|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 114 out of 114 for C2cd3

<< First    < Previous  |  Next >    Last >>
0.011s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Allele
C2cd3<Gt(AG0177)Wtsi> | MGI:3836403
Name: C2 calcium-dependent domain containing 3; gene trap AG0177, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
C2cd3<hty> | MGI:3836402
 
Name: C2 calcium-dependent domain containing 3; hearty
Allele Type: Chemically induced (ENU)
•
•
•
•
•
Genotype
Genotype
Symbol: C2cd3/C2cd3
Background: involves: 129P2/OlaHsd * C3H/He
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
DO Term
DOID:0060958 | orofaciodigital syndrome XIV
•
•
•
•
•
Genotype
Genotype
Symbol: C2cd3/C2cd3
Background: involves: C3H/He * C57BL/6
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR037775 | C2_C2CD3
Type: Domain
Description: C2cd3 is a novel C2 domain-containing protein specific to vertebrates. C2cd3 functions in regulator of cilia formation, Hedgehog signaling, and mouse embryonic development []. Mutations in C2cd3 mice resulted in lethality in some cases and exencephaly, a twisted body axis, and pericardial edema in others []. It is required for centriole elongation []. Mutations in the human C2cd3 gene cause Orofaciodigital syndrome 14, which is characterised by malformations of the face, oral cavity, and digits []. It plays an important part in centriolar distal appendage assembly and ciliary vesicle docking in mammals []. C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements: type I and type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions [, , , ].
•
•
•
•
•
Genotype
Genotype
Symbol: C2cd3/C2cd3
Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Protein
Q52KB6
Organism: Mus musculus/domesticus
Length: 2323  
Fragment?: false
•
•
•
•
•
Protein
E9Q526
Organism: Mus musculus/domesticus
Length: 2130  
Fragment?: false
•
•
•
•
•
Protein
D3Z640
Organism: Mus musculus/domesticus
Length: 1566  
Fragment?: true
•
•
•
•
•
Publication
8771209 | -
First Author: Ponting CP
Year: 1996
Journal: Protein Sci
Title: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin.
Volume: 5
Issue: 1
Pages: 162-6
•
•
•
•
•
Publication
9632630 | -
First Author: Rizo J
Year: 1998
Journal: J Biol Chem
Title: C2-domains, structure and function of a universal Ca2+-binding domain.
Volume: 273
Issue: 26
Pages: 15879-82
•
•
•
•
•
Publication
8976547 | -
First Author: Nalefski EA
Year: 1996
Journal: Protein Sci
Title: The C2 domain calcium-binding motif: structural and functional diversity.
Volume: 5
Issue: 12
Pages: 2375-90
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom