Type |
Details |
Score |
DO Term |
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•
•
•
•
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Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal domain of the centrosomal proteins Cep63 and Deup1. Cep63 regulates mother-centriole-dependent centriole duplication, whereas Deup1 governs deuterosome assembly for large-scale de novo centriole biogenesis []. |
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•
•
•
•
•
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Publication |
First Author: |
Kodani A |
Year: |
2015 |
Journal: |
Elife |
Title: |
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. |
Volume: |
4 |
|
|
|
•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
601
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
397
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
351
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
536
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
295
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshimori N |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. |
Volume: |
28 |
Issue: |
14 |
Pages: |
2066-76 |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Cep72 is a centrosomal protein that interacts with Kizuna and plays an important role in maintaining microtubule-organizing activity and structural integrity of the centrosome. It is required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) []and for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization []. |
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•
•
•
•
•
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Protein Domain |
Type: |
Family |
Description: |
Centriole amplification is controlled by two duplicated genes, Cep63 (centrosomal protein of 63kDa) and Deup1 (Deuterosome assembly protein 1).Cep63 regulates mother-centriole-dependent centriole duplication, whereas Deup1 is involved in large-scale de novo centriole biogenesis. Deup1, previously known as coiled-coil domain-containing protein 67, is a structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deup1 binds to Cep152 and then recruits Plk4 to activate centriole biogenesis []. |
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•
•
•
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•
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Publication |
First Author: |
Watanabe Y |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
Autophagy controls centrosome number by degrading Cep63. |
Volume: |
7 |
|
Pages: |
13508 |
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•
•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
646
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
470
 |
Fragment?: |
true |
|
•
•
•
•
•
|