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Search results 101 to 154 out of 154 for C5ar2

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0.021s

Type

Details

Score

Publication

- | J:155721

First Author:	Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year:	2010
Journal:	Database Download
Title:	Consensus CDS project

•

Publication

- | J:85324

First Author:	Mouse Genome Informatics Group
Year:	2003
Journal:	Database Procedure
Title:	Automatic Encodes (AutoE) Reference

•

Publication

- | J:53168

First Author:	Bairoch A
Year:	1999
Journal:	Database Release
Title:	SWISS-PROT Annotated protein sequence database

•

Publication

- | J:91388

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations

•

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

•

Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

•

Publication

30971430 | J:280420

First Author:	Yu S
Year:	2019
Journal:	J Biol Chem
Title:	The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages.
Volume:	294
Issue:	21
Pages:	8384-8394

•

Allele

C5ar2<em1Smoc> | MGI:7288581

Name:	complement component 5a receptor 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Allele

Tg(CD2-C5ar2)9Hgr | MGI:6295375

Name:	transgene insertion 9, Peter Heeger
Allele Type:	Transgenic
Attribute String:	Inserted expressed sequence

•

Allele

C5ar1<tm1(C5AR1)Smoc> | MGI:7288580

Name:	complement component 5a receptor 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Humanized sequence, Inserted expressed sequence

•

Strain

MGI:6474880 | C57BL/6JSmoc-C5ar2<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Allele

C5ar2<tm1(C5AR2)Smoc> | MGI:7288582

Name:	complement component 5a receptor 2; targeted mutation 1, Shanghai Model Organisms Center
Allele Type:	Targeted
Attribute String:	Humanized sequence, Inserted expressed sequence

•

Strain

MGI:6295379 | STOCK Tg(CD2-C5ar2)9Hgr/J

Attribute String:

transgenic, mutant stock

•

Allele

C5ar2<tm1.1Kohl> | MGI:7432879

Name:	complement component 5a receptor 2; targeted mutation 1.1, Jorg Kohl
Allele Type:	Targeted
Attribute String:	Conditional ready, Reporter

•

Strain

MGI:6428279 | C57BL/6JSmoc-C5ar1<tm1(C5AR1)Smoc> C5ar2<tm1(C5AR2)Smoc>/Smoc

Attribute String:

coisogenic, mutant strain, targeted mutation

•

Protein Domain

IPR002234 | Anphylx_rcpt_C3a/C5a1-2

Type:

Family

Description:

The activation of the complement cascade produces a number of small fragments that are bioactive: potent chemoattractants and secretagogues that act on immune and non-immune cells []. Similar peptides can also be released by the actions of non-complement proteases, for instance during clotting []. Initially these were termed anaphylatoxins because of their effect on mast cell histamine release, but were reclassified as complement component peptides. They include C3a and C5a, which are involved immune response [], neural development and organ regeneration [, ]. A third peptide, C4a, has a similar structure, but it is inactive in humans []. Since the primary function of complement component peptides is in inflammation, they are important targets for the development of anti-inflammatory therapies [].The anaphylatoxin chemotactic receptors (also known as complement peptide receptors) are a group of rhodopsin-like G-protein coupled receptors (GPCRs) [, , , ]. There are three subtypes: C3a anaphylatoxin chemotactic receptor (C3AR1) [], C5a anaphylatoxin chemotactic receptor (C5AR1) []and C5a anaphylatoxin chemotactic receptor C5L2 (C5AR2) []. Both C3AR1 and C5AR1 receptors are classical GPCRs. However, C5AR2 appears to be permanently uncoupled from G proteins but can associate with beta-arrestin []. Nevertheless, it has been shown that activation of both C5AR1 and C5AR2 is required for a full pro-inflammatory response, particularly in mice []. Several receptor antagonists have been reported [, , , ], although none, so far, have been show to be effective in humans. This entry represents C3a anaphylatoxin chemotactic receptors and C5a anaphylatoxin chemotactic receptor 1/2.

•

Protein Domain

IPR027809 | Anaphtx_C5AR2

Type:

Family

Description:

The activation of the complement cascade produces a number of small fragments that are bioactive: potent chemoattractants and secretagogues that act on immune and non-immune cells []. Similar peptides can also be released by the actions of non-complement proteases, for instance during clotting []. Initially these were termed anaphylatoxins because of their effect on mast cell histamine release, but were reclassified as complement component peptides. They include C3a and C5a, which are involved immune response [], neural development and organ regeneration [, ]. A third peptide, C4a, has a similar structure, but it is inactive in humans []. Since the primary function of complement component peptides is in inflammation, they are important targets for the development of anti-inflammatory therapies [].The anaphylatoxin chemotactic receptors (also known as complement peptide receptors) are a group of rhodopsin-like G-protein coupled receptors (GPCRs) [, , , ]. There are three subtypes: C3a anaphylatoxin chemotactic receptor (C3AR1) [], C5a anaphylatoxin chemotactic receptor (C5AR1) []and C5a anaphylatoxin chemotactic receptor C5L2 (C5AR2) []. Both C3AR1 and C5AR1 receptors are classical GPCRs. However, C5AR2 appears to be permanently uncoupled from G proteins but can associate with beta-arrestin []. Nevertheless, it has been shown that activation of both C5AR1 and C5AR2 is required for a full pro-inflammatory response, particularly in mice []. Several receptor antagonists have been reported [, , , ], although none, so far, have been show to be effective in humans. This entry represents C5AR2, also known as complement component 5a receptor 2.

•

Publication

34582793 | J:316937

First Author:	Pandey S
Year:	2021
Journal:	Mol Cell
Title:	Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors.
Volume:	81
Issue:	22
Pages:	4605-4621.e11

•

Publication

9108406 | -

First Author:	Hartmann K
Year:	1997
Journal:	Blood
Title:	C3a and C5a stimulate chemotaxis of human mast cells.
Volume:	89
Issue:	8
Pages:	2863-70

•

Publication

22500977 | -

First Author:	Bellows-Peterson ML
Year:	2012
Journal:	J Med Chem
Title:	De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation.
Volume:	55
Issue:	9
Pages:	4159-68

•

Publication

8156000 | -

First Author:	Takafuji S
Year:	1994
Journal:	Int Arch Allergy Immunol
Title:	Degranulation from human eosinophils stimulated with C3a and C5a.
Volume:	104 Suppl 1
Issue:	1
Pages:	27-9

•

Publication

19265162 | -

First Author:	Schraufstatter IU
Year:	2009
Journal:	J Immunol
Title:	C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation.
Volume:	182
Issue:	6
Pages:	3827-36

•

Publication

21918196 | J:179305

First Author:	Bera MM
Year:	2011
Journal:	J Immunol
Title:	Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins.
Volume:	187
Issue:	8
Pages:	4245-55

•

Publication

23074214 | J:214214

First Author:	Yu M
Year:	2012
Journal:	Invest Ophthalmol Vis Sci
Title:	A novel role of complement in retinal degeneration.
Volume:	53
Issue:	12
Pages:	7684-92

•

Publication

22205026 | J:180756

First Author:	Banda NK
Year:	2012
Journal:	J Immunol
Title:	Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice.
Volume:	188
Issue:	3
Pages:	1469-78

•

Protein Domain

IPR001644 | Anaphtx_C3AR1

Type:

Family

Description:

The activation of the complement cascade produces a number of small fragments that are bioactive: potent chemoattractants and secretagogues that act on immune and non-immune cells []. Similar peptides can also be released by the actions of non-complement proteases, for instance during clotting []. Initially these were termed anaphylatoxins because of their effect on mast cell histamine release, but were reclassified as complement component peptides. They include C3a and C5a, which are involved immune response [], neural development and organ regeneration [, ]. A third peptide, C4a, has a similar structure, but it is inactive in humans []. Since the primary function of complement component peptides is in inflammation, they are important targets for the development of anti-inflammatory therapies [].The anaphylatoxin chemotactic receptors (also known as complement peptide receptors) are a group of rhodopsin-like G-protein coupled receptors (GPCRs) [, , , ]. There are three subtypes: C3a anaphylatoxin chemotactic receptor (C3AR1) [], C5a anaphylatoxin chemotactic receptor (C5AR1) []and C5a anaphylatoxin chemotactic receptor C5L2 (C5AR2) []. Both C3AR1 and C5AR1 receptors are classical GPCRs. However, C5AR2 appears to be permanently uncoupled from G proteins but can associate with beta-arrestin []. Nevertheless, it has been shown that activation of both C5AR1 and C5AR2 is required for a full pro-inflammatory response, particularly in mice []. Several receptor antagonists have been reported [, , , ], although none, so far, have been show to be effective in humans. This entry represents C3AR1, also known as complement component 3a receptor 1 and C3aR []. It appears to be widely expressed in different lymphoid tissues, providing evidence for a central role in inflammatory processes []. This receptor stimulates chemotaxis [], granule enzyme release [, ]and increases phosphorylated-ERK1/2 production []. C3AR1 may provide a theraputic avenue for the treatment of asthma [], retinal degeneration [], and rheumatoid arthritis [].

