|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 141 out of 141 for Atg14

<< First    < Previous  |  Next >    Last >>
0.021s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
18843052 | -
First Author: Itakura E
Year: 2008
Journal: Mol Biol Cell
Title: Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.
Volume: 19
Issue: 12
Pages: 5360-72
•
•
•
•
•
Publication
25686604 | -
First Author: Diao J
Year: 2015
Journal: Nature
Title: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Volume: 520
Issue: 7548
Pages: 563-6
•
•
•
•
•
Publication
26450213 | -
First Author: Rostislavleva K
Year: 2015
Journal: Science
Title: Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes.
Volume: 350
Issue: 6257
Pages: aac7365
•
•
•
•
•
Publication
12244127 | -
First Author: Burda P
Year: 2002
Journal: J Cell Sci
Title: Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.
Volume: 115
Issue: Pt 20
Pages: 3889-900
•
•
•
•
•
Protein Domain
IPR040939 | Vps38
Type: Family
Description: This entry includes Vps38 from budding yeasts. Vps38 is involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II [].The class III phosphatidylinositol-3-kinase (PI3K) known as Vps34 regulates intracellular membrane trafficking in endocytic sorting, cytokinesis and autophagy. Vps34 forms complexes with other proteins: Vps15, Vps30 (encoded by VPS30/ATG6 in yeast, equivalent to mammalian Beclin 1, encoded by BECN1) and either Vps38 (UVRAG) or Atg14 (ATG14L). Although the N-terminal domains of Vps30, Vps38 and Atg14 differ, the overall similarity of their domain organizations suggests that these proteins may have evolved from a common ancestor [].
•
•
•
•
•
Protein
Q8CDJ3
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
•
•
•
•
•
Protein
Q9QYL9
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: true
•
•
•
•
•
Publication
19050071 | -
First Author: Sun Q
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.
Volume: 105
Issue: 49
Pages: 19211-6
•
•
•
•
•
Publication
16799551 | -
First Author: Liang C
Year: 2006
Journal: Nat Cell Biol
Title: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG.
Volume: 8
Issue: 7
Pages: 688-99
•
•
•
•
•
Protein Domain
IPR018791 | UV_resistance/autophagy_Atg14
Type: Family
Description: This entry includes Atg14 (autophagy-related protein 14) from budding yeasts, Vps38 from fission yeasts and their homologues, Atg14L/Bakor (beclin-1-associated autophagy-related key regulator) and UVRAG (UV irradiation resistance-associated gene), from animals. Atg14 is a hydrophilic protein with a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole [].Barkor positively regulates autophagy through its interaction with Beclin-1, with decreased levels of autophagosome formation observed when Barkor expression is eliminated []. UVRAG is also a Beclin1 binding protein that positively stimulate starvation-induced autophagy []. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I (Vps34, Vps15, Vps30/Atg6, and Atg14) is involved in autophagy, andcomplex II (Vps34, Vps15, Vps30/Atg6, and Vps38) functions in the vacuolar protein sorting pathway []. In mammals, complex II is also involved in autophagy []. The mammalian counterparts of Vps34, Vps15, and Vps30/Atg6 are Vps34, p150, and Beclin 1, respectively, and UV irradiation resistance-associated gene (UVRAG) has been identified as identical to yeast Vps38 [].
•
•
•
•
•
Publication
11157979 | -
First Author: Kihara A
Year: 2001
Journal: J Cell Biol
Title: Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.
Volume: 152
Issue: 3
Pages: 519-30
•
•
•
•
•
Publication
26687681 | J:232813
First Author: Liu CC
Year: 2016
Journal: Mol Cell
Title: Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.
Volume: 61
Issue: 1
Pages: 84-97
•
•
•
•
•
Publication
9712845 | -
First Author: Kametaka S
Year: 1998
Journal: J Biol Chem
Title: Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.
