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Search results 101 to 106 out of 106 for Cc2d1b

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Type Details Score
Protein Domain
IPR037772 | C2_Freud
Type: Domain
Description: The cc2d1a gene family consists of two homologues, CC2D1A (Freud-1) and CC2D1B (Freud-2). Freud-1 is a calcium-regulated repressor of serotonine receptor 5-HT1A and dopamine-D2 receptor expression [, ]. Mutations in cc2d1a has been linked to nonsyndromic mental retardation [, ].CC2D1A/freud-1 and CC2D1B/freud-2 share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 domain. The Freud-1 C2 domain is thought to be calcium insensitive and it lacks several acidic residues that mediate calcium binding of the PKC C2 domain. In addition, it contains a poly-basic insert that is not present in calcium-dependent C2 domains and may function as a nuclear localization signal []. The Freud-1 C2 domain appears to be essential for its DNA binding and repressor function; it may mediate protein-protein interactions [].
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Protein
Q8K1A6
Organism: Mus musculus/domesticus
Length: 943  
Fragment?: false
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Protein
Q8BRN9
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
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Protein
F6XC25
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: true
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Protein
E9PX94
Organism: Mus musculus/domesticus
Length: 897  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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