•

Publication

15833747 | -

First Author:	Kalant D
Year:	2005
Journal:	J Biol Chem
Title:	C5L2 is a functional receptor for acylation-stimulating protein.
Volume:	280
Issue:	25
Pages:	23936-44

•

Publication

8702752 | -

First Author:	Ames RS
Year:	1996
Journal:	J Biol Chem
Title:	Molecular cloning and characterization of the human anaphylatoxin C3a receptor.
Volume:	271
Issue:	34
Pages:	20231-4

•

Publication

17603557 | -

First Author:	Monk PN
Year:	2007
Journal:	Br J Pharmacol
Title:	Function, structure and therapeutic potential of complement C5a receptors.
Volume:	152
Issue:	4
Pages:	429-48

•

Publication

19025115 | -

First Author:	Amara U
Year:	2008
Journal:	Adv Exp Med Biol
Title:	Interaction between the coagulation and complement system.
Volume:	632

Pages:	71-9

•

Publication

19601884 | -

First Author:	Peng Q
Year:	2009
Journal:	Inflamm Allergy Drug Targets
Title:	The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.
Volume:	8
Issue:	3
Pages:	236-46

•

Publication

22118769 | -

First Author:	Carmona-Fontaine C
Year:	2011
Journal:	Dev Cell
Title:	Complement fragment C3a controls mutual cell attraction during collective cell migration.
Volume:	21
Issue:	6
Pages:	1026-37

•

Publication

19477527 | -

First Author:	Klos A
Year:	2009
Journal:	Mol Immunol
Title:	The role of the anaphylatoxins in health and disease.
Volume:	46
Issue:	14
Pages:	2753-66

•

Publication

9725198 | J:49259

First Author:	Lienenklaus S
Year:	1998
Journal:	J Immunol
Title:	Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.
Volume:	161
Issue:	5
Pages:	2089-93

•

Publication

2528484 | -

First Author:	Fukuoka Y
Year:	1989
Journal:	Dermatologica
Title:	Characterization of receptors to the anaphylatoxins on isolated cells.
Volume:	179 Suppl 1

Pages:	35-40

•

Publication

11165367 | -

First Author:	Lee DK
Year:	2001
Journal:	Brain Res Mol Brain Res
Title:	Identification of four novel human G protein-coupled receptors expressed in the brain.
Volume:	86
Issue:	1-2
Pages:	13-22

•

Publication

8011297 | -

First Author:	Gerard C
Year:	1994
Journal:	Annu Rev Immunol
Title:	C5A anaphylatoxin and its seven transmembrane-segment receptor.
Volume:	12

Pages:	775-808

•

Publication

8605247 | -

First Author:	Roglic A
Year:	1996
Journal:	Biochim Biophys Acta
Title:	cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.
Volume:	1305
Issue:	1-2
Pages:	39-43

•

Publication

1847994 | -

First Author:	Gerard NP
Year:	1991
Journal:	Nature
Title:	The chemotactic receptor for human C5a anaphylatoxin.
Volume:	349
Issue:	6310
Pages:	614-7

•

Publication

12429062 | -

First Author:	Joost P
Year:	2002
Journal:	Genome Biol
Title:	Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands.
Volume:	3
Issue:	11
Pages:	RESEARCH0063

•

Publication

11342658 | -

First Author:	Ames RS
Year:	2001
Journal:	J Immunol
Title:	Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.
Volume:	166
Issue:	10
Pages:	6341-8

•

Publication

16154494 | -

First Author:	Mathieu MC
Year:	2005
Journal:	Immunol Lett
Title:	The C3a receptor antagonist SB 290157 has agonist activity.
Volume:	100
Issue:	2
Pages:	139-45

•

Publication

14570896 | -

First Author:	Otto M
Year:	2004
Journal:	J Biol Chem
Title:	C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.
Volume:	279
Issue:	1
Pages:	142-51

•

Publication

8765043 | -

First Author:	Crass T
Year:	1996
Journal:	Eur J Immunol
Title:	Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.
Volume:	26
Issue:	8
Pages:	1944-50

•

Protein

Q8BW93

Organism:	Mus musculus/domesticus
Length:	344
Fragment?:	false

•

Protein

O09047

Organism:	Mus musculus/domesticus
Length:	477
Fragment?:	false

•

Protein

Q5U7A4

Organism:	Mus musculus/domesticus
Length:	477
Fragment?:	false

•

Protein

E9QQ21

Organism:	Mus musculus/domesticus
Length:	358
Fragment?:	false

•

Protein

Q8C6R2

Organism:	Mus musculus/domesticus
Length:	477
Fragment?:	false

•

Protein

Q3U4N3

Organism:	Mus musculus/domesticus
Length:	226
Fragment?:	true

•

Protein

E9PVQ2

Organism:	Mus musculus/domesticus
Length:	358
Fragment?:	false

•

Protein

P30993

Organism:	Mus musculus/domesticus
Length:	351
Fragment?:	false

•

Protein

Q3UCS9

Organism:	Mus musculus/domesticus
Length:	301
Fragment?:	true

•

Protein

A0A1B0GT01

Organism:	Mus musculus/domesticus
Length:	181
Fragment?:	true

•

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