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Search results 101 to 200 out of 1163 for Cdc6

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Type Details Score
Publication
27717094 | J:315590
First Author: Fujiwara K
Year: 2016
Journal: Genes Cells
Title: Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.
Volume: 21
Issue: 11
Pages: 1176-1194
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Publication
22516201 | J:183999
First Author: Ouseph MM
Year: 2012
Journal: Dev Cell
Title: Atypical E2F repressors and activators coordinate placental development.
Volume: 22
Issue: 4
Pages: 849-62
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Publication
32071286 | J:339443
First Author: Zocchi L
Year: 2020
Journal: Oncogenesis
Title: Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression.
Volume: 9
Issue: 2
Pages: 25
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Publication
20530543 | J:161950
First Author: O'Brien KB
Year: 2010
Journal: Development
Title: CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells.
Volume: 137
Issue: 13
Pages: 2147-56
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Publication
22403008 | J:187480
First Author: Westendorp B
Year: 2012
Journal: FASEB J
Title: The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy.
Volume: 26
Issue: 6
Pages: 2569-79
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Publication
32703236 | J:305174
First Author: Dong X
Year: 2020
Journal: Mol Brain
Title: Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis.
Volume: 13
Issue: 1
Pages: 104
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Publication
27694478 | J:268403
First Author: Zhou L
Year: 2017
Journal: FASEB J
Title: Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.
Volume: 31
Issue: 1
Pages: 132-147
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Publication
34746147 | J:314268
 
First Author: Akagawa R
Year: 2021
Journal: Front Cell Dev Biol
Title: Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.
Volume: 9
Pages: 753175
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 77
Description: Essential for interaction with CDC6
Type: site
End: 77
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Publication
18458079 | J:138120
First Author: Kan Q
Year: 2008
Journal: J Biol Chem
Title: Cdc6 determines utilization of p21(WAF1/CIP1)-dependent damage checkpoint in S phase cells.
Volume: 283
Issue: 26
Pages: 17864-72
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Publication
9520412 | J:46820
First Author: Yan Z
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
Volume: 95
Issue: 7
Pages: 3603-8
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Publication
14672932 | J:114136
First Author: Cook JG
Year: 2004
Journal: J Biol Chem
Title: The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.
Volume: 279
Issue: 10
Pages: 9625-33
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Publication
10629059 | J:59996
First Author: Yan Z
Year: 2000
Journal: Mol Cell Biol
Title: PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells.
Volume: 20
Issue: 3
Pages: 1021-9
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Publication
18541154 | J:140786
First Author: Mallik I
Year: 2008
Journal: Biochim Biophys Acta
Title: Androgen regulates Cdc6 transcription through interactions between androgen receptor and E2F transcription factor in prostate cancer cells.
Volume: 1783
Issue: 10
Pages: 1737-44
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Publication
20466002 | J:161318
First Author: Arakawa-Takeuchi S
Year: 2010
Journal: FEBS Lett
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.
Volume: 584
Issue: 13
Pages: 2779-85
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Allele
Cdcs6<C3H/HeJBir> | MGI:2159178
 
Name: cytokine deficiency colitis susceptibility 6; C3H/HeJBir
Allele Type: QTL
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Allele
Cdcs6<C57BL/6J> | MGI:2159179
 
