Type |
Details |
Score |
Publication |
First Author: |
Yu WN |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. |
Volume: |
12 |
Issue: |
4 |
Pages: |
610-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen K |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation. |
Volume: |
32 |
Issue: |
11 |
Pages: |
108151 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo W |
Year: |
2015 |
Journal: |
Development |
Title: |
Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development. |
Volume: |
142 |
Issue: |
4 |
Pages: |
732-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schiekofer S |
Year: |
2006 |
Journal: |
Physiol Genomics |
Title: |
Microarray analysis of Akt1 activation in transgenic mouse hearts reveals transcript expression profiles associated with compensatory hypertrophy and failure. |
Volume: |
27 |
Issue: |
2 |
Pages: |
156-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim EK |
Year: |
2011 |
Journal: |
Oncogene |
Title: |
Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis. |
Volume: |
30 |
Issue: |
26 |
Pages: |
2954-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saji M |
Year: |
2011 |
Journal: |
Oncogene |
Title: |
Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. |
Volume: |
30 |
Issue: |
42 |
Pages: |
4307-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gwag T |
Year: |
2013 |
Journal: |
Arch Biochem Biophys |
Title: |
Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. |
Volume: |
537 |
Issue: |
1 |
Pages: |
21-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Symons JD |
Year: |
2009 |
Journal: |
Circ Res |
Title: |
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. |
Volume: |
104 |
Issue: |
9 |
Pages: |
1085-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arranz A |
Year: |
2008 |
Journal: |
Mol Immunol |
Title: |
Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide. |
Volume: |
45 |
Issue: |
10 |
Pages: |
2970-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tucka J |
Year: |
2014 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. |
Volume: |
34 |
Issue: |
11 |
Pages: |
2421-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watson KL |
Year: |
2013 |
Journal: |
BMC Cancer |
Title: |
Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice. |
Volume: |
13 |
|
Pages: |
375 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sinor-Anderson A |
Year: |
2011 |
Journal: |
Dev Neurobiol |
Title: |
Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex. |
Volume: |
71 |
Issue: |
9 |
Pages: |
759-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng XD |
Year: |
2003 |
Journal: |
Genes Dev |
Title: |
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. |
Volume: |
17 |
Issue: |
11 |
Pages: |
1352-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen WS |
Year: |
2001 |
Journal: |
Genes Dev |
Title: |
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. |
Volume: |
15 |
Issue: |
17 |
Pages: |
2203-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ezell SA |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The protein kinase Akt1 regulates the interferon response through phosphorylation of the transcriptional repressor EMSY. |
Volume: |
109 |
Issue: |
10 |
Pages: |
E613-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao L |
Year: |
2010 |
Journal: |
Cell Death Differ |
Title: |
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation. |
Volume: |
17 |
Issue: |
9 |
Pages: |
1448-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2012 |
Journal: |
Mol Cell Biochem |
Title: |
mTOR-rictor is the Ser473 kinase for AKT1 in mouse one-cell stage embryos. |
Volume: |
361 |
Issue: |
1-2 |
Pages: |
249-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim IY |
Year: |
2021 |
Journal: |
Korean J Intern Med |
Title: |
Role of Akt1 in renal fibrosis and tubular dedifferentiation during the progression of acute kidney injury to chronic kidney disease. |
Volume: |
36 |
Issue: |
4 |
Pages: |
962-974 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim IY |
Year: |
2023 |
Journal: |
Exp Cell Res |
Title: |
Akt1 is involved in renal fibrosis and tubular apoptosis in a murine model of acute kidney injury-to-chronic kidney disease transition. |
Volume: |
424 |
Issue: |
2 |
Pages: |
113509 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6754112 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-06-22 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1771322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7287487 |
Age: |
embryonic day 14.5 |
Image: |
5D 11Prom-Cre; Sox9; Pten<+/+> |
Note: |
Phosphorylation of Akt1 was reduced in proliferative chondrocytes of 11Prom-Cre; Sox9; Pten<+/+> conditional mutant. |
Specimen Label: |
5D 11Prom-Cre; Sox9; Pten<+/+> |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy R |
Year: |
2017 |
Journal: |
J Mol Cell Cardiol |
Title: |
Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines. |
Volume: |
112 |
|
Pages: |
83-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernández-Hernando C |
Year: |
2009 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. |
