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Search results 101 to 200 out of 207 for Ccl25

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:4885270
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945773
Age: embryonic day 15.5
Image: g01480 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g01480 E15.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4885270
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945773
Age: postnatal day 7
Image: g01480 P7
Specimen Label: g01480 P7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4885270
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945773
Age: postnatal day 42
Image: g01480 Adult
Specimen Label: g01480 Adult
Detected: true
Specimen Num: 4
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Publication
19164599 | J:147173
First Author: Sultana DA
Year: 2009
Journal: Blood
Title: Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
Volume: 113
Issue: 13
Pages: 2976-87
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Publication
9285413 | J:42501
First Author: Vicari AP
Year: 1997
Journal: Immunity
Title: TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.
Volume: 7
Issue: 2
Pages: 291-301
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Publication
11981810 | J:76539
First Author: Townson JR
Year: 2002
Journal: Eur J Immunol
Title: Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR.
Volume: 32
Issue: 5
Pages: 1230-41
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Publication
21421850 | J:172753
First Author: Desanti GE
Year: 2011
Journal: J Immunol
Title: Clonal analysis reveals uniformity in the molecular profile and lineage potential of CCR9(+) and CCR9(-) thymus-settling progenitors.
Volume: 186
Issue: 9
Pages: 5227-35
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Publication
10623805 | J:59297
First Author: Norment AM
Year: 2000
Journal: J Immunol
Title: Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling.
Volume: 164
Issue: 2
Pages: 639-48
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Publication
18439426 | J:136667
First Author: Apostolaki M
Year: 2008
Journal: Gastroenterology
Title: Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.
Volume: 134
Issue: 7
Pages: 2025-35
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Publication
19923453 | J:157503
First Author: Laan M
Year: 2009
Journal: J Immunol
Title: Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes.
Volume: 183
Issue: 12
Pages: 7682-91
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Publication
20504947 | J:164924
First Author: Stimamiglio MA
Year: 2010
Journal: J Leukoc Biol
Title: EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonization.
Volume: 88
Issue: 3
Pages: 483-94
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Publication
27060907 | J:320345
First Author: Montero-Herradón S
Year: 2016
Journal: Histochem Cell Biol
Title: Eph/ephrin-B-mediated cell-to-cell interactions govern MTS20(+) thymic epithelial cell development.
Volume: 146
Issue: 2
Pages: 167-82
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Publication
16809609 | J:139461
First Author: Liu C
Year: 2006
Journal: Blood
Title: Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization.
Volume: 108
Issue: 8
Pages: 2531-9
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Publication
21937690 | J:178890
First Author: Heinonen KM
Year: 2011
Journal: Blood
Title: Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.
Volume: 118
Issue: 19
Pages: 5163-73
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Publication
11093154 | J:71805
First Author: Bleul CC
Year: 2000
Journal: Eur J Immunol
Title: Chemokines define distinct microenvironments in the developing thymus.
Volume: 30
Issue: 12
Pages: 3371-9
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Publication
23750244 | J:203143
First Author: Bryson JL
Year: 2013
Journal: PLoS One
Title: Cell-autonomous defects in thymic epithelial cells disrupt endothelial-perivascular cell interactions in the mouse thymus.
Volume: 8
Issue: 6
Pages: e65196
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Publication
20043899 | J:157956
First Author: Gordon J
Year: 2010
Journal: Dev Biol
Title: Evidence for an early role for BMP4 signaling in thymus and parathyroid morphogenesis.
Volume: 339
Issue: 1
Pages: 141-54
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Publication
39040069 | J:352089
First Author: Grammer C
Year: 2024
Journal: iScience
Title: Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development.
Volume: 27
Issue: 7
Pages: 110258
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Publication
17625108 | J:124645
First Author: Itoi M
Year: 2007
Journal: Int Immunol
Title: Mesenchymal cells are required for functional development of thymic epithelial cells.
Volume: 19
Issue: 8
Pages: 953-64
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Publication
19234195 | J:146244
First Author: Zuklys S
Year: 2009
Journal: J Immunol
Title: Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
Volume: 182
Issue: 5
Pages: 2997-3007
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Publication
12080938 | J:76755
First Author: IUIS/WHO Subcommittee on Chemokine Nomenclature.
Year: 2002
Journal: J Immunol Methods
Title: Chemokine/chemokine receptor nomenclature.
Volume: 262
Issue: 1-2
Pages: 1-3
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
17158094 | J:149208
First Author: Itoi M
Year: 2007
Journal: Int Immunol
Title: Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus.
Volume: 19
Issue: 2
Pages: 127-32
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Allele
Ccl25<em1Smoc> | MGI:7288705
Name: C-C motif chemokine ligand 25; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6354587 | C57BL/6JSmoc-Ccl25<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
20431621 | J:160613
First Author: Phee H
Year: 2010
Journal: Nat Immunol
Title: Regulation of thymocyte positive selection and motility by GIT2.
Volume: 11
Issue: 6
Pages: 503-11
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HT Experiment
GSE33268 | Synergistic, context-dependent and hierarchical functions of hematopoietic progenitor niche components.
Series Id: E-GEOD-33268
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
19027330 | J:142925
First Author: Choi YI
Year: 2008
Journal: Immunity
Title: PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.
Volume: 29
Issue: 6
Pages: 888-98
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Publication
19289576 | J:147871
First Author: Gossens K
Year: 2009
Journal: J Exp Med
Title: Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25.
Volume: 206
Issue: 4
Pages: 761-78
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Publication
16582913 | J:112592
First Author: Staton TL
Year: 2006
Journal: Nat Immunol
Title: CD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.
Volume: 7
Issue: 5
Pages: 482-8
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Publication
34930780 | J:331501
First Author: Nishijima H
Year: 2022
Journal: J Immunol
Title: Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens.
Volume: 208
Issue: 2
Pages: 303-320
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Publication
35254403 | J:354641
 
