Type |
Details |
Score |
Publication |
First Author: |
Collins N |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation. |
Volume: |
7 |
|
Pages: |
11514 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lieberam I |
Year: |
2005 |
Journal: |
Neuron |
Title: |
A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. |
Volume: |
47 |
Issue: |
5 |
Pages: |
667-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishikii H |
Year: |
2016 |
Journal: |
Blood |
Title: |
DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease. |
Volume: |
128 |
Issue: |
24 |
Pages: |
2846-2858 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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•
•
•
•
•
|
Publication |
First Author: |
NIH Mouse Knockout Inventory |
Year: |
2004 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the NIH Mouse Knockout Inventory |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2018 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Haque NS |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
CC chemokine CCL1 receptor CCR8 mediates conversion of mesenchymal stem cells to embryoid bodies expressing FOXP3+CCR8+ regulatory T cells. |
Volume: |
14 |
Issue: |
7 |
Pages: |
e0218944 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernardini G |
Year: |
1998 |
Journal: |
Eur J Immunol |
Title: |
Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. |
Volume: |
28 |
Issue: |
2 |
Pages: |
582-8 |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine receptor 8; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine receptor 8; endonuclease-mediated mutation 4, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine receptor 8; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine receptor 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
C-C motif chemokine receptor 8; targeted mutation 1, Sergio A Lira |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ccr8/Ccr8 |
Background: |
involves: 129S/SvEv * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Delacher M |
Year: |
2021 |
Journal: |
Immunity |
Title: |
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory TÂ cells. |
Volume: |
54 |
Issue: |
4 |
Pages: |
702-720.e17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roos RS |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Identification of CCR8, the receptor for the human CC chemokine I-309. |
Volume: |
272 |
Issue: |
28 |
Pages: |
17251-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garlisi CG |
Year: |
1999 |
Journal: |
Eur J Immunol |
Title: |
The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. |
Volume: |
29 |
Issue: |
10 |
Pages: |
3210-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howard OM |
Year: |
2000 |
Journal: |
Blood |
Title: |
LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. |
Volume: |
96 |
Issue: |
3 |
Pages: |
840-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dairaghi DJ |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
HHV8-encoded vMIP-I selectively engages chemokine receptor CCR8. Agonist and antagonist profiles of viral chemokines. |
Volume: |
274 |
Issue: |
31 |
Pages: |
21569-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haque NS |
Year: |
2004 |
Journal: |
Blood |
Title: |
Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. |
Volume: |
103 |
Issue: |
4 |
Pages: |
1296-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaplan AP |
Year: |
2001 |
Journal: |
Int Arch Allergy Immunol |
Title: |
Chemokines, chemokine receptors and allergy. |
Volume: |
124 |
Issue: |
4 |
Pages: |
423-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Napolitano M |
Year: |
1999 |
Journal: |
Forum (Genova) |
Title: |
Structure and function of the CC chemokine receptor (CCR) 8. |
Volume: |
9 |
Issue: |
4 |
Pages: |
315-24 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role []. They have a wide range of effects in many different cell types beyond the immune system, including, for example, various cells of the central nervous system [], and endothelial cells, where they may act as either angiogenic or angiostatic factors [].The chemokine family is divided into four classes based on the number and spacing of their conserved cysteines: 2 Cys residues may be adjacent (the CC family); separated by an intervening residue (the CXC family); have only one of the first two Cys residues (C chemokines); or contain both cysteines, separated by three intervening residues (CX3C chemokines).Chemokines exert their effects by binding to rhodopsin-like G protein-coupled receptors on the surface of cells. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium ions, which cause a cellular response, including the onset of chemotaxis. There are over fifty distinct chemokines and least 18 human chemokine receptors []. Although the receptors bind only a single class of chemokines, they often bind several members of the same class with high affinity. Chemokine receptors are preferentially expressed on important functional subsets of dendritic cells, monocytes and lymphocytes, including Langerhans cells and T helper cells [, ]. Chemokines and their receptors can also be subclassified into homeostatic leukocyte homing molecules (CXCR4, CXCR5, CCR7, CCR9) versus inflammatory/inducible molecules (CXCR1, CXCR2, CXCR3, CCR1-6, CX3CR1).CC chemokine receptors are a subfamily of the chemokine receptors that specifically bind and respond to cytokines of the CC chemokine family. There are currently ten members of the CC chemokine receptor subfamily, named CCR1 to 10. The receptors receptors are found in monocytes, lymphocytes, basophils and eosinophils.This entry represents CC chemokine receptor 8 (CCR8), which it is expressed predominantly in lymphoid tissues [, ]and has also been found in glomerular podocytes []and human umbilical vein endothelial cells (HUVECs) []. CCR8 is associated with Th2 lymphocytes, which are critical for allergy, and has a role in lymphocyte activation, migration, proliferation and differentiation and in allergic diseases [, , ]. CCR8 binds to CCL1 (also known as I-309) [, ]and to CCL16 (also known as liver expressed chemokine) []. It also exhibits a high affinity for three chemokines of viral origin: vMIP-I, vMIP-II and vMCC-I. |
