| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1903828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4B |
|
| Specimen Label: |
4B |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3525528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4B |
|
| Specimen Label: |
4B |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3280928 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4B |
|
| Specimen Label: |
4B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3518728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4B |
|
| Specimen Label: |
4B |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3518728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4C |
|
| Specimen Label: |
4C |
| Detected: |
false |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689419 |
| Pattern: |
Not Specified |
| Stage: |
TS19 |
| Assay Id: |
MGI:6189722 |
| Age: |
embryonic day 11.5 |
|
|
| Specimen Label: |
Table S2 - E11.5 - Accn2 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689421 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6189722 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
Table S2 - E13.5 - Accn2 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689424 |
| Pattern: |
Not Specified |
| Stage: |
TS24 |
| Assay Id: |
MGI:6189722 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
Table S2 - E15.5 - Accn2 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689426 |
| Pattern: |
Not Specified |
| Stage: |
TS26 |
| Assay Id: |
MGI:6189722 |
| Age: |
embryonic day 18.5 |
|
|
| Specimen Label: |
Table S2 - E18.5 - Accn2 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189722 |
| Age: |
postnatal day 4 |
|
|
| Specimen Label: |
Table S2 - P4 - Accn2 |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189722 |
| Age: |
postnatal day 14 |
|
|
| Specimen Label: |
Table S2 - P14 - Accn2 |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6166812 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-07-25 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1689428 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6189722 |
| Age: |
postnatal day 28 |
|
|
| Specimen Label: |
Table S2 - P28 - Accn2 |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3521728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4B |
|
| Specimen Label: |
4B |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:1194943 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2011-11-09 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3521728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5295280 |
| Age: |
postnatal |
| Image: |
4C |
|
| Specimen Label: |
4C |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wemmie JA |
| Year: |
2002 |
| Journal: |
Neuron |
| Title: |
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. |
| Volume: |
34 |
| Issue: |
3 |
| Pages: |
463-77 |
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•
•
•
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Kozlenkov A |
| Year: |
2014 |
| Journal: |
J Physiol |
| Title: |
Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. |
| Volume: |
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2021 |
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Elife |
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ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. |
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Front Cell Neurosci |
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Changes in H+, K+, and Ca2+ Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels. |
| Volume: |
15 |
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PLoS One |
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Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice. |
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e0166089 |
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Proc Natl Acad Sci U S A |
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Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. |
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Differential regulation of locomotor activity to acute and chronic cocaine administration by acid-sensing ion channel 1a and 2 in adult mice. |
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246 |
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170-8 |
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Jing L |
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PLoS One |
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The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking. |
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e26909 |
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Peng Z |
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ASIC3 Mediates Itch Sensation in Response to Coincident Stimulation by Acid and Nonproton Ligand. |
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Am J Physiol Cell Physiol |
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RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia. |
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Trac PT |
| Year: |
2017 |
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Am J Physiol Lung Cell Mol Physiol |
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Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC. |
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Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal. |
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Acid sensing ion channels in dorsal spinal cord neurons. |
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A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
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83 |
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2 |
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309-323 |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
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International Mouse Strain Resource |
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2014 |
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Database Download |
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MGI download of germline transmission data for alleles from IMSR strain data |
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Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Database Release |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Hansen GM |
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2008 |
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Genome Res |
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Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
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10 |
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1670-9 |
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| First Author: |
The Gene Ontology Consortium |
| Year: |
2014 |
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| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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DDB, FB, MGI, GOA, ZFIN curators |
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2001 |
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| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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Mouse Genome Informatics Scientific Curators |
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2003 |
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| Title: |
MGI Sequence Curation Reference |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Adams DJ |
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2024 |
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Nature |
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Genetic determinants of micronucleus formation in vivo. |
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627 |
| Issue: |
8002 |
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Zambrowicz BP |
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2003 |
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Proc Natl Acad Sci U S A |
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
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GemPharmatech |
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Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
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2008 |
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Database Download |
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Mouse Gene Trap Data Load from dbGSS |
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Cyagen Biosciences Inc. |
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AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
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2011 |
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Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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GOA curators |
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2016 |
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| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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The Jackson Laboratory Mouse Radiation Hybrid Database |
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2004 |
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Database Release |
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Mouse T31 Radiation Hybrid Data Load |
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Nature |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
| Volume: |
420 |
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The Gene Ontology Consortium |
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2010 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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MGI Genome Annotation Group and UniGene Staff |
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2015 |
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Database Download |
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MGI-UniGene Interconnection Effort |
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Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
| Year: |
2010 |
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| Title: |
Annotation inferences using phylogenetic trees |
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Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
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Database Release |
| Title: |
Entrez Gene Load |
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| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
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Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
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| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
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| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
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Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
| Allele |
| Name: |
acid-sensing ion channel 1; targeted mutation 1.2, Cheng-Chang Lien |
| Allele Type: |
Targeted |
| Attribute String: |
Null/knockout |
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•
•
•
|
| Allele |
| Name: |
acid-sensing ion channel 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
526
 |
| Fragment?: |
false |
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•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
559
 |
| Fragment?: |
false |
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•
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| Publication |
| First Author: |
Richter TA |
| Year: |
2004 |
| Journal: |
J Neurosci |
| Title: |
Acid-sensing ion channel-2 is not necessary for sour taste in mice. |
| Volume: |
24 |
| Issue: |
16 |
| Pages: |
4088-91 |
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| Publication |
| First Author: |
Plomaritas DR |
| Year: |
2014 |
| Journal: |
Am J Physiol Lung Cell Mol Physiol |
| Title: |
Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle. |
| Volume: |
307 |
| Issue: |
5 |
| Pages: |
L419-30 |
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| Publication |
| First Author: |
Hu ZL |
| Year: |
2010 |
| Journal: |
Am J Physiol Cell Physiol |
| Title: |
Disruption of PICK1 attenuates the function of ASICs and PKC regulation of ASICs. |
| Volume: |
299 |
| Issue: |
6 |
| Pages: |
C1355-62 |
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| Publication |
| First Author: |
Sluka KA |
| Year: |
2003 |
| Journal: |
Pain |
| Title: |
Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. |
| Volume: |
106 |
| Issue: |
3 |
| Pages: |
229-39 |
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| Publication |
| First Author: |
Detweiler ND |
| Year: |
2019 |
| Journal: |
J Appl Physiol (1985) |
| Title: |
Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension. |
| Volume: |
127 |
| Issue: |
2 |
| Pages: |
393-407 |
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•
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| Publication |
| First Author: |
Dusenkova S |
| Year: |
2014 |
| Journal: |
Am J Physiol Gastrointest Liver Physiol |
| Title: |
The expression profile of acid-sensing ion channel (ASIC) subunits ASIC1a, ASIC1b, ASIC2a, ASIC2b, and ASIC3 in the esophageal vagal afferent nerve subtypes. |
| Volume: |
307 |
| Issue: |
9 |
| Pages: |
G922-30 |
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