Volume: |
29 |
Issue: |
12 |
Pages: |
2033-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen YW |
Year: |
2014 |
Journal: |
Schizophr Bull |
Title: |
A sex- and region-specific role of Akt1 in the modulation of methamphetamine-induced hyperlocomotion and striatal neuronal activity: implications in schizophrenia and methamphetamine-induced psychosis. |
Volume: |
40 |
Issue: |
2 |
Pages: |
388-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. |
Volume: |
281 |
Issue: |
42 |
Pages: |
31380-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maroulakou IG |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. |
Volume: |
67 |
Issue: |
1 |
Pages: |
167-77 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6754112 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-06-22 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1771322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7287487 |
Age: |
embryonic day 14.5 |
Image: |
5D 11Prom-Cre; Sox9; Pten |
Note: |
Phosphorylation levels of Akt1 were higher in the 11Prom-Cre; Sox9; Pten proliferative chondrocytes than in 11Prom-Cre; Sox9; Pten<+/+>. |
Specimen Label: |
5D 11Prom-Cre; Sox9; Pten |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsen F |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. |
Volume: |
33 |
Issue: |
24 |
Pages: |
4947-59 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
1 |
Description: |
Proline-rich AKT1 substrate 1 |
Type: |
chain |
End: |
257 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiong X |
Year: |
2014 |
Journal: |
Neurobiol Dis |
Title: |
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways. |
Volume: |
66 |
|
Pages: |
43-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malla R |
Year: |
2015 |
Journal: |
Biochem Pharmacol |
Title: |
Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways. |
Volume: |
96 |
Issue: |
1 |
Pages: |
65-75 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
203
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuttle RL |
Year: |
2001 |
Journal: |
Nat Med |
Title: |
Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. |
Volume: |
7 |
Issue: |
10 |
Pages: |
1133-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kobayashi H |
Year: |
2010 |
Journal: |
Nat Cell Biol |
Title: |
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. |
Volume: |
12 |
Issue: |
11 |
Pages: |
1046-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cho H |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. |
Volume: |
276 |
Issue: |
42 |
Pages: |
38349-52 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Proline-rich AKT1 substrate 1 protein (AKT1S1, PRAS40) is part of the mammalian target of rapamycin complex 1 (mTORC1, contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR), which regulates cell growth and survival in response to nutrient and hormonal signals []. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Q |
Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development. |
Volume: |
30 |
Issue: |
14 |
Pages: |
3711-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang CY |
Year: |
2009 |
Journal: |
Sci Signal |
Title: |
Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. |
Volume: |
2 |
Issue: |
62 |
Pages: |
ra11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ha T |
Year: |
2005 |
Journal: |
Free Radic Biol Med |
Title: |
Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo. |
Volume: |
39 |
Issue: |
12 |
Pages: |
1570-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsui T |
Year: |
2006 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Effects of chronic Akt activation on glucose uptake in the heart. |
Volume: |
290 |
Issue: |
5 |
Pages: |
E789-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukai Y |
Year: |
2006 |
Journal: |
J Clin Invest |
Title: |
Decreased vascular lesion formation in mice with inducible endothelial-specific expression of protein kinase Akt. |
Volume: |
116 |
Issue: |
2 |
Pages: |
334-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blandino-Rosano M |
Year: |
2012 |
Journal: |
Diabetologia |
Title: |
Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip. |
Volume: |
55 |
Issue: |
5 |
Pages: |
1380-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cordón-Barris L |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zurashvili T |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival. |
Volume: |
33 |
Issue: |
5 |
Pages: |
1027-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wende AR |
Year: |
2015 |
Journal: |
Mol Cell Biol |
Title: |
Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes. |
Volume: |
35 |
Issue: |
5 |
Pages: |
831-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hutchinson J |
Year: |
2001 |
Journal: |
Mol Cell Biol |
Title: |
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. |
Volume: |
21 |
Issue: |
6 |
Pages: |
2203-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsui T |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. |
Volume: |
277 |
Issue: |
25 |
Pages: |
