Type |
Details |
Score |
Publication |
First Author: |
Tamura S |
Year: |
2016 |
Journal: |
Blood |
Title: |
Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2. |
Volume: |
127 |
Issue: |
13 |
Pages: |
1701-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bender M |
Year: |
2013 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. |
Volume: |
33 |
Issue: |
5 |
Pages: |
926-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wichaiyo S |
Year: |
2019 |
Journal: |
Haematologica |
Title: |
Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice. |
Volume: |
104 |
Issue: |
8 |
Pages: |
1648-1660 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manne BK |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2). |
Volume: |
288 |
Issue: |
11 |
Pages: |
7717-7726 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bem D |
Year: |
2015 |
Journal: |
Blood |
Title: |
VPS33B regulates protein sorting into and maturation of α-granule progenitor organelles in mouse megakaryocytes. |
Volume: |
126 |
Issue: |
2 |
Pages: |
133-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Z |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function. |
Volume: |
5 |
Issue: |
13 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Chauhan A |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1939 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kardeby C |
Year: |
2019 |
Journal: |
Blood Adv |
Title: |
Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα. |
Volume: |
3 |
Issue: |
3 |
Pages: |
275-287 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alshahrani MM |
Year: |
2014 |
Journal: |
Blood |
Title: |
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo. |
Volume: |
124 |
Issue: |
15 |
Pages: |
2431-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakamura Y |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells. |
Volume: |
9 |
Issue: |
1 |
Pages: |
15958 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acton SE |
Year: |
2014 |
Journal: |
Nature |
Title: |
Dendritic cells control fibroblastic reticular network tension and lymph node expansion. |
Volume: |
514 |
Issue: |
7523 |
Pages: |
498-502 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lax S |
Year: |
2017 |
Journal: |
Am J Physiol Lung Cell Mol Physiol |
Title: |
Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse. |
Volume: |
313 |
Issue: |
6 |
Pages: |
L1016-L1029 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rayes J |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
The podoplanin-CLEC-2 axis inhibits inflammation in sepsis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
2239 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alshehri OM |
Year: |
2015 |
Journal: |
Biochem J |
Title: |
Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. |
Volume: |
468 |
Issue: |
3 |
Pages: |
459-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Osada M |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. |
Volume: |
287 |
Issue: |
26 |
Pages: |
22241-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manne BK |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. |
Volume: |
290 |
Issue: |
18 |
Pages: |
11557-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lorenz V |
Year: |
2015 |
Journal: |
Blood |
Title: |
Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. |
Volume: |
125 |
Issue: |
26 |
Pages: |
4069-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sung PS |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. |
Volume: |
10 |
Issue: |
1 |
Pages: |
2402 |
|
•
•
•
•
•
|
Publication |
First Author: |
Finney BA |
Year: |
2012 |
Journal: |
Blood |
Title: |
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. |
Volume: |
119 |
Issue: |
7 |
Pages: |
1747-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan Y |
Year: |
2014 |
Journal: |
Blood |
Title: |
Podoplanin requires sialylated O-glycans for stable expression on lymphatic endothelial cells and for interaction with platelets. |
Volume: |
124 |
Issue: |
24 |
Pages: |
3656-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hughes CE |
Year: |
2015 |
Journal: |
Blood |
Title: |
The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. |
Volume: |
125 |
Issue: |
1 |
Pages: |
144-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki-Inoue K |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. |
Volume: |
285 |
Issue: |
32 |
Pages: |
24494-507 |
|
•
•
•
•
•
|
Publication |
First Author: |
Navarro-Núñez L |
Year: |
2015 |
Journal: |
Thromb Haemost |
Title: |
Platelet adhesion to podoplanin under flow is mediated by the receptor CLEC-2 and stabilised by Src/Syk-dependent platelet signalling. |
Volume: |
113 |
Issue: |
5 |
Pages: |
1109-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mazharian A |
Year: |
2012 |
Journal: |
Sci Signal |
Title: |
Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. |
Volume: |
5 |
Issue: |
248 |
Pages: |
ra78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Séverin S |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. |
Volume: |
286 |
Issue: |
6 |
Pages: |
4107-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hitchcock JR |
Year: |
2015 |
Journal: |
J Clin Invest |
Title: |
Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets. |
Volume: |
125 |
Issue: |
12 |
Pages: |
4429-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Malehmir M |
Year: |
2019 |
Journal: |
Nat Med |
Title: |
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. |
Volume: |
25 |
Issue: |
4 |
Pages: |
641-655 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haining EJ |
Year: |
2017 |
Journal: |
Platelets |
Title: |
Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. |
Volume: |
28 |
Issue: |
7 |
Pages: |
629-642 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lowe KL |
Year: |
2015 |
Journal: |
Blood |
Title: |
Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. |
Volume: |
125 |
Issue: |
24 |
Pages: |
3769-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2018 |
Journal: |
Development |
Title: |
Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels. |
Volume: |
145 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tang C |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. |
Volume: |
11 |
Issue: |
20 |
Pages: |
9791-9804 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsukiji N |
Year: |
2018 |
Journal: |
Blood |
Title: |
Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction. |
Volume: |
132 |
Issue: |
11 |
Pages: |
1167-1179 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoover C |
Year: |
2021 |
Journal: |
Blood |
Title: |
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. |
Volume: |
137 |
Issue: |
20 |
Pages: |
2756-2769 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mutant Mouse Regional Resource Centers |
Year: |
2004 |
Journal: |
Unpublished |
Title: |
Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Coulpier F |
Year: |
2009 |
Journal: |
Glia |
Title: |
Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. |
Volume: |
57 |
Issue: |
13 |
Pages: |
1450-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang T |
Year: |
2010 |
Journal: |
Nat Biotechnol |
Title: |
A mouse knockout library for secreted and transmembrane proteins. |
Volume: |
28 |
Issue: |
7 |
Pages: |
749-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lexicon Genetics, Inc |
Year: |
2011 |
Journal: |
Database Download |
Title: |
MGI download of Lexicon knockout data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lennon G |
Year: |
1999 |
Journal: |
Database Download |
Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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|
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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|
•
•
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•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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|
•
•
•
•
•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
•
•
•
•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
•
•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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|
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
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|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
C-type lectin domain family 1, member b; targeted mutation 1.2, Consortium for Functional Glycomics |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
C-type lectin domain family 9, member a; targeted mutation 1.2, Consortium for Functional Glycomics |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
C-type lectin domain family 1, member b; targeted mutation 1, Mark L Kahn |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
C-type lectin domain family 1, member b; targeted mutation 1.1, Consortium for Functional Glycomics |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
C-type lectin domain family 9, member a; targeted mutation 1.1, Consortium for Functional Glycomics |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Clec1b/Clec1b |
Background: |
involves: 129S4/SvJae * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|