| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689619 |
| Pattern: |
Widespread |
| Stage: |
TS19 |
| Assay Id: |
MGI:4945886 |
| Age: |
embryonic day 11.5 |
| Image: |
g01906 E11.5 |
|
| Specimen Label: |
g01906 E11.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7262727 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-04-19 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603921 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7262736 |
| Age: |
embryonic day 13.5 |
| Image: |
S3Bi |
|
| Specimen Label: |
S3Bi |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7262727 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-04-19 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1603921 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:7262736 |
| Age: |
embryonic day 13.5 |
| Image: |
S3Bii |
|
| Specimen Label: |
S3Bii |
| Detected: |
false |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7262727 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-04-19 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3187722 |
| Pattern: |
Not Specified |
| Stage: |
TS22 |
| Assay Id: |
MGI:7262736 |
| Age: |
embryonic day 14.5 |
| Image: |
6Bi/S3A |
|
| Specimen Label: |
6Bi/S3A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:7262727 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2022-04-19 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3187722 |
|
| Stage: |
TS22 |
| Assay Id: |
MGI:7262736 |
| Age: |
embryonic day 14.5 |
| Image: |
6BII |
|
| Specimen Label: |
6BII |
| Detected: |
false |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3267328 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3267328 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274128 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3274128 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1609219 |
| Pattern: |
Widespread |
| Stage: |
TS19 |
| Assay Id: |
MGI:4945886 |
| Age: |
embryonic day 11.5 |
| Image: |
g01906 E11.5 |
|
| Specimen Label: |
g01906 E11.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266028 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266028 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754028 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1754028 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280923 |
| Pattern: |
Widespread |
| Stage: |
TS23 |
| Assay Id: |
MGI:4945886 |
| Age: |
embryonic day 15.5 |
| Image: |
g01906 E15.5 |
|
| Specimen Label: |
g01906 E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280928 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280928 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3266523 |
| Pattern: |
Widespread |
| Stage: |
TS23 |
| Assay Id: |
MGI:4945886 |
| Age: |
embryonic day 15.5 |
| Image: |
g01906 E15.5 |
|
| Specimen Label: |
g01906 E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757723 |
| Pattern: |
Widespread |
| Stage: |
TS23 |
| Assay Id: |
MGI:4945886 |
| Age: |
embryonic day 15.5 |
| Image: |
g01906 E15.5 |
|
| Specimen Label: |
g01906 E15.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 7 |
| Image: |
g01906 P7 |
|
| Specimen Label: |
g01906 P7 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:4885393 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-04-11 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1757728 |
| Pattern: |
Widespread |
| Stage: |
TS28 |
| Assay Id: |
MGI:4945886 |
| Age: |
postnatal day 42 |
| Image: |
g01906 Adult |
|
| Specimen Label: |
g01906 Adult |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
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Nibbs RJB |
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1997 |
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M. musculus mRNA for beta-chemokine receptor D6 |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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| Publication |
| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
|
| Title: |
Annotation inferences using phylogenetic trees |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
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•
•
•
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| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
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| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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•
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| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
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| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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•
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| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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•
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•
•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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•
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
| Allele |
| Name: |
atypical chemokine receptor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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•
•
•
•
•
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| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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•