Name: cytokine deficiency colitis susceptibility 6; C57BL/6J
Allele Type: QTL
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Interaction Experiment
Kundu LR (2010)
Description: Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.
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Publication
12628342 | -
First Author: Pelizon C
Year: 2003
Journal: Trends Cell Biol
Title: Down to the origin: Cdc6 protein and the competence to replicate.
Volume: 13
Issue: 3
Pages: 110-3
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Publication
15004237 | -
First Author: Ofir Y
Year: 2004
Journal: Mol Biol Cell
Title: The role and regulation of the preRC component Cdc6 in the initiation of premeiotic DNA replication.
Volume: 15
Issue: 5
Pages: 2230-42
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Publication
16228006 | -
First Author: Speck C
Year: 2005
Journal: Nat Struct Mol Biol
Title: ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.
Volume: 12
Issue: 11
Pages: 965-71
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Genotype
Genotype
Symbol: Cdcs6/?
Background: involves: B6.129P2-Il10/Lt * C3Bir.129P2(B6)-Il10/Lt
Zygosity: ot
Has Mutant Allele: true
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Pathway
R-MMU-69017 | CDK-mediated phosphorylation and removal of Cdc6
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Pathway
R-MMU-68689 | CDC6 association with the ORC:origin complex
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DO Term
DOID:0080516 | Meier-Gorlin syndrome 5
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Publication
16387651 | -
First Author: Randell JC
Year: 2006
Journal: Mol Cell
Title: Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.
Volume: 21
Issue: 1
Pages: 29-39
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Publication
23752926 | -
First Author: Wlodarchak N
Year: 2013
Journal: Cell Res
Title: Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.
Volume: 23
Issue: 7
Pages: 931-46
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Publication
20421204 | -
First Author: Kundu LR
Year: 2010
Journal: Nucleic Acids Res
Title: Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex.
Volume: 38
Issue: 16
Pages: 5409-18
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Publication
18320024 | -
First Author: Crevel G
Year: 2008
Journal: PLoS One
Title: The human TPR protein TTC4 is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells.
Volume: 3
Issue: 3
Pages: e0001737
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Publication
27191968 | J:248758
First Author: Zschemisch NH
Year: 2016
Journal: PLoS One
Title: Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.
Volume: 11
Issue: 5
Pages: e0155821
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GO Term
GO:0140530 | MCM complex loading
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Protein
O89033
Organism: Mus musculus/domesticus
Length: 562  
Fragment?: false
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Publication
11707574 | J:72978
First Author: Farmer MA
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
Volume: 98
Issue: 24
Pages: 13820-5
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Protein
Q9Z1N2
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein Coding Gene
MGI:1913884 | Mcm8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein Coding Gene
MGI:1328306 | Orc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347043 | Orc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1354944 | Orc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1328337 | Orc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929285 | Orc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1347044 | Orc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9WUJ8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q9WUV0
Organism: Mus musculus/domesticus
Length: 435  
Fragment?: false
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Protein
O88708
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
Q60862
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q9JK30
Organism: Mus musculus/domesticus
Length: 715  
Fragment?: false
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Publication
20130679 | -
First Author: Kawakami H
Year: 2010
Journal: Biochem Cell Biol
Title: DnaA, ORC, and Cdc6: similarity beyond the domains of life and diversity.
Volume: 88
Issue: 1
Pages: 49-62
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Publication
19344485 | -
First Author: Duncker BP
Year: 2009
Journal: Genome Biol
Title: The origin recognition complex protein family.
Volume: 10
Issue: 3
Pages: 214
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Publication
18048387 | -
First Author: Borlado LR
Year: 2008
Journal: Carcinogenesis
Title: CDC6: from DNA replication to cell cycle checkpoints and oncogenesis.
Volume: 29
Issue: 2
Pages: 237-43
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Protein Domain
IPR015163 | Cdc6_C
Type: Domain
Description: Cdc6 (also known as Cell division cycle 6 or Cdc18) functions as a regulator at the early stages of DNA replication, by helping to recruit and load the Minichromosome Maintenance Complex (MCM) onto DNA and may have additional roles in the control of mitotic entry. Precise duplication of chromosomal DNA is required for genomic stability during replication. Cdc6 has an essential role in DNA replication and irregular expression of Cdc6 may lead to genomic instability. Cdc6 over-expression is observed in many cancerous lesions. DNA replication begins when an origin recognition complex (ORC) binds to a replication origin site on the chromatin. Studies indicate that Cdc6 interacts with ORC through the Orc1 subunit, and that this association increases the specificity of the ORC-origins interaction. Further studies suggest that hydrolysis of Cdc6-bound ATP promotes the association of the replication licensing factor Cdt1 with origins through an interaction with Orc6 and this in turn promotes the loading of MCM2-7 helicase onto chromatin. The MCM2-7 complex promotes the unwinding of DNA origins, and the binding of additional factors to initiate the DNA replication. S-Cdk (S-phase cyclin and cyclin-dependent kinase complex) prevents rereplication by causing the Cdc6 protein to dissociate from ORC and prevents the Cdc6 and MCM proteins from reassembling at any origin. By phosphorylating Cdc6, S-Cdk also triggers Cdc6's ubiquitination. The Cdc6 protein is composed of three domains, an N-terminal AAA+ domain with Walker A and B, and Sensor-1 and -2 motifs. The central region contains a conserved nucleotide binding/ATPase domain and is a member of the ATPase superfamily. [, , , , ].The C-terminal domain of cell division control protein 6 (CDC6) assumes a winged helix fold, with a five α-helical bundle (α15-α19) structure, backed on one side by three beta strands (β6-β8). It has been shown that this domain acts as a DNA-localisation factor, however its exact function is, as yet, unknown. Putative functions include: (1) mediation of protein-protein interactions and (2) regulation of nucleotide binding and hydrolysis. Mutagenesis studies have shown that this domain is essential for appropriate CDC6 activity [].
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Publication
16950245 | J:114390
First Author: Auth T
Year: 2006
Journal: Exp Cell Res
Title: Interaction between HP1alpha and replication proteins in mammalian cells.
Volume: 312
Issue: 17
Pages: 3349-59
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Publication
28467906 | J:255887
First Author: Muñoz S
Year: 2017
Journal: Cell Rep
Title: In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias.
Volume: 19
Issue: 5
Pages: 928-938
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Publication
11030343 | -
First Author: Liu J
Year: 2000
Journal: Mol Cell
Title: Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.
Volume: 6
Issue: 3
Pages: 637-48
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Protein
Q8BZQ7
Organism: Mus musculus/domesticus
Length: 837  
Fragment?: false
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Publication
14993212 | J:114148
First Author: Sugimoto N
Year: 2004
Journal: J Biol Chem
Title: Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Volume: 279
Issue: 19
Pages: 19691-7
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Publication
28074012 | J:259463
 
First Author: Gamell C
Year: 2017
Journal: Sci Signal
Title: Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Volume: 10
Issue: 461
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Publication
17556357 | J:124806
First Author: Srinivasan SV
Year: 2007
Journal: J Biol Chem
Title: RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
Volume: 282
Issue: 33
Pages: 23867-77
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Publication
19703996 | J:153998
First Author: Salsi V
Year: 2009
Journal: Mol Cell Biol
Title: HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin.
Volume: 29
Issue: 21
Pages: 5775-88
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Publication
19822658 | J:155123
First Author: Ma HT
Year: 2009
Journal: Mol Cell Biol
Title: Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis.
Volume: 29
Issue: 24
Pages: 6500-14
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Protein Coding Gene
MGI:1926790 | Fzr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1329034 | Ccne2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9Z238
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q9R1K5
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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