22896-901 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun JF |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Microvascular patterning is controlled by fine-tuning the Akt signal. |
Volume: |
102 |
Issue: |
1 |
Pages: |
128-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao C |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition. |
Volume: |
178 |
Issue: |
9 |
Pages: |
5443-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Phung TL |
Year: |
2006 |
Journal: |
Cancer Cell |
Title: |
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. |
Volume: |
10 |
Issue: |
2 |
Pages: |
159-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jones RG |
Year: |
2000 |
Journal: |
J Exp Med |
Title: |
Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. |
Volume: |
191 |
Issue: |
10 |
Pages: |
1721-34 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Figlia G |
Year: |
2017 |
Journal: |
Elife |
Title: |
Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Elghazi L |
Year: |
2009 |
Journal: |
Gastroenterology |
Title: |
Regulation of pancreas plasticity and malignant transformation by Akt signaling. |
Volume: |
136 |
Issue: |
3 |
Pages: |
1091-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shioi T |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Akt/protein kinase B promotes organ growth in transgenic mice. |
Volume: |
22 |
Issue: |
8 |
Pages: |
2799-809 |
|
•
•
•
•
•
|
Publication |
First Author: |
Emamian ES |
Year: |
2004 |
Journal: |
Nat Genet |
Title: |
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. |
Volume: |
36 |
Issue: |
2 |
Pages: |
131-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jee HJ |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS. |
Volume: |
383 |
Issue: |
3 |
Pages: |
358-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Izumiya Y |
Year: |
2008 |
Journal: |
Cell Metab |
Title: |
Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. |
Volume: |
7 |
Issue: |
2 |
Pages: |
159-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee MY |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. |
Volume: |
38 |
Issue: |
4 |
Pages: |
870-879 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zemanovic S |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance. |
Volume: |
25 |
Issue: |
9 |
Pages: |
2605-2616.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo J |
Year: |
2019 |
Journal: |
Nat Cell Biol |
Title: |
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. |
Volume: |
21 |
Issue: |
2 |
Pages: |
226-237 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riol-Blanco L |
Year: |
2009 |
Journal: |
Nat Immunol |
Title: |
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. |
Volume: |
10 |
Issue: |
7 |
Pages: |
753-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2015 |
Journal: |
Blood |
Title: |
Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. |
Volume: |
126 |
Issue: |
5 |
Pages: |
640-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luckey SW |
Year: |
2009 |
Journal: |
J Mol Cell Cardiol |
Title: |
The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy. |
Volume: |
46 |
Issue: |
5 |
Pages: |
739-47 |
|
•
•
•
•
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Publication |
First Author: |
Yasui T |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation. |
Volume: |
109 |
Issue: |
51 |
Pages: |
21022-7 |
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Publication |
First Author: |
Schleicher M |
Year: |
2009 |
Journal: |
Sci Signal |
Title: |
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. |
Volume: |
2 |
Issue: |
82 |
Pages: |
ra41 |
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Publication |
First Author: |
Skeen JE |
Year: |
2006 |
Journal: |
Cancer Cell |
Title: |
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. |
Volume: |
10 |
Issue: |
4 |
Pages: |
269-80 |
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Publication |
First Author: |
Shearin AL |
Year: |
2016 |
Journal: |
Mol Metab |
Title: |
Lack of AKT in adipocytes causes severe lipodystrophy. |
Volume: |
5 |
Issue: |
7 |
Pages: |
472-479 |
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Publication |
First Author: |
Lin Y |
Year: |
2012 |
Journal: |
Mol Cell |
Title: |
Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. |
Volume: |
48 |
Issue: |
4 |
Pages: |
627-40 |
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Publication |
First Author: |
Kerr BA |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. |
Volume: |
7 |
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Pages: |
10960 |
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Publication |
First Author: |
Roy A |
Year: |
2015 |
Journal: |
Elife |
Title: |
Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. |
Volume: |
4 |
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Publication |
First Author: |
Rogers R |
Year: |
2008 |
Journal: |
Toxicol Sci |
Title: |
Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis. |
Volume: |
106 |
Issue: |
2 |
Pages: |
497-508 |
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Publication |
