Type |
Details |
Score |
Publication |
First Author: |
Kissing S |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Vacuolar ATPase in phagosome-lysosome fusion. |
Volume: |
290 |
Issue: |
22 |
Pages: |
14166-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Periyasamy R |
Year: |
2019 |
Journal: |
Peptides |
Title: |
Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. |
Volume: |
114 |
|
Pages: |
17-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu C |
Year: |
2020 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
ELABELA antagonizes intrarenal renin-angiotensin system to lower blood pressure and protects against renal injury. |
Volume: |
318 |
Issue: |
5 |
Pages: |
F1122-F1135 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanda A |
Year: |
2013 |
Journal: |
J Neurosci |
Title: |
Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. |
Volume: |
33 |
Issue: |
49 |
Pages: |
19341-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2017 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
Prorenin receptor controls renal branching morphogenesis via Wnt/β-catenin signaling. |
Volume: |
312 |
Issue: |
3 |
Pages: |
F407-F417 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee DY |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
DJ-1 regulates the expression of renal (pro)renin receptor via reactive oxygen species-mediated epigenetic modification. |
Volume: |
1850 |
Issue: |
2 |
Pages: |
426-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Riquier-Brison ADM |
Year: |
2018 |
Journal: |
Am J Physiol Renal Physiol |
Title: |
The macula densa prorenin receptor is essential in renin release and blood pressure control. |
Volume: |
315 |
Issue: |
3 |
Pages: |
F521-F534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Contrepas A |
Year: |
2009 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
A role of the (pro)renin receptor in neuronal cell differentiation. |
Volume: |
297 |
Issue: |
2 |
Pages: |
R250-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2015 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein. |
Volume: |
309 |
Issue: |
2 |
Pages: |
R138-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshida N |
Year: |
2019 |
Journal: |
Aging Cell |
Title: |
(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis. |
Volume: |
18 |
Issue: |
5 |
Pages: |
e12991 |
|
•
•
•
•
•
|
Publication |
First Author: |
Satofuka S |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
(Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system. |
Volume: |
173 |
Issue: |
6 |
Pages: |
1911-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
2019 |
Journal: |
JCI Insight |
Title: |
Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability. |
Volume: |
4 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2024 |
Journal: |
Pediatr Res |
Title: |
Deletion of the prorenin receptor in the ureteric bud in mice inhibits Dot1/H3K79 pathway. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cruciat CM |
Year: |
2010 |
Journal: |
Science |
Title: |
Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. |
Volume: |
327 |
Issue: |
5964 |
Pages: |
459-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng H |
Year: |
2011 |
Journal: |
J Am Soc Nephrol |
Title: |
Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro)renin receptor expression. |
Volume: |
22 |
Issue: |
7 |
Pages: |
1240-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang J |
Year: |
2013 |
Journal: |
Hypertension |
Title: |
Targeted deletion of murine CEACAM 1 activates PI3K-Akt signaling and contributes to the expression of (Pro)renin receptor via CREB family and NF-κB transcription factors. |
Volume: |
62 |
Issue: |
2 |
Pages: |
317-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2018 |
Journal: |
Physiol Rep |
Title: |
Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension. |
Volume: |
6 |
Issue: |
7 |
Pages: |
e13644 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ye D |
Year: |
2021 |
Journal: |
Front Cardiovasc Med |
Title: |
(Pro)renin Receptor Inhibition Reduces Plasma Cholesterol and Triglycerides but Does Not Attenuate Atherosclerosis in Atherosclerotic Mice. |
Volume: |
8 |
|
Pages: |
725203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2019 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
(Pro)renin receptor regulates lung development via the Wnt/β-catenin signaling pathway. |
Volume: |
317 |
Issue: |
2 |
Pages: |
L202-L211 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cuffe JS |
Year: |
2014 |
Journal: |
Placenta |
Title: |
The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. |
Volume: |
35 |
Issue: |
11 |
Pages: |
953-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yosypiv IV |
Year: |
2019 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Stromal prorenin receptor is critical for normal kidney development. |
Volume: |
316 |
Issue: |
5 |
Pages: |
R640-R650 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bodzęta A |
Year: |
2017 |
Journal: |
Cell Rep |
Title: |
The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery. |
Volume: |
20 |
Issue: |
6 |
Pages: |
1348-1359 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e63835 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuncdemir SN |
Year: |
2015 |
Journal: |
Cereb Cortex |
Title: |
miRNAs are Essential for the Survival and Maturation of Cortical Interneurons. |
Volume: |
25 |
Issue: |
7 |
Pages: |
1842-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song R |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
Prorenin receptor is critical for nephron progenitors. |
Volume: |
409 |
Issue: |
2 |
Pages: |
382-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taconic |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from Taconic website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mutant Mouse Regional Resource Centers |
Year: |
2004 |
Journal: |
Unpublished |
Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Blackshaw S |
Year: |
2004 |
Journal: |
PLoS Biol |
Title: |
Genomic analysis of mouse retinal development. |
Volume: |
2 |
Issue: |
9 |
Pages: |
E247 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
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•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
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•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
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•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
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•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
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•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
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Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
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•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
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•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE67541 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Guida MC |
Year: |
2018 |
Journal: |
Mol Biol Cell |
Title: |
ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum. |
Volume: |
29 |
Issue: |
18 |
Pages: |
2156-2164 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells. |
|
•
•
•
•
•
|
Allele |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 7.1, Genoway |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
intergenic site 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Epitope tag, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Volkhard Lindner |
Allele Type: |
Transgenic |
Attribute String: |
Conditional ready, Epitope tag, Inserted expressed sequence, Reporter |
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•
•
•
•
•
|
DO Term |
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•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
350
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
350
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen G |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. |
Volume: |
109 |
Issue: |
11 |
Pages: |
1417-27 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
The sequences featured in this family are similar to a region of the human renin receptor () that bears a putative transmembrane spanning segment []. The renin receptor is involved in intracellular signal transduction by the activation of the ERK1/ERK2 pathway, and it also serves to increase the efficiency of angiotensinogen cleavage by receptor-bound renin, therefore facilitating angiotensin II generation and action on a cell surface []. This family also includes ATPase H(+)-transporting accessory protein 2 (also known asATP6AP2, and renin homologue receptor). ATP6AP2 functions as both a receptor in the planar cell polarity (PCP), as well as being involved in the assembly of the proton-transporting vacuolar (V)-ATPase protein pump []. |
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•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2005 |
Journal: |
Unpublished |
Title: |
Information obtained from The Jackson Laboratory, Bar Harbor, ME |
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•
•
•
•
•
|