|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 236 for Clps

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
HT Sample
GSM7233098
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 1
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Sample
GSM7233099
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 1
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Sample
GSM7233100
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 1
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Sample
GSM7233104
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Sample
GSM7233105
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Sample
GSM7233106
Organism Name: mouse, laboratory
Sex: Not Specified
Age: postnatal month 3
Stage: 28
Structure . Name: bone marrow
Notes: Ly6d- CLPs
Curation Status: Curated
•
•
•
•
•
HT Experiment
GSE230723 | The initial age-associated decline in early T-cell progenitors reflects fewer pre-thymic progenitors and altered signals in the bone marrow and thymus microenvironments
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
•
•
•
•
•
Protein Domain
IPR003769 | ClpS_core
Type: Domain
Description: In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [].ClpS is a small alpha/beta protein that consists of three α-helices connected to three antiparallel β-strands []. The protein has a globular shape, with a curved layer of three antiparallel α-helices over a twisted antiparallel β-sheet. Dimerization of ClpS may occur through its N-terminal domain. This short extended N-terminal region in ClpS is followed by the central seven-residue β-strand, which is flanked by two other β-strands in a small β-sheet.
•
•
•
•
•
Publication
19770039 | -
First Author: Mouton L
Year: 2009
Journal: Res Microbiol
Title: Identification of a polymorphic collagen-like protein in the crustacean bacteria Pasteuria ramosa.
Volume: 160
Issue: 10
Pages: 792-9
•
•
•
•
•
Protein Domain
IPR031929 | CLP_mid
Type: Domain
Description: This domain is the conserved central region of bacterial collagen-like proteins (CLPs). Similar to animal collagens, bacterial CLPs contain the G-X-Y repeat motifs []. They are involved in pathogenicity, immune response elicitation and host-parasite interactions, possibly evolving as mimics of host proteins containing G-X-Y motifs [].
•
•
•
•
•
Publication
19833765 | J:154864
First Author: Inlay MA
Year: 2009
Journal: Genes Dev
Title: Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Volume: 23
Issue: 20
Pages: 2376-81
•
•
•
•
•
Publication
12514733 | J:127026
First Author: Allman D
Year: 2003
Journal: Nat Immunol
Title: Thymopoiesis independent of common lymphoid progenitors.
Volume: 4
Issue: 2
Pages: 168-74
•
•
•
•
•
Publication
11931773 | -
First Author: Dougan DA
Year: 2002
Journal: Mol Cell
Title: ClpS, a substrate modulator of the ClpAP machine.
Volume: 9
Issue: 3
Pages: 673-83
•
•
•
•
•
Publication
15358624 | J:96514
First Author: Nemeth MJ
Year: 2005
Journal: Blood
Title: Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors.
Volume: 105
Issue: 2
Pages: 627-34
•
•
•
•
•
Publication
18927436 | J:144570
First Author: Serwold T
Year: 2009
Journal: Blood
Title: Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Volume: 113
Issue: 4
Pages: 807-15
•
•
•
•
•
Publication
31434684 | J:282740
First Author: Liu B
Year: 2019
Journal: J Exp Med
Title: Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.
Volume: 216
Issue: 11
Pages: 2653-2668
•
•
•
•
•
Publication
15767371 | J:97990
First Author: Dias S
Year: 2005
Journal: J Exp Med
Title: Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors.
Volume: 201
Issue: 6
Pages: 971-9
•
•
•
•
•
Publication
21874025 | J:176454
First Author: Ota N
Year: 2011
Journal: Nat Immunol
Title: IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
Volume: 12
Issue: 10
Pages: 941-8
•
•
•
•
•
Publication
35603175 | J:325056
 
First Author: Peña-Pérez L
Year: 2022
Journal: Front Immunol
Title: FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors.
Volume: 13
Pages: 880668
•
•
•
•
•
Publication
21808010 | J:175608
First Author: Barber CL
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells.
Volume: 108
Issue: 33
Pages: 13700-4
•
•
•
•
•
Publication
24145513 | J:207729
First Author: Chen YL
Year: 2013
Journal: J Exp Med
Title: A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
Volume: 210
Issue: 12
Pages: 2515-22
•
•
•
•
•
Publication
31442915 | J:290454
 
First Author: Edrees MAH
Year: 2019
Journal: Mol Immunol
Title: Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis.
Volume: 114
Pages: 314-322
•
•
•
•
•
Publication
16365147 | J:118827
First Author: Borghesi L
Year: 2005
Journal: J Exp Med
Title: E47 is required for V(D)J recombinase activity in common lymphoid progenitors.
Volume: 202
Issue: 12
Pages: 1669-77
•
•
•
•
•
Publication
25326751 | J:260242
First Author: Sutherland TE
Year: 2014
Journal: Nat Immunol
Title: Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.
Volume: 15
Issue: 12
Pages: 1116-25
•
•
•
•
•
Publication
15385956 | J:93308
First Author: Zeng H
Year: 2004
Journal: EMBO J
Title: Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.
Volume: 23
Issue: 20
Pages: 4116-25
•
•
•
•
•
Publication
27068476 | J:235178
First Author: Ghaedi M
Year: 2016
Journal: Cell Rep
Title: Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development.
Volume: 15
Issue: 3
Pages: 471-480
•
•
•
•
•
Publication
25344725 | J:254162
First Author: Itoh-Nakadai A
Year: 2014
Journal: Nat Immunol
Title: The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Volume: 15
Issue: 12
Pages: 1171-80
•
•
•
•
•
Publication
11927910 | J:76234
First Author: Gounari F
Year: 2002
Journal: Nat Immunol
Title: Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Volume: 3
Issue: 5
Pages: 489-96
•
•
•
•
•
Publication
16407117 | J:105665
First Author: Hsu CL
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.
Volume: 103
Issue: 3
Pages: 672-7
•
•
•
•
•
Publication
33436573 | J:300887
First Author: Fougeroux C
Year: 2021
Journal: Nat Commun
Title: Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Volume: 12
Issue: 1
Pages: 324
•
•
•
•
•
Publication
21726633 | -
First Author: McElroy K
Year: 2011
Journal: Res Microbiol
Title: Characterisation of a large family of polymorphic collagen-like proteins in the endospore-forming bacterium Pasteuria ramosa.
Volume: 162
Issue: 7
Pages: 701-14
•
•
•
•
•
Protein
Q3TKQ2
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: true
•
•
•
•
•
Protein
Q497M7
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: true
•
•
•
•
•
Protein
Q3V1R9
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: true
•
•
•
•
•
Publication
16945912 | J:113745
First Author: Nemeth MJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation.
Volume: 103
Issue: 37
Pages: 13783-8
•
•
•
•
•
Publication
12208884 | J:119428
First Author: Miller JP
Year: 2002
Journal: J Exp Med
Title: The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7.
Volume: 196
Issue: 5
Pages: 705-11
•
•
•
•
•
Publication
19246338 | J:148420
First Author: Vogt TK
Year: 2009
Journal: Blood
Title: Novel function for interleukin-7 in dendritic cell development.
Volume: 113
Issue: 17
Pages: 3961-8
•
•
•
•
•
Publication
24205225 | J:209230
First Author: Medina KL
Year: 2013
Journal: PLoS One
Title: Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.
Volume: 8
Issue: 10
Pages: e78408
•
•
•
•
•
Publication
16301633 | J:122144
First Author: Yang GX
Year: 2005
Journal: J Immunol
Title: Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.
Volume: 175
Issue: 11
Pages: 7281-7
•
•
•
•
•
Publication
17244677 | J:132963
First Author: Sanyal M
Year: 2007
Journal: Blood
Title: B-cell development fails in the absence of the Pbx1 proto-oncogene.
Volume: 109
Issue: 10
Pages: 4191-9
•
•
•
•
•
Publication
14769852 | J:119401
First Author: Borghesi L
Year: 2004
Journal: J Exp Med
Title: B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.
Volume: 199
Issue: 4
Pages: 491-502
•
•
•
•
•
Publication
21652681 | J:176937
First Author: Tsapogas P
Year: 2011
Journal: Blood
Title: IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Volume: 118
Issue: 5
Pages: 1283-90
•
•
•
•
•
Publication
18714008 | J:138947
First Author: Zandi S
Year: 2008
Journal: J Immunol
Title: EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors.
Volume: 181
Issue: 5
Pages: 3364-72
•
•
•
•
•
Publication
23213261 | J:323799
First Author: Mansson R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.
Volume: 109
Issue: 51
Pages: 21028-33
•
•
•
•
•
Publication
23230003 | J:194616
First Author: Yu Y
Year: 2012
Journal: J Exp Med
Title: Bcl11a is essential for lymphoid development and negatively regulates p53.
Volume: 209
Issue: 13
Pages: 2467-83
•
•
•
•
•
Publication
17940206 | J:130688
First Author: Kuo YH
Year: 2008
Journal: Blood
Title: Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
Volume: 111
Issue: 3
Pages: 1543-51
•
•
•
•
•
Publication
25676235 | J:229734
First Author: Yokota T
Year: 2015
Journal: Eur J Immunol
Title: Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy.
Volume: 45
Issue: 5
Pages: 1390-401
•
•
•
•
•
Publication
24357619 | J:206388
First Author: Liu B
Year: 2014
Journal: EMBO J
Title: PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells.
Volume: 33
Issue: 2
Pages: 101-13
•
•
•
•
•
Publication
17664352 | J:150332
First Author: Ishikawa F
Year: 2007
Journal: Blood
Title: The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.
Volume: 110
Issue: 10
Pages: 3591-660
•
•
•
•
•
Publication
27681176 | J:239336
First Author: Gasco S
Year: 2016
Journal: Am J Physiol Cell Physiol
Title: Hematopoietic stem and progenitor cells as novel prognostic biomarkers of longevity in a murine model for amyotrophic lateral sclerosis.
Volume: 311
Issue: 6
Pages: C910-C919
•
•
•
•
•
Publication
29323738 | J:307405
First Author: Lu X
Year: 2018
Journal: J Cell Biochem
Title: An epididymis-specific secretory protein Clpsl2 critically regulates sperm motility, acrosomal integrity, and male fertility.
Volume: 119
Issue: 6
Pages: 4760-4774
•
•
•
•
•
Protein
O70481
Organism: Mus musculus/domesticus
Length: 1757  
Fragment?: false
•
•
•
•
•
Protein
Q6WKZ8
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
•
•
•
•
•
Protein
Q3UHE0
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
•
•
•
•
•
Protein
Q3UPU3
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
•
•
•
•
•
Protein
Q2M4I1
Organism: Mus musculus/domesticus
Length: 1757  
Fragment?: false
•
•
•
•
•
Publication
16311597 | J:105229
First Author: Zenker M
Year: 2005
Journal: Nat Genet
Title: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Volume: 37
Issue: 12
Pages: 1345-50
•
•
•
•
•
Publication
29649217 | -
First Author: Chitturi J
Year: 2018
Journal: PLoS Genet
Title: The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
Volume: 14
Issue: 4
Pages: e1007303
•
•
•
•
•
Publication
30117535 | -
First Author: Vicente J
Year: 2019
Journal: New Phytol
Title: Distinct branches of the N-end rule pathway modulate the plant immune response.
