Type |
Details |
Score |
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
Year: |
2001 |
|
Title: |
LocusLink Collaboration |
|
|
|
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
206
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Cully M |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. |
Volume: |
65 |
Issue: |
22 |
Pages: |
10363-70 |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Publication |
First Author: |
Stetefeld J |
Year: |
2000 |
Journal: |
Nat Struct Biol |
Title: |
Crystal structure of a naturally occurring parallel right-handed coiled coil tetramer. |
Volume: |
7 |
Issue: |
9 |
Pages: |
772-6 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
SO Term |
|
•
•
•
•
•
|
ncRNA Gene |
Type: |
antisense_lncRNA_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Peters J |
Year: |
1996 |
Journal: |
J Mol Biol |
Title: |
Hyperthermostable surface layer protein tetrabrachion from the archaebacterium Staphylothermus marinus: evidence for the presence of a right-handed coiled coil derived from the primary structure. |
Volume: |
257 |
Issue: |
5 |
Pages: |
1031-41 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Bloor S |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Signal processing by its coil zipper domain activates IKK gamma. |
Volume: |
105 |
Issue: |
4 |
Pages: |
1279-84 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogawa S |
Year: |
1998 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. |
Volume: |
251 |
Issue: |
2 |
Pages: |
515-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Still IH |
Year: |
2004 |
Journal: |
BMC Evol Biol |
Title: |
Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. |
Volume: |
4 |
|
Pages: |
16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Omori K |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Girdin is phosphorylated on tyrosine 1798 when associated with structures required for migration. |
Volume: |
458 |
Issue: |
4 |
Pages: |
934-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng L |
Year: |
2018 |
Journal: |
PLoS Biol |
Title: |
Negative regulation of amino acid signaling by MAPK-regulated 4F2hc/Girdin complex. |
Volume: |
16 |
Issue: |
3 |
Pages: |
e2005090 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamura Y |
Year: |
2015 |
Journal: |
Cancer Res |
Title: |
Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression. |
Volume: |
75 |
Issue: |
5 |
Pages: |
813-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muramatsu A |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin. |
Volume: |
463 |
Issue: |
4 |
Pages: |
999-1005 |
|
•
•
•
•
•
|
Publication |
First Author: |
Armstrong LC |
Year: |
1999 |
Journal: |
GenBank Submission |
Title: |
Mus musculus short coiled coil protein SCOCO (Scoc) mRNA, complete cds |
|
|
Pages: |
AF115778 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Guyot R |
Year: |
2010 |
Journal: |
BMC Mol Biol |
Title: |
The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR. |
Volume: |
11 |
|
Pages: |
3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pogenberg V |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif. |
Volume: |
48 |
Issue: |
2 |
Pages: |
934-948 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ota H |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA. |
Volume: |
5 |
|
Pages: |
4532 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozbek S |
Year: |
2002 |
Journal: |
EMBO J |
Title: |
Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3). |
Volume: |
21 |
Issue: |
22 |
Pages: |
5960-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
McFarlane A |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
The pentameric channel of COMPcc in complex with different fatty acids. |
Volume: |
7 |
Issue: |
11 |
Pages: |
e48130 |
|
•
•
•
•
•
|
Publication |
First Author: |
Efimov VP |
Year: |
1996 |
Journal: |
Proteins |
Title: |
Crystallization and preliminary crystallographic study of the pentamerizing domain from cartilage oligomeric matrix protein: a five-stranded alpha-helical bundle. |
Volume: |
24 |
Issue: |
2 |
Pages: |
259-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams JC |
Year: |
2011 |
Journal: |
Cold Spring Harb Perspect Biol |
Title: |
The thrombospondins. |
Volume: |
3 |
Issue: |
10 |
Pages: |
a009712 |
|
•
•
•
•
•
|
Publication |
First Author: |
Posey KL |
Year: |
2004 |
Journal: |
Int J Biochem Cell Biol |
Title: |
Role of TSP-5/COMP in pseudoachondroplasia. |
Volume: |
36 |
Issue: |
6 |
Pages: |
1005-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Posey KL |
Year: |
2008 |
Journal: |
Cell Mol Life Sci |
Title: |
Model systems for studying skeletal dysplasias caused by TSP-5/COMP mutations. |
Volume: |
65 |
Issue: |
5 |
Pages: |
687-99 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal coiled coil region of TSP-5, also known as cartilage oligomeric matrix protein (COMP). It forms a pentameric left-handed coiled coil (COMPcc) with a channel that is a unique carrier for lipophilic compounds []. It is known to bind hydrophilic signaling molecules such as vitamin D3 and vitamin A, making it a possible targeted drug delivery system []. TSP-5/COMP is expressed in all types of cartilage as well as in the vitreous of the eye, tendons, vascular smooth muscle cells, and heart. The pentamer is stabilized by inter-subunit disulfide bonds formed between cysteine residues adjacent to the C-terminal end of the coiled coil region []. TSP-5 is essential for modulating the phenotypic transition of vascular smooth muscle cells and vascular remodeling. Mutations in TSP-5 result in two different inherited chondrodysplasias and osteoarthritic phenotypes: pseudoachondroplasia and multiple epithelial dysplasia []. Deficiency of TSP-5 causes dilated cardiomyopathy (DCM), a common cause of congestive heart failure []. Early increase in serum TSP-5 is associated with joint damage progression in patients with rheumatoid arthritis, thus representing a novel indicator of an activated destructive process in the joint []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu Q |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Antiparallel coiled-coil-mediated dimerization of myosin X. |