First Author: |
Luo DZ |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Lithium for schizophrenia: supporting evidence from a 12-year, nationwide health insurance database and from Akt1-deficient mouse and cellular models. |
Volume: |
10 |
Issue: |
1 |
Pages: |
647 |
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Publication |
First Author: |
Gao F |
Year: |
2017 |
Journal: |
Cancer Lett |
Title: |
Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis. |
Volume: |
402 |
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Pages: |
177-189 |
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Publication |
First Author: |
Akasaki Y |
Year: |
2014 |
Journal: |
Aging Cell |
Title: |
Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism. |
Volume: |
13 |
Issue: |
1 |
Pages: |
80-91 |
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Publication |
First Author: |
Yung HW |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. |
Volume: |
173 |
Issue: |
2 |
Pages: |
451-62 |
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Publication |
First Author: |
Singh S |
Year: |
2016 |
Journal: |
Stem Cells |
Title: |
AKT Signaling Prevailing in Mesenchymal Stromal Cells Modulates the Functionality of Hematopoietic Stem Cells via Intercellular Communication. |
Volume: |
34 |
Issue: |
9 |
Pages: |
2354-67 |
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Publication |
First Author: |
Brown C |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Subfertility caused by altered follicular development and oocyte growth in female mice lacking PKB alpha/Akt1. |
Volume: |
82 |
Issue: |
2 |
Pages: |
246-56 |
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Publication |
First Author: |
Segrelles C |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis. |
Volume: |
67 |
Issue: |
22 |
Pages: |
10879-88 |
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Publication |
First Author: |
Hauge H |
Year: |
2009 |
Journal: |
Cell Signal |
Title: |
Evidence for the involvement of FAM110C protein in cell spreading and migration. |
Volume: |
21 |
Issue: |
12 |
Pages: |
1866-73 |
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Publication |
First Author: |
Guha M |
Year: |
2010 |
Journal: |
Mol Biol Cell |
Title: |
Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2. |
Volume: |
21 |
Issue: |
20 |
Pages: |
3578-89 |
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Publication |
First Author: |
Blaustein M |
Year: |
2021 |
Journal: |
Front Cell Dev Biol |
Title: |
Akt Is S-Palmitoylated: A New Layer of Regulation for Akt. |
Volume: |
9 |
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Pages: |
626404 |
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Publication |
First Author: |
Hanatani S |
Year: |
2014 |
Journal: |
J Am Soc Nephrol |
Title: |
Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease. |
Volume: |
25 |
Issue: |
12 |
Pages: |
2800-11 |
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Publication |
First Author: |
Ding L |
Year: |
2012 |
Journal: |
Cell Metab |
Title: |
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. |
Volume: |
15 |
Issue: |
6 |
Pages: |
861-72 |
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Publication |
First Author: |
Guo SL |
Year: |
2013 |
Journal: |
Nat Commun |
Title: |
Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. |
Volume: |
4 |
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Pages: |
2544 |
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Publication |
First Author: |
Wong H |
Year: |
2020 |
Journal: |
Elife |
Title: |
Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders. |
Volume: |
9 |
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Publication |
First Author: |
Levenga J |
Year: |
2017 |
Journal: |
Elife |
Title: |
AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. |
Volume: |
6 |
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Publication |
First Author: |
Wang Q |
Year: |
2016 |
Journal: |
Cancer Cell |
Title: |
Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms. |
Volume: |
29 |
Issue: |
4 |
Pages: |
523-535 |
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Publication |
First Author: |
Chen M |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
Identification of XAF1 as an endogenous AKT inhibitor. |
Volume: |
42 |
Issue: |
7 |
Pages: |
112690 |
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Publication |
First Author: |
Matheny RW Jr |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Role of Akt isoforms in IGF-I-mediated signaling and survival in myoblasts. |
Volume: |
389 |
Issue: |
1 |
Pages: |
117-21 |
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Publication |
First Author: |
Ren B |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. |
Volume: |
120 |
Issue: |
4 |
Pages: |
1217-28 |
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Publication |
First Author: |
Fang L |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation. |
Volume: |
55 |
Issue: |
4 |
Pages: |
537-51 |
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