First Author: Fang Z
Year: 2022
Journal: J Exp Med
Title: Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV.
Volume: 219
Issue: 4
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Publication
23152546 | J:193138
First Author: Bunting MD
Year: 2013
Journal: Blood
Title: CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity.
Volume: 121
Issue: 1
Pages: 118-28
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Publication
35154092 | J:325887
 
First Author: Manhas KR
Year: 2022
Journal: Front Immunol
Title: Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4β7 Integrin and Direct Their Migration In Vitro.
Volume: 13
Pages: 746484
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Publication
26230654 | J:238602
First Author: Evans-Marin HL
Year: 2015
Journal: PLoS One
Title: Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development.
Volume: 10
Issue: 7
Pages: e0134100
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Publication
17521370 | J:125641
First Author: García-Zepeda EA
Year: 2007
Journal: Immunology
Title: Janus kinase 3-deficient T lymphocytes have an intrinsic defect in CCR7-mediated homing to peripheral lymphoid organs.
Volume: 122
Issue: 2
Pages: 247-60
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Publication
15147562 | J:90510
First Author: Soldevila G
Year: 2004
Journal: Immunology
Title: Impaired chemokine-induced migration during T-cell development in the absence of Jak 3.
Volume: 112
Issue: 2
Pages: 191-200
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Publication
23547118 | J:195497
First Author: Agnello D
Year: 2013
Journal: J Immunol
Title: Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine.
Volume: 190
Issue: 9
Pages: 4836-47
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Publication
17490434 | J:125643
First Author: Elgbratt K
Year: 2007
Journal: Immunology
Title: Aberrant T-cell ontogeny and defective thymocyte and colonic T-cell chemotactic migration in colitis-prone Galphai2-deficient mice.
Volume: 122
Issue: 2
Pages: 199-209
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Publication
17911179 | J:130023
First Author: Svensson M
Year: 2008
Journal: J Leukoc Biol
Title: Involvement of CCR9 at multiple stages of adult T lymphopoiesis.
Volume: 83
Issue: 1
Pages: 156-64
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Publication
14744993 | J:90891
First Author: Pabst O
Year: 2004
Journal: J Exp Med
Title: Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine.
Volume: 199
Issue: 3
Pages: 411-6
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Publication
31550172 | J:297603
First Author: Kim SM
Year: 2019
Journal: FASEB J
Title: Axl is a key regulator of intestinal γδ T-cell homeostasis.
Volume: 33
Issue: 12
Pages: 13386-13397
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Publication
33859647 | J:316070
 
First Author: Han J
Year: 2021
Journal: Front Immunol
Title: High-Oxygen Submersion Fetal Thymus Organ Cultures Enable FOXN1-Dependent and -Independent Support of T Lymphopoiesis.
Volume: 12
Pages: 652665
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Publication
31755547 | J:288853
First Author: Pathak M
Year: 2020
Journal: Eur J Immunol
Title: CCR9 signaling in dendritic cells drives the differentiation of Foxp3+ Tregs and suppresses the allergic IgE response in the gut.
Volume: 50
Issue: 3
Pages: 404-417
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Publication
32533638 | J:297717
First Author: Matti C
Year: 2020
Journal: J Leukoc Biol
Title: CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
Volume: 107
Issue: 6
Pages: 1137-1154
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Publication
32714327 | J:329637
 
First Author: Wilhelmson AS
Year: 2020
Journal: Front Immunol
Title: Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice.
Volume: 11
Pages: 1342
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Publication
25248373 | J:329837
First Author: Yokoyama W
Year: 2014
Journal: Arthritis Res Ther
Title: Abrogation of CC chemokine receptor 9 ameliorates collagen-induced arthritis of mice.
Volume: 16
Issue: 5
Pages: 445
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Publication
24638065 | J:233563
First Author: Bunting MD
Year: 2014
Journal: Immunol Cell Biol
Title: CCR6 supports migration and differentiation of a subset of DN1 early thymocyte progenitors but is not required for thymic nTreg development.
Volume: 92
Issue: 6
Pages: 489-98
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Publication
18056919 | J:128946
First Author: Penido C
Year: 2008
Journal: Int Immunol
Title: Involvement of CC chemokines in gammadelta T lymphocyte trafficking during allergic inflammation: the role of CCL2/CCR2 pathway.
Volume: 20
Issue: 1
Pages: 129-39
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Publication
25810451 | J:242682
First Author: Alfaro D
Year: 2015
Journal: J Leukoc Biol
Title: EphB2 and EphB3 play an important role in the lymphoid seeding of murine adult thymus.
Volume: 98
Issue: 6
Pages: 883-96
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Publication
33399911 | J:305647
First Author: Amiya T
Year: 2021
Journal: Diabetologia
Title: C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.
Volume: 64
Issue: 3
Pages: 603-617
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Publication
10229797 | J:54920
First Author: Zaballos A
Year: 1999
Journal: J Immunol
Title: Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.
Volume: 162
Issue: 10
Pages: 5671-5
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Publication
10498628 | -
First Author: Youn BS
Year: 1999
Journal: Blood
Title: TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor.
Volume: 94
Issue: 7
Pages: 2533-6
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Publication
11159507 | -
First Author: Carramolino L
Year: 2001
Journal: Blood
Title: Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs.
Volume: 97
Issue: 4
Pages: 850-7
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Publication
16253981 | -
First Author: Honczarenko M
Year: 2006
Journal: Stem Cells
Title: Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors.
Volume: 24
Issue: 4
Pages: 1030-41
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Publication
11046037 | -
First Author: Papadakis KA
Year: 2000
Journal: J Immunol
Title: The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system.
Volume: 165
Issue: 9
Pages: 5069-76
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Publication
11487533 | -
First Author: Papadakis KA
Year: 2001
Journal: Gastroenterology
Title: CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.
Volume: 121
Issue: 2
Pages: 246-54
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Publication
15623660 | -
First Author: Singh S
Year: 2004
Journal: Clin Cancer Res
Title: Expression and functional role of CCR9 in prostate cancer cell migration and invasion.
Volume: 10
Issue: 24
Pages: 8743-50
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Protein Domain
IPR004069 | Chemokine_CCR9
Type: Family
Description: Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 9 (CCR9), which was previously designated as the orphan receptors GPR28 and GPR 9-6. CCR9 is expressed predominantly in the thymus, in both mature and immature T cells, and is also found in the lymph nodes, spleen, glomerular podocytes, bone marrow stromal cells and the small intestine [, , , , ]. Transfected cells expressing CCR9 receptor bind specifically to CCL25 (also known as Thymus-Expressed Chemokine) []. This interaction may play a pivotal role in T-cell migration in the thymus []. CCR9 activation has also been shown to influence cancer cell migration, invasion and matrix metallopeptidase expression, which together may affect prostate cancer metastasis [].
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Publication
32050001 | J:285315
First Author: Jodeleit H
Year: 2020
Journal: PLoS One
Title: Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis.
Volume: 15
Issue: 2
Pages: e0228615
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Protein
Q9WUT7
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
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Protein
F8WIS0
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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