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Search results 101 to 122 out of 122 for Castor1

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Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
28066558 | -
 
First Author: Gai Z
Year: 2016
Journal: Cell Discov
Title: Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.
Volume: 2
Pages: 16051
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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Publication
16305752 | -
 
First Author: Harhay GP
Year: 2005
Journal: BMC Genomics
Title: Characterization of 954 bovine full-CDS cDNA sequences.
Volume: 6
Pages: 166
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Protein Domain
IPR026249 | CASTOR_fam
Type: Family
Description: CASTOR family members are well-conserved in eukaryotes (including human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish) [, ]. Three subtypes, designated CASTOR1, CASTOR2 and CASTOR3, have been identified in humans.CASTOR1 can form homodimers and bind arginine. It can also form heterodimers with CASTOR2 []. The arginine binding of CASTOR1 disrupts the CASTOR1-GATOR2 interaction, and this triggers downstream activation of mTORC1 []. Therefore, CASTOR1 functions as an intracellular arginine sensor for the mTORC1 Pathway [, ]. Interestingly, CASTOR1 shares substantial structural homology with the lysine-binding regulatory domain of prokaryotic aspartate kinases [].
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Protein Domain
IPR040778 | CASTOR1_N
Type: Domain
Description: CASTOR1 (Cytosolic arginine sensor for mTORC1 subunit 1) has been identified as the cytosolic arginine sensor for the mTORC1 pathway. In the absence of arginine, CASTOR1 binds to GATOR2 and inhibits mTORC1 signaling; whereas in the presence of arginine, CASTOR1 interacts with arginine and no longer associates with GATOR2. The arginine sits in a pocket between the N-terminal domain (NTD) and the C-terminal domain (CTD) of CASTOR1. The CASTOR1-NTD on the opposite side of the arginine-binding site was identified to mediate direct physical interaction with its downstream effector GATOR2, via GATOR2 subunit Mios [].
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Protein
Q8CAB8
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Publication
30956113 | J:275686
First Author: Jung JW
Year: 2019
Journal: Cell Metab
Title: Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.
Volume: 29
Issue: 6
Pages: 1306-1319.e7
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Publication
32951297 | J:296938
First Author: Del Llano E
Year: 2020
Journal: Aging Cell
Title: Age-related differences in the translational landscape of mammalian oocytes.
Volume: 19
Issue: 10
Pages: e13231
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