Volume: 221
Issue: 2
Pages: 988-1000
•
•
•
•
•
Protein Domain
IPR044046 | E3_ligase_UBR-like_C
Type: Domain
Description: UBR box family is a unique class of E3 ligases that recognise N-degrons or structurally related determinants for ubiquitin-dependent proteolysis. They belong to the N-end rule pathway which relates the identity of the N-terminal residue of a protein with its half-life, recognising destabilising ones. Some of the functions of this pathway include the control of peptide import, the fidelity of chromosome segregation, the regulation of apoptosis, as well as regulation of meiosis in yeasts and metazoans, leaf senescence in plants, and cardiovascular development in mammals []. These proteins contain an N-terminal UBR box (a substrate-binding domain), which is highly conserved among UBR family members, a cysteine- and histidine-rich RING (RING-H2) domain, which is present in a larger class of E3 ubiquitin ligases and some additional domains that vary among UBR family members, like these described in UBR1 []: ClpS, a region of sequence similarity to prokaryotic ClpS which acts as an accessory subunit that contributes to recognition of degrons by the ATP-dependent protease ClpAP, a BRR (basic residue-rich region), a conserved motif that contributes to the binding of yeast UBR1 to the E2 enzyme RAD6, and conserved regions [, , ].This entry represents the C-terminal domain which includes a conserved region found in E3 ubiquitin-protein ligase UBR1, 2, 3 from animals, UBR1/11 from fission yeast, and also in PRT6 from Arabidopsis thaliana [].
•
•
•
•
•
Protein Domain
IPR001223 | Glyco_hydro18_cat
Type: Domain
Description: O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrateand a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.The glycosyl hydrolases family 18 (GH18) is widely distributed in all kingdoms and contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase-like lectins (chi-lectins/proteins (CLPs). Chitinases () are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases () hydrolyze the beta-1,4 linkage in the chitobiose core of N-linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property []. This family also includes glycoproteins from mammals, such as oviduct-specific glycoproteins.The catalytic domain of GH18s has a common (beta/alpha)8 triosephosphate isomerase (TIM)-barrel structure, which consists of a barrel-like framework made from eight internal parallel β-strands that are alternately connected by eight exterior α-helices. The active site motif DxxDxDxE is essential for the activity of the GH18 catalytic domain. [, , ].
•
•
•
•
•
Publication
28704388 | J:244151
First Author: Kurkewich JL
Year: 2017
Journal: PLoS Genet
Title: The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.
Volume: 13
Issue: 7
Pages: e1006887
•
•
•
•
•
Publication
25294623 | J:317248
 
First Author: Ohno M
Year: 2014
Journal: BMC Mol Biol
Title: Establishment of a quantitative PCR system for discriminating chitinase-like proteins: catalytically inactive breast regression protein-39 and Ym1 are constitutive genes in mouse lung.
Volume: 15
Pages: 23
•
•
•
•
•
Publication
22742450 | -
First Author: Schimpl M
Year: 2012
Journal: Biochem J
Title: Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.
Volume: 446
Issue: 1
Pages: 149-57
•
•
•
•
•
Publication
22859955 | -
First Author: Stals I
Year: 2012
Journal: PLoS One
Title: High resolution crystal structure of the endo-N-Acetyl-β-D-glucosaminidase responsible for the deglycosylation of Hypocrea jecorina cellulases.
Volume: 7
Issue: 7
Pages: e40854
•
•
•
•
•
Publication
24380021 | -
First Author: Madhuprakash J
Year: 2013
Journal: Int J Biochem Mol Biol
Title: Structure of chitinase D from Serratia proteamaculans reveals the structural basis of its dual action of hydrolysis and transglycosylation.
Volume: 4
Issue: 4
Pages: 166-78
•
•
•
•
•
Publication
27195754 | -
First Author: Li T
Year: 2016
Journal: PLoS Genet
Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
Volume: 12
Issue: 5
Pages: e1006054
•
•
•
•
•
Protein
B3DFI9
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: true
•
•
•
•
•
Publication
22550243 | -
First Author: Lee CG
Year: 2012
Journal: Proc Am Thorac Soc
Title: Chitinase-like proteins in lung injury, repair, and metastasis.
