Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Allele |
Name: |
centromere protein A; targeted mutation 1, Stefan Dimitrov |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Epitope tag |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
267
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
269
 |
Fragment?: |
false |
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•
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Protein Domain |
Type: |
Family |
Description: |
This entry includes CENP-Q and Fta7 proteins. CENP-Q is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. Fta7 is the equivalent component of the fission yeast Sim4 complex []. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC []. Fta7 is the equivalent component of the fission yeast Sim4 complex []. |
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Publication |
First Author: |
Yu L |
Year: |
2021 |
Journal: |
Development |
Title: |
Loss of ESRP1 blocks mouse oocyte development and leads to female infertility. |
Volume: |
148 |
Issue: |
2 |
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Publication |
First Author: |
Foltz DR |
Year: |
2006 |
Journal: |
Nat Cell Biol |
Title: |
The human CENP-A centromeric nucleosome-associated complex. |
Volume: |
8 |
Issue: |
5 |
Pages: |
458-69 |
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Publication |
First Author: |
Liu X |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
Molecular analysis of kinetochore architecture in fission yeast. |
Volume: |
24 |
Issue: |
16 |
Pages: |
2919-30 |
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