|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 211 for Clp1

<< First    < Previous  |  Next >    Last >>
0.019s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_13
Specimen Label: euxassay_003330_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_14
Specimen Label: euxassay_003330_14
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_15
Specimen Label: euxassay_003330_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_16
Specimen Label: euxassay_003330_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_17
Specimen Label: euxassay_003330_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_18
Specimen Label: euxassay_003330_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_19
Specimen Label: euxassay_003330_19
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_20
Specimen Label: euxassay_003330_20
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_21
Specimen Label: euxassay_003330_21
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_22
Specimen Label: euxassay_003330_22
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_23
Specimen Label: euxassay_003330_23
Detected: true
Specimen Num: 23
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:1380298
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1831123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823933
Age: embryonic day 14.5
Image: euxassay_003330_24
Specimen Label: euxassay_003330_24
Detected: true
Specimen Num: 24
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795320
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8296
Specimen Label: GUDMAP:8296
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2917320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8293
Specimen Label: GUDMAP:8293
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760520
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8296
Specimen Label: GUDMAP:8296
Detected: false
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737517
Stage: TS17
Assay Id: MGI:5540828
Age: embryonic day 10.5
Image: GUDMAP:8292
Specimen Label: GUDMAP:8292
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797320
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8293
Specimen Label: GUDMAP:8293
Detected: false
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3087020
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8294
Specimen Label: GUDMAP:8294
Detected: false
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3053620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8293
Specimen Label: GUDMAP:8293
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:2892420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8295
Specimen Label: GUDMAP:8295
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4846017
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540828
Age: embryonic day 12.5
Image: GUDMAP:8295
Specimen Label: GUDMAP:8295
Detected: true
Specimen Num: 4
•
•
•
•
•
Publication
21491542 | J:171615
First Author: Georgas KM
Year: 2011
Journal: Dev Dyn
Title: Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Volume: 240
Issue: 6
Pages: 1600-12
•
•
•
•
•
Publication
- | J:342612
       
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
•
•
•
•
•
Publication
19334288 | J:148410
First Author: Combes AN
Year: 2009
Journal: Dev Dyn
Title: Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Volume: 238
Issue: 5
Pages: 1033-41
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 1
Description: Polyribonucleotide 5'-hydroxyl-kinase Clp1
Type: chain
End: 425
•
•
•
•
•
HT Experiment
E-GEOD-35924 | CLP1 links tRNA metabolism to progressive motor-neuron loss
Series Id: GSE35924
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein
Q8R409
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
•
•
•
•
•
Publication
22216186 | -
First Author: Holbein S
Year: 2011
Journal: PLoS One
Title: The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation.
Volume: 6
Issue: 12
Pages: e29139
•
•
•
•
•
Publication
21993299 | -
First Author: Ghazy MA
Year: 2012
Journal: Nucleic Acids Res
Title: The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.
Volume: 40
Issue: 3
Pages: 1214-25
•
•
•
•
•
Protein
Q8K4Q8
Organism: Mus musculus/domesticus
Length: 742  
Fragment?: false
•
•
•
•
•
Protein Coding Gene
MGI:2385923 | Hexim1
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Allele
Clp1<tm1.1Pngr> | MGI:5554792
Name: CLP1, cleavage and polyadenylation factor I subunit; targeted mutation 1.1, Josef M Penninger
Allele Type: Targeted
Attribute String: Not Specified
•
•
•
•
•
Allele
Clp1<em1Slac> | MGI:6759435
Name: CLP1, cleavage and polyadenylation factor I subunit; endonuclease-mediated mutation 1, Susan L Ackerman
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
•
•
•
•
•
Genotype
Genotype
Symbol: Clp1/Clp1
Background: CBA.Cg-Clp1
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
DO Term
DOID:0060279 | pontocerebellar hypoplasia type 10
•
•
•
•
•
Genotype
Genotype
Symbol: Clp1/Clp1
Background: C57BL/6J-Clp1/J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Clp1/Clp1
Background: C57BL/6J-Clp1/Clp1
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR010655 | Clp1_C
Type: Domain
Description: The yeast Clp1 is a subunit of cleavage factor IA (CF IA) and is involved in mRNA cleavage and polyadenylation []. Clp1 also mediates interactions between CF IA and another complex of the yeast mRNA cleavage and polyadenylation machinery, the Cleavage-Polyadenylation Factor (CPF) []. It seems that human Clp1 and yeast Clp1 are not functional orthologues []. Human Clp1, and its archeal homologue [], but not yeast Clp1, are 5'-OH polynucleotide kinases. In humans Clp1 functions as a RNA kinase important in tRNA splicing [, ], and is also implicated in mRNA and siRNA maturation [, , ].This entry represents the C-terminal domain of Clp1.