Volume: 273
Issue: 35
Pages: 22284-91
•
•
•
•
•
Publication
20643123 | -
First Author: Thoresen SB
Year: 2010
Journal: Exp Cell Res
Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
Volume: 316
Issue: 20
Pages: 3368-78
•
•
•
•
•
Protein Domain
IPR038274 | Atg6/Beclin_C_sf
Type: Homologous_superfamily
Description: In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 links Vps30 to Vps34 and plays an important role in vacuolar protein sorting []. The C-terminal of Vps30 contains a globular fold comprised of three β-sheet-α-helix repeats (also known as beta-alpha repeated, autophagy-specific (BARA) domain) and is required for autophagy through the targeting of complex I to the pre-autophagosomal structure. The N-terminal of Vps30 is required for vacuolar protein sorting []. Beclin, the mammalian homologue of yeast Atg6/Vps30, isa tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [, ].
•
•
•
•
•
Protein Domain
IPR007243 | Atg6/Beclin
Type: Family
Description: In yeasts, vacuolar protein sorting-associated protein 30 (Vps30), also known as autophagy-related protein 6 (Atg6), is a common component of two distinct phosphatidylinositol 3-kinase complexes. In complex I, Atg14 links Vps30 to Vps34 lipid kinase and plays a specific role in autophagy, while in complex II, Vps38 links Vps30 to Vps34 and plays an important role in vacuolar protein sorting []. The C-terminal of Vps30 contains a globular fold comprised of three β-sheet-α-helix repeats (also known as beta-alpha repeated, autophagy-specific (BARA) domain) and is required for autophagy through the targeting of complex I to the pre-autophagosomal structure. The N-terminal of Vps30 is required for vacuolar protein sorting []. Beclin, the mammalian homologue of yeast Atg6/Vps30, is a tumour suppressor that coordinately regulates the autophagy and membrane trafficking involved in several physiological and pathological processes [, ].
•
•
•
•
•
Publication
22437838 | -
First Author: Noda NN
Year: 2012
Journal: J Biol Chem
Title: Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.
Volume: 287
Issue: 20
Pages: 16256-66
•
•
•
•
•
Publication
29317496 | J:262334
First Author: Croft T
Year: 2018
Journal: J Biol Chem
Title: A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae.
Volume: 293
Issue: 8
Pages: 2927-2938
•
•
•
•
•
Publication
33495338 | J:302581
 
First Author: Wijshake T
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin.
Volume: 118
Issue: 5
•
•
•
•
•
Protein
Q8K245
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
•
•
•
•
•
Protein
Q8BJ94
Organism: Mus musculus/domesticus
Length: 465  
Fragment?: false
•
•
•
•
•
Protein
Q8BXW8
Organism: Mus musculus/domesticus
Length: 698  
Fragment?: false
•
•
•
•
•
Protein
F7CVL9
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
•
•
•
•
•
Publication
22170155 | -
First Author: Wirawan E
Year: 2012
Journal: Autophagy
Title: Beclin1: a role in membrane dynamics and beyond.
Volume: 8
Issue: 1
Pages: 6-17
•
•
•
•
•
Protein
E9PX06
Organism: Mus musculus/domesticus
Length: 46  
Fragment?: false
•
•
•
•
•
Protein
F7DB15
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
•
•
•
•
•
Protein
E9QAM0
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
•
•
•
•
•
Protein
O88597
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
•
•
•
•
•
Protein
P0DM65
Organism: Mus musculus/domesticus
Length: 447  
Fragment?: false
•
•
•
•
•
Protein
A0A0J9YUN7
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: false
•
•
•
•
•
Protein
E9PYD6
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
•
•
•
•
•
Publication
21311563 | -
First Author: Kang R
Year: 2011
Journal: Cell Death Differ
Title: The Beclin 1 network regulates autophagy and apoptosis.
Volume: 18
Issue: 4
Pages: 571-80
•
•
•
•
•
Protein
F7C090
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom