Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1684628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
liver |
Detected: |
false |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1672828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
lung |
Detected: |
false |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
ovary |
Detected: |
false |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3598828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
skeletal muscle |
Detected: |
false |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
skin |
Detected: |
false |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
spleen |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
testis |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876828 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
thymus |
Detected: |
false |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Western blot |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649235 |
Age: |
postnatal |
Image: |
6 |
|
Specimen Label: |
uterus |
Detected: |
false |
Specimen Num: |
12 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
8/A |
|
Specimen Label: |
8/A |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929328 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
|
Note: |
Expression is present in sperm located in the lumen of the epididymal duct. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3044528 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
8/A |
|
Specimen Label: |
8/A |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3148628 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7A |
Note: |
No expression in round or elongating spermatids. |
Specimen Label: |
7A |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148628 |
Pattern: |
Diffuse |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7B |
Note: |
Expression present in elongating spermatids. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7C |
|
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7D |
|
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7E |
|
Specimen Label: |
7E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1929128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
|
Note: |
Expression is present in sperm located in the lumen of the epididymal duct. |
Specimen Label: |
not shown |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Absent |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7A |
Note: |
No expression in round or elongating spermatids. |
Specimen Label: |
7A |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Diffuse |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7B |
Note: |
Expression present in elongating spermatids. |
Specimen Label: |
7B |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7C |
|
Specimen Label: |
7C |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7D |
|
Specimen Label: |
7D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7E |
|
Specimen Label: |
7E |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7F |
|
Specimen Label: |
7F |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7G |
|
Specimen Label: |
7G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3576128 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7H |
Note: |
Expression is present in the testicular sperm, present at the luminal surface of the seminiferous epithelium. It is not present in cells located apically in the seminiferous epithelium. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7F |
|
Specimen Label: |
7F |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7G |
|
Specimen Label: |
7G |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
7H |
Note: |
Expression is present in the testicular sperm, present at the luminal surface of the seminiferous epithelium. It is not present in cells located apically in the seminiferous epithelium. |
Specimen Label: |
7H |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5649232 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2015-08-19 |
Strength: |
Strong |
Sex: |
Male |
Emaps: |
EMAPS:3148828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:5649236 |
Age: |
postnatal adult |
Image: |
8/A |
Note: |
Expression is present in sperm located in the lumen of the epididymal duct. |
Specimen Label: |
8/A |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang X |
Year: |
2016 |
Journal: |
Am J Transl Res |
Title: |
FSCB phosphorylation regulates mouse spermatozoa capacitation through suppressing SUMOylation of ROPN1/ROPN1L. |
Volume: |
8 |
Issue: |
6 |
Pages: |
2776-82 |
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; wild type |
Allele Type: |
Not Specified |
|
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; endonuclease-mediated mutation 4, GemPharmatech Co., Ltd |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; endonuclease-mediated mutation 1, Baylor College of Medicine |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
endonuclease-mediated mutation, mutant stock |
|
•
•
•
•
•
|
Allele |
Name: |
fibrous sheath CABYR binding protein; endonuclease-mediated mutation 2, Research Institute for Microbial Diseases, Osaka University |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fscb/Fscb |
Background: |
C57BL/6N-Fscb/BayMmucd |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2020 |
Journal: |
Biol Reprod |
Title: |
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†. |
Volume: |
103 |
Issue: |
2 |
Pages: |
183-194 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
endonuclease-mediated mutation, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Fscb/Fscb |
Background: |
involves: C57BL/6NJcl * DBA/2NJcl |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1074
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1062
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Fibrous sheath CABYR (Calcium Binding Tyrosine-(Y)-Phosphorylation Regulated) binding protein (FSCB) is a testis- and sperm-specific protein that is expressed post-meiotically and localised in mouse sperm flagella. FSCB homologues are present in other mammals, including rat and human. Conserved motifs in FSCB include PXXP, proline-rich and extensin-like regions [].FSCB is regulated by protein kinase A (PKA)-mediated tryrosine phosphorylation. Its capacity of being phosphorylated and binding to calcium enhances the spermatozoa flagellar movement, spermatozoa capacitation and activation. FSCB phosphorylation activates spermatozoa motility and inhibits SUMOylation of two crucial proteins ROPN1/ROPN1L that are associated with PKA/A kinase activity and spermatozoa motility []. |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|