•
•
•
•
•
Publication
19299550 | -
First Author: Jain R
Year: 2009
Journal: RNA
Title: Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1.
Volume: 15
Issue: 5
Pages: 923-31
•
•
•
•
•
Publication
17495927 | -
First Author: Weitzer S
Year: 2007
Journal: Nature
Title: The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.
Volume: 447
Issue: 7141
Pages: 222-6
•
•
•
•
•
Publication
17786051 | -
First Author: Weitzer S
Year: 2007
Journal: Cell Cycle
Title: hClp1: a novel kinase revitalizes RNA metabolism.
Volume: 6
Issue: 17
Pages: 2133-7
•
•
•
•
•
Protein Domain
IPR038238 | Clp1_C_sf
Type: Homologous_superfamily
Description: The yeast Clp1 is a subunit of cleavage factor IA (CF IA) and is involved in mRNA cleavage and polyadenylation []. Clp1 also mediates interactions between CF IA and another complex of the yeast mRNA cleavage and polyadenylation machinery, the Cleavage-Polyadenylation Factor (CPF) []. It seems that human Clp1 and yeast Clp1 are not functional orthologues []. Human Clp1, and its archeal homologue [], but not yeast Clp1, are 5'-OH polynucleotide kinases. In humans Clp1 functions as a RNA kinase important in tRNA splicing [, ], and is also implicated in mRNA and siRNA maturation [, , ].Clp1 contains three domains, a small N-terminal beta sandwich domain, a C-terminal domain containing a novel alpha/β-fold and a central domain that binds ATP []. This entry represents the Clp1 C-terminal domain superfamily.
•
•
•
•
•
Publication
20814424 | -
First Author: Braglia P
Year: 2010
Journal: EMBO Rep
Title: Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I.
Volume: 11
Issue: 10
Pages: 758-64
•
•
•
•
•
Publication
21063389 | -
First Author: Heindl K
Year: 2010
Journal: EMBO J
Title: Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing.
Volume: 29
Issue: 24
Pages: 4161-71
•
•
•
•
•
Protein Domain
IPR045116 | Clp1/Grc3
Type: Family
Description: This entry includes Clp1 and Grc3/NOL9.Polyribonucleotide 5-hydroxyl-kinase Clp1 is a component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation []. It is involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation []. Human Clp1 can also function as a tRNA splicing enzyme [, ]. In human, mutations in Clp1 affect tRNA biogenesis and lead to impairment of both peripheral and central nervous system function, causing severe motor-sensory defects, cortical dysgenesis and microcephaly [].Grc3 and its homologue, NOL9, are polynucleotide 5'-kinases involved in rRNA processing [, ].
•
•
•
•
•
Publication
15109492 | -
First Author: Paushkin SV
Year: 2004
Journal: Cell
Title: Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.
Volume: 117
Issue: 3
Pages: 311-21
•
•
•
•
•
Protein Domain
IPR038239 | Clp1_N_sf
Type: Homologous_superfamily
Description: Clp1 function involves some degree of adenine or guanine nucleotide binding and participates in the 3' end processing of mRNAs in eukaryotes []. Both human Clp1 (hsClp1) and Saccharomyces cerevisiae Clp1 (scClp1) were identified as components of the pre-mRNA 3end-processing machinery. Whereas hsClp1 was shown to also be part of the tRNA endonuclease complex, scClp1 exclusively contributes to mRNA maturation and appears to be enzymatically inactive.Clp1 contains three domains, a small N-terminal beta sandwich domain, a C-terminal domain containing a novel alpha/β-fold and a central domain that binds ATP [, ]. This entry represents the N-terminal domain involved in DNA binding [].
•
•
•
•
•
Protein Domain
IPR032324 | Clp1_N
Type: Domain
Description: Clp1 function involves some degree of adenine or guanine nucleotide binding and participates in the 3' end processing of mRNAs in eukaryotes []. Both human Clp1 (hsClp1) and Saccharomyces cerevisiae Clp1 (scClp1) were identified as components of the pre-mRNA 3end-processing machinery. WhereashsClp1 was shown to also be part of the tRNA endonuclease complex, scClp1 exclusively contributes to mRNA maturation and appears to be enzymatically inactive.Clp1 contains three domains, a small N-terminal beta sandwich domain involved in DNA binding [], a C-terminal domain containing a novel alpha/β-fold and a central domain that binds ATP [, ]. This entry represents the short N-terminal domain of the pre-mRNA cleavage complex II protein Clp1.
•
•
•
•
•
Protein Domain
IPR032319 | CLP1_P
Type: Domain
Description: This entry represents the P-loop containing domain of Clp1, a mRNA cleavage and polyadenylation factor. Clp1 is essential for 3'-end processing of mRNAs. This domain carries the P-loop suggesting it is the region that binds adenine or guanine nucleotide [].
•
•
•
•
•
Publication
24813946 | -
First Author: Dikfidan A
Year: 2014
Journal: Mol Cell
Title: RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.
Volume: 54
Issue: 6
Pages: 975-86
•
•
•
•
•
Publication
24508575 | -
 
First Author: Dupin AF
Year: 2014
Journal: Biochimie
Title: Structural basis for ATP loss by Clp1p in a G135R mutant protein.
Volume: 101
Pages: 203-7
•
•
•
•
•
Publication
17151076 | -
First Author: Noble CG
Year: 2007
Journal: Nucleic Acids Res
Title: Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.
Volume: 35
Issue: 1
Pages: 87-99
•
•
•
•
•
Protein
Q3TZX8
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
•
•
•
•
•
Publication
17375192 | J:129336
First Author: Rathinam C
Year: 2007
Journal: PLoS One
Title: Transcriptional repressor Gfi1 integrates cytokine-receptor signals controlling B-cell differentiation.
Volume: 2
Issue: 3
Pages: e306
•
•
•
•
•
Protein
A5HLW0
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: true
•
•
•
•
•
Protein
Q8R2P5
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: true
•
•
•
•
•
Protein
Q99KH9
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: true
•
•
•
•
•
Protein
A5HLW1
Organism: Mus musculus/domesticus
Length: 1254  
Fragment?: true
•
•
•
•
•
Protein
F6UFZ5
Organism: Mus musculus/domesticus
Length: 1476  
Fragment?: true
•
•
•
•
•
Protein
Q8K0S1
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: true
•
•
•
•
•
Protein
Q6PCW0
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR045154 | PCF11-like
Type: Family
Description: This entry includes Pcf11 and related proteins from animals, fungi and plants.PCF11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [, , ]. It has been reported that PCF11-mediated termination is essential for vertebrate development and its own levels are maintained by an auto-regulatory mechanism involving premature termination of its transcript []. PCF11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [, ].
•
•
•
•
•
Protein Domain
IPR021605 | CFIA_Pcf11_C
Type: Domain
Description: This entry represents the Clp1-interacting domain of Pcf11, found towards the C-terminal end of these proteins.PCF11 is a subunit and essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination [, , ]. It has been reported that PCF11-mediated termination is essential for vertebrate development and its own levels are maintained by an auto-regulatory mechanism involving premature termination of its transcript []. PCF11 binds to Clp1, another subunit of CFIA whose interaction is responsible for maintaining a tight coupling between the Clp1 nucleotide binding subunit and the other components of the polyadenylation machinery [, ].
•
•
•
•
•
Publication
12727883 | -
First Author: Sadowski M
Year: 2003
Journal: EMBO J
Title: Independent functions of yeast Pcf11p in pre-mRNA 3' end processing and in transcription termination.
Volume: 22
Issue: 9
Pages: 2167-77
•
•
•
•
•
Publication
30819644 | -
First Author: Kamieniarz-Gdula K
Year: 2019
Journal: Mol Cell
Title: Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination.
Volume: 74
Issue: 1
Pages: 158-172.e9
•
•
•
•
•
Publication
30139799 | -
First Author: Schäfer P
Year: 2018
Journal: RNA
Title: Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.
Volume: 24
Issue: 12
Pages: 1721-1737
•
•
•
•
•
Publication
32143824 | J:306312
First Author: Inoue M
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2.
Volume: 525
Issue: 3
Pages: 726-732
•
•
•
•
•
Publication
18923139 | -
First Author: Waples WG
Year: 2009
Journal: Mol Biol Cell
Title: Putting the brake on FEAR: Tof2 promotes the biphasic release of Cdc14 phosphatase during mitotic exit.
Volume: 20
Issue: 1
Pages: 245-55
•
•
•
•
•
Publication
18595708 | -
First Author: Geil C
Year: 2008
Journal: Curr Biol
Title: A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis.
Volume: 18
Issue: 13
Pages: 1001-5
•
•
•
•
•
Publication
24006256 | -
First Author: Yu ZY
Year: 2013
Journal: J Cell Sci
Title: Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase.
Volume: 126
Issue: Pt 21
Pages: 4995-5004
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom