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Search results 101 to 200 out of 207 for Ccl11

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Type Details Score
Publication
19525930 | J:150352
First Author: Takeda A
Year: 2009
Journal: Nature
Title: CCR3 is a target for age-related macular degeneration diagnosis and therapy.
Volume: 460
Issue: 7252
Pages: 225-30
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Publication
20219953 | J:160350
First Author: Queto T
Year: 2010
Journal: J Leukoc Biol
Title: Cysteinyl-leukotriene type 1 receptors transduce a critical signal for the up-regulation of eosinophilopoiesis by interleukin-13 and eotaxin in murine bone marrow.
Volume: 87
Issue: 5
Pages: 885-93
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Publication
17177681 | J:135913
First Author: Sharkhuu T
Year: 2006
Journal: Clin Exp Allergy
Title: Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.
Volume: 36
Issue: 12
Pages: 1575-83
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Publication
11694459 | J:114421
First Author: Yang M
Year: 2001
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin.
Volume: 25
Issue: 4
Pages: 522-30
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Publication
20543112 | J:161593
First Author: Zuo L
Year: 2010
Journal: J Immunol
Title: IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R alpha 2-inhibited pathway.
Volume: 185
Issue: 1
Pages: 660-9
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Publication
27181207 | J:240215
First Author: Farmaki E
Year: 2016
Journal: Oncogene
Title: A CCL8 gradient drives breast cancer cell dissemination.
Volume: 35
Issue: 49
Pages: 6309-6318
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Publication
16547273 | J:129866
First Author: Fritz DK
Year: 2006
Journal: J Immunol
Title: Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6.
Volume: 176
Issue: 7
Pages: 4352-60
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Publication
19799897 | J:155478
First Author: Fritz DK
Year: 2009
Journal: Exp Cell Res
Title: Oncostatin M (OSM) primes IL-13- and IL-4-induced eotaxin responses in fibroblasts: regulation of the type-II IL-4 receptor chains IL-4Ralpha and IL-13Ralpha1.
Volume: 315
Issue: 20
Pages: 3486-99
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Publication
25847238 | J:222567
First Author: Ji YR
Year: 2015
Journal: J Biol Chem
Title: Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice.
Volume: 290
Issue: 20
Pages: 12804-11
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Publication
25595646 | J:232274
First Author: Williams AE
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.
Volume: 308
Issue: 6
Pages: L539-49
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Publication
18480254 | J:136343
First Author: Munitz A
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
Volume: 105
Issue: 20
Pages: 7240-5
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Publication
10995569 | J:64704
First Author: Cohen-Tannoudji M
Year: 2000
Journal: Genomics
Title: A 2-Mb YAC/BAC-based physical map of the ovum mutant (Om) locus region on mouse chromosome 11.
Volume: 68
Issue: 3
Pages: 273-82
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Publication
34893605 | J:317198
First Author: Yang Y
Year: 2021
Journal: Nat Commun
Title: Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.
Volume: 12
Issue: 1
Pages: 7186
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Publication
25209981 | J:217209
First Author: Cottle DL
Year: 2015
Journal: Hum Mol Genet
Title: Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis.
Volume: 24
Issue: 2
Pages: 436-49
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Publication
9177770 | J:40728
First Author: Krulová M
Year: 1997
Journal: Genomics
Title: IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.
Volume: 42
Issue: 1
Pages: 11-5
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Publication
27022143 | J:233073
First Author: de Valle E
Year: 2016
Journal: J Exp Med
Title: NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
Volume: 213
Issue: 4
Pages: 621-41
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Publication
23213461 | J:185338
First Author: Boucherat O
Year: 2012
Journal: Biol Open
Title: The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways.
Volume: 1
Issue: 7
Pages: 677-91
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Publication
12080938 | J:76755
First Author: IUIS/WHO Subcommittee on Chemokine Nomenclature.
Year: 2002
Journal: J Immunol Methods
Title: Chemokine/chemokine receptor nomenclature.
Volume: 262
Issue: 1-2
Pages: 1-3
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25336190 | J:218087
First Author: Yang J
Year: 2014
Journal: Cancer Res
Title: Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.
Volume: 74
Issue: 24
Pages: 7274-84
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Publication
23562811 | J:195493
First Author: Waddell A
Year: 2013
Journal: J Immunol
Title: Intestinal CCL11 and eosinophilic inflammation is regulated by myeloid cell-specific RelA/p65 in mice.
