| Type |
Details |
Score |
| Protein Domain |
| Type: |
Family |
| Description: |
This family represents Arylsulfatase B (ARSB) and its paralogues, ARSI and ARSJ. ARSB removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation [, ]. It is involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium []. ARSI displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1. Arylsulfatase activity has been detected in the secretion medium of retinal cell line, but no activity has been recorded when measured in cell extracts [, ]. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 21, Baljit Khakh |
| Allele Type: |
Transgenic |
| Attribute String: |
Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
198
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kirk JS |
| Year: |
2024 |
| Journal: |
Cell Stem Cell |
| Title: |
Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells. |
| Volume: |
31 |
| Issue: |
8 |
| Pages: |
1203-1221.e7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hotter GS |
| Year: |
2001 |
| Journal: |
FEMS Microbiol Lett |
| Title: |
Identification of a cadmium-induced gene in Mycobacterium bovis and Mycobacterium tuberculosis. |
| Volume: |
200 |
| Issue: |
2 |
| Pages: |
151-5 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Trivalent organoarsenical cleaving enzyme from Thermomonospora curvata (ArsI), Cadmium-induced protein CadI from Mycobacterium tuberculosis, and related bacterial proteins. ArsI is a nonhaeme iron-dependent dioxygenase that can break carbon-arsenic bonds, playing a role in the detoxification of environmental organoarsenical compounds. It catalyses the oxygen-dependent demethylation of highly toxic methylarsonous acid (MAs(III)) to arsenite, which can then be exported out of the cell [, ]. Proteins in this entry contain a VOC (Vicinal Oxygen Chelate) domain (). Members of this family have an invariant CC sequence motif at about position 95, and have poorly conserved C-terminal regions that frequently contain at least one addition CC motif []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Haustein MD |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway. |
| Volume: |
82 |
| Issue: |
2 |
| Pages: |
413-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Buono M |
| Year: |
2010 |
| Journal: |
Cell Mol Life Sci |
| Title: |
Sulfatase activities towards the regulation of cell metabolism and signaling in mammals. |
| Volume: |
67 |
| Issue: |
5 |
| Pages: |
769-80 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Obaya AJ |
| Year: |
2006 |
| Journal: |
Gene |
| Title: |
Molecular cloning and initial characterization of three novel human sulfatases. |
| Volume: |
372 |
|
| Pages: |
110-7 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
534
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
573
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
598
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
534
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
431
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
598
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
614
 |
| Fragment?: |
false |
|
•
•
•
•
•
|