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| Publication |
| First Author: |
Zheng X |
| Year: |
2022 |
| Journal: |
Kidney360 |
| Title: |
Endothelial Cell-Specific Molecule-1 Inhibits Albuminuria in Diabetic Mice. |
| Volume: |
3 |
| Issue: |
12 |
| Pages: |
2059-2076 |
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•
•
•
•
|
| Publication |
| First Author: |
Gowhari Shabgah A |
| Year: |
2022 |
| Journal: |
Front Immunol |
| Title: |
The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? |
| Volume: |
13 |
|
| Pages: |
861931 |
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•
•
•
•
|
| Publication |
| First Author: |
Zou YR |
| Year: |
1998 |
| Journal: |
Nature |
| Title: |
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. |
| Volume: |
393 |
| Issue: |
6685 |
| Pages: |
595-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Kitchen SG |
| Year: |
1997 |
| Journal: |
J Virol |
| Title: |
CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus. |
| Volume: |
71 |
| Issue: |
9 |
| Pages: |
6928-34 |
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•
•
•
•
•
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| Publication |
| First Author: |
Anton PA |
| Year: |
2000 |
| Journal: |
AIDS |
| Title: |
Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue. |
| Volume: |
14 |
| Issue: |
12 |
| Pages: |
1761-5 |
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•
•
•
•
|
| Publication |
| First Author: |
Inngjerdingen M |
| Year: |
2001 |
| Journal: |
Blood |
| Title: |
Expression and regulation of chemokine receptors in human natural killer cells. |
| Volume: |
97 |
| Issue: |
2 |
| Pages: |
367-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Iikura M |
| Year: |
2001 |
| Journal: |
J Leukoc Biol |
| Title: |
Chemokine receptors in human basophils: inducible expression of functional CXCR4. |
| Volume: |
70 |
| Issue: |
1 |
| Pages: |
113-20 |
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•
•
•
•
|
| Publication |
| First Author: |
Gupta SK |
| Year: |
1998 |
| Journal: |
J Biol Chem |
| Title: |
Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. |
| Volume: |
273 |
| Issue: |
7 |
| Pages: |
4282-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lu M |
| Year: |
2002 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. |
| Volume: |
99 |
| Issue: |
10 |
| Pages: |
7090-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nie Y |
| Year: |
2008 |
| Journal: |
J Exp Med |
| Title: |
CXCR4 is required for the quiescence of primitive hematopoietic cells. |
| Volume: |
205 |
| Issue: |
4 |
| Pages: |
777-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zamarchi R |
| Year: |
2002 |
| Journal: |
Clin Exp Immunol |
| Title: |
Expression and functional activity of CXCR-4 and CCR-5 chemokine receptors in human thymocytes. |
| Volume: |
127 |
| Issue: |
2 |
| Pages: |
321-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun Y |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation. |
| Volume: |
277 |
| Issue: |
51 |
| Pages: |
49212-9 |
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•
•
•
•
•
|
| Publication |
| First Author: |
Jordan NJ |
| Year: |
1999 |
| Journal: |
J Clin Invest |
| Title: |
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. |
| Volume: |
104 |
| Issue: |
8 |
| Pages: |
1061-9 |
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•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
CXC chemokine receptor 4 (CXCR4), also known as fusin, which is a specific receptor for a CXCL12 (or SDF1). CXCR4 has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types [, , , , ]. In addition, CXCR4 can also be found on vascular endothelial cells and neuronal/nerve cells []. Upon binding to CXCR4, CXCL12 causes mobilisation of intracellular calcium and chemotaxis [, , ]. CXCL12 is known to be important in hematopoietic stem cell homing to the bone marrow and in hematopoietic stem cell quiescence. CXCR4 has a rather broad activity, and has been linked to cardiac, cerebellar gastric vasculature development [, ]and to hematopoiesis []. Atypical chemokine receptor 2 (ACKR2/D6) []is a chemokine-scavenging receptor or chemokine decoy receptor. It is capable of internalising and effectively scavenging its ligands through beta-arrestin-dependent activation of the cofilin pathway [, ]. ACKR2 is highly promiscuous and can bin the majority of (if not all) inflammatory CC-chemokines []. It plays an essential role in the resolution of the inflammatory response [, , ]. Although it lacks the canonical DRYLAIV motif necessary for classical signalling, ACKR2/D6 may be involved in 'atypical' signaling pathways downstream of ligand binding []. It has been shown to be involved in regulating vessel density []. |
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•
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•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
128
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
272
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Huber TB |
| Year: |
2002 |
| Journal: |
J Immunol |
| Title: |
Expression of functional CCR and CXCR chemokine receptors in podocytes. |
| Volume: |
168 |
| Issue: |
12 |
| Pages: |
6244-52 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
359
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
359
 |
| Fragment?: |
false |
|
•
•
•
•
•
|