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Search results 101 to 189 out of 189 for Abi2

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:6712250
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1784126
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7282028
Age: embryonic day 18.5
Note: High levels of expression at tips of migrating secondary lens fiber, particularly at transition zone.
Specimen Label: 4B1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6712263
Age: embryonic day 16.0
Specimen Label: 3B inset
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3280924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6712263
Age: embryonic day 16.0
Note: Expression particularly prominent in olfactory bulb.
Specimen Label: 3B
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712263
Age: postnatal day 7
Specimen Label: 4B
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1617716
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6712263
Age: embryonic day 10.0
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Widespread
Stage: TS20
Assay Id: MGI:6712263
Age: embryonic day 12.0
Note: Elevated expression along full length of spinal cord.
Specimen Label: E12 not shown
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6712263
Age: embryonic day 12.0
Note: Elevated expression in developing brain.
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6712263
Age: postnatal day 0
Specimen Label: P0 not shown
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609816
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:6712263
Age: embryonic day 10.0
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6712251
Assay Type: RNA in situ
Annotation Date: 2021-05-28
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3561128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6712263
Age: postnatal adult
Specimen Label: 5L
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
 
Probe: MGI:4428792
Assay Type: RNA in situ
Annotation Date: 2019-12-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3806722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6380694
Age: embryonic day 14.5
Image: 1C1
Specimen Label: 1C1
Detected: true
Specimen Num: 1
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Publication
16401422 | J:104623
First Author: Zipfel PA
Year: 2006
Journal: Curr Biol
Title: Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.
Volume: 16
Issue: 1
Pages: 35-46
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Publication
18632609 | J:172965
First Author: Kano S
Year: 2008
Journal: Cancer Res
Title: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
Volume: 68
Issue: 14
Pages: 5572-80
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Publication
22617848 | J:210153
First Author: Xie MJ
Year: 2013
Journal: Cereb Cortex
Title: WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration.
Volume: 23
Issue: 6
Pages: 1410-23
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Publication
10995551 | J:72871
First Author: Courtney KD
Year: 2000
Journal: Mol Cell Neurosci
Title: Localization and phosphorylation of Abl-interactor proteins, Abi-1 and Abi-2, in the developing nervous system.
Volume: 16
Issue: 3
Pages: 244-57
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Publication
15143189 | J:91021
First Author: Echarri A
Year: 2004
Journal: Mol Cell Biol
Title: Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels.
Volume: 24
Issue: 11
Pages: 4979-93
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Publication
21173240 | J:169009
First Author: Ring C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.
Volume: 108
Issue: 1
Pages: 149-54
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Publication
35108541 | J:320846
First Author: Avilés EC
Year: 2022
Journal: Cell Rep
Title: Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Volume: 38
Issue: 5
Pages: 110307
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Publication
29911975 | J:264145
   
First Author: Fan L
Year: 2018
Journal: Elife
Title: Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.
Volume: 7
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Publication
32673396 | J:313432
 
First Author: Qi Y
Year: 2020
Journal: J Cell Biol
Title: PTEN dephosphorylates Abi1 to promote epithelial morphogenesis.
Volume: 219
Issue: 9
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Publication
21945075 | J:178484
First Author: Maddala R
Year: 2011
Journal: Dev Biol
Title: Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.
Volume: 360
Issue: 1
Pages: 30-43
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Publication
20376577 | J:168170
First Author: Inoue T
Year: 2011
Journal: Stem Cell Rev
Title: APOA-1 is a novel marker of erythroid cell maturation from hematopoietic stem cells in mice and humans.
Volume: 7
Issue: 1
Pages: 43-52
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Publication
26930384 | J:231595
First Author: Gurdziel K
Year: 2016
Journal: Dev Dyn
Title: Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.
Volume: 245
Issue: 5
Pages: 614-26
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
18161990 | -
First Author: Jung JH
Year: 2008
Journal: Biochemistry
Title: Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
Volume: 47
Issue: 3
Pages: 1094-104
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Allele
Abi2<em1Smoc> | MGI:7288050
Name: abl interactor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
 