Volume: 190
Issue: 9
Pages: 4773-85
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GO Term
GO:0071954 | chemokine (C-C motif) ligand 11 production
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Publication
30650360 | J:281032
First Author: Boscolo Sesillo F
Year: 2019
Journal: Cell Rep
Title: Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy.
Volume: 26
Issue: 3
Pages: 689-701.e6
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Publication
30778250 | J:282542
First Author: Hollande C
Year: 2019
Journal: Nat Immunol
Title: Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth.
Volume: 20
Issue: 3
Pages: 257-264
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Publication
28855579 | J:256564
First Author: Imai Y
Year: 2017
Journal: Sci Rep
Title: Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice.
Volume: 7
Issue: 1
Pages: 10053
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Publication
12629149 | J:82285
First Author: Pinho V
Year: 2003
Journal: J Leukoc Biol
Title: The role of CCL22 (MDC) for the recruitment of eosinophils during allergic pleurisy in mice.
Volume: 73
Issue: 3
Pages: 356-62
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Publication
38195933 | J:352213
First Author: Bhattacharyya S
Year: 2024
Journal: Nat Cancer
Title: Autotaxin-lysolipid signaling suppresses a CCL11-eosinophil axis to promote pancreatic cancer progression.
Volume: 5
Issue: 2
Pages: 283-298
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HT Experiment
E-GEOD-57516 | Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
Series Id: GSE57516
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
20606167 | J:165873
First Author: Otero K
Year: 2010
Journal: Blood
Title: Nonredundant role of CCRL2 in lung dendritic cell trafficking.
Volume: 116
Issue: 16
Pages: 2942-9
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Publication
26321245 | J:325817
First Author: Chien SJ
Year: 2015
Journal: Exp Mol Pathol
Title: The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice.
Volume: 99
Issue: 3
Pages: 460-7
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Publication
16274458 | J:116833
First Author: Renninger ML
Year: 2005
Journal: Exp Dermatol
Title: Increased expression of chemokines in the skin of chronic proliferative dermatitis mutant mice.
Volume: 14
Issue: 12
Pages: 906-13
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Publication
18778361 | J:142417
First Author: Cardoso CR
Year: 2008
Journal: Clin Exp Immunol
Title: B cells are involved in the modulation of pathogenic gut immune response in food-allergic enteropathy.
Volume: 154
Issue: 2
Pages: 153-61
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Publication
18250447 | J:131994
First Author: Castilow EM
Year: 2008
Journal: J Immunol
Title: IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease.
Volume: 180
Issue: 4
Pages: 2376-84
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Publication
19843944 | J:156795
First Author: Carlens J
Year: 2009
Journal: J Immunol
Title: Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
Volume: 183
Issue: 9
Pages: 5600-7
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Publication
26432866 | J:233085
First Author: Fakih D
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation.
Volume: 309
Issue: 11
Pages: L1333-43
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Publication
18250471 | J:131976
First Author: Su YC
Year: 2008
Journal: J Immunol
Title: Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation.
Volume: 180
Issue: 4
Pages: 2600-7
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Publication
37170891 | J:351867
First Author: Hong H
Year: 2024
Journal: J Leukoc Biol
Title: Myeloid Bmal1 deletion suppresses the house dust mite-induced chronic lung allergy.
Volume: 115
Issue: 1
Pages: 164-176
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Publication
18441309 | J:141704
First Author: Ueta M
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice.
Volume: 49
Issue: 8
Pages: 3387-94
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Publication
21908591 | J:180029
First Author: Weng M
Year: 2011
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Eosinophils are necessary for pulmonary arterial remodeling in a mouse model of eosinophilic inflammation-induced pulmonary hypertension.
Volume: 301
Issue: 6
Pages: L927-36
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Publication
20505141 | J:161445
First Author: Torres D
Year: 2010
Journal: J Immunol
Title: Double-stranded RNA exacerbates pulmonary allergic reaction through TLR3: implication of airway epithelium and dendritic cells.
Volume: 185
Issue: 1
Pages: 451-9
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Publication
19542471 | J:149965
First Author: Percopo CM
Year: 2009
Journal: J Immunol
Title: Pulmonary eosinophils and their role in immunopathologic responses to formalin-inactivated pneumonia virus of mice.
Volume: 183
Issue: 1
Pages: 604-12
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Publication
19893035 | J:155325
First Author: Vieira AT
Year: 2009
Journal: Am J Pathol
Title: Treatment with a novel chemokine-binding protein or eosinophil lineage-ablation protects mice from experimental colitis.
Volume: 175
Issue: 6
Pages: 2382-91
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Publication
29967467 | J:268394
First Author: Lee EH
Year: 2018
Journal: Sci Rep
Title: Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.
Volume: 8
Issue: 1
Pages: 9894
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Publication
27881708 | J:298316
First Author: Kanai K
Year: 2017
Journal: J Immunol
Title: IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice.
Volume: 198
Issue: 1
Pages: 119-127
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Publication
21268008 | J:173132
First Author: Paulissen G
Year: 2011
Journal: Eur J Immunol
Title: ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation.
Volume: 41
Issue: 2
Pages: 380-91
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Publication
17095748 | J:135929
First Author: Whitehead GS
Year: 2007
Journal: Am J Respir Crit Care Med
Title: The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.
Volume: 175
Issue: 3
Pages: 243-9
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Publication
37441611 | J:346972
 
First Author: Yang X
Year: 2023
Journal: Front Neurol
Title: Qi-fu-yin attenuated cognitive disorders in 5xFAD mice of Alzheimer's disease animal model by regulating immunity.
Volume: 14
Pages: 1183764
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Publication
31270368 | J:286812
First Author: Blanco-Pérez F
Year: 2019
Journal: Sci Rep
Title: CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis.
Volume: 9
Issue: 1
Pages: 9608
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Publication
29975102 | J:266172
First Author: Gahring LC
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.
Volume: 315
Issue: 4
Pages: L553-L562
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Publication
11777981 | J:73740
First Author: Michalec L
Year: 2002
Journal: J Immunol
Title: CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation.
Volume: 168
Issue: 2
Pages: 846-52
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Publication
27768790 | J:254683
First Author: Wang H
Year: 2016
Journal: Invest Ophthalmol Vis Sci
Title: Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration.
Volume: 57
Issue: 13
Pages: 5525-5534
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Publication
30168637 | J:267369
First Author: Büttner R
Year: 2018
Journal: Aging Cell
Title: Inflammaging impairs peripheral nerve maintenance and regeneration.
Volume: 17
Issue: 6
Pages: e12833
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Publication
31492743 | J:280781
First Author: Neamah WH
Year: 2019
Journal: J Immunol
Title: AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes.
Volume: 203
Issue: 7
Pages: 1830-1844
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Publication
9625760 | -
First Author: Cole KE
Year: 1998
Journal: J Exp Med
Title: Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3.
Volume: 187
Issue: 12
Pages: 2009-21
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Publication
9660793 | -
First Author: Weng Y
Year: 1998
Journal: J Biol Chem
Title: Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
Volume: 273
Issue: 29
Pages: 18288-91
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Publication
9064356 | -
First Author: Loetscher M
Year: 1996
Journal: J Exp Med
Title: Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.
Volume: 184
Issue: 3
Pages: 963-9
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Publication
11310833 | -
First Author: García-López MA
Year: 2001
Journal: Lab Invest
Title: CXCR3 chemokine receptor distribution in normal and inflamed tissues: expression on activated lymphocytes, endothelial cells, and dendritic cells.
Volume: 81
Issue: 3
Pages: 409-18
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Publication
12173928 | -
First Author: Booth V
Year: 2002
Journal: Biochemistry
Title: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Volume: 41
Issue: 33
Pages: 10418-25
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Publication
10233762 | -
First Author: Tensen CP
Year: 1999
Journal: J Invest Dermatol
Title: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).
Volume: 112
Issue: 5
Pages: 716-22
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Publication
12750173 | -
First Author: Smit MJ
Year: 2003
Journal: Blood
Title: CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase.
Volume: 102
Issue: 6
Pages: 1959-65
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Publication
11085753 | J:65916
First Author: Hancock WW
Year: 2000
Journal: J Exp Med
Title: Requirement of the chemokine receptor CXCR3 for acute allograft rejection.
Volume: 192
Issue: 10
Pages: 1515-20
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Publication
10525042 | -
First Author: Mach F
Year: 1999
Journal: J Clin Invest
Title: Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells.
Volume: 104
Issue: 8
Pages: 1041-50
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Publication
15254596 | J:91359
First Author: Jiang D
Year: 2004
Journal: J Clin Invest
Title: Regulation of pulmonary fibrosis by chemokine receptor CXCR3.
Volume: 114
Issue: 2
Pages: 291-9
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Publication
12415259 | J:132575
First Author: Frigerio S
Year: 2002
Journal: Nat Med
Title: Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis.
Volume: 8
Issue: 12
Pages: 1414-20
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Publication
17538187 | J:153194
First Author: Panzer U
Year: 2007
Journal: J Am Soc Nephrol
Title: Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Volume: 18
Issue: 7
Pages: 2071-84
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Publication
9466968 | -
First Author: Qin S
Year: 1998
Journal: J Clin Invest
Title: The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.
Volume: 101
Issue: 4
Pages: 746-54
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Publication
16127166 | -
First Author: Curbishley SM
Year: 2005
Journal: Am J Pathol
Title: CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
Volume: 167
Issue: 3
Pages: 887-99
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Publication
10605606 | -
 
First Author: Loetscher P
Year: 2000
Journal: Adv Immunol
Title: Chemokines and their receptors in lymphocyte traffic and HIV infection.
Volume: 74
Pages: 127-80
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Publication
9987599 | -
First Author: Zlotnik A
Year: 1999
Journal: Crit Rev Immunol
Title: Recent advances in chemokines and chemokine receptors.
Volume: 19
Issue: 1
Pages: 1-47
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Publication
17600132 | J:123926
First Author: Yates CC
Year: 2007
Journal: Am J Pathol
Title: Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor.
Volume: 171
Issue: 2
Pages: 484-95
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Publication
12884299 | -
First Author: Xanthou G
Year: 2003
Journal: Eur J Immunol
Title: CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.
Volume: 33
Issue: 8
Pages: 2241-50
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Protein Domain
IPR004070 | Chemokine_CXCR3
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).The CXC chemokine receptors are a subfamily of chemokine receptors that specifically bind and respond to cytokines of the CXC chemokine family. There are currently seven known CXC chemokine receptors in mammals, CXCR1 through to CXCR7.This entry represents CXCR3, which is expressed in natural killer cells and activated T lymphocytes but not in resting T lymphocytes, B lymphocytes, monocytes or granulocytes [, ]. CXCR3 also appears to be constitutively expressed on endothelial cells of medium and large blood vessels []. CXCR3 is able to regulate leukocyte trafficking and binding to various chemokines inducing various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration [, , , ]. The main role of CXCR3 is the selective recruitment of effector T cells in both normal tissues and inflammation []and it is involved in a number of T cell-mediated inflammatory diseases, such as autoimmune diseases, delayed-type hypersensitivity responses, certain viral diseases and acute transplant rejection []. It has been implicated in atherosclerosis [], pulmonary fibrosis [], type 1 diabetes []and nephrotoxic nephritis [], and has been implicated in wound healing [].CXCR3 is the receptor for CXCL9 (Mig), CXCL10 (IP10) and CXCL11 (I-TAC), [, , , ], which are upregulated in response to interferon-gamma and are potent chemoattractants for activated T cells [, ]. All three chemokines elicit an increase in intracellular Ca2+ levels and activate phosphoinositide 3-kinase and mitogen-activated protein kinase (MAPK) []. CXCR3 is also capable of binding a number of CC chemokines with moderate affinity, including CCL11 (eotaxin), CCL13, CCL20, CCL7, CCL5 []. However, it has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [].
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Publication
24465642 | J:225167
First Author: Potter CS
Year: 2014
Journal: PLoS One
Title: Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.
Volume: 9
Issue: 1
Pages: e85666
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Publication
29183288 | J:271780
First Author: Cloots RHE
Year: 2017
Journal: BMC Pulm Med
Title: Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
Volume: 17
Issue: 1
Pages: 158
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Publication
18322238 | J:132953
First Author: Goplen N
Year: 2008
Journal: J Immunol
Title: A phosphosite screen identifies autocrine TGF-beta-driven activation of protein kinase R as a survival-limiting factor for eosinophils.
Volume: 180
Issue: 6
Pages: 4256-64
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Publication
25451296 | J:221447
 
First Author: de Miranda AS
Year: 2015
Journal: Neuroscience
Title: Evidence for the contribution of adult neurogenesis and hippocampal cell death in experimental cerebral malaria cognitive outcome.
Volume: 284
Pages: 920-33
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Publication
37574015 | J:358409
First Author: Jacobse J
Year: 2023
Journal: Cell Mol Gastroenterol Hepatol
Title: Eosinophils Exert Antitumorigenic Effects in the Development of Esophageal Squamous Cell Carcinoma.
Volume: 16
Issue: 6
Pages: 961-983
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Publication
25243059 | J:355947
 
First Author: Steegenga WT
Year: 2014
Journal: Biol Sex Differ
Title: Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice.
Volume: 5
Pages: 11
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Publication
10699158 | -
First Author: Murphy PM
Year: 2000
Journal: Pharmacol Rev
Title: International union of pharmacology. XXII. Nomenclature for chemokine receptors.
Volume: 52
Issue: 1
Pages: 145-76
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