Volume: |
109 |
Issue: |
43 |
Pages: |
17388-93 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This coiled coil domain is found in unconventional myosin-X and is responsible for its dimerisation [, ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bashford AL |
Year: |
2022 |
Journal: |
Hum Mol Genet |
Title: |
Hippocampals neurogenesis is impaired in mice with a deletion in the coiled coil domain of Talpid3-implications for Joubert syndrome. |
Volume: |
31 |
Issue: |
19 |
Pages: |
3245-3265 |
|
•
•
•
•
•
|
Publication |
First Author: |
Strassel C |
Year: |
2009 |
Journal: |
Haematologica |
Title: |
Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome. |
Volume: |
94 |
Issue: |
6 |
Pages: |
800-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pritchard C |
Year: |
2006 |
Journal: |
Genome Biol |
Title: |
The contributions of normal variation and genetic background to mammalian gene expression. |
Volume: |
7 |
Issue: |
3 |
Pages: |
R26 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, African clawed |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyake H |
Year: |
2011 |
Journal: |
Circ Res |
Title: |
The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury. |
Volume: |
108 |
Issue: |
10 |
Pages: |
1170-9 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Stefancsik R |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Identification and mutagenesis of a highly conserved domain in troponin T responsible for troponin I binding: potential role for coiled coil interaction. |
Volume: |
95 |
Issue: |
3 |
Pages: |
957-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nie S |
Year: |
2016 |
Journal: |
Structure |
Title: |
Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. |
Volume: |
24 |
Issue: |
1 |
Pages: |
80-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nejsum LN |
Year: |
2005 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
NKCC1 and NHE1 are abundantly expressed in the basolateral plasma membrane of secretory coil cells in rat, mouse, and human sweat glands. |
Volume: |
289 |
Issue: |
2 |
Pages: |
C333-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nahorski MS |
Year: |
2016 |
Journal: |
Brain |
Title: |
CCDC88A mutations cause PEHO-like syndrome in humans and mouse. |
Volume: |
139 |
Issue: |
Pt 4 |
Pages: |
1036-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakai T |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. |
Volume: |
34 |
Issue: |
45 |
Pages: |
14995-5008 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito T |
Year: |
2013 |
Journal: |
Am J Pathol |
Title: |
Girdin and its phosphorylation dynamically regulate neonatal vascular development and pathological neovascularization in the retina. |
Volume: |
182 |
Issue: |
2 |
Pages: |
586-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burkhard P |
Year: |
2000 |
Journal: |
Structure |
Title: |
The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. |
Volume: |
8 |
Issue: |
3 |
Pages: |
223-30 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is predominantly found in the actin-bundling protein cortexillin I and II from Dictyostelium discoideum (Slime mold). The domain has a structure consisting of an 18-heptad-repeat α-helical coiled-coil, and is a prerequisite for the assembly of Cortexillin I []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
66
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Swanson L |
Year: |
2020 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin. |
Volume: |
117 |
Issue: |
43 |
Pages: |
26895-26906 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitamura T |
Year: |
2008 |
Journal: |
Nat Cell Biol |
Title: |
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. |
Volume: |
10 |
Issue: |
3 |
Pages: |
329-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamakawa T |
Year: |
2020 |
Journal: |
Bone |
Title: |
Novel gene Merlot inhibits differentiation and promotes apoptosis of osteoclasts. |
Volume: |
138 |
|
Pages: |
115494 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang R |
Year: |
2003 |
Journal: |
FEBS Lett |
Title: |
Homodimerization through coiled-coil regions enhances activity of the myotonic dystrophy protein kinase. |
Volume: |
546 |
Issue: |
2-3 |
Pages: |
281-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found in the myotonic dystrophy protein kinase (DMPK) and adopts a coiled coil structure. It plays a role in dimerisation []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Asai M |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Similar phenotypes of Girdin germ-line and conditional knockout mice indicate a crucial role for Girdin in the nestin lineage. |
Volume: |
426 |
Issue: |
4 |
Pages: |
533-8 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|