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Search results 101 to 200 out of 1211 for Aim2

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGP_CBAJ_G0016545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0016652 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0016649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0016723 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0016675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017245 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016215 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028153 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0015720 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
26590313 | J:256647
First Author: Schattgen SA
Year: 2016
Journal: J Immunol
Title: Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Volume: 196
Issue: 1
Pages: 29-33
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GXD Expression
GXD Expression
Probe: MGI:3763264
Assay Type: In situ reporter (knock in)
Annotation Date: 2025-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1666819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7861733
Age: embryonic day 11.5
Image: 3E GFP
Note: Expression in melanoblasts co-localized with Pmel expression
Specimen Label: 3E GFP
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:7861661
Assay Type: RNA in situ
Annotation Date: 2025-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7861723
Age: embryonic day 12.5
Image: 3F WT
Specimen Label: 3F WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7861661
Assay Type: RNA in situ
Annotation Date: 2025-02-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1603920
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:7861723
Age: embryonic day 12.5
Image: 3F Ednrb-/-
Note: Expression increased compared to wild type.
Specimen Label: 3F Ednrb-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:7861661
Assay Type: RNA in situ
Annotation Date: 2025-02-14
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:7861723
Age: embryonic day 12.5
Image: 3F Ednrb-/-;Aim2-/-
Note: Expression completely absent.
Specimen Label: 3F Ednrb-/-;Aim2-/-
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:3763264
Assay Type: In situ reporter (knock in)
Annotation Date: 2025-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7861733
Age: embryonic day 11.5
Image: 3E GFP
Note: Expression in melanoblasts co-localized with Pmel expression
Specimen Label: 3E GFP
Detected: true
Specimen Num: 1
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Publication
22116829 | J:180587
First Author: Panchanathan R
Year: 2012
Journal: J Immunol
Title: Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.
Volume: 188
Issue: 1
Pages: 270-8
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Publication
32760056 | J:294734
First Author: Xiao J
Year: 2020
Journal: PLoS Biol
Title: Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
Volume: 18
Issue: 8
Pages: e3000807
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Publication
23115038 | J:190664
First Author: Ulland TK
Year: 2013
Journal: Infect Immun
Title: Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation.
Volume: 81
Issue: 1
Pages: 201-8
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Publication
27926940 | J:248122
First Author: Periasamy S
Year: 2016
Journal: PLoS Pathog
Title: Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia.
Volume: 12
Issue: 12
Pages: e1006059
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Publication
20566831 | J:162019
First Author: Tsuchiya K
Year: 2010
Journal: J Immunol
Title: Involvement of absent in melanoma 2 in inflammasome activation in macrophages infected with Listeria monocytogenes.
Volume: 185
Issue: 2
Pages: 1186-95
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Publication
23460746 | J:194921
First Author: Gomes MT
Year: 2013
Journal: J Immunol
Title: Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection.
Volume: 190
Issue: 7
Pages: 3629-38
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Publication
22474394 | J:183609
First Author: Ge J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
Volume: 109
Issue: 16
Pages: 6193-8
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Publication
22871040 | J:233448
 
First Author: Cridland JA
Year: 2012
Journal: BMC Evol Biol
Title: The mammalian PYHIN gene family: phylogeny, evolution and expression.
Volume: 12
Pages: 140
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Publication
27496731 | J:234263
First Author: Gray EE
Year: 2016
Journal: Immunity
Title: The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.
Volume: 45
Issue: 2
Pages: 255-66
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Publication
29203515 | J:295917
First Author: Costa Franco MM
Year: 2018
Journal: J Immunol
Title: Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation.
Volume: 200
Issue: 2
Pages: 607-622
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Publication
32421904 | J:304482
First Author: Greaney AJ
Year: 2020
Journal: J Leukoc Biol
Title: Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event.
Volume: 108
Issue: 3
Pages: 773-786
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Publication
39555938 | J:359864
 
First Author: Chen Y
Year: 2024
Journal: Development
Title: The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast proliferation during early development.
Volume: 151
Issue: 22
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Publication
29618653 | J:293546
 
First Author: Robinson KM
Year: 2018
Journal: JCI Insight
Title: The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice.
Volume: 3
Issue: 7
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Publication
24828532 | J:211268
First Author: Kailasan Vanaja S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
Volume: 111
Issue: 21
Pages: 7765-70
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Publication
25781467 | J:245563
First Author: Sivaraman V
Year: 2015
Journal: PLoS Pathog
Title: Yersinia pestis activates both IL-1β and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague.
Volume: 11
Issue: 3
Pages: e1004688
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Publication
28314590 | J:243901
First Author: Wang Y
Year: 2017
Journal: Immunity
Title: Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection.
Volume: 46
Issue: 3
Pages: 393-404
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Publication
29255077 | J:258134
First Author: Yan S
Year: 2018
Journal: J Immunol
Title: Deficiency of the AIM2-ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection.
Volume: 200
Issue: 3
Pages: 1016-1026
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Publication
29049365 | J:246993
First Author: Kader M
Year: 2017
Journal: PLoS Pathog
Title: MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock.
Volume: 13
Issue: 10
Pages: e1006644
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Publication
22308473 | J:182023
First Author: Creasey EA
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: The protein SdhA maintains the integrity of the Legionella-containing vacuole.
Volume: 109
Issue: 9
Pages: 3481-6
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Publication
22342844 | J:187340
First Author: Shimada K
Year: 2012
Journal: Immunity
Title: Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Volume: 36
Issue: 3
Pages: 401-14
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Protein
Q91VJ1
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Publication
38860764 | J:354143
First Author: Moran EA
Year: 2024
Journal: mBio
Title: IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.
Volume: 15
Issue: 7
Pages: e0120924
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Publication
21151103 | J:169252
First Author: Nakahira K
Year: 2011
Journal: Nat Immunol
Title: Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Volume: 12
Issue: 3
Pages: 222-30
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Publication
27011353 | J:269692
 
First Author: Sanman LE
Year: 2016
Journal: Elife
Title: Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death.
Volume: 5
Pages: e13663
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Publication
30748031 | J:276897
First Author: Lacey CA
Year: 2019
Journal: J Leukoc Biol
Title: IFN-γ-dependent nitric oxide suppresses Brucella-induced arthritis by inhibition of inflammasome activation.
Volume: 106
Issue: 1
Pages: 27-34
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Publication
22461621 | J:185438
First Author: Liu Z
Year: 2012
Journal: J Biol Chem
Title: Role of inflammasomes in host defense against Citrobacter rodentium infection.
Volume: 287
Issue: 20
Pages: 16955-64
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Publication
29842985 | J:326008
First Author: McNair NN
Year: 2018
Journal: Microbes Infect
Title: Inflammasome components caspase-1 and adaptor protein apoptosis-associated speck-like proteins are important in resistance to Cryptosporidium parvum.
Volume: 20
Issue: 6
Pages: 369-375
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Publication
27270401 | J:259950
First Author: Park YH
Year: 2016
Journal: Nat Immunol
Title: Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.
Volume: 17
Issue: 8
Pages: 914-21
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Publication
24919149 | J:264437
First Author: Xu H
Year: 2014
Journal: Nature
Title: Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.
Volume: 513
Issue: 7517
Pages: 237-41
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Publication
32041990 | J:287378
First Author: Wooff Y
Year: 2020
Journal: Sci Rep
Title: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration.
Volume: 10
Issue: 1
Pages: 2263
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Publication
33440153 | J:304290
First Author: Dos Santos LI
Year: 2021
Journal: Cell Rep
Title: Disrupted Iron Metabolism and Mortality during Co-infection with Malaria and an Intestinal Gram-Negative Extracellular Pathogen.
Volume: 34
Issue: 2
Pages: 108613
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Publication
28537251 | J:246061
 
First Author: Yao Y
Year: 2017
Journal: Nat Commun
Title: Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin.
Volume: 8
Pages: 15402
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Publication
27365531 | J:325821
First Author: Duffy EB
Year: 2016
Journal: J Leukoc Biol
Title: FcγR mediates TLR2- and Syk-dependent NLRP3 inflammasome activation by inactivated Francisella tularensis LVS immune complexes.
Volume: 100
Issue: 6
Pages: 1335-1347
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Publication
33268895 | J:299968
First Author: Briard B
Year: 2020
Journal: Nature
Title: Galactosaminogalactan activates the inflammasome to provide host protection.
Volume: 588
Issue: 7839
Pages: 688-692
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Publication
26572062 | J:234520
First Author: Yang D
Year: 2015
Journal: Immunity
Title: Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.
Volume: 43
Issue: 5
Pages: 923-32
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Publication
29321274 | J:258250
First Author: Kuriakose T
Year: 2018
Journal: J Immunol
Title: IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection.
Volume: 200
Issue: 4
Pages: 1489-1495
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Publication
31511697 | J:279977
First Author: Samir P
Year: 2019
Journal: Nature
Title: DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
Volume: 573
Issue: 7775
Pages: 590-594
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Publication
29352265 | J:305141
First Author: Li Y
Year: 2018
Journal: Cell Death Differ
Title: Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection.
Volume: 25
Issue: 7
Pages: 1304-1318
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Publication
27551156 | J:237236
First Author: Qi X
Year: 2016
Journal: J Exp Med
Title: Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection.
Volume: 213
Issue: 10
Pages: 2081-97
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Publication
29353059 | J:261112
First Author: Place DE
Year: 2018
Journal: Am J Pathol
Title: ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
Volume: 188
Issue: 4
Pages: 1021-1030
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Publication
31719149 | J:286548
First Author: Dasari TK
Year: 2020
Journal: J Biol Chem
Title: The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.
Volume: 295
Issue: 11
Pages: 3394-3400
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Publication
35906252 | J:343418
First Author: Feng S
Year: 2022
Journal: Nat Commun
Title: Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.
Volume: 13
Issue: 1
Pages: 4395
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Publication
30794604 | J:271835
First Author: Rodriguez AE
Year: 2019
Journal: PLoS One
Title: Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.
Volume: 14
Issue: 2
Pages: e0212236
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Publication
23045604 | J:190914
First Author: Brunette RL
Year: 2012
Journal: J Exp Med
Title: Extensive evolutionary and functional diversity among mammalian AIM2-like receptors.
Volume: 209
Issue: 11
Pages: 1969-83
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Publication
22002608 | J:193522
First Author: Kayagaki N
Year: 2011
Journal: Nature
Title: Non-canonical inflammasome activation targets caspase-11.
Volume: 479
Issue: 7371
Pages: 117-21
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Publication
28636595 | J:243487
First Author: Zhu S
Year: 2017
Journal: Nature
Title: Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Volume: 546
Issue: 7660
Pages: 667-670
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Publication
21565393 | J:173245
First Author: Elinav E
Year: 2011
Journal: Cell
Title: NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
Volume: 145
Issue: 5
Pages: 745-57
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Publication
26384545 | J:233785
First Author: Dupaul-Chicoine J
Year: 2015
Journal: Immunity
Title: The Nlrp3 Inflammasome Suppresses Colorectal Cancer Metastatic Growth in the Liver by Promoting Natural Killer Cell Tumoricidal Activity.
Volume: 43
Issue: 4
Pages: 751-63
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Publication
38053332 | J:348863
First Author: Kumar SRP
Year: 2024
Journal: Mol Ther
Title: TLR9-independent CD8(+) T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling.
Volume: 32
Issue: 2
Pages: 325-339
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Publication
32758418 | J:291704
First Author: Kitamoto S
Year: 2020
Journal: Cell
Title: The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Volume: 182
Issue: 2
Pages: 447-462.e14
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Publication
23887873 | J:201075
First Author: Kayagaki N
Year: 2013
Journal: Science
Title: Noncanonical inflammasome activation by intracellular LPS independent of TLR4.
Volume: 341
Issue: 6151
Pages: 1246-9
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Publication
33124745 | J:301384
First Author: Finethy R
Year: 2020
Journal: EMBO Rep
Title: Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock.
Volume: 21
Issue: 11
Pages: e50830
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Publication
29030458 | J:251807
First Author: Swanson KV
Year: 2017
Journal: J Exp Med
Title: A noncanonical function of cGAMP in inflammasome priming and activation.
Volume: 214
Issue: 12
Pages: 3611-3626
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Publication
34686350 | J:320929
First Author: Karki R
Year: 2021
Journal: Cell Rep
Title: ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Volume: 37
Issue: 3
Pages: 109858
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Publication
32763970 | J:298138
First Author: Zheng M
Year: 2020
Journal: J Biol Chem
Title: Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection.
Volume: 295
Issue: 41
Pages: 14040-14052
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Publication
32298652 | J:290292
First Author: Zheng M
Year: 2020
Journal: Cell
Title: Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Volume: 181
Issue: 3
Pages: 674-687.e13
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Publication
26008898 | J:224778
First Author: Kim ML
Year: 2015
Journal: J Exp Med
Title: Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.
Volume: 212
Issue: 6
Pages: 927-38
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Publication
31169521 | J:295265
First Author: Miyabe C
Year: 2019
Journal: J Clin Invest
Title: Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis.
Volume: 129
Issue: 9
Pages: 3610-3624
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Publication
30485804 | J:270778
First Author: Vince JE
Year: 2018
Journal: Cell Rep
Title: The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
Volume: 25
Issue: 9
Pages: 2339-2353.e4
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Publication
27509078 | J:236919
First Author: Mohammadi N
Year: 2016
Journal: PLoS One
Title: Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection.
Volume: 11
Issue: 8
Pages: e0160249
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Publication
30510167 | J:287363
First Author: Briard B
Year: 2019
Journal: Nat Microbiol
Title: Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.
Volume: 4
Issue: 2
Pages: 316-327
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Publication
27917412 | J:290369
 
First Author: Kuriakose T
Year: 2016
Journal: Sci Immunol
Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Volume: 1
Issue: 2
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Publication
29576451 | J:262477
First Author: Karki R
Year: 2018
Journal: Cell
Title: IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.
Volume: 173
Issue: 4
Pages: 920-933.e13
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Publication
34526512 | J:354631
First Author: Yang C
Year: 2021
Journal: Nat Commun
Title: Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.
Volume: 12
Issue: 1
Pages: 5454
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Publication
38409108 | J:361094
First Author: Han JH
Year: 2024
Journal: Nat Commun
Title: NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.
Volume: 15
Issue: 1
Pages: 1739
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Publication
39033542 | J:360967
First Author: Ma H
Year: 2024
Journal: Adv Sci (Weinh)
Title: Gasdermin D Mediated Mitochondrial Metabolism Orchestrate Neurogenesis Through LDHA During Embryonic Development.
Volume: 11
Issue: 35
Pages: e2402285
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Publication
30937919 | J:346788
First Author: Schwartz C
Year: 2019
Journal: Allergy
Title: Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.
Volume: 74
Issue: 10
Pages: 1920-1933
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GO Term
GO:0140970 | AIM2 inflammasome complex assembly
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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