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Search results 101 to 200 out of 211 for Atg4b

0.021s
Type Details Score
GXD Expression
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945781
Age: embryonic day 11.5
Image: g01516 E11.5
Specimen Label: g01516 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 7
Image: g01516 P7
Specimen Label: g01516 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133496
Specimen Label: MRC Harwell_2133496
Detected: true
Specimen Num: 11
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 7
Image: g01516 P7
Specimen Label: g01516 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945781
Age: embryonic day 11.5
Image: g01516 E11.5
Specimen Label: g01516 E11.5
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1683328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133499
Specimen Label: MRC Harwell_2133499
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 7
Image: g01516 P7
Specimen Label: g01516 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945781
Age: embryonic day 15.5
Image: g01516 E15.5
Specimen Label: g01516 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 7
Image: g01516 P7
Specimen Label: g01516 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945781
Age: embryonic day 15.5
Image: g01516 E15.5
Specimen Label: g01516 E15.5
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1702128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133494
Specimen Label: MRC Harwell_2133494
Detected: true
Specimen Num: 9
GXD Expression
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945781
Age: embryonic day 15.5
Image: g01516 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01516 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 7
Image: g01516 P7
Specimen Label: g01516 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4884438
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945781
Age: postnatal day 42
Image: g01516 Adult
Note: Expression was region specific and scattered.
Specimen Label: g01516 Adult
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3281228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133498
Specimen Label: MRC Harwell_2133498
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133491
Specimen Label: MRC Harwell_2133491
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133492
Specimen Label: MRC Harwell_2133492
Detected: true
Specimen Num: 7
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133495
Specimen Label: MRC Harwell_2133495
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691687
Age: postnatal adult
Image: MRC Harwell_2133497
Specimen Label: MRC Harwell_2133497
Detected: true
Specimen Num: 1
Publication
First Author: Vicinanza M
Year: 2015
Journal: Mol Cell
Title: PI(5)P regulates autophagosome biogenesis.
Volume: 57
Issue: 2
Pages: 219-34
Publication  
First Author: Muciño-Hernández G
Year: 2023
Journal: J Cell Sci
Title: Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.
Volume: 136
Issue: 1
Publication
First Author: Matsuzawa-Ishimoto Y
Year: 2020
Journal: Blood
Title: An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.
Volume: 135
Issue: 26
Pages: 2388-2401
Publication
First Author: Kang YA
Year: 2012
Journal: Mol Cell Biol
Title: Autophagy driven by a master regulator of hematopoiesis.
Volume: 32
Issue: 1
Pages: 226-39
Publication
First Author: Martin PK
Year: 2018
Journal: Nat Microbiol
Title: Autophagy proteins suppress protective type I interferon signalling in response to the murine gut microbiota.
Volume: 3
Issue: 10
Pages: 1131-1141
Publication
First Author: DeSelm CJ
Year: 2011
Journal: Dev Cell
Title: Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
Volume: 21
Issue: 5
Pages: 966-74
Publication
First Author: Komatsu M
Year: 2007
Journal: Cell
Title: Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Volume: 131
Issue: 6
Pages: 1149-63
Publication
First Author: Kimmey JM
Year: 2015
Journal: Nature
Title: Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Volume: 528
Issue: 7583
Pages: 565-9
Publication
First Author: Lu Q
Year: 2016
Journal: Cell Host Microbe
Title: Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis.
Volume: 19
Issue: 1
Pages: 102-13
Publication
First Author: Park S
Year: 2016
Journal: Cell Host Microbe
Title: Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.
Volume: 19
Issue: 1
Pages: 91-101
Publication
First Author: de Iriarte Rodríguez R
Year: 2015
Journal: Hear Res
Title: Age-regulated function of autophagy in the mouse inner ear.
Volume: 330
Issue: Pt A
Pages: 39-50
Publication
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication      
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Sun L
Year: 2022
Journal: Sci Adv
Title: Deacetylation of ATG4B promotes autophagy initiation under starvation.
Volume: 8
Issue: 31
Pages: eabo0412
Publication
First Author: Yang Z
Year: 2015
Journal: J Biol Chem
Title: ATG4B (Autophagin-1) phosphorylation modulates autophagy.
Volume: 290
Issue: 44
Pages: 26549-61
UniProt Feature
Begin: 1
Description: Cysteine protease ATG4B
Type: chain
End: 393
UniProt Feature
Begin: 120
Description: Cleavage; by ATG4B
Type: site
End: 121
UniProt Feature
Begin: 116
Description: Cleavage; by ATG4B
Type: site
End: 117
UniProt Feature
Begin: 116
Description: Cleavage; by ATG4B
Type: site
End: 117
UniProt Feature
Begin: 120
Description: Cleavage; by ATG4B
Type: site
End: 121
UniProt Feature
Begin: 116
Description: Cleavage; by ATG4B
Type: site
End: 117
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false
Publication  
First Author: Kurdi A
Year: 2017
Journal: Biochem Pharmacol
Title: ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice.
Volume: 138
Pages: 150-162
Publication
First Author: Li Y
Year: 2017
Journal: Autophagy
Title: Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.
Volume: 13
Issue: 7
Pages: 1145-1160
Interaction Experiment
Description: Transactivation of Atg4b by C/EBP promotes autophagy to facilitate adipogenesis.
Publication
First Author: Mariño G
Year: 2019
Journal: J Biol Chem
Title: Withdrawal: Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy.
Volume: 294
Issue: 4
Pages: 1431
Publication
First Author: Bosc D
Year: 2018
Journal: Sci Rep
Title: A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B.
Volume: 8
Issue: 1
Pages: 11653
Publication
First Author: Durgan J
Year: 2021
Journal: Mol Cell
Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
Volume: 81
Issue: 9
Pages: 2031-2040.e8
Protein Domain
Type: Family
Description: ATG4B is one of the four mammalian Atg4 homologues, also known as autophagins, mediating both proteolytic activation and delipidation of ATG8 family proteins [, ]. It is required for Required for canonical autophagy (macroautophagy), non-canonical autophagy as well as for mitophagy []. ATG4B is a cysteine protease required for autophagy and acts to proteolytically prime and recycle its substrate MAP1LC3B (also referred to as LC3), where cleavage generates a C-terminal glycine required for LC3 conjugation to lipids in autophagosomes [, ].
Allele
Name: collagen, type I, alpha 1; targeted mutation 1.1, Bjorn Knollmann
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
Strain
Attribute String: mutant stock, targeted mutation
Publication
First Author: Tamargo-Gómez I
Year: 2023
Journal: Autophagy
Title: Analysis of ATG4C function in vivo.
Volume: 19
Issue: 11
Pages: 2912-2933
Publication
First Author: Noguera-Ortega E
Year: 2018
Journal: Cancer Discov
Title: Autophagy in the Tumor or in the Host: Which Plays a Greater Supportive Role?
Volume: 8
Issue: 3
Pages: 266-268
Publication      
First Author: Yang A
Year: 2018
Journal: Cancer Discov
Title: Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms.
Publication
First Author: Ha BH
Year: 2008
Journal: J Biol Chem
Title: Structural basis for Ufm1 processing by UfSP1.
Volume: 283
Issue: 21
Pages: 14893-900
Publication
First Author: Barbero-Camps E
Year: 2018
Journal: Autophagy
Title: Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion.
Volume: 14
Issue: 7
Pages: 1129-1154
Publication  
First Author: Altmann C
Year: 2016
Journal: Neurobiol Dis
Title: Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.
Volume: 96
Pages: 294-311