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•
•
•
•
•
|
Publication |
First Author: |
Wang C |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e30793 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang J |
Year: |
2024 |
Journal: |
Cell Mol Immunol |
Title: |
Targeting the glucocorticoid receptor-CCR8 axis mediated bone marrow T cell sequestration enhances infiltration of anti-tumor T cells in intracranial cancers. |
Volume: |
21 |
Issue: |
10 |
Pages: |
1145-1157 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lim JY |
Year: |
2017 |
Journal: |
J Invest Dermatol |
Title: |
Mesenchymal Stem Cells (MSCs) Attenuate Cutaneous Sclerodermatous Graft-Versus-Host Disease (Scl-GVHD) through Inhibition of Immune Cell Infiltration in a Mouse Model. |
Volume: |
137 |
Issue: |
9 |
Pages: |
1895-1904 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lüttichau HR |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. |
Volume: |
278 |
Issue: |
13 |
Pages: |
10928-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tweedy J |
Year: |
2015 |
Journal: |
J Gen Virol |
Title: |
Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators. |
Volume: |
96 |
Issue: |
Pt 2 |
Pages: |
370-89 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Human herpesvirus 6A (HHV-6A) and HHV-6B are classified as roseoloviruses and are highly prevalent in the human population. Roseolovirus reactivation in an immunocompromised host can cause severe pathologies []. HHV6 A/B encode two putative chemokine receptors and a chemokine-like protein. The HHV6 U83 gene encodes a CC chemokine, which functions as a highly selective and efficacious agonist for the human CCR2 receptor, both in respect of signal transduction and the ability to induce chemotaxis. Homologues of the U83 gene products are found in Human cytomegalovirus encoded chemokines vCXC1 and vCXC2.HHV-6 U83, also known as vCCL4, contains a region with the CC/CX3C chemokine motif and a glycosaminoglycan (GAG)-binding epitope, BBXB (B being a basic residue), found right before the third Cys residue, which very likely forms a disulfide bridge back to the first Cys of the protein []. This gene is the only HHV-6A/B divergent gene that is specific for these viruses. The U83 chemokine gene is distinct between HHV-6A and HHV-6B strains, encoding up to 13 amino acid differences. The HHV-6A (U83A) and HHV-6B (U83B) chemokines have distinct specificities which determine chemoattraction or diversion of different leukocyte subsets for infection or immune evasion, thus an early component of cellular tropism as well as mediator of innate immunity. U83 also has a varied gene structure, with N-terminal length variation determining production of the encoded mature secreted chemokine, coupled with control by cell-directed splicing which truncates the chemokine gene early in replication to encode an antagonist. The 'long' active form of U83A has a unique broad specificity for receptors CCR1, CCR4, CCR5, CCR6 and CCR8 present on plasmacytoid and myeloid dendritic and monocyte/macrophage antigen presenting cells, as well as both TH1 and TH2 skin homing lymphocytes and NK cells; it is also amongst the highest affinity ligands for CCR5 and inhibits HIV-1 binding at this coreceptor. U83A can both block and divert human chemokine action while occupying the human chemokine receptors []. |
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•
•
•
•
•
|
Publication |
First Author: |
Chen FY |
Year: |
2022 |
Journal: |
Phytomedicine |
Title: |
Distepharinamide, a novel dimeric proaporphine alkaloid from Diploclisia glaucescens, inhibits the differentiation and proliferative expansion of CD4(+)Foxp3(+) regulatory T cells. |
Volume: |
107 |
|
Pages: |
154482 |
|
•
•
•
•
•
|
Publication |
First Author: |
Staheli JP |
Year: |
2016 |
Journal: |
J Virol |
Title: |
Complete Unique Genome Sequence, Expression Profile, and Salivary Gland Tissue Tropism of the Herpesvirus 7 Homolog in Pigtailed Macaques. |
Volume: |
90 |
Issue: |
15 |
Pages: |
6657-74 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
353
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Huber TB |
Year: |
2002 |
Journal: |
J Immunol |
Title: |
Expression of functional CCR and CXCR chemokine receptors in podocytes. |
Volume: |
168 |
Issue: |
12 |
Pages: |
6244-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Q |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. |
Volume: |
95 |
Issue: |
16 |
Pages: |
9448-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horuk R |
Year: |
2001 |
Journal: |
Cytokine Growth Factor Rev |
Title: |
Chemokine receptors. |
Volume: |
12 |
Issue: |
4 |
Pages: |
313-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Charbonnier AS |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cells. |
Volume: |
190 |
Issue: |
12 |
Pages: |
1755-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sallusto F |
Year: |
1998 |
Journal: |
J Exp Med |
Title: |
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. |
Volume: |
187 |
Issue: |
6 |
Pages: |
875-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strieter RM |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. |
Volume: |
270 |
Issue: |
45 |
Pages: |
27348-57 |
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Publication |
First Author: |
Zlotnik A |
Year: |
2000 |
Journal: |
Immunity |
Title: |
Chemokines: a new classification system and their role in immunity. |
Volume: |
12 |
Issue: |
2 |
Pages: |
121-7 |
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