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MGI Direct Data Submission |
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Information obtained from the NIH Mouse Knockout Inventory |
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Ko MS |
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2000 |
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Development |
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Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
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1737-49 |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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| Title: |
Mouse Synonym Curation |
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•
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Mouse Genome Informatics Scientific Curators |
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2003 |
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Data Curation Using Mouse Genome Assembly |
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
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•
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Brief Funct Genomic Proteomic |
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EUCOMM--the European conditional mouse mutagenesis program. |
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Nucleic Acids Res |
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
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•
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International Knockout Mouse Consortium |
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2014 |
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MGI download of modified allele data from IKMC and creation of new knockout alleles |
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Velocigene |
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2008 |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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•
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International Mouse Strain Resource |
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Database Download |
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MGI download of germline transmission data for alleles from IMSR strain data |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Helmholtz Zentrum Muenchen GmbH |
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MGI Direct Data Submission |
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Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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Mouse Gene Trap Data Load from dbGSS |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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| Gene |
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•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
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•
•
•
•
•
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| Gene |
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•
•
•
•
•
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| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
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•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
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•
•
•
•
•
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| Gene |
| Type: |
gene |
| Organism: |
cattle |
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•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
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•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
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•
•
•
•
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Pisareva VP |
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2011 |
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EMBO J |
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Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. |
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9 |
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•
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•
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| Allele |
| Name: |
ATP-binding cassette, sub-family E member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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| Protein Domain |
| Type: |
Family |
| Description: |
Pelota (known as DOM34 in yeast) binds Hbs1, which is EF1-alpha-related subfamily GTPase, and is considered to play a crucial role in mRNA surveillance for protein synthesis []. It is involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. Pelota/Hbs1 were shown to promote dissociation of stalled elongation complexes and release of intact peptidyl-tRNA in the presence of the ATP-binding cassette protein ABCE1 []. Pelota is conserved in eukaryotes and archaea []. |
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| Publication |
| First Author: |
Zaninello M |
| Year: |
2024 |
| Journal: |
Sci Adv |
| Title: |
CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. |
| Volume: |
10 |
| Issue: |
22 |
| Pages: |
eadn2050 |
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| Publication |
| First Author: |
Sudmant PH |
| Year: |
2018 |
| Journal: |
Cell Rep |
| Title: |
Widespread Accumulation of Ribosome-Associated Isolated 3' UTRs in Neuronal Cell Populations of the Aging Brain. |
| Volume: |
25 |
| Issue: |
9 |
| Pages: |
2447-2456.e4 |
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•
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| Publication |
| First Author: |
Doma MK |
| Year: |
2007 |
| Journal: |
Cell |
| Title: |
RNA quality control in eukaryotes. |
| Volume: |
131 |
| Issue: |
4 |
| Pages: |
660-8 |
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| Publication |
| First Author: |
Martinand C |
| Year: |
1999 |
| Journal: |
J Virol |
| Title: |
RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. |
| Volume: |
73 |
| Issue: |
1 |
| Pages: |
290-6 |
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•
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| Publication |
| First Author: |
Graille M |
| Year: |
2008 |
| Journal: |
J Biol Chem |
| Title: |
Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay. |
| Volume: |
283 |
| Issue: |
11 |
| Pages: |
7145-54 |
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| Publication |
| First Author: |
Kobayashi K |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex. |
| Volume: |
107 |
| Issue: |
41 |
| Pages: |
17575-9 |
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| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
Pelota (known as DOM34 in yeast) binds Hbs1, which is EF1-alpha-related subfamily GTPase, andis considered to play a crucial role in mRNA surveillance for protein synthesis []. It is involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. Pelota/Hbs1 were shown to promote dissociation of stalled elongation complexes and release of intact peptidyl-tRNA in the presence of the ATP-binding cassette protein ABCE1 []. Pelota is conserved in eukaryotes and archaea [].Dom34 and Pelota are organised in three domains. The N-terminal domain, annotated as domain A in Pelota [], represented by this entry, adopts a Sm-fold that is often involved in the recognition of mRNA stem loops or in the recruitment of mRNA degradation machinery []. |
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry represents the ABCE family of ATP-binding cassette (ABC) transporters and solely comprises of the ABCE1 gene product (also known as RNase L inhibitor, RLI1) [, , ]. RLI1 contains 2 nucleotide-binding domains (NBDs) typical of the ABC transporter protein superfamily []; however, it lacks the transmembrane domains required for membrane transport functions [, ]. RLI1 was first identified as an endoribonuclease inhibitor that interacts directly with RNase L to prevent it from binding 2-5A (5'-phosphorylated 2',5'-linked oligo- adenylates) []. RNase L plays a major role in the anti-viral and anti-proliferative activities ofinterferons, and its inhibition by RLI1 occurs in a concentration-dependent manner [, ]. Recently, RLI1 has been shown to be essential for the assembly of immature HIV-1 capsids in insect cells and higher eukaryotic cell types []. RLI1 expression is induced during HIV type I infection, and is understood to bind HIV-1 Gag (p55) polypeptides following their translation, and to promote their assembly into immature HIV-1 capsids [, , ]. |
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| Publication |
| First Author: |
Key J |
| Year: |
2020 |
| Journal: |
Cells |
| Title: |
Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence. |
| Volume: |
9 |
| Issue: |
10 |
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| Publication |
| First Author: |
Zimmerman C |
| Year: |
2002 |
| Journal: |
Nature |
| Title: |
Identification of a host protein essential for assembly of immature HIV-1 capsids. |
| Volume: |
415 |
| Issue: |
6867 |
| Pages: |
88-92 |
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| Publication |
| First Author: |
Bisbal C |
| Year: |
1995 |
| Journal: |
J Biol Chem |
| Title: |
Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. |
| Volume: |
270 |
| Issue: |
22 |
| Pages: |
13308-17 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
385
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
385
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Saito K |
| Year: |
2010 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis. |
| Volume: |
107 |
| Issue: |
45 |
| Pages: |
19242-7 |
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| Publication |
| First Author: |
Dean M |
| Year: |
2001 |
| Journal: |
Genome Res |
| Title: |
The human ATP-binding cassette (ABC) transporter superfamily. |
| Volume: |
11 |
| Issue: |
7 |
| Pages: |
1156-66 |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
599
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
599
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
599
 |
| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
599
 |
| Fragment?: |
false |
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| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
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