Probe: MGI:7282022
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282030
Age: embryonic day 16.5
Note: Co-localization with Abi2 along secondary lens fiber cell-cell borders.
Specimen Label: 4C1a/c
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7282022
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784124
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282030
Age: embryonic day 16.5
Note: Co-localization with Abi2 along secondary lens fiber cell-cell borders.
Specimen Label: 4C2c/d
Detected: true
Specimen Num: 2
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Strain
MGI:7717913 | C57BL/6JSmoc-Abi2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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GXD Expression
GXD Expression
 
Probe: MGI:7282022
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282030
Age: embryonic day 16.5
Note: Co-localization with Abi2 at tips of secondary lens fibers at epithelial cell-fiber interface (EFI).
Specimen Label: 4C4
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:7282022
Assay Type: Immunohistochemistry
Annotation Date: 2022-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:7282030
Age: embryonic day 16.5
Note: Expression colocalized with Abi2 at cell-cell borders and along lateral ventricle.
Specimen Label: 7A2/A3
Detected: true
Specimen Num: 4
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Publication
18261908 | -
First Author: Pollitt AY
Year: 2008
Journal: Curr Biol
Title: Abi mutants in Dictyostelium reveal specific roles for the SCAR/WAVE complex in cytokinesis.
Volume: 18
Issue: 3
Pages: 203-10
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Protein Domain
IPR028457 | ABI
Type: Family
Description: This entry represents the ABI family, which includes Abi1, Abi2 and Abi3. They are SH3 domain-containing proteins that are involved in regulation of actin organisation. Abi1, Abi2 and Abi3 all participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [, , ]. This entry also include Abl interactor homologue (abiA) from Dictyostelium discoideum (Slime mold). abiA is part of a Scar/WAVE complex that is required for proper cytokinesis [].
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Protein Domain
IPR035726 | Abi2_SH3
Type: Domain
Description: Abi2 is a component of the WAVE1 complex. It localises to sites of actin polymerisation at the tips of lamellipodia and filopodia []. Mice deficient with Abi2 show defects in orientation and migration of lens fibres, neuronal migration, dendritic spine morphology, as well as deficiencies in learning and memory []. Abi proteins are adaptor proteins serving as binding partners and substrates of Abl tyrosine kinases. They are involved in regulating actin cytoskeletal reorganization and play important roles in membrane-ruffling, endocytosis, cell motility, and cell migration. Abi proteins contain a homeobox homology domain, a proline-rich region, and a SH3 domain []. The SH3 domain of Abi binds to a PxxP motif in Abl [].This entry represents the SH3 domain of Abi2.
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Publication
12672821 | J:83872
First Author: Tani K
Year: 2003
Journal: J Biol Chem
Title: Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
Volume: 278
Issue: 24
Pages: 21685-92
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Publication
22617151 | -
First Author: Kotula L
Year: 2012
Journal: FEBS Lett
Title: Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
Volume: 586
Issue: 17
Pages: 2790-4
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Protein Domain
IPR028456 | ABI1
Type: Family
Description: Abl-interactor (Abi) proteins are targets of Abl-family nonreceptor tyrosine kinases and are required for cytoskeletal reorganization []. Abi1 and Abi2 play an important role in actin cytoskeleton dynamics through participation in several multiprotein complexes. They participate in the formation of the Abi/WAVE complex, which regulates Arp2/3-mediated actin filament nucleation and actin network assembly [, , ].Abi1 promotes tyrosine phosphorylation of mammalian enabled (Mena) by c-Abl kinase []. It is essential for WAVE2 complex integrity and embryonic survival in mice []. Abi1 and the p85 regulatory subunit of PI-3 kinase may be the link between actin cytoskeleton remodelling and growth receptor signalling [].
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Protein
Q8BZP5
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Publication
12011975 | -
First Author: Ichigotani Y
Year: 2002
Journal: Int J Mol Med
Title: In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review).
Volume: 9
Issue: 6
Pages: 591-5
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Protein
Q3UBL3
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
Q8CBW3
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
B7ZCU2
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
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Protein
Q3TMI0
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
B7ZCU4
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
Q3TJR5
Organism: Mus musculus/domesticus
Length: 475  
Fragment?: false
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Protein
J3QNK8
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q3TJ64
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
Q6AXD3
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
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Protein
Q3UAH6
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
B7ZCU3
Organism: Mus musculus/domesticus
Length: 452  
Fragment?: false
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Protein
B7ZCU0
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
B7ZCU5
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q3TPY5
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q8BYZ1
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
F6RXN4
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Protein
A2A621
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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