Volume: 9
Issue: 2
Pages: 57-61
•
•
•
•
•
Publication
8831791 | -
First Author: Terwisscha van Scheltinga AC
Year: 1996
Journal: J Mol Biol
Title: The 1.8 A resolution structure of hevamine, a plant chitinase/lysozyme, and analysis of the conserved sequence and structure motifs of glycosyl hydrolase family 18.
Volume: 262
Issue: 2
Pages: 243-57
•
•
•
•
•
Publication
22796096 | -
First Author: Tzelepis GD
Year: 2012
Journal: Fungal Genet Biol
Title: Functional analysis of glycoside hydrolase family 18 and 20 genes in Neurospora crassa.
Volume: 49
Issue: 9
Pages: 717-30
•
•
•
•
•
Publication
20868765 | -
First Author: Badariotti F
Year: 2011
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Identification of three singular glycosyl hydrolase family 18 members from the oyster Crassostrea gigas: Structural characterization, phylogenetic analysis and gene expression.
Volume: 158
Issue: 1
Pages: 56-63
•
•
•
•
•
Publication
23717482 | -
First Author: Patil DN
Year: 2013
Journal: PLoS One
Title: Structural investigation of a novel N-acetyl glucosamine binding chi-lectin which reveals evolutionary relationship with class III chitinases.
Volume: 8
Issue: 5
Pages: e63779
•
•
•
•
•
Publication
25232743 | -
First Author: Junges Â
Year: 2014
Journal: PLoS One
Title: Genomic analyses and transcriptional profiles of the glycoside hydrolase family 18 genes of the entomopathogenic fungus Metarhizium anisopliae.
Volume: 9
Issue: 9
Pages: e107864
•
•
•
•
•
Publication
20553502 | -
First Author: Tsuji H
Year: 2010
Journal: FEBS J
Title: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus- the role of conserved residues in the active site.
Volume: 277
Issue: 12
Pages: 2683-95
•
•
•
•
•
Protein Domain
IPR001579 | Glyco_hydro_18_chit_AS
Type: Active_site
Description: The glycosyl hydrolases family 18 (GH18) [E1]is widely distributed in all kingdoms, including viruses, bacteria, plants, fungi and animals. The GH18 family contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC ) hydrolyse the beta-1,4 linkage in the chitobiose core of N-linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property. The catalytic domain of GH18s may be connected to one or several substrate binding modules (CBMs), which enhance binding of enzymes to insoluble substrates. Certain GH18s also contain peptide signals for localization such as an N-terminal secretion peptide, a C-terminal glycosyl-phosphatidylinositol (GPI) anchor signal for attachment to the plasma-membrane, or N- or O-linked glycosylation sites for oligosaccharide modifications [, , , , , , , , ].The catalytic domain of GH18s has a common (beta/alpha)8 triosephosphate isomerase (TIM)-barrel structure, which consists of a barrel-like framework made from eight internal parallel β-strands that are alternately connected by eight exterior alpha helices. The active site motifDxxDxDxE is essential for the activity of the GH18 catalytic domain. The Glu (E) in this motif acts as the catalytic proton donor, and the last Asp (D(3))is supposed to contribute to the stabilization of the essential distortion of the substrate [, , , , ].This entry represents the active site of GH18.
•
•
•
•
•
Protein
F6RU51
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
•
•
•
•
•
Protein
D3YWG2
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
•
•
•
•
•
Protein
Q99MJ5
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
•
•
•
•
•
Protein
Q8CJF6
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
•
•
•
•
•
Protein
A0A1B0GSH5
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
•
•
•
•
•
Protein
F7D8T8
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
•
•
•
•
•
Protein
G8JL55
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: true
•
•
•
•
•
Protein
Q9CRU8
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
•
•
•
•
•
Protein
Q9D7Q1
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
•
•
•
•
•
Protein
Q8R242
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom