Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhan Y |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells. |
Volume: |
187 |
Issue: |
4 |
Pages: |
1566-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grabow S |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities. |
Volume: |
24 |
Issue: |
12 |
Pages: |
3285-3295.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grutzmacher C |
Year: |
2010 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Opposing effects of bim and bcl-2 on lung endothelial cell migration. |
Volume: |
299 |
Issue: |
5 |
Pages: |
L607-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Putcha GV |
Year: |
2002 |
Journal: |
J Cell Biol |
Title: |
Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. |
Volume: |
157 |
Issue: |
3 |
Pages: |
441-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen HC |
Year: |
2015 |
Journal: |
Nat Cell Biol |
Title: |
An interconnected hierarchical model of cell death regulation by the BCL-2 family. |
Volume: |
17 |
Issue: |
10 |
Pages: |
1270-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
ElInati E |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes. |
Volume: |
11 |
Issue: |
1 |
Pages: |
2598 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moujalled D |
Year: |
2011 |
Journal: |
EMBO Rep |
Title: |
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim. |
Volume: |
12 |
Issue: |
1 |
Pages: |
77-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei D |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. |
Volume: |
8 |
Issue: |
7 |
Pages: |
e67793 |
|
•
•
•
•
•
|
Publication |
First Author: |
Villunger A |
Year: |
2003 |
Journal: |
Blood |
Title: |
Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival. |
Volume: |
101 |
Issue: |
6 |
Pages: |
2393-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe M |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms. |
Volume: |
11 |
Issue: |
1 |
Pages: |
6264 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2001 |
Journal: |
Mol Cell |
Title: |
PUMA induces the rapid apoptosis of colorectal cancer cells. |
Volume: |
7 |
Issue: |
3 |
Pages: |
673-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurtulus S |
Year: |
2011 |
Journal: |
J Immunol |
Title: |
Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. |
Volume: |
186 |
Issue: |
10 |
Pages: |
5729-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Orelio C |
Year: |
2004 |
Journal: |
Blood |
Title: |
The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. |
Volume: |
103 |
Issue: |
11 |
Pages: |
4084-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayer CT |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. |
Volume: |
117 |
Issue: |
40 |
Pages: |
24957-24963 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen PM |
Year: |
2020 |
Journal: |
Cell Death Differ |
Title: |
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. |
Volume: |
27 |
Issue: |
2 |
Pages: |
742-757 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ni HM |
Year: |
2008 |
Journal: |
Apoptosis |
Title: |
The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice. |
Volume: |
13 |
Issue: |
1 |
Pages: |
53-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han J |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. |
Volume: |
98 |
Issue: |
20 |
Pages: |
11318-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donaldson M |
Year: |
2009 |
Journal: |
Cell Death Differ |
Title: |
p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis. |
Volume: |
16 |
Issue: |
1 |
Pages: |
125-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogilvy S |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. |
Volume: |
96 |
Issue: |
26 |
Pages: |
14943-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
139
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Opferman JT |
Year: |
2003 |
Journal: |
Nature |
Title: |
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. |
Volume: |
426 |
Issue: |
6967 |
Pages: |
671-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Certo M |
Year: |
2006 |
Journal: |
Cancer Cell |
Title: |
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. |
Volume: |
9 |
Issue: |
5 |
Pages: |
351-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tardivel A |
Year: |
2004 |
Journal: |
Eur J Immunol |
Title: |
The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. |
Volume: |
34 |
Issue: |
2 |
Pages: |
509-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lagasse E |
Year: |
1994 |
Journal: |
J Exp Med |
Title: |
bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. |
Volume: |
179 |
Issue: |
3 |
Pages: |
1047-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Llambi F |
Year: |
2011 |
Journal: |
Mol Cell |
Title: |
A unified model of mammalian BCL-2 protein family interactions at the mitochondria. |
Volume: |
44 |
Issue: |
4 |
Pages: |
517-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hübner A |
Year: |
2010 |
Journal: |
Mol Cell Biol |
Title: |
Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo. |
Volume: |
30 |
Issue: |
1 |
Pages: |
98-105 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi Y |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. |
Volume: |
25 |
Issue: |
21 |
Pages: |
9369-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Contreras AU |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
Deacetylation of p53 induces autophagy by suppressing Bmf expression. |
Volume: |
201 |
Issue: |
3 |
Pages: |
427-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doerflinger M |
Year: |
2015 |
Journal: |
FEBS J |
Title: |
BH3-only proteins: a 20-year stock-take. |
Volume: |
282 |
Issue: |
6 |
Pages: |
1006-16 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Akashi K |
Year: |
1997 |
Journal: |
Cell |
Title: |
Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. |
Volume: |
89 |
Issue: |
7 |
Pages: |
1033-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Michaelidis TM |
Year: |
1996 |
Journal: |
Neuron |
Title: |
Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. |
Volume: |
17 |
Issue: |
1 |
Pages: |
75-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Einat H |
Year: |
2005 |
Journal: |
Behav Brain Res |
Title: |
Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. |
Volume: |
165 |
Issue: |
2 |
Pages: |
172-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hata R |
Year: |
1999 |
Journal: |
Metab Brain Dis |
Title: |
Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. |
Volume: |
14 |
Issue: |
2 |
Pages: |
117-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boot-Handford RP |
Year: |
1998 |
Journal: |
Int J Exp Pathol |
Title: |
The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. |
Volume: |
79 |
Issue: |
5 |
Pages: |
329-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cellerino A |
Year: |
1999 |
Journal: |
Neuroreport |
Title: |
Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice. |
Volume: |
10 |
Issue: |
5 |
Pages: |
1091-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gillardon F |
Year: |
1999 |
Journal: |
Cell Death Differ |
Title: |
Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. |
Volume: |
6 |
Issue: |
1 |
Pages: |
55-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strasser A |
Year: |
1990 |
Journal: |
Nature |
Title: |
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. |
Volume: |
348 |
Issue: |
6299 |
Pages: |
331-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cory S |
Year: |
1994 |
Journal: |
Philos Trans R Soc Lond B Biol Sci |
Title: |
Insights from transgenic mice regarding the role of bcl-2 in normal and neoplastic lymphoid cells. |
Volume: |
345 |
Issue: |
1313 |
Pages: |
289-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Puthalakath H |
Year: |
2001 |
Journal: |
Science |
Title: |
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. |
Volume: |
293 |
Issue: |
5536 |
Pages: |
1829-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Willis SN |
Year: |
2007 |
Journal: |
Science |
Title: |
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. |
Volume: |
315 |
Issue: |
5813 |
Pages: |
856-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bruckheimer EM |
Year: |
2000 |
Journal: |
Oncogene |
Title: |
Bcl-2 accelerates multistep prostate carcinogenesis in vivo. |
Volume: |
19 |
Issue: |
46 |
Pages: |
5251-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner TH |
Year: |
2007 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. |
Volume: |
292 |
Issue: |
4 |
Pages: |
R1751-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sentman CL |
Year: |
1991 |
Journal: |
Cell |
Title: |
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. |
Volume: |
67 |
Issue: |
5 |
Pages: |
879-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchell C |
Year: |
2009 |
Journal: |
Am J Pathol |
Title: |
Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice. |
Volume: |
175 |
Issue: |
5 |
Pages: |
1929-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mitchell C |
Year: |
2011 |
Journal: |
Lab Invest |
Title: |
Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease. |
Volume: |
91 |
Issue: |
2 |
Pages: |
273-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fleury M |
Year: |
2010 |
Journal: |
Int J Dev Biol |
Title: |
Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosis. |
Volume: |
54 |
Issue: |
6-7 |
Pages: |
1067-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu Y |
Year: |
2004 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. |
Volume: |
101 |
Issue: |
20 |
Pages: |
7681-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernández ÁF |
Year: |
2018 |
Journal: |
Nature |
Title: |
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. |
Volume: |
558 |
Issue: |
7708 |
Pages: |
136-140 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strasser A |
Year: |
1994 |
Journal: |
Nature |
Title: |
Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. |
Volume: |
368 |
Issue: |
6470 |
Pages: |
457-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pritchard DM |
Year: |
1999 |
Journal: |
Oncogene |
Title: |
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. |
Volume: |
18 |
Issue: |
51 |
Pages: |
7287-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vila M |
Year: |
2001 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. |
Volume: |
98 |
Issue: |
5 |
Pages: |
2837-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tzimagiorgis G |
Year: |
1996 |
Journal: |
Nucleic Acids Res |
Title: |
Introduction of the negative selection marker into replacement vectors by a single ligation step. |
Volume: |
24 |
Issue: |
17 |
Pages: |
3476-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeudy S |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Bcl-2 inhibits the innate immune response during early pathogenesis of murine congenital muscular dystrophy. |
Volume: |
6 |
Issue: |
8 |
Pages: |
e22369 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei Y |
Year: |
2015 |
Journal: |
Elife |
Title: |
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. |
Volume: |
4 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lawlor KE |
Year: |
2013 |
Journal: |
J Leukoc Biol |
Title: |
Bcl-2 overexpression ameliorates immune complex-mediated arthritis by altering FcγRIIb expression and monocyte homeostasis. |
Volume: |
93 |
Issue: |
4 |
Pages: |
585-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strasser A |
Year: |
1996 |
Journal: |
EMBO J |
Title: |
Progenitor tumours from Emu-bcl-2-myc transgenic mice have lymphomyeloid differentiation potential and reveal developmental differences in cell survival. |
Volume: |
15 |
Issue: |
15 |
Pages: |
3823-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yao Z |
Year: |
2009 |
Journal: |
Eur J Immunol |
Title: |
Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells. |
Volume: |
39 |
Issue: |
3 |
Pages: |
763-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strasser A |
Year: |
1991 |
Journal: |
Cell |
Title: |
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. |
Volume: |
67 |
Issue: |
5 |
Pages: |
889-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Maraskovsky E |
Year: |
1997 |
Journal: |
Cell |
Title: |
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. |
Volume: |
89 |
Issue: |
7 |
Pages: |
1011-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
de Vries GJ |
Year: |
2008 |
Journal: |
Endocrinology |
Title: |
Sexual differentiation of vasopressin innervation of the brain: cell death versus phenotypic differentiation. |
Volume: |
149 |
Issue: |
9 |
Pages: |
4632-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knudson CM |
Year: |
1997 |
Journal: |
Nat Genet |
Title: |
Bcl-2 and Bax function independently to regulate cell death. |
Volume: |
16 |
Issue: |
4 |
Pages: |
358-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steele AD |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. |
Volume: |
27 |
Issue: |
47 |
Pages: |
13022-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schorr K |
Year: |
1999 |
Journal: |
Cancer Res |
Title: |
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. |
Volume: |
59 |
Issue: |
11 |
Pages: |
2541-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kondo M |
Year: |
1997 |
Journal: |
Immunity |
Title: |
Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice. |
Volume: |
7 |
Issue: |
1 |
Pages: |
155-62 |
|
•
•
•
•
•
|